GREMLIN Database
YEDS - Putative outer membrane protein YedS
UniProt: P76335 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14042
Length: 397 (327)
Sequences: 5460 (3885)
Seq/√Len: 214.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_Y60_G3.8751.00
63_G75_G3.5131.00
318_Y346_K3.4491.00
72_T103_G3.4221.00
76_Q99_F3.2501.00
64_E72_T3.2011.00
74_Y101_G3.1091.00
264_V306_Y2.9641.00
156_N168_F2.8701.00
366_Y387_D2.7191.00
219_A253_W2.5221.00
270_Y298_Q2.4741.00
312_L352_A2.4711.00
121_D153_T2.4521.00
154_Y157_N2.4491.00
40_G83_A2.4001.00
38_V83_A2.3901.00
62_K76_Q2.3601.00
272_E298_Q2.3201.00
74_Y109_T2.3171.00
74_Y111_D2.3061.00
320_Q346_K2.3041.00
313_R355_Y2.2851.00
170_L205_M2.2701.00
217_L257_A2.2661.00
223_N251_E2.2551.00
118_V171_Q2.2521.00
356_F362_T2.2271.00
353_T361_S2.2081.00
34_L61_F2.1931.00
168_F207_T2.1911.00
361_S394_V2.1411.00
308_F314_P2.1341.00
97_L116_Y2.0551.00
16_A20_N2.0191.00
162_L167_N2.0061.00
261_A266_L1.9671.00
118_V169_A1.9641.00
103_G109_T1.9631.00
151_V171_Q1.9441.00
167_N208_S1.9201.00
71_F102_L1.9141.00
35_Y78_E1.8951.00
312_L354_Y1.8921.00
114_R149_N1.8901.00
219_A255_V1.8821.00
71_F106_Q1.8791.00
84_N176_N1.8681.00
35_Y76_Q1.8101.00
37_K58_R1.7611.00
360_M395_Y1.7231.00
362_T393_L1.7091.00
110_F152_A1.6941.00
112_Y152_A1.6931.00
370_L385_T1.6801.00
39_V363_Y1.6721.00
79_F93_T1.6621.00
92_N149_N1.6301.00
314_P352_A1.6201.00
221_Y253_W1.5981.00
305_Q313_R1.5951.00
74_Y103_G1.5901.00
263_N306_Y1.5801.00
35_Y62_K1.5781.00
157_N163_V1.5741.00
257_A268_A1.5591.00
58_R78_E1.5571.00
361_S396_Q1.5381.00
215_L259_Y1.5361.00
58_R96_R1.5341.00
267_A303_V1.5331.00
67_I73_G1.5311.00
80_N96_R1.5231.00
359_N395_Y1.5181.00
223_N249_T1.4961.00
155_R169_A1.4591.00
59_I79_F1.4491.00
266_L304_A1.4491.00
66_Q70_Q1.4421.00
311_G352_A1.4231.00
217_L255_V1.4221.00
211_F214_G1.4161.00
368_I385_T1.4161.00
34_L59_I1.4121.00
72_T105_G1.3981.00
111_D153_T1.3651.00
82_G87_E1.3641.00
78_E96_R1.3551.00
258_K267_A1.3521.00
318_Y348_V1.3501.00
307_Q313_R1.3471.00
152_A174_G1.3461.00
111_D155_R1.3441.00
107_N154_Y1.3191.00
55_S394_V1.3071.00
122_V218_G1.3051.00
108_G154_Y1.3031.00
126_T216_S1.3021.00
368_I387_D1.3001.00
173_Q202_G1.2961.00
269_M301_E1.2941.00
111_D115_N1.2931.00
76_Q97_L1.2841.00
210_D216_S1.2831.00
115_N151_V1.2811.00
74_Y99_F1.2781.00
92_N95_T1.2631.00
97_L115_N1.2631.00
148_A202_G1.2601.00
41_L53_D1.2571.00
264_V304_A1.2421.00
90_K95_T1.2271.00
214_G259_Y1.2241.00
65_T357_N1.2241.00
317_A349_D1.2231.00
304_A316_I1.2191.00
258_K265_Y1.2071.00
171_Q204_G1.2031.00
260_D265_Y1.2001.00
43_Y390_A1.1991.00
71_F107_N1.1981.00
151_V173_Q1.1961.00
172_Y203_F1.1821.00
107_N110_F1.1821.00
311_G355_Y1.1821.00
272_E296_K1.1801.00
316_I348_V1.1741.00
156_N165_G1.1741.00
215_L257_A1.1681.00
364_V391_V1.1561.00
79_F88_S1.1531.00
260_D263_N1.1511.00
371_L383_I1.1501.00
96_R147_R1.1421.00
119_V220_A1.1401.00
253_W272_E1.1351.00
66_Q72_T1.1331.00
264_V268_A1.1321.00
109_T153_T1.1271.00
309_D312_L1.1221.00
41_L390_A1.1181.00
37_K396_Q1.1121.00
268_A300_F1.1121.00
64_E74_Y1.1101.00
10_V13_L1.1031.00
73_G100_A1.1031.00
32_L75_G1.1031.00
308_F312_L1.0991.00
38_V81_I1.0981.00
320_Q344_L1.0921.00
268_A302_V1.0871.00
221_Y251_E1.0861.00
99_F111_D1.0791.00
363_Y392_G1.0771.00
71_F105_G1.0751.00
216_S258_K1.0701.00
17_G20_N1.0621.00
299_N321_S1.0601.00
166_L211_F1.0591.00
345_V369_N1.0561.00
351_G365_D1.0451.00
148_A151_V1.0431.00
344_L372_D1.0351.00
153_T171_Q1.0311.00
4_K8_M1.0301.00
46_D387_D1.0291.00
315_S353_T1.0271.00
58_R147_R1.0231.00
345_V371_L1.0231.00
364_V389_V1.0221.00
322_K344_L1.0201.00
77_W94_A1.0131.00
170_L203_F1.0091.00
315_S351_G1.0081.00
167_N210_D1.0061.00
206_S220_A1.0031.00
254_T271_A1.0001.00
348_V368_I0.9991.00
70_Q105_G0.9971.00
77_W98_A0.9961.00
7_A10_V0.9931.00
64_E103_G0.9911.00
303_V317_A0.9911.00
166_L207_T0.9781.00
119_V252_A0.9731.00
129_L351_G0.9701.00
316_I350_I0.9611.00
40_G84_N0.9591.00
31_K64_E0.9581.00
57_A81_I0.9571.00
260_D307_Q0.9521.00
65_T359_N0.9471.00
6_L10_V0.9441.00
128_M317_A0.9421.00
298_Q324_K0.9390.99
117_G148_A0.9350.99
360_M393_L0.9300.99
122_V206_S0.9280.99
119_V254_T0.9220.99
260_D306_Y0.9200.99
355_Y361_S0.9180.99
170_L207_T0.9140.99
54_M361_S0.9090.99
73_G102_L0.9090.99
308_F352_A0.9000.99
157_N162_L0.8990.99
37_K394_V0.8920.99
263_N307_Q0.8910.99
55_S396_Q0.8900.99
128_M305_Q0.8890.99
173_Q176_N0.8810.99
39_V52_G0.8780.99
169_A206_S0.8770.99
65_T360_M0.8700.99
115_N153_T0.8670.99
15_V18_A0.8670.99
80_N95_T0.8640.99
176_N179_G0.8630.99
129_L315_S0.8620.99
128_M303_V0.8610.99
301_E319_L0.8600.99
30_N65_T0.8570.99
11_P16_A0.8550.99
41_L55_S0.8520.99
122_V208_S0.8510.99
86_P94_A0.8490.99
297_T321_S0.8480.99
60_G78_E0.8470.99
265_Y305_Q0.8470.99
356_F360_M0.8460.99
267_A305_Q0.8430.99
55_S361_S0.8420.99
156_N170_L0.8410.99
9_L12_A0.8400.99
218_G256_G0.8370.99
103_G106_Q0.8250.99
118_V220_A0.8240.99
33_D62_K0.8240.99
8_M11_P0.8230.99
82_G85_G0.8230.99
308_F311_G0.8220.99
349_D367_K0.8210.99
366_Y389_V0.8190.99
68_A357_N0.8150.99
250_A273_T0.8130.99
298_Q322_K0.8110.99
47_D386_D0.8100.99
265_Y307_Q0.8050.98
300_F322_K0.8050.98
122_V155_R0.8040.98
99_F115_N0.8010.98
65_T68_A0.7990.98
353_T394_V0.7960.98
118_V204_G0.7920.98
299_N319_L0.7910.98
118_V206_S0.7870.98
88_S93_T0.7850.98
116_Y120_Y0.7780.98
155_R167_N0.7750.98
305_Q315_S0.7740.98
253_W298_Q0.7740.98
313_R353_T0.7720.98
162_L210_D0.7690.98
16_A19_A0.7690.98
132_F135_D0.7620.98
371_L375_D0.7620.98
121_D155_R0.7620.98
203_F207_T0.7610.98
5_V8_M0.7590.98
148_A171_Q0.7560.98
153_T169_A0.7540.98
119_V204_G0.7530.98
273_T297_T0.7520.98
129_L317_A0.7490.98
126_T256_G0.7460.97
7_A11_P0.7440.97
125_W208_S0.7390.97
59_I93_T0.7380.97
66_Q69_D0.7370.97
8_M12_A0.7370.97
128_M301_E0.7360.97
274_R296_K0.7280.97
65_T395_Y0.7250.97
150_G176_N0.7250.97
198_E225_D0.7120.97
5_V9_L0.7110.97
377_F380_A0.7080.97
46_D383_I0.7050.96
270_Y300_F0.7050.96
109_T155_R0.7040.96
84_N150_G0.7030.96
60_G96_R0.7030.96
311_G354_Y0.7020.96
261_A264_V0.7010.96
114_R147_R0.6990.96
310_F354_Y0.6990.96
301_E317_A0.6990.96
3_R6_L0.6980.96
4_K7_A0.6970.96
179_G196_S0.6940.96
30_N66_Q0.6900.96
9_L13_L0.6900.96
58_R80_N0.6850.96
365_D390_A0.6840.96
15_V20_N0.6800.96
123_E254_T0.6780.96
350_I366_Y0.6770.96
133_G136_T0.6710.95
117_G204_G0.6710.95
204_G222_X0.6710.95
105_G154_Y0.6700.95
370_L384_A0.6700.95
168_F205_M0.6680.95
116_Y147_R0.6640.95
323_G343_D0.6630.95
178_S196_S0.6610.95
391_V395_Y0.6590.95
100_A357_N0.6530.95
122_V169_A0.6530.95
70_Q106_Q0.6510.94
208_S218_G0.6500.94
4_K15_V0.6500.94
59_I81_I0.6490.94
45_S388_I0.6480.94
352_A364_V0.6480.94
154_Y163_V0.6470.94
214_G261_A0.6470.94
91_G95_T0.6470.94
344_L370_L0.6470.94
82_G89_D0.6450.94
80_N94_A0.6440.94
137_Y140_A0.6430.94
43_Y388_I0.6400.94
35_Y96_R0.6340.94
67_I70_Q0.6330.94
32_L63_G0.6330.94
250_A275_N0.6290.93
228_D231_V0.6290.93
80_N147_R0.6260.93
347_Y369_N0.6210.93
105_G110_F0.6210.93
4_K9_L0.6210.93
212_D259_Y0.6190.93
296_K322_K0.6180.93
201_D225_D0.6170.93
349_D365_D0.6160.93
65_T73_G0.6150.93
9_L15_V0.6110.92
44_F387_D0.6100.92
29_G33_D0.6090.92
90_K93_T0.6070.92
56_Y116_Y0.6060.92
172_Y201_D0.6030.92
6_L11_P0.6030.92
129_L135_D0.6030.92
101_G111_D0.6010.92
53_D390_A0.5990.92
10_V106_Q0.5980.92
157_N165_G0.5980.92
202_G224_S0.5960.91
41_L363_Y0.5930.91
319_L347_Y0.5930.91
6_L13_L0.5920.91
44_F389_V0.5900.91
107_N157_N0.5890.91
348_V370_L0.5870.91
126_T267_A0.5870.91
156_N163_V0.5870.91
178_S198_E0.5850.91
296_K324_K0.5850.91
79_F94_A0.5830.91
348_V385_T0.5810.90
375_D383_I0.5800.90
5_V13_L0.5800.90
12_A20_N0.5790.90
321_S345_V0.5790.90
2_K5_V0.5790.90
4_K11_P0.5770.90
127_D133_G0.5770.90
300_F304_A0.5750.90
131_E135_D0.5750.90
112_Y115_N0.5730.90
43_Y367_K0.5730.90
307_Q311_G0.5730.90
136_T146_G0.5720.90
29_G66_Q0.5710.90
51_D83_A0.5710.90
127_D132_F0.5710.90
40_G43_Y0.5690.89
57_A83_A0.5660.89
328_G343_D0.5640.89
253_W270_Y0.5620.89
148_A173_Q0.5620.89
165_G209_Y0.5610.89
357_N360_M0.5600.89
204_G251_E0.5600.89
6_L9_L0.5590.89
44_F368_I0.5580.89
85_G94_A0.5580.89
53_D56_Y0.5580.89
353_T396_Q0.5570.88
32_L65_T0.5550.88
56_Y95_T0.5530.88
67_I360_M0.5530.88
65_T75_G0.5530.88
93_T98_A0.5530.88
197_K201_D0.5500.88
157_N164_D0.5490.88
156_N166_L0.5490.88
211_F257_A0.5480.88
357_N395_Y0.5460.88
271_A297_T0.5460.88
269_M303_V0.5440.87
255_V270_Y0.5430.87
54_M351_G0.5430.87
211_F215_L0.5420.87
74_Y153_T0.5420.87
66_Q358_K0.5410.87
145_N222_X0.5380.87
142_N220_A0.5380.87
139_G142_N0.5370.87
41_L392_G0.5350.86
40_G44_F0.5350.86
56_Y80_N0.5350.86
275_N297_T0.5340.86
346_K372_D0.5340.86
171_Q202_G0.5340.86
392_G397_F0.5320.86
3_R10_V0.5320.86
306_Y312_L0.5320.86
350_I364_V0.5310.86
95_T98_A0.5310.86
123_E269_M0.5310.86
129_L136_T0.5300.86
138_A141_D0.5290.86
156_N167_N0.5290.86
177_E199_N0.5280.86
58_R97_L0.5280.86
307_Q355_Y0.5270.86
216_S219_A0.5270.86
157_N167_N0.5260.86
117_G222_X0.5260.86
154_Y168_F0.5260.86
216_S260_D0.5260.86
176_N196_S0.5250.85
275_N278_P0.5240.85
264_V308_F0.5230.85
295_N325_D0.5220.85
40_G390_A0.5220.85
54_M353_T0.5210.85
300_F320_Q0.5190.85
10_V15_V0.5180.85
75_G94_A0.5170.85
211_F217_L0.5160.84
102_L105_G0.5160.84
175_N179_G0.5150.84
199_N226_R0.5140.84
132_F136_T0.5140.84
52_G83_A0.5140.84
79_F98_A0.5130.84
56_Y130_P0.5130.84
7_A13_L0.5120.84
108_G157_N0.5120.84
12_A15_V0.5120.84
5_V17_G0.5120.84
346_K370_L0.5120.84
31_K34_L0.5120.84
232_G246_G0.5110.84
385_T388_I0.5110.84
31_K63_G0.5100.84
6_L12_A0.5100.84
325_D372_D0.5080.84
134_G365_D0.5080.84
89_D95_T0.5070.83
271_A299_N0.5070.83
73_G360_M0.5070.83
319_L349_D0.5060.83
214_G219_A0.5050.83
54_M394_V0.5040.83
367_K388_I0.5040.83
271_A301_E0.5040.83
178_S197_K0.5040.83
4_K16_A0.5030.83
165_G211_F0.5020.83
88_S92_N0.5020.83
211_F219_A0.5010.83
68_A395_Y0.5010.83
101_G109_T0.5000.83
52_G57_A0.5000.83
297_T323_G0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j1nA 3 0.8615 100 0.313 Contact Map
1phoA 3 0.8186 100 0.316 Contact Map
3nsgA 3 0.8388 100 0.316 Contact Map
2zfgA 3 0.8262 100 0.334 Contact Map
2fgqX 3 0.7683 100 0.347 Contact Map
3vy8X 3 0.8111 100 0.369 Contact Map
3wi5A 3 0.7506 100 0.403 Contact Map
2porA 3 0.733 100 0.44 Contact Map
3prnA 3 0.6826 100 0.455 Contact Map
2o4vA 3 0.8539 99.3 0.802 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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