GREMLIN Database
YEDQ - Probable diguanylate cyclase YedQ
UniProt: P76330 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14040
Length: 564 (438)
Sequences: 2219 (1949)
Seq/√Len: 93.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
468_R471_D6.3521.00
433_I523_L6.3281.00
387_M391_Q5.0521.00
412_L482_C4.4951.00
439_H555_R4.2341.00
431_S527_S4.0821.00
396_W400_H3.8131.00
433_I497_A3.7721.00
529_E532_G3.7311.00
498_E501_R3.5341.00
535_D538_Q3.2841.00
550_A559_F3.2211.00
454_R457_S2.9521.00
505_N556_N2.8831.00
425_T468_R2.7741.00
467_L473_A2.7631.00
501_R558_V2.7351.00
504_L521_A2.6791.00
434_Q547_L2.6721.00
245_D249_Y2.6671.00
520_S556_N2.6221.00
407_Y411_A2.6111.00
419_L422_L2.6111.00
267_L271_I2.5841.00
459_A504_L2.5071.00
544_D548_Y2.5051.00
416_A536_F2.4901.00
412_L484_I2.4681.00
493_A497_A2.4361.00
498_E502_L2.4171.00
485_L496_V2.4091.00
178_S182_F2.3871.00
438_D522_S2.1911.00
449_H544_D2.1831.00
431_S493_A2.1531.00
458_H461_G2.1421.00
450_Q541_S2.1231.00
462_L508_E2.1181.00
243_P252_G2.1111.00
415_K472_V2.0631.00
532_G542_L2.0431.00
388_Y391_Q2.0361.00
455_V519_I2.0261.00
441_K445_D2.0181.00
406_L460_A2.0011.00
445_D548_Y2.0011.00
411_A415_K1.9951.00
437_L521_A1.9941.00
407_Y472_V1.9891.00
525_V558_V1.9611.00
391_Q395_Q1.9531.00
449_H548_Y1.9481.00
277_G382_R1.9281.00
443_I455_V1.9001.00
392_S395_Q1.8961.00
488_A492_E1.8911.00
305_R353_G1.8791.00
267_L272_D1.8651.00
489_S492_E1.8601.00
497_A525_V1.8301.00
463_I473_A1.8221.00
501_R505_N1.8181.00
437_L459_A1.8021.00
479_E520_S1.7931.00
283_D287_R1.7921.00
411_A472_V1.7701.00
441_K544_D1.7691.00
478_G544_D1.7691.00
479_E547_L1.7441.00
437_L456_L1.7071.00
140_L144_N1.7021.00
463_I500_I1.6651.00
553_A559_F1.6621.00
529_E542_L1.6441.00
434_Q482_C1.6371.00
436_D548_Y1.6361.00
441_K449_H1.6331.00
478_G548_Y1.6221.00
280_Q288_F1.6101.00
412_L474_G1.6101.00
455_V509_M1.6051.00
435_V483_V1.6031.00
369_F373_L1.5801.00
449_H480_E1.5581.00
437_L520_S1.5541.00
243_P250_W1.5361.00
501_R556_N1.5331.00
541_S545_R1.5171.00
384_V388_Y1.5041.00
445_D544_D1.5001.00
301_I305_R1.4961.00
455_V479_E1.4851.00
449_H478_G1.4821.00
439_H479_E1.4791.00
443_I517_I1.4631.00
531_T542_L1.4611.00
441_K548_Y1.4511.00
434_Q479_E1.4481.00
477_G548_Y1.4451.00
549_L552_Q1.4431.00
419_L486_P1.4330.99
477_G544_D1.4320.99
384_V391_Q1.4250.99
435_V523_L1.4240.99
280_Q379_V1.4230.99
399_W410_G1.4160.99
436_D445_D1.4160.99
458_H462_L1.4150.99
411_A414_E1.4070.99
292_S383_M1.4060.99
266_F271_I1.3870.99
433_I483_V1.3850.99
438_D554_G1.3840.99
443_I511_I1.3780.99
301_I353_G1.3620.99
204_T230_H1.3550.99
479_E555_R1.3550.99
440_F456_L1.3520.99
425_T471_D1.3500.99
461_G464_S1.3320.99
445_D449_H1.3270.99
514_S517_I1.3260.99
547_L555_R1.3230.99
436_D441_K1.3230.99
406_L473_A1.3100.99
480_E544_D1.3100.99
435_V521_A1.3090.99
419_L430_F1.3070.99
483_V500_I1.3070.99
436_D544_D1.3030.99
390_L397_Q1.2970.99
447_F515_T1.2770.99
501_R520_S1.2700.99
497_A558_V1.2660.99
550_A554_G1.2560.99
263_M267_L1.2530.99
339_G346_T1.2470.99
439_H547_L1.2460.99
359_S385_S1.2420.99
393_S397_Q1.2400.98
414_E472_V1.2400.98
361_A382_R1.2270.98
431_S488_A1.2260.98
383_M387_M1.2170.98
292_S295_D1.2150.98
245_D251_Y1.2010.98
383_M391_Q1.1960.98
528_S532_G1.1960.98
444_N452_G1.1770.98
437_L479_E1.1760.98
531_T560_A1.1750.98
480_E548_Y1.1700.98
445_D478_G1.1680.98
413_F476_V1.1630.98
476_V479_E1.1600.98
529_E539_L1.1570.98
550_A557_R1.1500.98
442_A446_R1.1470.97
437_L478_G1.1450.97
391_Q394_L1.1330.97
522_S544_D1.1280.97
158_G162_R1.1220.97
202_Y208_F1.1200.97
455_V474_G1.1190.97
175_M255_G1.1170.97
278_E292_S1.1120.97
548_Y555_R1.1060.97
264_Q267_L1.1050.97
423_C430_F1.1010.97
327_R331_W1.0990.97
415_K418_P1.0970.97
278_E381_R1.0950.97
430_F539_L1.0950.97
378_Y381_R1.0930.97
488_A493_A1.0880.97
144_N147_L1.0780.96
463_I467_L1.0730.96
428_H487_G1.0690.96
527_S560_A1.0680.96
133_L137_G1.0680.96
292_S385_S1.0640.96
526_S539_L1.0590.96
522_S548_Y1.0550.96
462_L509_M1.0540.96
316_H319_R1.0540.96
419_L472_V1.0520.96
366_W376_S1.0440.96
132_A143_E1.0430.96
412_L432_V1.0380.95
447_F455_V1.0350.95
494_A558_V1.0320.95
266_F272_D1.0300.95
414_E418_P1.0250.95
128_G131_D1.0240.95
445_D480_E1.0210.95
400_H479_E1.0200.95
208_F253_V1.0200.95
455_V511_I1.0190.95
352_R356_G1.0180.95
201_G204_T1.0060.95
258_I263_M1.0030.95
511_I517_I1.0010.94
549_L553_A1.0000.94
462_L511_I0.9960.94
224_F239_T0.9960.94
497_A523_L0.9920.94
157_V161_L0.9890.94
549_L559_F0.9860.94
352_R355_F0.9860.94
434_Q540_Q0.9790.94
434_Q476_V0.9750.94
466_S499_R0.9720.94
133_L144_N0.9710.94
416_A484_I0.9680.93
508_E511_I0.9680.93
479_E558_V0.9640.93
397_Q443_I0.9640.93
399_W411_A0.9630.93
520_S554_G0.9600.93
443_I509_M0.9590.93
178_S184_V0.9560.93
137_G140_L0.9550.93
362_L379_V0.9550.93
281_L376_S0.9530.93
365_L378_Y0.9430.93
526_S542_L0.9430.93
386_N389_V0.9430.93
446_R541_S0.9410.92
526_S532_G0.9370.92
467_L496_V0.9360.92
390_L394_L0.9320.92
176_Y181_G0.9260.92
439_H442_A0.9260.92
281_L292_S0.9250.92
451_A511_I0.9200.92
468_R499_R0.9180.91
337_F340_V0.9150.91
438_D544_D0.9140.91
351_V354_D0.9130.91
475_R480_E0.9060.91
364_L377_W0.9050.91
265_Q268_R0.9040.91
208_F252_G0.9030.91
268_R273_K0.9030.91
129_V136_E0.8960.90
542_L561_S0.8950.90
361_A387_M0.8930.90
410_G479_E0.8900.90
395_Q399_W0.8820.90
476_V540_Q0.8800.90
136_E139_L0.8800.90
181_G186_T0.8790.90
160_L163_L0.8780.90
526_S529_E0.8780.90
282_Y288_F0.8740.89
440_F459_A0.8720.89
434_Q455_V0.8720.89
476_V482_C0.8710.89
454_R513_K0.8710.89
129_V133_L0.8700.89
239_T257_S0.8690.89
438_D548_Y0.8690.89
312_Q319_R0.8680.89
372_M383_M0.8640.89
202_Y207_W0.8640.89
496_V499_R0.8620.89
442_A479_E0.8600.89
445_D477_G0.8590.89
114_W118_L0.8580.88
451_A517_I0.8580.88
199_Y202_Y0.8570.88
400_H411_A0.8550.88
355_F359_S0.8500.88
309_L313_A0.8490.88
161_L164_A0.8490.88
400_H547_L0.8480.88
466_S503_K0.8480.88
223_W226_S0.8430.88
223_W227_Q0.8400.87
160_L164_A0.8360.87
509_M519_I0.8350.87
430_F528_S0.8330.87
402_T410_G0.8320.87
498_E558_V0.8280.87
522_S554_G0.8270.87
436_D551_K0.8260.87
302_F305_R0.8250.86
441_K480_E0.8230.86
407_Y415_K0.8220.86
278_E298_T0.8210.86
425_T470_Q0.8190.86
300_N355_F0.8120.86
142_R145_E0.8100.85
352_R358_I0.8100.85
474_G482_C0.8100.85
154_A158_G0.8080.85
467_L483_V0.8070.85
459_A463_I0.8070.85
479_E556_N0.8070.85
477_G555_R0.8070.85
459_A519_I0.8060.85
494_A498_E0.8060.85
329_V333_R0.7970.85
528_S539_L0.7970.85
528_S531_T0.7970.85
389_V393_S0.7970.85
455_V476_V0.7950.84
319_R323_R0.7930.84
473_A483_V0.7910.84
468_R488_A0.7870.84
432_V539_L0.7870.84
412_L540_Q0.7860.84
438_D441_K0.7850.84
436_D449_H0.7840.84
156_E161_L0.7840.84
449_H522_S0.7830.83
409_R453_D0.7800.83
236_P239_T0.7800.83
510_L516_T0.7800.83
291_S296_H0.7780.83
178_S181_G0.7770.83
335_D339_G0.7760.83
417_R536_F0.7760.83
473_A500_I0.7760.83
485_L493_A0.7750.83
175_M183_Y0.7720.83
432_V540_Q0.7720.83
393_S396_W0.7720.83
137_G144_N0.7710.83
462_L501_R0.7710.83
400_H407_Y0.7690.82
398_A477_G0.7670.82
115_K119_N0.7640.82
282_Y377_W0.7640.82
410_G555_R0.7630.82
466_S500_I0.7610.82
398_A547_L0.7590.82
311_A315_E0.7550.81
436_D477_G0.7550.81
433_I525_V0.7540.81
111_E114_W0.7530.81
131_D134_V0.7510.81
479_E548_Y0.7500.81
387_M390_L0.7480.81
135_S138_N0.7480.81
224_F238_V0.7480.81
544_D555_R0.7470.80
504_L519_I0.7430.80
350_G354_D0.7420.80
528_S547_L0.7420.80
318_T359_S0.7420.80
437_L547_L0.7410.80
398_A544_D0.7370.80
478_G522_S0.7350.79
532_G539_L0.7340.79
415_K419_L0.7320.79
201_G207_W0.7310.79
274_N277_G0.7260.79
479_E511_I0.7250.78
277_G281_L0.7250.78
236_P242_V0.7240.78
268_R272_D0.7230.78
125_P130_S0.7220.78
206_P209_I0.7190.78
397_Q410_G0.7170.78
451_A454_R0.7170.78
462_L479_E0.7170.78
211_H241_S0.7160.78
229_E233_N0.7160.78
200_Y204_T0.7150.78
480_E522_S0.7150.78
438_D445_D0.7150.78
133_L136_E0.7140.77
132_A136_E0.7130.77
501_R523_L0.7130.77
254_L259_P0.7120.77
278_E383_M0.7110.77
140_L148_D0.7080.77
241_S253_V0.7080.77
277_G361_A0.7080.77
468_R496_V0.7060.77
441_K478_G0.7030.76
444_N478_G0.7030.76
415_K484_I0.7030.76
288_F328_Y0.7020.76
201_G205_Q0.7020.76
409_R449_H0.7010.76
396_W479_E0.7010.76
366_W374_L0.7000.76
440_F554_G0.7000.76
447_F479_E0.6990.76
531_T539_L0.6960.76
438_D449_H0.6920.75
113_A116_I0.6890.75
227_Q239_T0.6890.75
128_G140_L0.6880.75
493_A527_S0.6860.75
291_S299_G0.6840.74
212_S250_W0.6820.74
420_A430_F0.6810.74
438_D555_R0.6800.74
522_S551_K0.6780.74
435_V463_I0.6780.74
394_L399_W0.6780.74
403_L452_G0.6760.73
181_G208_F0.6750.73
479_E517_I0.6740.73
438_D478_G0.6740.73
407_Y474_G0.6720.73
354_D358_I0.6720.73
222_R226_S0.6700.73
399_W547_L0.6670.73
422_L425_T0.6660.72
432_V526_S0.6660.72
316_H320_G0.6650.72
128_G132_A0.6650.72
384_V387_M0.6650.72
361_A365_L0.6640.72
492_E495_E0.6640.72
477_G480_E0.6640.72
377_W381_R0.6640.72
493_A525_V0.6620.72
113_A119_N0.6610.72
171_V187_Q0.6600.72
282_Y311_A0.6590.72
176_Y244_V0.6580.71
124_L132_A0.6570.71
441_K453_D0.6550.71
201_G226_S0.6550.71
419_L425_T0.6550.71
168_S187_Q0.6540.71
436_D478_G0.6520.71
445_D551_K0.6510.71
362_L365_L0.6490.70
237_Q257_S0.6480.70
544_D551_K0.6480.70
355_F358_I0.6480.70
478_G547_L0.6460.70
327_R340_V0.6440.70
463_I483_V0.6430.70
436_D475_R0.6430.70
204_T236_P0.6420.70
174_A256_M0.6420.70
454_R458_H0.6390.69
452_G478_G0.6380.69
311_A316_H0.6370.69
240_V243_P0.6370.69
355_F383_M0.6370.69
476_V547_L0.6370.69
490_L530_E0.6360.69
453_D544_D0.6340.69
125_P136_E0.6330.69
475_R478_G0.6300.68
136_E140_L0.6300.68
436_D453_D0.6300.68
210_G214_R0.6300.68
489_S557_R0.6290.68
240_V252_G0.6290.68
440_F550_A0.6280.68
376_S380_I0.6270.68
141_S148_D0.6260.68
398_A440_F0.6250.68
235_E259_P0.6220.67
175_M181_G0.6220.67
339_G354_D0.6190.67
511_I547_L0.6190.67
226_S229_E0.6180.67
295_D306_E0.6180.67
112_H115_K0.6170.67
327_R339_G0.6150.66
453_D475_R0.6150.66
122_R130_S0.6140.66
468_R548_Y0.6140.66
173_Q257_S0.6120.66
207_W230_H0.6100.66
288_F364_L0.6100.66
221_V234_T0.6100.66
442_A520_S0.6100.66
138_N142_R0.6090.66
305_R309_L0.6090.66
203_V208_F0.6090.66
143_E162_R0.6070.65
497_A554_G0.6070.65
430_F484_I0.6070.65
238_V252_G0.6070.65
267_L273_K0.6060.65
132_A146_S0.6040.65
554_G557_R0.6040.65
205_Q209_I0.6040.65
420_A532_G0.6030.65
413_F474_G0.6030.65
278_E385_S0.6020.65
350_G359_S0.6010.65
393_S456_L0.6010.65
400_H410_G0.6000.64
383_M386_N0.5990.64
281_L378_Y0.5990.64
443_I519_I0.5980.64
311_A317_D0.5980.64
299_G306_E0.5970.64
351_V355_F0.5970.64
324_M328_Y0.5970.64
173_Q187_Q0.5960.64
275_L385_S0.5960.64
405_R460_A0.5940.64
415_K474_G0.5900.63
459_A509_M0.5900.63
421_K469_A0.5900.63
204_T226_S0.5880.63
291_S301_I0.5870.63
221_V225_T0.5870.63
434_Q520_S0.5860.63
432_V450_Q0.5860.63
229_E234_T0.5860.63
279_Y292_S0.5850.62
159_Y163_L0.5840.62
132_A141_S0.5830.62
545_R556_N0.5830.62
303_D307_L0.5830.62
438_D520_S0.5820.62
153_A161_L0.5810.62
449_H477_G0.5810.62
167_S171_V0.5810.62
441_K522_S0.5800.62
398_A441_K0.5790.62
161_L167_S0.5780.62
141_S144_N0.5770.61
247_N251_Y0.5770.61
290_T303_D0.5770.61
294_P297_P0.5770.61
128_G135_S0.5760.61
460_A473_A0.5740.61
327_R337_F0.5730.61
353_G358_I0.5710.61
453_D478_G0.5710.61
136_E143_E0.5710.61
394_L486_P0.5700.61
430_F434_Q0.5670.60
243_P256_M0.5660.60
467_L471_D0.5660.60
142_R169_S0.5660.60
499_R504_L0.5650.60
257_S262_T0.5640.60
399_W414_E0.5640.60
383_M388_Y0.5630.60
174_A187_Q0.5620.59
398_A434_Q0.5620.59
323_R343_R0.5610.59
132_A135_S0.5610.59
436_D480_E0.5600.59
314_M318_T0.5600.59
113_A117_E0.5600.59
495_E499_R0.5590.59
209_I302_F0.5580.59
452_G551_K0.5570.59
404_T456_L0.5570.59
158_G161_L0.5570.59
224_F264_Q0.5560.59
529_E535_D0.5540.58
278_E295_D0.5530.58
176_Y255_G0.5520.58
438_D480_E0.5520.58
504_L509_M0.5520.58
331_W379_V0.5520.58
264_Q268_R0.5520.58
132_A148_D0.5510.58
547_L558_V0.5500.58
116_I119_N0.5500.58
400_H560_A0.5480.58
413_F537_E0.5470.57
390_L499_R0.5470.57
479_E501_R0.5470.57
159_Y162_R0.5470.57
323_R327_R0.5450.57
133_L162_R0.5450.57
447_F476_V0.5440.57
293_N297_P0.5440.57
479_E544_D0.5420.57
314_M353_G0.5420.57
183_Y186_T0.5410.57
208_F250_W0.5410.57
211_H243_P0.5400.56
282_Y555_R0.5400.56
328_Y332_E0.5400.56
445_D522_S0.5390.56
301_I351_V0.5390.56
434_Q523_L0.5390.56
466_S496_V0.5380.56
399_W407_Y0.5380.56
177_V183_Y0.5380.56
182_F201_G0.5370.56
445_D555_R0.5370.56
196_P200_Y0.5370.56
296_H299_G0.5360.56
291_S295_D0.5350.56
295_D381_R0.5350.56
211_H222_R0.5330.55
553_A557_R0.5330.55
183_Y241_S0.5330.55
124_L144_N0.5330.55
403_L444_N0.5320.55
134_V138_N0.5320.55
455_V547_L0.5310.55
522_S550_A0.5300.55
404_T444_N0.5300.55
523_L550_A0.5290.55
310_L316_H0.5290.55
129_V141_S0.5270.55
483_V497_A0.5260.54
500_I509_M0.5250.54
171_V256_M0.5250.54
382_R387_M0.5240.54
503_K506_E0.5220.54
538_Q542_L0.5220.54
475_R548_Y0.5210.54
188_P424_Q0.5210.54
548_Y551_K0.5210.54
266_F281_L0.5200.54
450_Q454_R0.5200.54
175_M206_P0.5200.54
520_S555_R0.5190.54
380_I383_M0.5190.54
299_G337_F0.5190.54
143_E161_L0.5190.54
297_P470_Q0.5180.53
471_D492_E0.5180.53
135_S145_E0.5170.53
311_A319_R0.5170.53
335_D342_V0.5150.53
393_S442_A0.5150.53
205_Q208_F0.5140.53
422_L470_Q0.5130.53
394_L422_L0.5120.53
400_H437_L0.5120.53
122_R143_E0.5100.52
320_G328_Y0.5100.52
352_R357_S0.5100.52
161_L198_R0.5090.52
123_T127_N0.5080.52
406_L463_I0.5080.52
128_G136_E0.5080.52
524_G543_A0.5070.52
435_V476_V0.5070.52
411_A419_L0.5070.52
557_R560_A0.5050.52
465_S503_K0.5040.51
444_N453_D0.5040.51
436_D452_G0.5030.51
256_M259_P0.5030.51
423_C528_S0.5030.51
320_G324_M0.5020.51
178_S187_Q0.5010.51
223_W243_P0.5010.51
458_H509_M0.5010.51
362_L366_W0.5010.51
447_F547_L0.5000.51
301_I355_F0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.727 100 0.546 Contact Map
4j40A 2 0 100 0.575 Contact Map
3ezuA 2 0.5603 100 0.579 Contact Map
4h54A 2 0.4823 100 0.587 Contact Map
4rnhA 2 0.2819 100 0.592 Contact Map
3pjxA 1 0.3138 100 0.592 Contact Map
3ignA 1 0.2943 100 0.605 Contact Map
3mtkA 2 0.2819 100 0.608 Contact Map
3breA 4 0.539 100 0.611 Contact Map
3i5cA 2 0.344 100 0.614 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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