GREMLIN Database
MPGP - Putative mannosyl-3-phosphoglycerate phosphatase
UniProt: P76329 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14039
Length: 271 (242)
Sequences: 11656 (9733)
Seq/√Len: 625.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_Q262_E4.3311.00
21_S256_G3.4631.00
211_G225_M3.1151.00
254_R257_P2.9201.00
8_L208_T2.8631.00
222_L228_A2.6661.00
196_I209_T2.6261.00
26_W258_E2.6131.00
28_P258_E2.5951.00
12_S43_V2.4711.00
20_D24_Y2.4081.00
236_R240_H2.4021.00
223_E241_L2.3471.00
47_S54_M2.3291.00
28_P265_D2.3021.00
193_N224_V2.2391.00
206_R224_V2.0771.00
187_G220_P2.0321.00
216_P237_E1.8971.00
27_Q31_P1.8861.00
91_I194_W1.8671.00
219_A241_L1.8301.00
7_P210_L1.8211.00
219_A238_G1.8201.00
35_R38_E1.8071.00
216_P235_N1.8051.00
9_L44_I1.8021.00
253_Q257_P1.7721.00
35_R265_D1.7621.00
36_L41_V1.7131.00
11_F192_A1.7081.00
205_K208_T1.6971.00
229_V263_G1.6931.00
96_S99_E1.6801.00
30_A60_T1.6681.00
230_I242_H1.6621.00
194_W198_T1.6611.00
228_A243_D1.6571.00
193_N197_A1.6271.00
35_R39_A1.6211.00
33_L43_V1.6211.00
236_R239_V1.6201.00
194_W197_A1.6141.00
227_Y243_D1.5801.00
189_D224_V1.5601.00
190_Q193_N1.5601.00
78_L81_Q1.5541.00
238_G241_L1.5431.00
14_L19_L1.5091.00
192_A221_L1.4901.00
31_P35_R1.4831.00
7_P41_V1.4821.00
211_G221_L1.4731.00
11_F46_C1.4581.00
42_P199_Y1.4441.00
93_S194_W1.4431.00
12_S212_L1.4371.00
250_W263_G1.4241.00
7_P208_T1.4131.00
107_L150_I1.4121.00
227_Y250_W1.3961.00
162_T166_N1.3951.00
250_W267_F1.3771.00
212_L260_W1.3721.00
26_W29_A1.3621.00
7_P227_Y1.3551.00
37_R64_Q1.3551.00
78_L82_W1.3501.00
28_P262_E1.3461.00
29_A258_E1.3321.00
99_E102_L1.3191.00
219_A223_E1.3171.00
230_I234_L1.3111.00
201_Q205_K1.3111.00
212_L263_G1.3101.00
32_W261_R1.2911.00
207_P226_D1.2871.00
196_I206_R1.2821.00
30_A34_T1.2741.00
206_R209_T1.2581.00
237_E240_H1.2361.00
92_I144_E1.2331.00
157_R160_Q1.2321.00
97_H101_S1.2291.00
102_L168_L1.2281.00
222_L238_G1.1871.00
93_S183_D1.1841.00
250_W266_H1.1741.00
232_K254_R1.1701.00
159_A163_A1.1691.00
263_G267_F1.1571.00
20_D256_G1.1571.00
260_W264_L1.1421.00
239_V251_R1.1351.00
28_P32_W1.1321.00
44_I195_I1.1321.00
106_T110_K1.1291.00
34_T38_E1.1271.00
67_P199_Y1.1261.00
110_K164_R1.1211.00
187_G190_Q1.1211.00
32_W265_D1.1141.00
211_G222_L1.1051.00
69_I191_A1.1041.00
147_V180_H1.1021.00
210_L267_F1.0971.00
169_G172_F1.0971.00
229_V252_T1.0961.00
11_F209_T1.0921.00
10_V36_L1.0831.00
252_T259_G1.0691.00
209_T225_M1.0661.00
14_L57_L1.0641.00
21_S255_E1.0621.00
9_L201_Q1.0561.00
10_V41_V1.0511.00
92_I146_S1.0511.00
215_G235_N1.0501.00
163_A166_N1.0401.00
210_L229_V1.0391.00
76_I194_W1.0301.00
235_N238_G1.0271.00
9_L196_I1.0251.00
206_R226_D1.0211.00
10_V264_L1.0191.00
169_G173_M1.0171.00
252_T263_G1.0151.00
196_I224_V1.0141.00
262_E266_H1.0131.00
233_G255_E1.0061.00
160_Q163_A1.0001.00
225_M228_A0.9971.00
34_T37_R0.9881.00
195_I199_Y0.9861.00
76_I91_I0.9851.00
137_A140_T0.9821.00
9_L209_T0.9791.00
253_Q259_G0.9771.00
263_G266_H0.9771.00
152_R157_R0.9771.00
106_T109_E0.9761.00
108_R124_A0.9761.00
94_G144_E0.9711.00
234_L239_V0.9701.00
34_T62_G0.9681.00
78_L83_Q0.9651.00
27_Q30_A0.9591.00
74_A186_A0.9591.00
193_N206_R0.9541.00
11_F44_I0.9501.00
261_R265_D0.9491.00
51_S70_A0.9471.00
160_Q164_R0.9441.00
18_L29_A0.9381.00
210_L263_G0.9381.00
155_D159_A0.9241.00
189_D220_P0.9221.00
70_A75_V0.9181.00
182_L187_G0.9171.00
192_A225_M0.9141.00
183_D186_A0.9131.00
12_S260_W0.9071.00
231_V259_G0.9061.00
29_A261_R0.9051.00
196_I201_Q0.9001.00
105_N109_E0.8971.00
229_V250_W0.8971.00
104_L108_R0.8961.00
101_S105_N0.8961.00
159_A162_T0.8931.00
126_I129_W0.8901.00
18_L33_L0.8891.00
230_I238_G0.8831.00
31_P34_T0.8741.00
44_I67_P0.8741.00
69_I195_I0.8721.00
170_L173_M0.8691.00
216_P219_A0.8681.00
210_L227_Y0.8661.00
232_K239_V0.8601.00
102_L105_N0.8591.00
46_C69_I0.8571.00
196_I226_D0.8491.00
76_I191_A0.8471.00
36_L43_V0.8431.00
93_S185_S0.8401.00
98_G102_L0.8391.00
47_S70_A0.8371.00
67_P195_I0.8271.00
50_T71_E0.8231.00
70_A77_Q0.8231.00
10_V210_L0.8161.00
232_K257_P0.8131.00
20_D26_W0.8121.00
231_V252_T0.8101.00
106_T164_R0.8091.00
113_F116_T0.8061.00
12_S18_L0.7961.00
95_I183_D0.7901.00
262_E265_D0.7891.00
209_T226_D0.7841.00
102_L106_T0.7811.00
209_T224_V0.7731.00
158_M162_T0.7721.00
117_T122_D0.7701.00
237_E241_L0.7691.00
232_K253_Q0.7641.00
94_G146_S0.7641.00
128_E131_G0.7611.00
29_A32_W0.7581.00
117_T120_D0.7571.00
80_E83_Q0.7571.00
164_R168_L0.7531.00
116_T122_D0.7511.00
51_S77_Q0.7431.00
226_D243_D0.7431.00
75_V146_S0.7411.00
55_L59_K0.7401.00
152_R158_M0.7401.00
129_W133_S0.7401.00
41_V210_L0.7341.00
28_P261_R0.7341.00
243_D250_W0.7331.00
222_L241_L0.7331.00
192_A211_G0.7311.00
22_H256_G0.7311.00
14_L45_L0.7251.00
250_W262_E0.7231.00
32_W35_R0.7231.00
36_L264_L0.7181.00
54_M68_L0.7161.00
77_Q82_W0.7131.00
234_L238_G0.7101.00
231_V234_L0.7091.00
16_G231_V0.7071.00
149_L180_H0.7051.00
190_Q194_W0.7031.00
67_P78_L0.7001.00
109_E164_R0.6981.00
214_D234_L0.6931.00
186_A190_Q0.6901.00
79_A83_Q0.6871.00
171_Q184_A0.6871.00
114_K122_D0.6801.00
164_R167_E0.6781.00
79_A82_W0.6781.00
18_L25_D0.6771.00
45_L54_M0.6741.00
252_T262_E0.6701.00
141_Q144_E0.6641.00
9_L195_I0.6621.00
20_D255_E0.6621.00
97_H144_E0.6611.00
208_T226_D0.6611.00
126_I131_G0.6601.00
74_A183_D0.6561.00
54_M70_A0.6531.00
253_Q266_H0.6501.00
46_C221_L0.6421.00
71_E74_A0.6421.00
243_D251_R0.6421.00
48_S217_N0.6411.00
193_N196_I0.6411.00
72_N180_H0.6411.00
28_P31_P0.6381.00
98_G101_S0.6381.00
71_E180_H0.6381.00
51_S55_L0.6361.00
110_K160_Q0.6361.00
228_A238_G0.6361.00
130_T133_S0.6331.00
114_K121_V0.6321.00
29_A33_L0.6301.00
238_G242_H0.6301.00
14_L18_L0.6291.00
220_P223_E0.6291.00
67_P79_A0.6281.00
212_L229_V0.6281.00
7_P42_P0.6251.00
68_L79_A0.6221.00
233_G254_R0.6211.00
14_L54_M0.6191.00
133_S136_Q0.6181.00
149_L178_F0.6171.00
233_G239_V0.6161.00
58_Q68_L0.6151.00
131_G134_R0.6131.00
106_T168_L0.6131.00
250_W253_Q0.6111.00
222_L242_H0.6101.00
130_T134_R0.6101.00
189_D193_N0.6091.00
214_D231_V0.6081.00
112_H116_T0.6051.00
137_A141_Q0.6031.00
227_Y263_G0.5911.00
130_T135_S0.5901.00
163_A167_E0.5891.00
129_W134_R0.5871.00
71_E75_V0.5861.00
106_T165_L0.5851.00
211_G228_A0.5851.00
19_L255_E0.5841.00
129_W132_L0.5841.00
230_I241_L0.5831.00
175_G215_G0.5751.00
116_T121_V0.5731.00
25_D30_A0.5731.00
200_Q205_K0.5721.00
18_L45_L0.5701.00
8_L41_V0.5691.00
45_L58_Q0.5691.00
42_P67_P0.5661.00
107_L111_E0.5631.00
18_L255_E0.5621.00
258_E261_R0.5611.00
126_I130_T0.5611.00
100_I104_L0.5601.00
31_P265_D0.5601.00
76_I195_I0.5551.00
71_E178_F0.5541.00
231_V255_E0.5521.00
212_L252_T0.5521.00
37_R65_G0.5521.00
174_Q180_H0.5511.00
228_A242_H0.5511.00
156_E160_Q0.5501.00
155_D176_A0.5501.00
253_Q263_G0.5501.00
258_E262_E0.5481.00
122_D125_T0.5471.00
10_V212_L0.5451.00
32_W36_L0.5440.99
216_P238_G0.5390.99
138_A141_Q0.5380.99
201_Q209_T0.5370.99
71_E146_S0.5360.99
26_W261_R0.5360.99
175_G178_F0.5340.99
41_V208_T0.5300.99
51_S71_E0.5290.99
147_V174_Q0.5290.99
18_L260_W0.5290.99
101_S141_Q0.5270.99
115_F121_V0.5270.99
46_C72_N0.5220.99
92_I118_F0.5210.99
42_P201_Q0.5200.99
50_T53_E0.5180.99
108_R113_F0.5180.99
64_Q67_P0.5160.99
78_L198_T0.5160.99
185_S190_Q0.5160.99
54_M57_L0.5150.99
100_I145_A0.5150.99
37_R62_G0.5140.99
192_A196_I0.5120.99
17_T217_N0.5110.99
25_D29_A0.5090.99
116_T119_D0.5090.99
76_I198_T0.5090.99
69_I76_I0.5080.99
235_N239_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgvA 3 0.9114 100 0.261 Contact Map
1nrwA 1 0.9077 100 0.262 Contact Map
2b30A 2 0.941 100 0.268 Contact Map
4qjbA 1 0.9336 100 0.291 Contact Map
3l7yA 1 0.9077 100 0.298 Contact Map
1rkqA 1 0.9299 100 0.305 Contact Map
3daoA 1 0.9225 100 0.306 Contact Map
1rlmA 1 0.9151 100 0.309 Contact Map
1nf2A 4 0.9151 100 0.309 Contact Map
3dnpA 2 0.9151 100 0.317 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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