MPGP - ECOLI - GREMLIN Contacts

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MPGP - Putative mannosyl-3-phosphoglycerate phosphatase

UniProt:	P76329	Sequences: MFSIQQPLLVFSDLDGTLLDSHSYDWQPAAPWLTRLREANVPVILCSSKTSAEMLYLQKTLGLQGLPLIAENGAVIQLAEQWQEIDGFPRIISGISHGEISLVLNTLREKEHFKFTTFDDVDDATIAEWTGLSRSQAALTQLHEASVTLIWRDSDERMAQFTARLNELGLQFMQGARFWHVLDASAGKDQAANWIIATYQQLSGKRPTTLGLGDGPNDAPLLEVMDYAVIVKGLNREGVHLHDEDPARVWRTQREGPEGWREGLDHFFSAR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14039
Length:	271 (242)
Sequences:	11656 (9733)
Seq/√Len:	625.7

ECOLI - MPGP YBJI SUPH YBHA COF YIDA YIGL
BACSU - YWPJ YWTE YITU YHAX YXEH YCSE YKRA NTDB
HALSA - PGP
SULSO - PGP1 PGP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
253_Q	262_E	4.331	1.00
21_S	256_G	3.463	1.00
211_G	225_M	3.115	1.00
254_R	257_P	2.920	1.00
8_L	208_T	2.863	1.00
222_L	228_A	2.666	1.00
196_I	209_T	2.626	1.00
26_W	258_E	2.613	1.00
28_P	258_E	2.595	1.00
12_S	43_V	2.471	1.00
20_D	24_Y	2.408	1.00
236_R	240_H	2.402	1.00
223_E	241_L	2.347	1.00
47_S	54_M	2.329	1.00
28_P	265_D	2.302	1.00
193_N	224_V	2.239	1.00
206_R	224_V	2.077	1.00
187_G	220_P	2.032	1.00
216_P	237_E	1.897	1.00
27_Q	31_P	1.886	1.00
91_I	194_W	1.867	1.00
219_A	241_L	1.830	1.00
7_P	210_L	1.821	1.00
219_A	238_G	1.820	1.00
35_R	38_E	1.807	1.00
216_P	235_N	1.805	1.00
9_L	44_I	1.802	1.00
253_Q	257_P	1.772	1.00
35_R	265_D	1.762	1.00
36_L	41_V	1.713	1.00
11_F	192_A	1.708	1.00
205_K	208_T	1.697	1.00
229_V	263_G	1.693	1.00
96_S	99_E	1.680	1.00
30_A	60_T	1.668	1.00
230_I	242_H	1.662	1.00
194_W	198_T	1.661	1.00
228_A	243_D	1.657	1.00
193_N	197_A	1.627	1.00
35_R	39_A	1.621	1.00
33_L	43_V	1.621	1.00
236_R	239_V	1.620	1.00
194_W	197_A	1.614	1.00
227_Y	243_D	1.580	1.00
189_D	224_V	1.560	1.00
190_Q	193_N	1.560	1.00
78_L	81_Q	1.554	1.00
238_G	241_L	1.543	1.00
14_L	19_L	1.509	1.00
192_A	221_L	1.490	1.00
31_P	35_R	1.483	1.00
7_P	41_V	1.482	1.00
211_G	221_L	1.473	1.00
11_F	46_C	1.458	1.00
42_P	199_Y	1.444	1.00
93_S	194_W	1.443	1.00
12_S	212_L	1.437	1.00
250_W	263_G	1.424	1.00
7_P	208_T	1.413	1.00
107_L	150_I	1.412	1.00
227_Y	250_W	1.396	1.00
162_T	166_N	1.395	1.00
250_W	267_F	1.377	1.00
212_L	260_W	1.372	1.00
26_W	29_A	1.362	1.00
7_P	227_Y	1.355	1.00
37_R	64_Q	1.355	1.00
78_L	82_W	1.350	1.00
28_P	262_E	1.346	1.00
29_A	258_E	1.332	1.00
99_E	102_L	1.319	1.00
219_A	223_E	1.317	1.00
230_I	234_L	1.311	1.00
201_Q	205_K	1.311	1.00
212_L	263_G	1.310	1.00
32_W	261_R	1.291	1.00
207_P	226_D	1.287	1.00
196_I	206_R	1.282	1.00
30_A	34_T	1.274	1.00
206_R	209_T	1.258	1.00
237_E	240_H	1.236	1.00
92_I	144_E	1.233	1.00
157_R	160_Q	1.232	1.00
97_H	101_S	1.229	1.00
102_L	168_L	1.228	1.00
222_L	238_G	1.187	1.00
93_S	183_D	1.184	1.00
250_W	266_H	1.174	1.00
232_K	254_R	1.170	1.00
159_A	163_A	1.169	1.00
263_G	267_F	1.157	1.00
20_D	256_G	1.157	1.00
260_W	264_L	1.142	1.00
239_V	251_R	1.135	1.00
28_P	32_W	1.132	1.00
44_I	195_I	1.132	1.00
106_T	110_K	1.129	1.00
34_T	38_E	1.127	1.00
67_P	199_Y	1.126	1.00
110_K	164_R	1.121	1.00
187_G	190_Q	1.121	1.00
32_W	265_D	1.114	1.00
211_G	222_L	1.105	1.00
69_I	191_A	1.104	1.00
147_V	180_H	1.102	1.00
210_L	267_F	1.097	1.00
169_G	172_F	1.097	1.00
229_V	252_T	1.096	1.00
11_F	209_T	1.092	1.00
10_V	36_L	1.083	1.00
252_T	259_G	1.069	1.00
209_T	225_M	1.066	1.00
14_L	57_L	1.064	1.00
21_S	255_E	1.062	1.00
9_L	201_Q	1.056	1.00
10_V	41_V	1.051	1.00
92_I	146_S	1.051	1.00
215_G	235_N	1.050	1.00
163_A	166_N	1.040	1.00
210_L	229_V	1.039	1.00
76_I	194_W	1.030	1.00
235_N	238_G	1.027	1.00
9_L	196_I	1.025	1.00
206_R	226_D	1.021	1.00
10_V	264_L	1.019	1.00
169_G	173_M	1.017	1.00
252_T	263_G	1.015	1.00
196_I	224_V	1.014	1.00
262_E	266_H	1.013	1.00
233_G	255_E	1.006	1.00
160_Q	163_A	1.000	1.00
225_M	228_A	0.997	1.00
34_T	37_R	0.988	1.00
195_I	199_Y	0.986	1.00
76_I	91_I	0.985	1.00
137_A	140_T	0.982	1.00
9_L	209_T	0.979	1.00
253_Q	259_G	0.977	1.00
263_G	266_H	0.977	1.00
152_R	157_R	0.977	1.00
106_T	109_E	0.976	1.00
108_R	124_A	0.976	1.00
94_G	144_E	0.971	1.00
234_L	239_V	0.970	1.00
34_T	62_G	0.968	1.00
78_L	83_Q	0.965	1.00
27_Q	30_A	0.959	1.00
74_A	186_A	0.959	1.00
193_N	206_R	0.954	1.00
11_F	44_I	0.950	1.00
261_R	265_D	0.949	1.00
51_S	70_A	0.947	1.00
160_Q	164_R	0.944	1.00
18_L	29_A	0.938	1.00
210_L	263_G	0.938	1.00
155_D	159_A	0.924	1.00
189_D	220_P	0.922	1.00
70_A	75_V	0.918	1.00
182_L	187_G	0.917	1.00
192_A	225_M	0.914	1.00
183_D	186_A	0.913	1.00
12_S	260_W	0.907	1.00
231_V	259_G	0.906	1.00
29_A	261_R	0.905	1.00
196_I	201_Q	0.900	1.00
105_N	109_E	0.897	1.00
229_V	250_W	0.897	1.00
104_L	108_R	0.896	1.00
101_S	105_N	0.896	1.00
159_A	162_T	0.893	1.00
126_I	129_W	0.890	1.00
18_L	33_L	0.889	1.00
230_I	238_G	0.883	1.00
31_P	34_T	0.874	1.00
44_I	67_P	0.874	1.00
69_I	195_I	0.872	1.00
170_L	173_M	0.869	1.00
216_P	219_A	0.868	1.00
210_L	227_Y	0.866	1.00
232_K	239_V	0.860	1.00
102_L	105_N	0.859	1.00
46_C	69_I	0.857	1.00
196_I	226_D	0.849	1.00
76_I	191_A	0.847	1.00
36_L	43_V	0.843	1.00
93_S	185_S	0.840	1.00
98_G	102_L	0.839	1.00
47_S	70_A	0.837	1.00
67_P	195_I	0.827	1.00
50_T	71_E	0.823	1.00
70_A	77_Q	0.823	1.00
10_V	210_L	0.816	1.00
232_K	257_P	0.813	1.00
20_D	26_W	0.812	1.00
231_V	252_T	0.810	1.00
106_T	164_R	0.809	1.00
113_F	116_T	0.806	1.00
12_S	18_L	0.796	1.00
95_I	183_D	0.790	1.00
262_E	265_D	0.789	1.00
209_T	226_D	0.784	1.00
102_L	106_T	0.781	1.00
209_T	224_V	0.773	1.00
158_M	162_T	0.772	1.00
117_T	122_D	0.770	1.00
237_E	241_L	0.769	1.00
232_K	253_Q	0.764	1.00
94_G	146_S	0.764	1.00
128_E	131_G	0.761	1.00
29_A	32_W	0.758	1.00
117_T	120_D	0.757	1.00
80_E	83_Q	0.757	1.00
164_R	168_L	0.753	1.00
116_T	122_D	0.751	1.00
51_S	77_Q	0.743	1.00
226_D	243_D	0.743	1.00
75_V	146_S	0.741	1.00
55_L	59_K	0.740	1.00
152_R	158_M	0.740	1.00
129_W	133_S	0.740	1.00
41_V	210_L	0.734	1.00
28_P	261_R	0.734	1.00
243_D	250_W	0.733	1.00
222_L	241_L	0.733	1.00
192_A	211_G	0.731	1.00
22_H	256_G	0.731	1.00
14_L	45_L	0.725	1.00
250_W	262_E	0.723	1.00
32_W	35_R	0.723	1.00
36_L	264_L	0.718	1.00
54_M	68_L	0.716	1.00
77_Q	82_W	0.713	1.00
234_L	238_G	0.710	1.00
231_V	234_L	0.709	1.00
16_G	231_V	0.707	1.00
149_L	180_H	0.705	1.00
190_Q	194_W	0.703	1.00
67_P	78_L	0.700	1.00
109_E	164_R	0.698	1.00
214_D	234_L	0.693	1.00
186_A	190_Q	0.690	1.00
79_A	83_Q	0.687	1.00
171_Q	184_A	0.687	1.00
114_K	122_D	0.680	1.00
164_R	167_E	0.678	1.00
79_A	82_W	0.678	1.00
18_L	25_D	0.677	1.00
45_L	54_M	0.674	1.00
252_T	262_E	0.670	1.00
141_Q	144_E	0.664	1.00
9_L	195_I	0.662	1.00
20_D	255_E	0.662	1.00
97_H	144_E	0.661	1.00
208_T	226_D	0.661	1.00
126_I	131_G	0.660	1.00
74_A	183_D	0.656	1.00
54_M	70_A	0.653	1.00
253_Q	266_H	0.650	1.00
46_C	221_L	0.642	1.00
71_E	74_A	0.642	1.00
243_D	251_R	0.642	1.00
48_S	217_N	0.641	1.00
193_N	196_I	0.641	1.00
72_N	180_H	0.641	1.00
28_P	31_P	0.638	1.00
98_G	101_S	0.638	1.00
71_E	180_H	0.638	1.00
51_S	55_L	0.636	1.00
110_K	160_Q	0.636	1.00
228_A	238_G	0.636	1.00
130_T	133_S	0.633	1.00
114_K	121_V	0.632	1.00
29_A	33_L	0.630	1.00
238_G	242_H	0.630	1.00
14_L	18_L	0.629	1.00
220_P	223_E	0.629	1.00
67_P	79_A	0.628	1.00
212_L	229_V	0.628	1.00
7_P	42_P	0.625	1.00
68_L	79_A	0.622	1.00
233_G	254_R	0.621	1.00
14_L	54_M	0.619	1.00
133_S	136_Q	0.618	1.00
149_L	178_F	0.617	1.00
233_G	239_V	0.616	1.00
58_Q	68_L	0.615	1.00
131_G	134_R	0.613	1.00
106_T	168_L	0.613	1.00
250_W	253_Q	0.611	1.00
222_L	242_H	0.610	1.00
130_T	134_R	0.610	1.00
189_D	193_N	0.609	1.00
214_D	231_V	0.608	1.00
112_H	116_T	0.605	1.00
137_A	141_Q	0.603	1.00
227_Y	263_G	0.591	1.00
130_T	135_S	0.590	1.00
163_A	167_E	0.589	1.00
129_W	134_R	0.587	1.00
71_E	75_V	0.586	1.00
106_T	165_L	0.585	1.00
211_G	228_A	0.585	1.00
19_L	255_E	0.584	1.00
129_W	132_L	0.584	1.00
230_I	241_L	0.583	1.00
175_G	215_G	0.575	1.00
116_T	121_V	0.573	1.00
25_D	30_A	0.573	1.00
200_Q	205_K	0.572	1.00
18_L	45_L	0.570	1.00
8_L	41_V	0.569	1.00
45_L	58_Q	0.569	1.00
42_P	67_P	0.566	1.00
107_L	111_E	0.563	1.00
18_L	255_E	0.562	1.00
258_E	261_R	0.561	1.00
126_I	130_T	0.561	1.00
100_I	104_L	0.560	1.00
31_P	265_D	0.560	1.00
76_I	195_I	0.555	1.00
71_E	178_F	0.554	1.00
231_V	255_E	0.552	1.00
212_L	252_T	0.552	1.00
37_R	65_G	0.552	1.00
174_Q	180_H	0.551	1.00
228_A	242_H	0.551	1.00
156_E	160_Q	0.550	1.00
155_D	176_A	0.550	1.00
253_Q	263_G	0.550	1.00
258_E	262_E	0.548	1.00
122_D	125_T	0.547	1.00
10_V	212_L	0.545	1.00
32_W	36_L	0.544	0.99
216_P	238_G	0.539	0.99
138_A	141_Q	0.538	0.99
201_Q	209_T	0.537	0.99
71_E	146_S	0.536	0.99
26_W	261_R	0.536	0.99
175_G	178_F	0.534	0.99
41_V	208_T	0.530	0.99
51_S	71_E	0.529	0.99
147_V	174_Q	0.529	0.99
18_L	260_W	0.529	0.99
101_S	141_Q	0.527	0.99
115_F	121_V	0.527	0.99
46_C	72_N	0.522	0.99
92_I	118_F	0.521	0.99
42_P	201_Q	0.520	0.99
50_T	53_E	0.518	0.99
108_R	113_F	0.518	0.99
64_Q	67_P	0.516	0.99
78_L	198_T	0.516	0.99
185_S	190_Q	0.516	0.99
54_M	57_L	0.515	0.99
100_I	145_A	0.515	0.99
37_R	62_G	0.514	0.99
192_A	196_I	0.512	0.99
17_T	217_N	0.511	0.99
25_D	29_A	0.509	0.99
116_T	119_D	0.509	0.99
76_I	198_T	0.509	0.99
69_I	76_I	0.508	0.99
235_N	239_V	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pgvA	3	0.9114	100	0.261	Contact Map
1nrwA	1	0.9077	100	0.262	Contact Map
2b30A	2	0.941	100	0.268	Contact Map
4qjbA	1	0.9336	100	0.291	Contact Map
3l7yA	1	0.9077	100	0.298	Contact Map
1rkqA	1	0.9299	100	0.305	Contact Map
3daoA	1	0.9225	100	0.306	Contact Map
1rlmA	1	0.9151	100	0.309	Contact Map
1nf2A	4	0.9151	100	0.309	Contact Map
3dnpA	2	0.9151	100	0.317	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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