GREMLIN Database
YEDN - Putative uncharacterized protein YedN
UniProt: P76321 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13281
Length: 173 (132)
Sequences: 26004 (21740)
Seq/√Len: 1892.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_K38_V2.9281.00
62_F82_N2.7131.00
38_V57_E2.6871.00
57_E77_Q2.5421.00
77_Q97_T2.4431.00
56_K76_T2.3681.00
82_N102_R2.2071.00
102_R122_D2.1731.00
97_T117_L2.1611.00
43_H62_F2.1071.00
76_T96_M2.1031.00
81_D99_S2.0971.00
37_E56_K2.0801.00
17_S37_E2.0021.00
72_S91_S1.9891.00
23_D43_H1.9791.00
45_G63_N1.9441.00
79_S99_S1.9071.00
35_W54_F1.9011.00
61_D79_S1.8761.00
96_M116_K1.8551.00
20_D40_Y1.8081.00
22_T40_Y1.7811.00
84_L103_N1.7461.00
60_L80_V1.7261.00
15_H35_W1.6901.00
101_Y119_N1.6641.00
40_Y59_E1.6611.00
64_N83_N1.6241.00
25_H44_N1.6081.00
132_P141_E1.5951.00
104_K123_N1.5841.00
70_K91_S1.5781.00
42_R59_E1.5271.00
59_E79_S1.5031.00
74_G94_K1.4911.00
54_F74_G1.4731.00
13_E16_N1.4291.00
80_V100_I1.4201.00
21_L41_L1.3661.00
99_S119_N1.3581.00
64_N84_L1.3491.00
94_K114_T1.3291.00
100_I120_C1.3231.00
41_L60_L1.3111.00
65_Y83_N1.3001.00
33_P36_I1.2181.00
61_D81_D1.2091.00
37_E54_F1.1881.00
17_S35_W1.1831.00
25_H45_G1.1561.00
13_E24_L1.1501.00
22_T42_R1.1401.00
16_N24_L1.1321.00
24_L44_N1.1301.00
44_N63_N1.1251.00
46_L63_N1.1181.00
89_D92_P1.1171.00
83_N103_N1.0981.00
103_N123_N1.0811.00
81_D101_Y1.0721.00
125_I129_Q1.0641.00
76_T94_K1.0581.00
110_A131_F1.0431.00
45_G64_N1.0331.00
42_R61_D1.0301.00
26_L44_N1.0101.00
66_M84_L1.0021.00
86_S106_W0.9941.00
56_K74_G0.9931.00
21_L24_L0.9891.00
48_T67_V0.9841.00
100_I103_N0.9751.00
63_N83_N0.9681.00
136_E140_M0.9621.00
128_I131_F0.9351.00
11_C14_L0.9271.00
84_L104_K0.9241.00
96_M114_T0.8871.00
106_W126_K0.8641.00
111_M114_T0.8581.00
132_P135_L0.8511.00
87_R107_X0.8451.00
139_R142_C0.8381.00
95_A98_I0.8281.00
66_M86_S0.8241.00
117_L140_M0.8201.00
131_F134_H0.8151.00
40_Y57_E0.8141.00
85_I103_N0.8031.00
46_L49_I0.8021.00
47_A66_M0.8001.00
26_L46_L0.7991.00
105_I123_N0.7981.00
103_N109_P0.7941.00
49_I66_M0.7931.00
68_F80_V0.7871.00
67_V87_R0.7871.00
47_A64_N0.7831.00
17_S20_D0.7801.00
104_K124_K0.7751.00
20_D38_V0.7741.00
96_M99_S0.7701.00
16_N19_L0.7651.00
59_E77_Q0.7631.00
93_S113_E0.7611.00
52_P55_C0.7591.00
101_Y121_G0.7581.00
131_F135_L0.7581.00
29_L41_L0.7571.00
55_C58_L0.7541.00
115_T118_F0.7531.00
137_K141_E0.7501.00
138_A141_E0.7501.00
133_N136_E0.7331.00
63_N103_N0.7301.00
46_L65_Y0.7281.00
19_L36_I0.7281.00
28_S31_P0.7271.00
40_Y44_N0.7191.00
27_G45_G0.7161.00
68_F71_V0.7081.00
41_L44_N0.7031.00
86_S104_K0.7021.00
119_N122_D0.7011.00
65_Y85_I0.7011.00
37_E40_Y0.6911.00
116_K119_N0.6881.00
125_I128_I0.6871.00
32_L35_W0.6861.00
20_D23_D0.6711.00
120_C123_N0.6711.00
116_K139_R0.6691.00
27_G47_A0.6681.00
49_I67_V0.6661.00
133_N141_E0.6621.00
31_P70_K0.6601.00
128_I134_H0.6591.00
13_E52_P0.6591.00
28_S49_I0.6501.00
87_R106_W0.6501.00
68_F89_D0.6491.00
44_N83_N0.6481.00
68_F72_S0.6481.00
114_T137_K0.6441.00
34_S53_K0.6431.00
106_W124_K0.6371.00
70_K110_A0.6321.00
56_K59_E0.6301.00
80_V85_I0.6251.00
123_N129_Q0.6221.00
116_K137_K0.6141.00
16_N33_P0.6111.00
14_L34_S0.6081.00
47_A86_S0.6051.00
121_G142_C0.6031.00
67_V86_S0.6021.00
69_P88_V0.5951.00
107_X110_A0.5931.00
124_K128_I0.5881.00
76_T79_S0.5821.00
99_S102_R0.5771.00
132_P140_M0.5761.00
89_D109_P0.5751.00
133_N140_M0.5741.00
11_C32_L0.5741.00
16_N36_I0.5711.00
118_F135_L0.5701.00
105_I125_I0.5691.00
12_V15_H0.5671.00
88_V92_P0.5661.00
20_D24_L0.5651.00
79_S82_N0.5621.00
13_E33_P0.5611.00
137_K140_M0.5581.00
80_V83_N0.5571.00
133_N138_A0.5561.00
131_F136_E0.5551.00
33_P112_P0.5491.00
69_P72_S0.5451.00
99_S117_L0.5421.00
109_P129_Q0.5371.00
78_V98_I0.5311.00
75_I78_V0.5281.00
135_L138_A0.5251.00
76_T116_K0.5251.00
118_F123_N0.5231.00
36_I39_L0.5231.00
129_Q134_H0.5181.00
70_K90_S0.5171.00
117_L139_R0.5151.00
34_S37_E0.5151.00
68_F88_V0.5141.00
26_L30_P0.5131.00
113_E116_K0.5091.00
131_F142_C0.5021.00
119_N123_N0.5011.00
98_I115_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cvrA 2 0.9364 99.8 0.411 Contact Map
4nkhA 2 0.9827 99.8 0.423 Contact Map
3g06A 1 0.9595 99.7 0.434 Contact Map
4ow2A 1 0.815 99.7 0.435 Contact Map
1jl5A 4 0.9133 99.7 0.448 Contact Map
2z81A 1 0.9827 99.7 0.466 Contact Map
4ecnA 1 1 99.6 0.478 Contact Map
3j0aA 1 0.9884 99.6 0.481 Contact Map
4ecoA 1 1 99.6 0.495 Contact Map
2o6qA 1 1 99.6 0.501 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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