GREMLIN Database
YEDL - Uncharacterized N-acetyltransferase YedL
UniProt: P76319 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13279
Length: 159 (133)
Sequences: 9805 (7727)
Seq/√Len: 670.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_L130_F3.5501.00
20_Y80_A2.8951.00
90_S127_K2.7491.00
52_V88_V2.7421.00
59_A83_Y2.7281.00
90_S128_H2.7001.00
62_G96_I2.6831.00
94_R128_H2.4821.00
93_L128_H2.3251.00
126_L132_D2.2731.00
97_L108_L2.2421.00
99_V103_R2.2161.00
50_W95_H2.2051.00
99_V102_D2.1881.00
54_E86_R2.0951.00
95_H98_Q2.0401.00
51_S58_L2.0071.00
54_E59_A1.9081.00
122_H126_L1.8291.00
53_W58_L1.7881.00
57_Q82_N1.7611.00
70_K106_H1.7531.00
48_T99_V1.6481.00
54_E83_Y1.6471.00
95_H99_V1.6301.00
66_L105_L1.6001.00
110_L125_Y1.5401.00
72_G105_L1.5261.00
60_G79_T1.5201.00
13_A16_A1.5171.00
53_W56_E1.4751.00
132_D135_P1.4451.00
112_T116_A1.4431.00
71_H109_S1.4401.00
49_F63_A1.4161.00
122_H132_D1.4041.00
123_Q126_L1.3921.00
72_G100_A1.3781.00
90_S94_R1.3161.00
15_Q19_A1.2821.00
19_A23_S1.2751.00
74_L93_L1.2711.00
13_A53_W1.2401.00
71_H107_R1.2341.00
98_Q102_D1.2121.00
12_P16_A1.2121.00
62_G92_I1.1921.00
50_W99_V1.1891.00
84_L120_A1.1851.00
64_L96_I1.1601.00
83_Y86_R1.1371.00
64_L99_V1.1261.00
16_A20_Y1.1051.00
94_R98_Q1.0941.00
87_G90_S1.0821.00
57_Q80_A1.0751.00
52_V60_G1.0751.00
121_C125_Y1.0641.00
119_T122_H1.0631.00
72_G108_L1.0621.00
79_T88_V1.0581.00
37_L40_Q1.0551.00
80_A83_Y1.0541.00
93_L125_Y1.0431.00
66_L103_R1.0421.00
97_L101_Q1.0381.00
34_S38_D0.9871.00
60_G88_V0.9801.00
20_Y82_N0.9781.00
28_Q120_A0.9771.00
37_L41_K0.9771.00
13_A58_L0.9631.00
48_T103_R0.9541.00
91_L94_R0.9461.00
110_L121_C0.9451.00
24_G81_P0.9381.00
108_L130_F0.9321.00
64_L100_A0.9241.00
88_V91_L0.9181.00
54_E57_Q0.9151.00
124_L128_H0.9131.00
112_T122_H0.9031.00
34_S42_L0.9031.00
16_A80_A0.9011.00
6_T48_T0.9001.00
77_M93_L0.8871.00
34_S37_L0.8851.00
137_A140_R0.8781.00
10_T53_W0.8771.00
113_G116_A0.8591.00
93_L124_L0.8541.00
62_G77_M0.8491.00
7_D11_H0.8441.00
17_L58_L0.8401.00
109_S133_C0.8401.00
91_L95_H0.8271.00
73_E76_S0.8261.00
59_A88_V0.8221.00
98_Q101_Q0.8201.00
100_A108_L0.8191.00
115_Q119_T0.8101.00
119_T123_Q0.8031.00
112_T121_C0.7771.00
13_A57_Q0.7721.00
52_V79_T0.7631.00
63_A75_K0.7601.00
21_H78_R0.7591.00
120_A123_Q0.7591.00
68_D71_H0.7541.00
12_P15_Q0.7481.00
116_A120_A0.7441.00
77_M125_Y0.7361.00
29_S32_E0.7331.00
107_R133_C0.7281.00
16_A57_Q0.7251.00
57_Q83_Y0.7201.00
35_H39_V0.7181.00
65_K75_K0.7121.00
35_H38_D0.7101.00
39_V43_R0.7071.00
67_L73_E0.7061.00
20_Y81_P0.7011.00
10_T13_A0.6901.00
73_E109_S0.6891.00
62_G74_L0.6861.00
94_R97_L0.6851.00
85_R120_A0.6851.00
21_H25_M0.6751.00
24_G28_Q0.6721.00
16_A19_A0.6671.00
116_A121_C0.6641.00
8_D11_H0.6641.00
6_T99_V0.6591.00
33_S37_L0.6551.00
93_L97_L0.6491.00
38_D42_L0.6481.00
23_S27_Q0.6461.00
100_A105_L0.6451.00
38_D41_K0.6421.00
25_M28_Q0.6361.00
85_R123_Q0.6351.00
7_D10_T0.6351.00
18_V22_I0.6341.00
14_V18_V0.6321.00
77_M128_H0.6281.00
90_S123_Q0.6261.00
18_V21_H0.6261.00
14_V61_I0.6251.00
52_V91_L0.6171.00
40_Q43_R0.6171.00
17_L78_R0.6101.00
123_Q127_K0.6041.00
21_H24_G0.6041.00
22_I25_M0.6011.00
74_L108_L0.6001.00
85_R127_K0.5961.00
8_D39_V0.5951.00
33_S38_D0.5941.00
74_L96_I0.5941.00
7_D51_S0.5931.00
6_T50_W0.5911.00
60_G92_I0.5881.00
49_F61_I0.5871.00
61_I116_A0.5871.00
70_K107_R0.5841.00
24_G84_L0.5781.00
33_S41_K0.5761.00
116_A122_H0.5731.00
101_Q104_C0.5721.00
44_N47_V0.5681.00
116_A119_T0.5661.00
112_T125_Y0.5641.00
64_L72_G0.5641.00
111_E137_A0.5511.00
11_H15_Q0.5511.00
74_L110_L0.5481.00
33_S36_A0.5431.00
59_A82_N0.5421.00
121_C124_L0.5411.00
17_L21_H0.5411.00
28_Q31_P0.5391.00
64_L103_R0.5391.00
77_M110_L0.5381.00
14_V49_F0.5371.00
24_G27_Q0.5331.00
85_R124_L0.5311.00
67_L109_S0.5301.00
86_R124_L0.5291.00
77_M121_C0.5260.99
134_E137_A0.5250.99
62_G93_L0.5200.99
50_W96_I0.5170.99
119_T126_L0.5160.99
73_E111_E0.5110.99
79_T92_I0.5110.99
84_L121_C0.5060.99
52_V92_I0.5050.99
18_V78_R0.5030.99
21_H29_S0.5010.99
65_K111_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lodA 1 0.8931 99.9 0.34 Contact Map
2j8mA 2 0.9874 99.9 0.365 Contact Map
3d8pA 1 0.9497 99.9 0.365 Contact Map
3dr6A 2 0.9811 99.9 0.367 Contact Map
1yx0A 1 0.9371 99.8 0.387 Contact Map
3fynA 2 0.8679 99.8 0.389 Contact Map
3fixA 2 0.8994 99.8 0.391 Contact Map
2fiaA 1 0.9434 99.8 0.392 Contact Map
2r7hA 2 0.9371 99.8 0.394 Contact Map
2oh1A 1 0.9119 99.8 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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