GREMLIN Database
YEDK - Putative SOS response-associated peptidase YedK
UniProt: P76318 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13278
Length: 222 (198)
Sequences: 3411 (2472)
Seq/√Len: 175.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_A128_M4.2301.00
44_V145_F4.1801.00
81_A148_V4.1441.00
46_L59_V4.0461.00
131_I146_L3.8011.00
97_I172_A3.3141.00
18_L127_F3.2831.00
102_G117_F2.6631.00
168_S171_A2.6481.00
114_Q203_P2.6251.00
128_M147_I2.4041.00
96_A130_A2.4001.00
78_V148_V2.3871.00
90_L133_S2.3611.00
48_S57_D2.3041.00
119_Y200_S2.1541.00
119_Y202_H2.1321.00
85_R88_K2.0641.00
134_T143_E2.0351.00
105_E160_H1.8781.00
97_I127_F1.8471.00
73_L86_M1.8191.00
118_I159_I1.8001.00
94_G133_S1.7871.00
82_A91_W1.7771.00
75_N160_H1.7631.00
103_W156_L1.7361.00
17_L172_A1.7271.00
109_E112_K1.7111.00
98_C145_F1.6921.00
76_A146_L1.6791.00
171_A174_E1.6721.00
54_L173_R1.6611.00
5_F44_V1.6541.00
194_V199_F1.6511.00
127_F172_A1.6351.00
153_D163_R1.6291.00
6_A117_F1.5981.00
64_A142_A1.5931.00
185_A188_I1.5911.00
81_A91_W1.5761.00
98_C147_I1.5601.00
9_Q101_D1.5241.00
10_T13_D1.5231.00
46_L145_F1.5081.00
118_I156_L1.5031.00
186_S190_A1.4961.00
38_V44_V1.4951.00
126_I199_F1.4591.00
120_R124_Q1.4441.00
12_E16_A1.4381.00
35_R42_T1.4081.00
154_Q157_V1.3871.00
136_F141_E1.3711.00
48_S55_H1.3601.00
7_Q38_V1.3391.00
150_A165_L1.2791.00
37_N115_P1.2781.00
134_T141_E1.2501.00
120_R126_I1.2451.00
107_K116_F1.2401.00
50_R53_H1.2381.00
112_K206_R1.2331.00
106_W113_K1.2131.00
80_T84_S1.2121.00
166_V199_F1.2031.00
155_G197_N1.2021.00
11_R15_L1.2021.00
35_R38_V1.1801.00
89_P93_H1.1741.00
169_P172_A1.1741.00
117_F202_H1.1731.00
48_S132_G1.1661.00
194_V197_N1.1631.00
5_F100_A1.1611.00
79_E162_R1.1591.00
116_F203_P1.1561.00
89_P92_Q1.1521.00
45_L56_L1.1411.00
98_C130_A1.1391.00
167_L171_A1.1321.00
94_G132_G1.1311.00
196_A199_F1.1171.00
118_I201_W1.1091.00
64_A144_G1.1051.00
129_A165_L1.1011.00
46_L96_A1.0961.00
97_I167_L1.0821.00
80_T87_F1.0501.00
59_V143_E1.0481.00
136_F140_D1.0400.99
90_L94_G1.0280.99
155_G199_F1.0190.99
64_A73_L1.0170.99
75_N105_E1.0170.99
185_A190_A1.0150.99
126_I172_A1.0130.99
151_A161_D1.0090.99
3_G74_I1.0070.99
121_A200_S1.0020.99
20_E56_L1.0010.99
120_R168_S0.9930.99
96_A132_G0.9870.99
41_G71_P0.9820.99
21_D53_H0.9810.99
9_Q125_P0.9710.99
63_Y144_G0.9650.99
177_R180_I0.9650.99
150_A153_D0.9570.99
62_G74_I0.9570.99
150_A163_R0.9560.99
103_W153_D0.9510.99
154_Q158_D0.9380.99
44_V98_C0.9370.99
46_L98_C0.9270.99
63_Y133_S0.9250.99
108_K113_K0.9060.99
41_G60_F0.9040.99
73_L87_F0.9010.99
4_R106_W0.9000.99
4_R37_N0.8970.98
108_K111_D0.8810.98
8_S101_D0.8770.98
155_G201_W0.8760.98
39_A42_T0.8690.98
155_G158_D0.8570.98
5_F45_L0.8550.98
37_N106_W0.8490.98
57_D143_E0.8470.98
47_L54_L0.8400.98
78_V150_A0.8400.98
174_E177_R0.8300.98
103_W158_D0.8280.97
81_A131_I0.8250.97
108_K112_K0.8110.97
20_E23_E0.8020.97
109_E114_Q0.7960.97
103_W166_V0.7850.97
119_Y123_G0.7830.96
120_R199_F0.7820.96
173_R177_R0.7780.96
7_Q45_L0.7770.96
147_I164_P0.7770.96
152_A161_D0.7700.96
106_W115_P0.7650.96
187_E190_A0.7620.96
130_A146_L0.7560.96
148_V165_L0.7550.96
2_C75_N0.7520.96
153_D158_D0.7470.95
50_R55_H0.7430.95
65_P68_W0.7410.95
120_R198_Q0.7380.95
61_W95_R0.7370.95
126_I166_V0.7330.95
9_Q13_D0.7310.95
182_G185_A0.7300.95
194_V198_Q0.7290.95
77_R105_E0.7290.95
76_A87_F0.7290.95
152_A155_G0.7210.94
66_G133_S0.7190.94
13_D16_A0.7190.94
63_Y73_L0.7150.94
39_A106_W0.7120.94
136_F139_G0.7060.94
5_F39_A0.7050.94
17_L124_Q0.7050.94
84_S87_F0.7020.94
61_W164_P0.6990.93
44_V61_W0.6940.93
89_P133_S0.6880.93
9_Q12_E0.6880.93
168_S198_Q0.6870.93
3_G40_P0.6870.93
36_Y115_P0.6870.93
5_F145_F0.6860.93
49_E52_E0.6840.93
150_A193_C0.6820.93
15_L22_I0.6820.93
6_A102_G0.6810.93
22_I53_H0.6790.92
45_L58_P0.6790.92
63_Y86_M0.6780.92
5_F38_V0.6750.92
178_Q181_S0.6730.92
66_G89_P0.6720.92
48_S143_E0.6700.92
18_L172_A0.6660.92
3_G106_W0.6660.92
88_K92_Q0.6640.92
105_E162_R0.6560.91
5_F99_F0.6540.91
93_H133_S0.6530.91
130_A147_I0.6530.91
137_E140_D0.6490.91
49_E54_L0.6480.91
107_K110_G0.6480.91
180_I186_S0.6480.91
100_A147_I0.6470.91
73_L146_L0.6460.90
80_T83_T0.6450.90
2_C160_H0.6450.90
120_R125_P0.6420.90
2_C105_E0.6410.90
37_N102_G0.6400.90
151_A157_V0.6350.90
151_A154_Q0.6330.90
156_L159_I0.6320.90
116_F159_I0.6310.89
102_G119_Y0.6300.89
39_A115_P0.6270.89
124_Q169_P0.6240.89
82_A92_Q0.6230.89
36_Y39_A0.6220.89
107_K158_D0.6210.89
74_I146_L0.6190.89
43_K58_P0.6160.88
63_Y71_P0.6150.88
112_K197_N0.6140.88
195_P198_Q0.6120.88
64_A135_P0.6120.88
31_E58_P0.6090.88
135_P142_A0.6080.88
174_E188_I0.6080.88
19_A173_R0.6050.87
47_L99_F0.6050.87
78_V165_L0.5950.87
152_A157_V0.5890.86
174_E187_E0.5890.86
107_K114_Q0.5860.86
101_D117_F0.5850.86
65_P69_D0.5820.85
15_L20_E0.5810.85
133_S144_G0.5790.85
12_E21_D0.5770.85
67_W70_K0.5770.85
9_Q14_Y0.5720.84
40_P74_I0.5720.84
203_P206_R0.5660.84
121_A198_Q0.5660.84
60_F142_A0.5650.84
99_F127_F0.5650.84
41_G74_I0.5640.84
128_M164_P0.5630.83
193_C198_Q0.5630.83
7_Q14_Y0.5600.83
153_D196_A0.5580.83
120_R123_G0.5550.83
59_V145_F0.5540.82
98_C128_M0.5540.82
18_L47_L0.5530.82
103_W164_P0.5510.82
107_K113_K0.5510.82
104_F162_R0.5490.82
76_A131_I0.5480.82
104_F204_V0.5460.82
153_D193_C0.5450.81
151_A170_E0.5420.81
32_P45_L0.5420.81
14_Y18_L0.5420.81
77_R160_H0.5410.81
171_A187_E0.5410.81
49_E173_R0.5410.81
68_W71_P0.5410.81
109_E116_F0.5370.80
4_R40_P0.5340.80
159_I201_W0.5340.80
63_Y90_L0.5330.80
180_I185_A0.5290.79
181_S187_E0.5270.79
17_L169_P0.5260.79
45_L145_F0.5260.79
5_F98_C0.5220.79
95_R178_Q0.5220.79
76_A81_A0.5220.79
46_L130_A0.5210.78
159_I163_R0.5200.78
118_I161_D0.5200.78
129_A167_L0.5190.78
7_Q10_T0.5160.78
104_F115_P0.5150.78
101_D125_P0.5140.78
6_A101_D0.5130.77
11_R31_E0.5130.77
108_K161_D0.5100.77
3_G41_G0.5100.77
116_F201_W0.5070.77
65_P144_G0.5050.76
79_E151_A0.5050.76
16_A21_D0.5040.76
64_A70_K0.5030.76
118_I150_A0.5030.76
139_G142_A0.5020.76
103_W199_F0.5020.76
193_C199_F0.5000.76
32_P58_P0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2icuA 1 0.955 100 0.019 Contact Map
2bdvA 1 0.9279 100 0.051 Contact Map
2f20A 1 0.973 100 0.067 Contact Map
2aegA 1 0.9054 100 0.112 Contact Map
1zn6A 1 0.8694 100 0.15 Contact Map
2gs0B 1 0.0631 11.6 0.959 Contact Map
3bsuA 1 0.2207 8 0.961 Contact Map
2b3gB 2 0.1081 6.7 0.963 Contact Map
4a7kA 2 0.2387 4.3 0.966 Contact Map
3aj1A 5 0.6216 3.9 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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