GREMLIN Database
DCYD - D-cysteine desulfhydrase
UniProt: P76316 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14038
Length: 328 (286)
Sequences: 22354 (12670)
Seq/√Len: 749.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_A95_C4.1161.00
34_E309_P3.4311.00
142_L145_R3.1821.00
23_Y34_E3.1581.00
188_S216_I2.7221.00
176_I311_L2.6561.00
267_E297_D2.6521.00
61_D65_E2.6441.00
274_L278_L2.5761.00
94_H125_Q2.5011.00
18_P178_Q2.4931.00
105_T117_L2.4661.00
221_S264_P2.4301.00
96_V125_Q2.3811.00
101_N130_D2.3241.00
214_E259_P2.3221.00
63_L93_L2.2751.00
69_T72_T2.2701.00
166_A170_V2.1741.00
69_T96_V2.1461.00
36_F309_P2.1051.00
96_V127_E2.0861.00
222_R265_N2.0771.00
264_P267_E2.0321.00
18_P179_Q2.0171.00
203_A215_L1.9971.00
174_L205_G1.9791.00
145_R149_Q1.9781.00
60_A91_L1.9721.00
61_D164_L1.9481.00
203_A256_Y1.9331.00
68_D72_T1.9071.00
160_G250_I1.9041.00
21_L311_L1.9041.00
193_S217_G1.8931.00
157_P160_G1.8921.00
291_A312_F1.8911.00
98_L146_V1.8831.00
218_V294_G1.8631.00
188_S304_F1.8551.00
169_Y208_H1.8461.00
230_K233_N1.7921.00
169_Y204_V1.7481.00
275_L283_L1.7431.00
186_I311_L1.7101.00
305_K308_G1.7051.00
45_M86_A1.6951.00
216_I259_P1.6871.00
36_F180_C1.6851.00
189_V206_L1.6811.00
274_L296_I1.6751.00
210_M213_S1.6651.00
189_V202_L1.6541.00
271_A293_A1.6491.00
144_T148_A1.6231.00
23_Y36_F1.6101.00
69_T94_H1.6091.00
187_S309_P1.6011.00
275_L292_M1.5961.00
116_R128_M1.5901.00
140_E144_T1.5861.00
187_S308_G1.5691.00
56_E60_A1.5471.00
188_S308_G1.5451.00
23_Y28_S1.5311.00
63_L91_L1.5071.00
173_A202_L1.5001.00
165_G168_G1.4581.00
271_A296_I1.4471.00
117_L120_D1.4381.00
190_V298_G1.4271.00
228_L232_V1.4261.00
141_E144_T1.4031.00
173_A206_L1.3961.00
207_E258_A1.3621.00
30_Y274_L1.3571.00
130_D133_T1.3561.00
190_V218_V1.3481.00
76_I81_V1.3341.00
116_R120_D1.3321.00
293_A297_D1.3281.00
188_S214_E1.3201.00
146_V150_G1.3091.00
105_T116_R1.3091.00
199_H257_F1.3051.00
205_G209_L1.3051.00
139_L143_A1.3011.00
221_S262_G1.2981.00
224_V228_L1.2681.00
37_I314_H1.2661.00
63_L66_G1.2661.00
60_A64_R1.2631.00
184_V309_P1.2621.00
231_V234_L1.2581.00
58_L162_N1.2561.00
228_L231_V1.2541.00
24_L37_I1.2481.00
57_F170_V1.2391.00
199_H217_G1.2381.00
59_A70_L1.2371.00
270_E274_L1.2351.00
61_D64_R1.2251.00
119_L124_T1.2251.00
267_E293_A1.2241.00
271_A292_M1.2151.00
26_R279_E1.2101.00
283_L314_H1.2101.00
173_A205_G1.2071.00
137_A141_E1.2041.00
180_C186_I1.1991.00
199_H215_L1.1941.00
99_L119_L1.1921.00
30_Y278_L1.1901.00
127_E142_L1.1821.00
239_A242_L1.1771.00
177_A205_G1.1701.00
22_E39_R1.1651.00
224_V262_G1.1611.00
20_P42_V1.1601.00
227_Q231_V1.1581.00
177_A209_L1.1531.00
101_N131_A1.1381.00
180_C184_V1.1371.00
204_V253_W1.1341.00
174_L178_Q1.1301.00
276_A282_L1.1291.00
81_V119_L1.1261.00
61_D163_A1.1241.00
267_E270_E1.1221.00
150_G153_P1.1171.00
185_N309_P1.1141.00
206_L213_S1.1111.00
266_D270_E1.1051.00
21_L180_C1.1021.00
21_L176_I1.0941.00
242_L290_K1.0881.00
102_P131_A1.0871.00
188_S310_I1.0731.00
259_P303_R1.0641.00
138_Q141_E1.0631.00
261_Y294_G1.0631.00
217_G260_G1.0621.00
263_V293_A1.0601.00
116_R126_I1.0521.00
141_E145_R1.0481.00
177_A210_M1.0451.00
229_P233_N1.0451.00
216_I261_Y1.0351.00
25_P29_D1.0201.00
180_C311_L1.0191.00
55_L83_Q1.0171.00
138_Q142_L1.0171.00
84_T95_C1.0141.00
57_F167_L1.0141.00
230_K234_L1.0131.00
272_V289_G1.0111.00
144_T147_E1.0111.00
297_D300_S1.0101.00
99_L128_M1.0001.00
26_R29_D0.9961.00
298_G303_R0.9951.00
57_F60_A0.9931.00
59_A91_L0.9911.00
288_T314_H0.9801.00
57_F61_D0.9801.00
59_A87_V0.9761.00
26_R278_L0.9751.00
202_L313_I0.9691.00
89_A95_C0.9601.00
261_Y297_D0.9571.00
304_F308_G0.9541.00
35_I295_L0.9511.00
273_K277_R0.9511.00
193_S199_H0.9491.00
86_A122_F0.9451.00
237_A243_E0.9441.00
240_K243_E0.9391.00
227_Q230_K0.9371.00
295_L312_F0.9361.00
170_V174_L0.9361.00
117_L121_L0.9341.00
176_I186_I0.9331.00
142_L146_V0.9271.00
120_D125_Q0.9231.00
147_E155_V0.9181.00
33_R308_G0.9071.00
83_Q87_V0.9011.00
85_A124_T0.8981.00
214_E258_A0.8971.00
236_Q239_A0.8941.00
271_A274_L0.8871.00
190_V216_I0.8821.00
172_S313_I0.8811.00
139_L142_L0.8801.00
205_G208_H0.8651.00
28_S31_L0.8591.00
238_I269_M0.8571.00
283_L288_T0.8551.00
174_L209_L0.8501.00
242_L245_T0.8471.00
191_V202_L0.8431.00
190_V295_L0.8421.00
168_G172_S0.8421.00
169_Y205_G0.8391.00
38_K175_E0.8351.00
251_L255_D0.8321.00
288_T315_T0.8301.00
89_A122_F0.8261.00
68_D152_R0.8251.00
246_A249_E0.8201.00
248_A251_L0.8181.00
98_L142_L0.8061.00
120_D128_M0.8011.00
39_R314_H0.8001.00
204_V208_H0.7991.00
39_R42_V0.7951.00
200_A251_L0.7921.00
86_A90_K0.7911.00
15_I56_E0.7881.00
19_T43_T0.7851.00
188_S298_G0.7831.00
31_L274_L0.7741.00
227_Q262_G0.7721.00
65_E163_A0.7701.00
145_R148_A0.7681.00
223_S229_P0.7681.00
24_L292_M0.7581.00
190_V294_G0.7551.00
27_F296_I0.7511.00
82_R118_L0.7501.00
214_E308_G0.7481.00
140_E143_A0.7391.00
98_L127_E0.7381.00
242_L286_V0.7371.00
137_A140_E0.7331.00
32_G306_D0.7321.00
237_A240_K0.7311.00
167_L170_V0.7281.00
37_I312_F0.7281.00
199_H253_W0.7251.00
254_D257_F0.7251.00
58_L156_I0.7231.00
298_G304_F0.7201.00
172_S202_L0.7191.00
61_D166_A0.7171.00
230_K260_G0.7141.00
185_N210_M0.7141.00
292_M312_F0.7141.00
177_A206_L0.7131.00
55_L87_V0.7091.00
82_R119_L0.7091.00
98_L129_C0.7081.00
97_A119_L0.7081.00
162_N165_G0.7071.00
25_P28_S0.7061.00
186_I213_S0.7051.00
29_D32_G0.7041.00
192_A315_T0.7011.00
172_S198_T0.6941.00
40_D53_R0.6901.00
229_P234_L0.6901.00
269_M285_P0.6891.00
161_S247_S0.6881.00
138_Q143_A0.6861.00
202_L206_L0.6851.00
147_E153_P0.6851.00
24_L279_E0.6831.00
96_V152_R0.6811.00
50_N198_T0.6811.00
95_C124_T0.6791.00
143_A147_E0.6771.00
160_G200_A0.6761.00
268_G290_K0.6751.00
229_P232_V0.6751.00
180_C309_P0.6711.00
37_I292_M0.6711.00
189_V313_I0.6701.00
220_V242_L0.6661.00
101_N134_D0.6651.00
70_L88_A0.6651.00
133_T138_Q0.6631.00
68_D94_H0.6631.00
172_S176_I0.6621.00
227_Q260_G0.6621.00
239_A268_G0.6611.00
166_A169_Y0.6601.00
225_A230_K0.6591.00
31_L296_I0.6591.00
101_N128_M0.6571.00
235_Q238_I0.6571.00
214_E303_R0.6561.00
292_M314_H0.6551.00
72_T84_T0.6531.00
300_S304_F0.6531.00
193_S260_G0.6511.00
28_S35_I0.6491.00
253_W257_F0.6481.00
33_R307_E0.6471.00
162_N168_G0.6461.00
216_I298_G0.6441.00
166_A204_V0.6421.00
162_N166_A0.6361.00
300_S303_R0.6351.00
118_L121_L0.6351.00
54_K58_L0.6351.00
228_L233_N0.6341.00
176_I202_L0.6331.00
78_S81_V0.6331.00
34_E307_E0.6321.00
17_A44_P0.6311.00
283_L289_G0.6281.00
177_A180_C0.6261.00
58_L164_L0.6261.00
81_V97_A0.6261.00
239_A245_T0.6251.00
45_M122_F0.6231.00
238_I241_E0.6231.00
275_L314_H0.6221.00
247_S251_L0.6151.00
251_L254_D0.6151.00
296_I300_S0.6131.00
99_L116_R0.6121.00
24_L27_F0.6121.00
253_W256_Y0.6101.00
225_A229_P0.6081.00
33_R310_I0.6071.00
186_I309_P0.6041.00
39_R281_I0.6021.00
16_G52_L0.6021.00
294_G298_G0.6011.00
27_F271_A0.6001.00
96_V150_G0.6001.00
224_V229_P0.5981.00
241_E244_L0.5971.00
96_V146_V0.5961.00
27_F292_M0.5941.00
53_R175_E0.5931.00
103_I116_R0.5921.00
200_A249_E0.5921.00
240_K245_T0.5921.00
21_L36_F0.5911.00
62_A66_G0.5911.00
269_M273_K0.5891.00
164_L168_G0.5871.00
236_Q240_K0.5831.00
275_L281_I0.5821.00
250_I254_D0.5821.00
94_H152_R0.5821.00
99_L103_I0.5811.00
30_Y296_I0.5811.00
275_L279_E0.5791.00
71_I146_V0.5781.00
28_S34_E0.5771.00
177_A184_V0.5761.00
218_V290_K0.5751.00
189_V213_S0.5751.00
133_T141_E0.5751.00
44_P52_L0.5741.00
272_V285_P0.5741.00
259_P298_G0.5731.00
299_I304_F0.5721.00
33_R299_I0.5711.00
61_D67_A0.5701.00
62_A154_Y0.5701.00
147_E150_G0.5691.00
238_I242_L0.5661.00
71_I153_P0.5651.00
191_V199_H0.5641.00
226_D229_P0.5641.00
71_I147_E0.5621.00
27_F31_L0.5621.00
192_A291_A0.5611.00
165_G251_L0.5541.00
98_L145_R0.5521.00
45_M49_G0.5491.00
218_V261_Y0.5481.00
54_K80_H0.5481.00
241_E245_T0.5471.00
146_V149_Q0.5471.00
21_L179_Q0.5451.00
68_D151_F0.5451.00
235_Q240_K0.5451.00
69_T152_R0.5451.00
222_R235_Q0.5441.00
12_L15_I0.5441.00
227_Q233_N0.5441.00
27_F274_L0.5411.00
265_N269_M0.5411.00
288_T291_A0.5411.00
58_L165_G0.5401.00
16_G56_E0.5391.00
178_Q209_L0.5381.00
57_F163_A0.5371.00
58_L155_V0.5371.00
238_I245_T0.5361.00
189_V215_L0.5341.00
154_Y157_P0.5321.00
131_A138_Q0.5321.00
252_L257_F0.5321.00
217_G257_F0.5321.00
85_A119_L0.5311.00
72_T97_A0.5301.00
228_L234_L0.5301.00
157_P161_S0.5291.00
156_I162_N0.5281.00
52_L86_A0.5271.00
17_A43_T0.5261.00
176_I313_I0.5251.00
153_P156_I0.5241.00
69_T145_R0.5211.00
207_E256_Y0.5211.00
190_V310_I0.5201.00
54_K165_G0.5201.00
226_D230_K0.5201.00
133_T140_E0.5191.00
134_D137_A0.5181.00
118_L122_F0.5171.00
304_F310_I0.5171.00
292_M296_I0.5121.00
97_A124_T0.5121.00
225_A246_A0.5101.00
63_L67_A0.5061.00
75_A156_I0.5041.00
85_A95_C0.5041.00
32_G305_K0.5041.00
295_L299_I0.5021.00
207_E255_D0.5021.00
270_E273_K0.5001.00
28_S32_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d9bA 2 0.997 100 0.156 Contact Map
1j0aA 5 0.9634 100 0.174 Contact Map
1f2dA 2 0.9787 100 0.182 Contact Map
1tzjA 4 0.9848 100 0.192 Contact Map
2gn0A 2 0.9329 100 0.197 Contact Map
1v71A 2 0.9268 100 0.198 Contact Map
3l6bA 2 0.9299 100 0.202 Contact Map
1tdjA 2 0.9268 100 0.207 Contact Map
4h27A 1 0.9055 100 0.215 Contact Map
2d1fA 2 0.9329 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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