GREMLIN Database
FLHB - Flagellar biosynthetic protein FlhB
UniProt: P76299 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14035
Length: 382 (348)
Sequences: 2427 (1867)
Seq/√Len: 100.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_E118_K6.4871.00
15_H19_K5.3481.00
19_K22_E4.5311.00
224_Q228_D4.5221.00
265_I304_G4.2491.00
128_N131_P4.0681.00
217_K220_R4.0631.00
14_P18_E3.7961.00
215_H219_L3.7661.00
12_P216_L3.4171.00
17_L216_L3.2801.00
258_D261_K3.1321.00
13_T226_I3.1051.00
299_R302_E3.0241.00
19_K23_E2.9811.00
258_D328_G2.9411.00
116_S119_S2.9051.00
20_A219_L2.8541.00
40_V102_V2.7471.00
242_R245_Q2.6341.00
222_S225_D2.6171.00
279_D282_K2.5671.00
243_I247_Q2.5391.00
18_E22_E2.4531.00
214_S218_K2.4361.00
222_S226_I2.4151.00
317_L342_V2.3811.00
265_I300_I2.3751.00
10_E223_R2.3321.00
25_Q215_H2.2991.00
298_L301_R2.2821.00
144_E147_K2.1731.00
17_L219_L2.1491.00
272_Y293_A2.0991.00
143_A210_F2.0931.00
140_Q214_S2.0921.00
118_K121_Q2.0531.00
22_E118_K2.0181.00
160_G164_W2.0141.00
259_V309_V1.9201.00
131_P134_K1.9121.00
166_H169_Q1.9041.00
242_R246_M1.8861.00
261_K277_Q1.8751.00
44_V98_G1.8601.00
210_F214_S1.8321.00
301_R305_A1.8161.00
303_I307_N1.8081.00
139_A217_K1.7621.00
25_Q218_K1.7481.00
125_S131_P1.7431.00
246_M250_A1.7331.00
36_L106_S1.7201.00
213_F217_K1.7061.00
158_V199_G1.6401.00
162_F195_L1.6311.00
283_M287_K1.6261.00
284_S330_Q1.6221.00
289_V309_V1.6081.00
345_W349_L1.6011.00
288_V325_A1.6001.00
272_Y294_G1.5981.00
28_R107_P1.5891.00
261_K289_V1.5841.00
157_S161_F1.5791.00
138_S141_T1.5631.00
272_Y315_P1.5451.00
41_G99_V1.5391.00
15_H233_S1.5161.00
11_A216_L1.5041.00
35_L204_V1.4981.00
164_W167_W1.4821.00
230_F234_E1.4751.00
274_V288_V1.4631.00
32_L204_V1.4451.00
42_V193_A1.4331.00
123_K126_K1.4311.00
208_V212_I1.4171.00
273_S298_L1.4001.00
245_Q249_A1.3760.99
273_S301_R1.3690.99
301_R313_E1.3680.99
251_A254_R1.3650.99
287_K330_Q1.3600.99
100_V103_A1.3570.99
104_L108_V1.3530.99
55_R90_L1.3370.99
32_L208_V1.3330.99
298_L313_E1.3280.99
166_H191_L1.3170.99
314_A341_E1.3140.99
277_Q283_M1.3090.99
319_R323_R1.3050.99
325_A329_Q1.3010.99
303_I306_E1.2870.99
32_L106_S1.2840.99
55_R87_E1.2790.99
176_E180_T1.2750.99
136_M145_L1.2750.99
20_A25_Q1.2690.99
121_Q125_S1.2620.99
258_D289_V1.2380.99
176_E184_N1.2350.99
140_Q144_E1.2350.99
17_L215_H1.2200.99
228_D232_Q1.2150.99
216_L220_R1.2140.99
266_V318_A1.2050.99
27_P215_H1.1940.98
312_L345_W1.1910.98
191_L195_L1.1900.98
86_R90_L1.1810.98
216_L219_L1.1810.98
132_G135_R1.1780.98
11_A14_P1.1740.98
305_A311_T1.1730.98
260_P303_I1.1710.98
39_L197_V1.1690.98
267_N313_E1.1650.98
248_R252_R1.1650.98
28_R111_G1.1570.98
346_V349_L1.1510.98
292_G300_I1.1380.98
87_E90_L1.1330.98
21_R114_V1.1330.98
223_R227_R1.1220.98
38_L197_V1.1190.98
274_V323_R1.1120.98
244_R248_R1.1110.98
274_V321_L1.1050.97
275_A290_A1.0900.97
134_K217_K1.0870.97
239_V242_R1.0870.97
298_L311_T1.0820.97
266_V310_P1.0790.97
258_D327_I1.0760.97
271_H294_G1.0740.97
136_M141_T1.0680.97
335_L342_V1.0630.97
212_I216_L1.0610.97
291_K325_A1.0540.97
92_L96_I1.0490.97
27_P212_I1.0490.97
149_I153_I1.0480.97
210_F213_F1.0450.96
223_R226_I1.0450.96
130_L134_K1.0430.96
142_G146_L1.0410.96
19_K118_K1.0380.96
268_N271_H1.0360.96
48_G98_G1.0300.96
215_H218_K1.0290.96
259_V300_I1.0290.96
206_F209_F1.0280.96
9_T223_R1.0270.96
249_A253_R1.0250.96
238_H241_G1.0230.96
17_L20_A1.0220.96
44_V48_G1.0190.96
288_V321_L1.0160.96
140_Q218_K1.0150.96
317_L339_V1.0140.96
157_S160_G1.0130.96
15_H18_E0.9970.95
63_G84_L0.9950.95
302_E305_A0.9790.95
139_A142_G0.9790.95
267_N311_T0.9730.95
110_L314_A0.9710.95
127_L130_L0.9700.95
262_A289_V0.9680.95
293_A322_Y0.9670.95
30_R144_E0.9640.94
57_S61_S0.9640.94
117_G120_L0.9640.94
36_L102_V0.9640.94
51_S55_R0.9600.94
330_Q336_Y0.9580.94
10_E226_I0.9570.94
263_D279_D0.9560.94
283_M330_Q0.9530.94
178_P181_A0.9480.94
15_H232_Q0.9460.94
35_L197_V0.9440.94
12_P17_L0.9420.94
93_L97_S0.9390.94
16_R232_Q0.9390.94
108_V113_L0.9370.94
272_Y323_R0.9350.94
6_D224_Q0.9330.93
11_A220_R0.9310.93
277_Q282_K0.9270.93
116_S120_L0.9240.93
12_P31_E0.9220.93
247_Q251_A0.9080.92
299_R303_I0.9060.92
41_G193_A0.9030.92
267_N305_A0.9000.92
51_S90_L0.8930.92
324_H334_Q0.8890.92
335_L343_L0.8890.92
320_A335_L0.8890.92
8_K12_P0.8840.91
245_Q252_R0.8770.91
36_L109_M0.8770.91
289_V327_I0.8770.91
111_G114_V0.8740.91
16_R19_K0.8740.91
247_Q250_A0.8720.91
153_I157_S0.8710.91
254_R257_A0.8670.91
13_T17_L0.8630.90
267_N301_R0.8530.90
37_I41_G0.8500.90
245_Q248_R0.8440.89
99_V257_A0.8410.89
82_I86_R0.8410.89
50_V54_R0.8410.89
259_V307_N0.8380.89
333_G336_Y0.8370.89
21_R112_G0.8330.89
27_P126_K0.8310.89
236_D239_V0.8310.89
139_A220_R0.8290.89
96_I100_V0.8280.89
53_A186_M0.8270.89
285_A330_Q0.8240.88
243_I253_R0.8170.88
187_D191_L0.8160.88
27_P208_V0.8140.88
326_E329_Q0.8130.88
130_L133_I0.8110.88
102_V106_S0.8100.87
289_V300_I0.8090.87
39_L43_S0.8060.87
21_R215_H0.8040.87
16_R224_Q0.8020.87
260_P307_N0.7950.86
78_L82_I0.7940.86
122_P125_S0.7910.86
103_A107_P0.7900.86
164_W168_P0.7870.86
30_R232_Q0.7860.86
91_A94_P0.7850.86
26_I111_G0.7840.86
56_L88_A0.7820.86
258_D277_Q0.7810.85
198_L202_P0.7810.85
107_P111_G0.7780.85
30_R107_P0.7770.85
263_D277_Q0.7760.85
150_L203_M0.7740.85
5_S222_S0.7740.85
83_L87_E0.7710.85
132_G136_M0.7660.84
139_A214_S0.7580.84
139_A213_F0.7580.84
331_I339_V0.7560.84
145_L148_A0.7550.84
144_E151_K0.7510.83
320_A324_H0.7490.83
31_E62_A0.7460.83
260_P300_I0.7420.82
120_L127_L0.7410.82
70_I189_V0.7400.82
169_Q184_N0.7400.82
145_L149_I0.7400.82
214_S217_K0.7390.82
298_L305_A0.7380.82
295_L298_L0.7340.82
8_K222_S0.7330.82
296_V327_I0.7310.82
13_T16_R0.7250.81
88_A92_L0.7250.81
268_N319_R0.7220.81
255_M299_R0.7210.81
247_Q347_W0.7210.81
25_Q219_L0.7170.80
233_S236_D0.7170.80
110_L208_V0.7150.80
121_Q134_K0.7150.80
35_L201_I0.7130.80
263_D343_L0.7130.80
131_P218_K0.7110.80
125_S128_N0.7100.80
270_T319_R0.7090.80
238_H243_I0.7090.80
243_I249_A0.7080.79
40_V98_G0.7070.79
290_A300_I0.7060.79
259_V327_I0.7050.79
95_L99_V0.7050.79
124_F128_N0.7010.79
97_S101_L0.7010.79
31_E204_V0.6980.78
23_E115_F0.6970.78
131_P135_R0.6950.78
177_S180_T0.6950.78
256_M260_P0.6930.78
58_G87_E0.6930.78
302_E306_E0.6920.78
100_V104_L0.6910.78
338_A342_V0.6890.78
111_G208_V0.6850.77
62_A83_L0.6850.77
332_P335_L0.6810.77
105_I109_M0.6800.77
43_S305_A0.6790.77
294_G298_L0.6770.76
344_A347_W0.6770.76
269_P319_R0.6770.76
148_A152_T0.6760.76
275_A292_G0.6730.76
232_Q236_D0.6730.76
257_A296_V0.6730.76
159_T196_V0.6730.76
316_P320_A0.6710.76
183_G187_D0.6710.76
173_L283_M0.6700.76
6_D11_A0.6680.75
315_P319_R0.6680.75
285_A336_Y0.6670.75
33_T37_I0.6630.75
161_F165_H0.6620.75
41_G45_I0.6620.75
255_M327_I0.6590.74
225_D228_D0.6590.74
52_L55_R0.6580.74
44_V95_L0.6570.74
124_F127_L0.6560.74
35_L200_V0.6550.74
26_I215_H0.6540.74
241_G251_A0.6530.74
12_P220_R0.6520.74
223_R231_K0.6510.73
121_Q137_F0.6490.73
26_I102_V0.6450.73
46_W190_G0.6450.73
98_G136_M0.6440.73
33_T111_G0.6430.73
180_T184_N0.6430.73
274_V315_P0.6400.72
277_Q287_K0.6400.72
150_L208_V0.6390.72
199_G203_M0.6390.72
100_V201_I0.6380.72
288_V343_L0.6360.72
54_R58_G0.6350.72
144_E251_A0.6340.72
262_A275_A0.6340.72
150_L154_L0.6330.71
205_G209_F0.6330.71
6_D9_T0.6330.71
11_A226_I0.6320.71
291_K326_E0.6300.71
217_K230_F0.6300.71
165_H195_L0.6280.71
321_L325_A0.6250.70
264_V342_V0.6250.70
141_T145_L0.6250.70
16_R212_I0.6230.70
230_F236_D0.6220.70
259_V303_I0.6210.70
340_A344_A0.6190.70
13_T230_F0.6180.70
55_R58_G0.6170.69
123_K323_R0.6160.69
12_P152_T0.6160.69
143_A146_L0.6150.69
158_V196_V0.6140.69
271_H319_R0.6140.69
173_L176_E0.6140.69
160_G165_H0.6120.69
58_G61_S0.6100.69
276_L331_I0.6080.68
138_S142_G0.6080.68
328_G344_A0.6080.68
89_M187_D0.6070.68
312_L342_V0.6050.68
166_H188_L0.6020.68
118_K123_K0.5990.67
288_V331_I0.5990.67
245_Q293_A0.5980.67
30_R253_R0.5970.67
263_D285_A0.5950.67
127_L131_P0.5940.67
51_S54_R0.5910.66
218_K343_L0.5900.66
128_N134_K0.5880.66
348_Q352_W0.5880.66
265_I275_A0.5860.66
280_E347_W0.5850.65
117_G312_L0.5850.65
8_K231_K0.5840.65
239_V243_I0.5830.65
21_R212_I0.5820.65
16_R225_D0.5810.65
249_A252_R0.5800.65
314_A342_V0.5800.65
273_S305_A0.5790.65
83_L86_R0.5780.64
158_V195_L0.5760.64
162_F191_L0.5760.64
294_G345_W0.5750.64
13_T170_M0.5740.64
5_S217_K0.5740.64
37_I99_V0.5730.64
133_I136_M0.5720.64
35_L252_R0.5710.64
310_P349_L0.5710.64
248_R313_E0.5700.63
31_E73_D0.5700.63
213_F218_K0.5690.63
335_L344_A0.5690.63
270_T294_G0.5690.63
296_V322_Y0.5680.63
59_M87_E0.5680.63
282_K287_K0.5670.63
120_L126_K0.5640.63
42_V197_V0.5630.62
194_L198_L0.5630.62
12_P16_R0.5630.62
301_R311_T0.5600.62
15_H22_E0.5600.62
144_E211_Q0.5600.62
272_Y298_L0.5590.62
256_M299_R0.5580.62
263_D347_W0.5570.62
256_M296_V0.5570.62
14_P226_I0.5550.61
54_R57_S0.5550.61
63_G67_D0.5550.61
103_A123_K0.5530.61
63_G66_F0.5530.61
48_G220_R0.5500.61
48_G51_S0.5490.61
66_F69_S0.5490.61
44_V102_V0.5480.60
248_R251_A0.5480.60
13_T216_L0.5480.60
323_R335_L0.5470.60
80_Q246_M0.5470.60
67_D70_I0.5470.60
8_K23_E0.5460.60
255_M300_I0.5450.60
46_W59_M0.5440.60
284_S287_K0.5440.60
134_K139_A0.5420.60
265_I273_S0.5420.60
108_V266_V0.5420.60
294_G319_R0.5420.60
96_I103_A0.5410.59
296_V299_R0.5410.59
19_K211_Q0.5400.59
20_A109_M0.5400.59
132_G254_R0.5400.59
33_T96_I0.5400.59
295_L302_E0.5400.59
246_M276_L0.5390.59
43_S47_F0.5370.59
293_A315_P0.5370.59
75_N79_G0.5360.59
298_L302_E0.5360.59
192_C199_G0.5350.59
13_T121_Q0.5350.59
154_L199_G0.5340.58
8_K287_K0.5340.58
243_I251_A0.5340.58
41_G186_M0.5320.58
256_M327_I0.5310.58
204_V346_V0.5310.58
293_A298_L0.5300.58
197_V201_I0.5300.58
103_A196_V0.5300.58
178_P202_P0.5290.58
54_R61_S0.5290.58
246_M249_A0.5280.58
264_V276_L0.5270.57
95_L338_A0.5270.57
7_D34_S0.5270.57
45_I48_G0.5260.57
173_L181_A0.5250.57
89_M93_L0.5250.57
289_V298_L0.5230.57
40_V48_G0.5230.57
276_L323_R0.5230.57
153_I156_G0.5210.57
169_Q173_L0.5200.56
113_L117_G0.5200.56
313_E341_E0.5190.56
6_D334_Q0.5190.56
31_E34_S0.5190.56
209_F212_I0.5170.56
123_K168_P0.5170.56
11_A232_Q0.5170.56
160_G163_L0.5160.56
277_Q289_V0.5160.56
141_T148_A0.5160.56
38_L200_V0.5160.56
127_L133_I0.5130.55
161_F164_W0.5120.55
302_E307_N0.5120.55
184_N188_L0.5120.55
125_S134_K0.5110.55
156_G280_E0.5110.55
12_P219_L0.5110.55
59_M213_F0.5110.55
337_A341_E0.5100.55
133_I137_F0.5100.55
339_V346_V0.5080.55
14_P22_E0.5080.55
73_D85_I0.5060.54
146_L234_E0.5050.54
257_A326_E0.5040.54
228_D233_S0.5040.54
92_L97_S0.5040.54
279_D283_M0.5030.54
288_V291_K0.5030.54
301_R315_P0.5010.54
53_A57_S0.5010.54
146_L149_I0.5010.54
283_M347_W0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jljA 2 0.301 100 0.561 Contact Map
3bzsA 1 0.2461 100 0.568 Contact Map
2jliA 1 0.2618 100 0.607 Contact Map
3t7yA 2 0.2461 100 0.71 Contact Map
3b0zB 1 0.2199 100 0.72 Contact Map
3c01E 2 0.2304 100 0.75 Contact Map
3b1sB 1 0.2225 100 0.755 Contact Map
3bzyB 3 0.2173 100 0.756 Contact Map
2vt1B 1 0.212 100 0.757 Contact Map
2ml9A 1 0.1518 99.9 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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