GREMLIN Database
FLHE - Flagellar protein FlhE
UniProt: P76297 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14013
Length: 130 (126)
Sequences: 127 (79)
Seq/√Len: 7.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_R110_G4.0060.96
60_Y86_Q2.9220.82
99_A130_R2.7710.78
102_L125_V2.7290.77
36_E108_V2.5290.71
35_G110_G2.3950.67
98_A118_L2.3240.64
60_Y72_V2.0950.56
106_W123_N2.0760.55
69_G129_Y2.0700.55
60_Y90_T2.0030.52
43_L128_N1.9910.52
14_V96_I1.9440.50
92_A122_R1.9110.49
29_I106_W1.8910.48
29_I72_V1.8820.48
20_G69_G1.7600.43
56_V79_R1.7520.43
33_H36_E1.7390.42
43_L62_L1.7180.41
29_I126_I1.7080.41
98_A112_G1.6940.41
10_F13_L1.6480.39
44_S130_R1.5540.35
20_G87_S1.5090.34
40_S60_Y1.4660.32
28_G123_N1.4490.32
33_H101_P1.4040.30
104_F123_N1.3960.30
28_G70_L1.3910.30
51_G63_I1.3900.30
25_S90_T1.3900.30
62_L120_V1.3800.30
62_L116_P1.3790.30
85_G129_Y1.3690.29
12_L16_A1.3660.29
59_R81_V1.3640.29
25_S51_G1.3580.29
85_G102_L1.3460.29
69_G118_L1.2970.27
34_R51_G1.2940.27
21_M34_R1.2750.26
115_I121_Q1.2680.26
28_G122_R1.2610.26
32_N41_A1.2510.26
21_M91_V1.2300.25
90_T96_I1.2230.25
108_V114_L1.2140.25
24_A79_R1.2030.24
16_A117_P1.1800.24
93_F102_L1.1730.23
91_V94_S1.1460.23
29_I60_Y1.1440.23
43_L125_V1.1250.22
37_S97_A1.1170.22
10_F70_L1.1020.22
60_Y119_K1.0820.21
66_T111_G1.0770.21
81_V90_T1.0590.20
52_L124_E1.0550.20
45_T122_R1.0540.20
35_G90_T1.0180.19
40_S59_R1.0090.19
14_V91_V1.0070.19
24_A102_L1.0050.19
6_A119_K0.9930.19
104_F118_L0.9910.19
24_A59_R0.9860.19
30_T41_A0.9790.19
12_L38_M0.9770.18
61_Q93_F0.9750.18
103_R108_V0.9520.18
48_P86_Q0.9460.18
83_L87_S0.9410.18
56_V127_V0.9400.18
66_T73_R0.9250.17
90_T110_G0.9120.17
51_G100_E0.9120.17
65_P128_N0.9090.17
66_T121_Q0.9090.17
33_H92_A0.9020.17
76_S105_I0.8950.17
49_A87_S0.8880.17
29_I36_E0.8830.16
29_I123_N0.8810.16
48_P71_R0.8790.16
69_G102_L0.8730.16
24_A93_F0.8700.16
48_P101_P0.8630.16
101_P107_E0.8600.16
31_L54_T0.8540.16
56_V114_L0.8460.16
35_G102_L0.8450.16
12_L130_R0.8420.16
29_I41_A0.8330.15
39_S84_E0.8320.15
30_T64_G0.8310.15
71_R97_A0.8300.15
38_M124_E0.8280.15
63_I130_R0.8280.15
63_I121_Q0.8270.15
68_S126_I0.8270.15
9_L21_M0.8140.15
46_R50_S0.8120.15
48_P117_P0.8090.15
10_F16_A0.8040.15
90_T93_F0.8010.15
7_I13_L0.7970.15
28_G98_A0.7810.14
15_Q79_R0.7660.14
98_A129_Y0.7540.14
62_L108_V0.7530.14
43_L108_V0.7510.14
66_T104_F0.7400.14
35_G93_F0.7400.14
51_G90_T0.7360.14
17_A42_P0.7000.13
106_W118_L0.6940.13
11_P129_Y0.6940.13
48_P66_T0.6870.13
15_Q97_A0.6850.13
39_S126_I0.6810.13
33_H72_V0.6770.13
32_N130_R0.6740.12
73_R97_A0.6660.12
112_G129_Y0.6620.12
85_G128_N0.6590.12
92_A102_L0.6580.12
17_A113_R0.6540.12
61_Q109_P0.6540.12
16_A99_A0.6520.12
33_H41_A0.6510.12
101_P109_P0.6490.12
25_S42_P0.6460.12
34_R91_V0.6450.12
57_A101_P0.6400.12
63_I83_L0.6370.12
19_E111_G0.6350.12
50_S97_A0.6330.12
100_E125_V0.6220.12
96_I100_E0.6180.12
60_Y92_A0.6150.11
18_G68_S0.6120.11
21_M42_P0.6070.11
26_S29_I0.6020.11
68_S111_G0.5950.11
12_L15_Q0.5920.11
5_L11_P0.5900.11
99_A113_R0.5870.11
93_F96_I0.5850.11
65_P81_V0.5830.11
13_L89_T0.5820.11
15_Q78_S0.5800.11
54_T64_G0.5800.11
24_A53_M0.5790.11
27_V33_H0.5770.11
24_A36_E0.5770.11
13_L27_V0.5760.11
83_L95_G0.5730.11
41_A81_V0.5710.11
64_G111_G0.5710.11
60_Y93_F0.5710.11
84_E102_L0.5700.11
6_A9_L0.5690.11
25_S55_L0.5650.11
6_A12_L0.5580.11
42_P116_P0.5560.11
83_L106_W0.5520.11
31_L73_R0.5470.10
24_A92_A0.5450.10
10_F84_E0.5420.10
38_M108_V0.5370.10
21_M124_E0.5370.10
76_S103_R0.5360.10
39_S96_I0.5350.10
63_I85_G0.5320.10
92_A95_G0.5250.10
70_L108_V0.5240.10
40_S122_R0.5240.10
47_Q123_N0.5210.10
13_L91_V0.5180.10
98_A125_V0.5140.10
43_L70_L0.5140.10
19_E34_R0.5120.10
40_S56_V0.5110.10
15_Q42_P0.5080.10
10_F59_R0.5070.10
44_S64_G0.5050.10
50_S127_V0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qxlA 1 0.8769 100 0.174 Contact Map
2v2tA 1 0.3462 15.6 0.945 Contact Map
3oa8B 3 0.6154 9.1 0.95 Contact Map
4tpkA 2 0.7615 5.5 0.955 Contact Map
1ukcA 2 0.8077 3.2 0.96 Contact Map
1jpyA 2 0.7692 2.9 0.961 Contact Map
2awgA 1 0.3154 2.6 0.962 Contact Map
4p02B 1 0.4769 2.3 0.963 Contact Map
3zbiC 1 0.1769 2.2 0.963 Contact Map
5a1uH 1 0 2.1 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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