GREMLIN Database
CMOB - tRNA (mo5U34)-methyltransferase
UniProt: P76291 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14034
Length: 323 (308)
Sequences: 559 (368)
Seq/√Len: 21.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
230_D314_K6.6831.00
302_D305_K5.0121.00
269_D321_R4.7101.00
114_V317_V4.4401.00
245_Q292_E4.3071.00
80_E84_R4.1401.00
229_I235_T3.9641.00
272_I318_L3.8001.00
137_M148_A3.6871.00
204_S207_E3.6111.00
247_R264_K3.4381.00
119_S221_E3.3461.00
141_I174_A3.3271.00
66_E70_P3.2781.00
123_G146_H3.0700.99
271_R319_I2.9190.99
131_C150_G2.7710.99
55_Y70_P2.7410.99
234_N257_A2.7240.99
95_S98_G2.6910.99
236_V257_A2.6630.98
275_V314_K2.6490.98
87_M290_V2.6420.98
84_R87_M2.6160.98
94_F133_S2.4850.98
255_A272_I2.4530.97
210_W265_C2.4380.97
72_S75_Q2.3570.97
280_T303_P2.3330.96
295_A303_P2.3280.96
97_Y167_L2.2150.95
133_S136_H2.1820.95
20_L24_P2.1040.94
84_R287_E2.0080.92
255_A275_V1.9730.91
193_V215_Q1.9610.91
259_K272_I1.9390.91
259_K318_L1.9310.90
277_V314_K1.9160.90
115_L143_A1.8200.87
277_V304_G1.8140.87
137_M174_A1.7950.87
252_I292_E1.7660.86
232_D235_T1.7660.86
299_D305_K1.7490.85
292_E296_D1.7400.85
96_L164_V1.7170.84
60_L143_A1.7070.84
95_S100_N1.6970.83
165_R169_G1.6730.83
127_L193_V1.6700.82
79_I167_L1.6160.80
73_A76_I1.5920.79
30_W155_Q1.5870.79
285_R295_A1.5440.77
165_R173_R1.5360.77
245_Q252_I1.5210.76
228_V316_A1.5200.76
148_A174_A1.5050.75
122_T301_H1.5030.75
192_T221_E1.5020.75
258_L318_L1.5000.75
285_R292_E1.4980.75
271_R321_R1.4880.74
259_K270_I1.4690.73
120_D124_R1.4640.73
114_V118_L1.4520.72
238_V264_K1.4370.72
232_D257_A1.4180.71
238_V257_A1.3990.70
246_M249_V1.3910.69
62_S112_D1.3720.68
124_R217_V1.3590.67
103_T136_H1.3520.67
195_S208_H1.3480.67
65_A70_P1.3410.66
124_R221_E1.3380.66
276_S317_V1.3360.66
147_L175_H1.3270.65
141_I170_N1.3200.65
38_L41_Q1.3160.65
46_V166_K1.3090.64
301_H305_K1.2940.63
227_L246_M1.2910.63
206_L265_C1.2790.62
240_G263_K1.2590.61
103_T133_S1.2570.61
196_M225_E1.2570.61
281_E307_V1.2540.61
141_I173_R1.2300.59
187_L214_D1.2110.58
36_H155_Q1.2080.58
124_R192_T1.2020.57
35_Q155_Q1.2010.57
158_L176_L1.1920.57
14_N147_L1.1840.56
149_V156_L1.1790.56
36_H247_R1.1760.56
268_V279_T1.1660.55
276_S279_T1.1580.55
14_N17_S1.1560.54
131_C137_M1.1360.53
245_Q307_V1.1350.53
19_W23_L1.1320.53
228_V318_L1.1270.53
101_I180_G1.1190.52
151_I180_G1.1180.52
141_I165_R1.1170.52
280_T295_A1.1050.51
82_L85_N1.0970.51
20_L82_L1.0880.50
21_E81_T1.0770.49
109_W279_T1.0760.49
119_S319_I1.0710.49
119_S321_R1.0690.49
229_I257_A1.0540.48
13_K17_S1.0510.48
22_T25_A1.0390.47
248_N278_T1.0370.47
54_P57_L1.0290.46
30_W215_Q1.0290.46
17_S21_E1.0190.45
170_N173_R1.0140.45
14_N18_H1.0080.45
235_T257_A0.9930.44
74_G78_R0.9900.43
55_Y66_E0.9880.43
106_R109_W0.9850.43
140_M194_F0.9850.43
87_M296_D0.9830.43
240_G310_Y0.9790.43
232_D236_V0.9760.43
285_R291_T0.9740.42
158_L162_E0.9680.42
120_D143_A0.9670.42
261_W288_W0.9600.42
255_A318_L0.9590.41
172_Q287_E0.9570.41
25_A29_N0.9550.41
129_V212_L0.9510.41
132_G145_A0.9470.41
129_V198_V0.9370.40
160_Q248_N0.9350.40
197_G200_Y0.9340.40
19_W26_Q0.9310.40
13_K172_Q0.9280.40
30_W36_H0.9260.39
213_K245_Q0.9240.39
52_I96_L0.9240.39
228_V246_M0.9150.39
58_D64_T0.9110.38
149_V174_A0.9100.38
252_I310_Y0.9100.38
115_L120_D0.9080.38
206_L250_Y0.9050.38
209_L265_C0.9040.38
149_V218_N0.9000.38
42_W195_S0.9000.38
30_W33_E0.8970.38
137_M176_L0.8930.37
69_E292_E0.8910.37
44_N78_R0.8890.37
114_V117_H0.8870.37
38_L291_T0.8860.37
169_G172_Q0.8770.36
84_R290_V0.8730.36
80_E287_E0.8680.36
183_Q264_K0.8680.36
89_W201_H0.8670.36
290_V305_K0.8660.36
36_H264_K0.8630.35
14_N318_L0.8540.35
35_Q247_R0.8480.35
22_T26_Q0.8460.34
301_H314_K0.8450.34
96_L167_L0.8390.34
61_H122_T0.8360.34
119_S124_R0.8360.34
139_R231_G0.8310.34
88_P135_Y0.8300.33
51_E76_I0.8290.33
167_L317_V0.8280.33
215_Q291_T0.8260.33
41_Q156_L0.8250.33
83_M163_A0.8190.33
122_T143_A0.8170.33
71_L75_Q0.8150.33
43_S57_L0.8140.33
127_L151_I0.8140.33
15_H314_K0.8090.32
113_R196_M0.8090.32
135_Y205_P0.8090.32
79_I96_L0.8070.32
66_E69_E0.8050.32
268_V321_R0.8030.32
240_G260_N0.7980.32
17_S94_F0.7980.32
76_I279_T0.7940.31
229_I254_S0.7930.31
280_T305_K0.7920.31
233_E256_L0.7910.31
181_I184_L0.7900.31
285_R317_V0.7830.31
17_S25_A0.7810.31
20_L26_Q0.7790.31
18_H25_A0.7770.30
37_G42_W0.7770.30
296_D320_A0.7670.30
192_T223_V0.7660.30
28_A295_A0.7650.30
281_E304_G0.7600.29
87_M289_M0.7590.29
29_N122_T0.7590.29
136_H154_T0.7590.29
127_L196_M0.7580.29
138_W208_H0.7580.29
276_S314_K0.7570.29
47_E61_H0.7570.29
118_L221_E0.7540.29
165_R174_A0.7500.29
123_G214_D0.7470.29
222_L274_D0.7430.29
100_N281_E0.7380.28
91_K243_Y0.7360.28
104_E107_S0.7350.28
82_L211_Q0.7350.28
116_P276_S0.7350.28
211_Q291_T0.7340.28
130_G201_H0.7330.28
97_Y166_K0.7330.28
285_R289_M0.7320.28
27_I161_F0.7310.28
193_V274_D0.7310.28
212_L258_L0.7300.28
111_W118_L0.7270.28
30_W35_Q0.7260.28
259_K263_K0.7250.28
43_S47_E0.7240.28
205_P251_F0.7220.27
38_L109_W0.7210.27
32_R35_Q0.7210.27
26_Q30_W0.7200.27
46_V165_R0.7180.27
90_R93_P0.7180.27
186_A214_D0.7170.27
41_Q48_F0.7170.27
18_H22_T0.7150.27
84_R305_K0.7130.27
21_E25_A0.7070.27
86_L160_Q0.7050.27
29_N33_E0.7040.26
300_P307_V0.7030.26
126_I241_D0.7030.26
287_E303_P0.7030.26
295_A321_R0.6980.26
78_R87_M0.6980.26
183_Q254_S0.6950.26
46_V79_I0.6940.26
54_P70_P0.6940.26
103_T185_P0.6930.26
125_T146_H0.6930.26
278_T294_L0.6910.26
211_Q215_Q0.6900.26
160_Q246_M0.6900.26
207_E210_W0.6880.26
133_S310_Y0.6880.26
14_N32_R0.6870.26
137_M291_T0.6850.26
242_R247_R0.6840.25
37_G41_Q0.6840.25
303_P307_V0.6840.25
276_S280_T0.6840.25
90_R197_G0.6830.25
227_L248_N0.6770.25
304_G311_P0.6770.25
295_A301_H0.6750.25
287_E318_L0.6750.25
43_S162_E0.6730.25
52_I73_A0.6730.25
157_F227_L0.6720.25
183_Q296_D0.6720.25
185_P204_S0.6720.25
212_L226_T0.6700.25
227_L249_V0.6690.25
193_V317_V0.6680.25
297_F310_Y0.6670.25
290_V295_A0.6660.25
263_K272_I0.6650.25
122_T188_K0.6640.24
253_P261_W0.6640.24
135_Y200_Y0.6630.24
115_L118_L0.6610.24
18_H279_T0.6590.24
22_T95_S0.6560.24
176_L292_E0.6560.24
151_I181_I0.6540.24
295_A304_G0.6530.24
132_G152_D0.6520.24
280_T307_V0.6520.24
86_L159_C0.6510.24
228_V255_A0.6480.24
191_D220_G0.6460.24
41_Q45_A0.6450.24
181_I265_C0.6450.24
69_E287_E0.6440.23
85_N241_D0.6420.23
207_E213_K0.6410.23
132_G151_I0.6390.23
115_L223_V0.6390.23
80_E99_V0.6380.23
135_Y197_G0.6380.23
17_S295_A0.6370.23
199_L227_L0.6370.23
19_W27_I0.6350.23
122_T146_H0.6340.23
162_E264_K0.6340.23
103_T108_D0.6300.23
113_R225_E0.6300.23
14_N265_C0.6270.23
96_L295_A0.6260.23
273_A319_I0.6260.23
168_L304_G0.6220.22
207_E289_M0.6220.22
278_T298_L0.6210.22
262_L320_A0.6200.22
89_W92_G0.6200.22
239_P243_Y0.6190.22
66_E250_Y0.6180.22
181_I208_H0.6180.22
193_V312_A0.6180.22
74_G81_T0.6170.22
299_D312_A0.6140.22
135_Y153_P0.6130.22
40_K44_N0.6120.22
280_T299_D0.6120.22
13_K18_H0.6110.22
147_L165_R0.6090.22
53_K172_Q0.6090.22
54_P58_D0.6080.22
151_I187_L0.6070.22
204_S289_M0.6070.22
246_M252_I0.6060.22
132_G208_H0.6050.22
234_N240_G0.6050.22
85_N99_V0.6040.22
246_M278_T0.6040.22
92_G105_W0.6030.22
111_W253_P0.6030.22
15_H18_H0.6010.22
51_E73_A0.6000.21
15_H75_Q0.6000.21
133_S295_A0.5980.21
41_Q81_T0.5960.21
200_Y248_N0.5960.21
104_E110_K0.5940.21
21_E28_A0.5940.21
169_G303_P0.5930.21
19_W24_P0.5920.21
257_A260_N0.5910.21
193_V270_I0.5910.21
135_Y239_P0.5910.21
42_W108_D0.5900.21
84_R99_V0.5900.21
56_R123_G0.5900.21
91_K105_W0.5870.21
24_P28_A0.5850.21
135_Y225_E0.5820.21
18_H100_N0.5810.21
125_T252_I0.5810.21
274_D317_V0.5810.21
25_A33_E0.5800.21
142_G212_L0.5800.21
132_G238_V0.5750.20
195_S199_L0.5740.20
187_L215_Q0.5730.20
88_P93_P0.5720.20
58_D61_H0.5700.20
22_T304_G0.5690.20
31_Q45_A0.5680.20
66_E292_E0.5680.20
74_G80_E0.5680.20
65_A168_L0.5680.20
14_N22_T0.5660.20
178_P196_M0.5650.20
186_A301_H0.5650.20
102_D105_W0.5640.20
64_T68_E0.5630.20
107_S205_P0.5630.20
105_W153_P0.5620.20
28_A51_E0.5600.20
13_K20_L0.5590.20
13_K280_T0.5580.20
39_F265_C0.5570.20
44_N81_T0.5560.20
214_D272_I0.5550.20
209_L222_L0.5540.19
240_G257_A0.5540.19
138_W251_F0.5520.19
153_P200_Y0.5520.19
162_E172_Q0.5490.19
281_E303_P0.5490.19
76_I304_G0.5490.19
114_V245_Q0.5490.19
153_P197_G0.5480.19
154_T295_A0.5470.19
88_P92_G0.5470.19
26_Q187_L0.5450.19
87_M291_T0.5450.19
287_E290_V0.5450.19
111_W194_F0.5450.19
169_G264_K0.5440.19
131_C216_L0.5410.19
301_H307_V0.5410.19
107_S110_K0.5380.19
135_Y243_Y0.5380.19
288_W313_P0.5380.19
31_Q291_T0.5370.19
210_W310_Y0.5360.19
206_L264_K0.5350.19
227_L244_A0.5350.19
163_A238_V0.5310.19
25_A188_K0.5300.18
44_N68_E0.5300.18
89_W93_P0.5290.18
24_P48_F0.5290.18
44_N48_F0.5280.18
279_T303_P0.5280.18
71_L76_I0.5270.18
58_D62_S0.5270.18
292_E304_G0.5260.18
14_N21_E0.5260.18
263_K318_L0.5260.18
83_M113_R0.5250.18
93_P105_W0.5220.18
92_G239_P0.5200.18
119_S259_K0.5200.18
281_E321_R0.5200.18
14_N125_T0.5200.18
230_D234_N0.5180.18
105_W110_K0.5160.18
72_S304_G0.5150.18
154_T247_R0.5150.18
285_R290_V0.5150.18
34_Q48_F0.5150.18
182_E231_G0.5140.18
127_L192_T0.5130.18
28_A317_V0.5110.18
47_E303_P0.5100.18
152_D176_L0.5090.18
38_L45_A0.5080.18
146_H302_D0.5060.18
279_T304_G0.5050.18
109_W289_M0.5050.18
263_K270_I0.5040.17
66_E98_G0.5040.17
203_R217_V0.5030.17
197_G225_E0.5030.17
43_S126_I0.5020.17
87_M118_L0.5020.17
103_T109_W0.5020.17
240_G297_F0.5010.17
127_L177_L0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p7cA 1 0.9845 100 0.457 Contact Map
4qnuA 2 1 100 0.503 Contact Map
3bkxA 2 0.7245 100 0.721 Contact Map
4ckbA 1 0.8978 100 0.738 Contact Map
2vdwA 1 0.743 100 0.744 Contact Map
3kkzA 2 0.709 100 0.748 Contact Map
3ocjA 1 0.7647 100 0.749 Contact Map
3f4kA 2 0.7337 100 0.751 Contact Map
2o57A 2 0.7709 100 0.754 Contact Map
3busA 1 0.7183 100 0.754 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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