GREMLIN Database
CMOA - tRNA (cmo5U34)-methyltransferase
UniProt: P76290 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14033
Length: 247 (205)
Sequences: 14949 (11332)
Seq/√Len: 791.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_Q84_K3.4561.00
144_Q220_N3.0381.00
92_P115_E3.0141.00
65_C87_A2.9081.00
151_Y223_F2.8071.00
127_S155_N2.7941.00
64_G134_T2.7361.00
86_I126_A2.6891.00
88_I116_G2.5451.00
61_Y126_A2.5191.00
149_K152_Q2.3911.00
92_P96_E2.3711.00
150_I160_L2.3591.00
95_I115_E2.3571.00
98_C113_V2.3441.00
144_Q148_D2.3151.00
71_T85_I2.2951.00
95_I113_V2.2621.00
84_K112_D2.2541.00
215_K219_H2.1831.00
97_R100_R2.1771.00
21_D91_S2.1111.00
63_L150_I2.0761.00
210_S213_T2.0641.00
86_I114_I2.0461.00
129_V150_I1.9651.00
129_V154_L1.9601.00
144_Q217_R1.9581.00
65_C71_T1.9201.00
154_L158_G1.9071.00
143_R217_R1.8541.00
123_I126_A1.8481.00
102_I113_V1.8121.00
55_Q58_T1.7631.00
59_Q86_I1.7421.00
72_L102_I1.7281.00
149_K153_G1.7281.00
90_N117_D1.7071.00
60_V74_V1.7051.00
76_R105_Y1.6871.00
154_L160_L1.6781.00
71_T87_A1.6451.00
63_L118_I1.5861.00
145_A148_D1.5651.00
60_V128_M1.5631.00
216_A220_N1.5591.00
119_R142_E1.5331.00
138_L146_L1.5051.00
72_L101_H1.4991.00
96_E99_R1.4991.00
118_I134_T1.4971.00
29_P67_L1.4801.00
64_G131_L1.4561.00
21_D93_A1.4401.00
29_P101_H1.4321.00
117_D120_D1.4311.00
86_I112_D1.4211.00
59_Q155_N1.4111.00
122_A149_K1.3991.00
47_G77_N1.3941.00
73_S76_R1.3911.00
116_G122_A1.3791.00
89_D95_I1.3751.00
59_Q126_A1.3751.00
144_Q221_A1.3611.00
123_I153_G1.3221.00
87_A113_V1.3131.00
154_L223_F1.3051.00
142_E145_A1.2711.00
93_A96_E1.2641.00
129_V153_G1.2571.00
59_Q125_N1.2521.00
59_Q127_S1.2251.00
72_L105_Y1.2051.00
58_T128_M1.2001.00
61_Y129_V1.1641.00
216_A219_H1.1531.00
99_R103_D1.1451.00
131_L134_T1.1451.00
20_F137_F1.1331.00
75_R110_P1.1261.00
121_I149_K1.0671.00
58_T83_C1.0671.00
72_L76_R1.0661.00
211_V230_F1.0661.00
146_L150_I1.0571.00
213_T216_A1.0511.00
121_I153_G1.0451.00
73_S77_N1.0361.00
136_Q164_E1.0361.00
68_G113_V1.0301.00
160_L218_L1.0161.00
150_I154_L1.0011.00
76_R107_A0.9961.00
91_S94_M0.9941.00
51_E77_N0.9871.00
88_I114_I0.9861.00
133_F136_Q0.9851.00
125_N155_N0.9841.00
57_G83_C0.9821.00
71_T111_V0.9821.00
135_L138_L0.9771.00
69_A73_S0.9721.00
134_T138_L0.9671.00
26_E97_R0.9621.00
133_F137_F0.9611.00
148_D152_Q0.9601.00
39_Y42_I0.9561.00
17_D21_D0.9521.00
65_C98_C0.9441.00
88_I121_I0.9431.00
215_K228_L0.9331.00
74_V130_V0.9281.00
102_I111_V0.9271.00
133_F163_S0.9271.00
87_A98_C0.9171.00
211_V215_K0.9111.00
69_A101_H0.9111.00
148_D221_A0.9101.00
147_L221_A0.8991.00
96_E100_R0.8961.00
128_M158_G0.8951.00
151_Y221_A0.8931.00
118_I138_L0.8921.00
27_V30_D0.8901.00
63_L88_I0.8841.00
70_A132_N0.8831.00
40_S44_S0.8771.00
89_D94_M0.8691.00
100_R103_D0.8641.00
135_L162_L0.8591.00
102_I105_Y0.8581.00
58_T127_S0.8581.00
164_E214_H0.8561.00
145_A149_K0.8551.00
45_M48_M0.8521.00
95_I99_R0.8501.00
68_G98_C0.8491.00
135_L146_L0.8491.00
147_L218_L0.8481.00
44_S48_M0.8471.00
39_Y43_I0.8461.00
67_L94_M0.8411.00
102_I107_A0.8371.00
132_N163_S0.8371.00
38_G42_I0.8351.00
54_V58_T0.8351.00
100_R104_A0.8321.00
67_L101_H0.8291.00
125_N152_Q0.8251.00
135_L147_L0.8181.00
65_C89_D0.8161.00
182_H186_R0.8111.00
195_I199_R0.8081.00
60_V85_I0.8071.00
107_A111_V0.8051.00
20_F136_Q0.8011.00
114_I123_I0.7961.00
181_H184_F0.7911.00
184_F188_N0.7841.00
176_L179_N0.7821.00
185_K188_N0.7801.00
92_P99_R0.7781.00
75_R107_A0.7751.00
128_M159_A0.7721.00
183_D186_R0.7691.00
189_G193_L0.7631.00
72_L113_V0.7601.00
126_A153_G0.7581.00
123_I149_K0.7451.00
175_E178_F0.7431.00
59_Q124_E0.7391.00
179_N183_D0.7391.00
71_T113_V0.7311.00
51_E54_V0.7191.00
63_L129_V0.7161.00
125_N153_G0.7151.00
167_S210_S0.7121.00
208_T214_H0.7101.00
189_G195_I0.7091.00
41_N44_S0.7051.00
211_V228_L0.7021.00
120_D149_K0.7011.00
25_A94_M0.6991.00
139_E142_E0.6961.00
120_D145_A0.6941.00
36_V39_Y0.6931.00
150_I162_L0.6931.00
147_L214_H0.6901.00
179_N182_H0.6891.00
143_R209_D0.6881.00
86_I123_I0.6881.00
32_I35_S0.6841.00
54_V128_M0.6841.00
189_G192_E0.6831.00
82_N85_I0.6801.00
102_I106_K0.6721.00
48_M51_E0.6711.00
46_I49_L0.6701.00
99_R112_D0.6661.00
212_E215_K0.6661.00
184_F187_A0.6661.00
217_R221_A0.6621.00
64_G90_N0.6611.00
186_R189_G0.6601.00
217_R220_N0.6571.00
123_I152_Q0.6521.00
18_W23_R0.6501.00
60_V83_C0.6461.00
36_V40_S0.6461.00
162_L218_L0.6451.00
42_I46_I0.6411.00
93_A97_R0.6411.00
65_C95_I0.6391.00
124_E152_Q0.6361.00
181_H186_R0.6341.00
31_M34_R0.6291.00
99_R113_V0.6291.00
61_Y153_G0.6251.00
180_M183_D0.6221.00
147_L217_R0.6201.00
95_I98_C0.6141.00
131_L160_L0.6141.00
72_L75_R0.6101.00
174_G178_F0.6101.00
63_L146_L0.6091.00
90_N115_E0.6071.00
97_R101_H0.6051.00
62_D65_C0.6041.00
33_Q40_S0.6021.00
135_L214_H0.6001.00
17_D115_E0.6001.00
70_A73_S0.5981.00
72_L107_A0.5961.00
70_A130_V0.5951.00
199_R202_L0.5941.00
94_M133_F0.5931.00
151_Y154_L0.5861.00
42_I45_M0.5841.00
49_L229_W0.5841.00
60_V130_V0.5791.00
160_L223_F0.5791.00
48_M52_R0.5791.00
62_D70_A0.5771.00
47_G51_E0.5751.00
37_P41_N0.5741.00
148_D220_N0.5731.00
101_H104_A0.5721.00
45_M229_W0.5701.00
129_V158_G0.5681.00
47_G50_A0.5671.00
64_G138_L0.5661.00
131_L138_L0.5641.00
194_E197_Q0.5611.00
183_D187_A0.5591.00
213_T217_R0.5581.00
48_M77_N0.5561.00
24_V27_V0.5561.00
46_I50_A0.5531.00
17_D90_N0.5531.00
49_L227_E0.5531.00
103_D106_K0.5511.00
67_L97_R0.5501.00
45_M49_L0.5501.00
50_A128_M0.5501.00
116_G121_I0.5451.00
147_L162_L0.5431.00
25_A29_P0.5431.00
29_P97_R0.5431.00
152_Q156_P0.5421.00
137_F164_E0.5421.00
195_I198_K0.5411.00
173_V176_L0.5401.00
131_L164_E0.5381.00
64_G118_I0.5361.00
122_A153_G0.5361.00
65_C113_V0.5341.00
136_Q165_K0.5341.00
212_E216_A0.5331.00
192_E195_I0.5331.00
44_S73_S0.5321.00
43_I46_I0.5321.00
62_D130_V0.5301.00
40_S73_S0.5291.00
67_L89_D0.5271.00
62_D85_I0.5271.00
71_T75_R0.5261.00
191_S195_I0.5251.00
133_F164_E0.5241.00
219_H225_H0.5231.00
29_P32_I0.5201.00
132_N136_Q0.5181.00
119_R146_L0.5161.00
133_F165_K0.5151.00
40_S43_I0.5121.00
75_R111_V0.5111.00
28_F67_L0.5101.00
197_Q200_S0.5071.00
38_G41_N0.5061.00
137_F165_K0.5051.00
20_F24_V0.5051.00
131_L162_L0.5051.00
193_L197_Q0.5031.00
118_I146_L0.5021.00
190_Y193_L0.5021.00
69_A72_L0.5011.00
202_L205_V0.5011.00
35_S137_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gekA 2 0.9352 100 0.324 Contact Map
3dtnA 2 0.9028 100 0.379 Contact Map
4obxA 2 0.8745 100 0.386 Contact Map
3bxoA 2 0.8664 100 0.426 Contact Map
4pneA 2 0.8583 100 0.432 Contact Map
1y8cA 1 0.8866 100 0.435 Contact Map
1wznA 4 0.8583 100 0.436 Contact Map
3pfgA 2 0.8866 100 0.44 Contact Map
3hnrA 1 0.7652 100 0.442 Contact Map
4kdcA 1 0.7976 100 0.443 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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