GREMLIN Database
YOBB - Uncharacterized protein YobB
UniProt: P76280 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14030
Length: 218 (209)
Sequences: 13347 (9616)
Seq/√Len: 665.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_K204_Q3.0451.00
118_G123_T2.9241.00
17_S20_E2.5451.00
25_H46_S2.4321.00
84_L97_A2.4051.00
183_L203_G2.3111.00
164_F167_Q2.3041.00
24_H198_S2.2661.00
185_D189_R2.2411.00
7_A202_V2.1651.00
26_L72_A2.0471.00
7_A37_C2.0341.00
158_A193_R2.0221.00
26_L68_P2.0221.00
30_R76_W1.9661.00
8_A175_A1.9501.00
127_V132_Q1.9111.00
8_A173_L1.9051.00
41_V144_T1.8861.00
91_R110_H1.8851.00
141_S211_Q1.8791.00
35_Q202_V1.8701.00
30_R75_T1.8371.00
38_Q120_R1.8281.00
79_T101_P1.8131.00
70_C99_F1.8121.00
194_A201_L1.7881.00
6_V173_L1.7801.00
40_L78_M1.7591.00
24_H27_E1.7361.00
79_T98_V1.7251.00
143_F170_I1.7101.00
26_L30_R1.7091.00
194_A199_L1.6801.00
159_R162_Q1.6781.00
14_R20_E1.6041.00
73_A80_I1.5921.00
96_I126_V1.5831.00
171_A186_E1.5801.00
30_R72_A1.5761.00
86_V95_G1.5741.00
69_L82_A1.5661.00
81_I98_V1.5571.00
161_L174_M1.5421.00
104_K107_G1.5421.00
192_V201_L1.5351.00
184_W190_L1.5301.00
123_T141_S1.5001.00
41_V175_A1.4831.00
81_I96_I1.4791.00
71_Y75_T1.4781.00
37_C202_V1.4671.00
25_H42_F1.4621.00
29_V80_I1.4581.00
9_A40_L1.4551.00
28_F31_A1.4511.00
31_A35_Q1.4441.00
66_L97_A1.4301.00
125_T135_D1.4191.00
81_I144_T1.4091.00
119_R122_R1.4021.00
173_L183_L1.3911.00
39_L144_T1.3911.00
27_E31_A1.3831.00
29_V40_L1.3781.00
209_G212_G1.3731.00
171_A191_I1.3591.00
22_V68_P1.3361.00
124_I142_L1.3331.00
132_Q143_F1.3201.00
79_T119_R1.3041.00
23_A27_E1.3011.00
59_A63_L1.2971.00
9_A42_F1.2931.00
158_A162_Q1.2921.00
72_A76_W1.2831.00
96_I146_G1.2781.00
185_D191_I1.2741.00
98_V126_V1.2741.00
134_M138_P1.2481.00
130_Q133_G1.2411.00
62_D66_L1.2411.00
127_V145_T1.2301.00
20_E23_A1.2121.00
132_Q145_T1.1951.00
32_A200_L1.1891.00
180_N193_R1.1811.00
23_A68_P1.1731.00
19_T23_A1.1611.00
88_Y93_I1.1581.00
47_L65_L1.1561.00
20_E24_H1.1491.00
9_A200_L1.1471.00
66_L99_F1.1451.00
28_F200_L1.1371.00
79_T100_A1.1291.00
180_N195_D1.1261.00
67_D70_C1.1211.00
29_V72_A1.1201.00
86_V93_I1.1161.00
159_R166_H1.1141.00
185_D209_G1.1131.00
9_A28_F1.1101.00
127_V131_P1.1071.00
165_S172_V1.1021.00
24_H28_F1.0921.00
77_R101_P1.0921.00
29_V78_M1.0911.00
59_A65_L1.0791.00
68_P71_Y1.0761.00
140_C143_F1.0751.00
101_P120_R1.0721.00
67_D71_Y1.0641.00
26_L75_T1.0601.00
81_I126_V1.0521.00
11_Y28_F1.0371.00
142_L173_L1.0281.00
161_L184_W1.0121.00
155_L162_Q0.9871.00
158_A182_A0.9831.00
22_V26_L0.9751.00
72_A75_T0.9721.00
161_L172_V0.9701.00
69_L80_I0.9701.00
154_L180_N0.9661.00
5_K202_V0.9631.00
93_I110_H0.9611.00
161_L182_A0.9571.00
68_P72_A0.9571.00
37_C40_L0.9491.00
133_G168_Y0.9431.00
14_R17_S0.9381.00
5_K35_Q0.9351.00
208_Q212_G0.9271.00
82_A99_F0.9271.00
165_S184_W0.9251.00
98_V117_L0.9231.00
119_R124_I0.9221.00
182_A190_L0.9221.00
136_M170_I0.9121.00
25_H69_L0.9091.00
71_Y74_T0.9051.00
60_P87_E0.9011.00
11_Y25_H0.8951.00
116_C123_T0.8921.00
208_Q211_Q0.8771.00
33_A78_M0.8771.00
26_L71_Y0.8691.00
8_A201_L0.8661.00
19_T64_S0.8601.00
31_A34_R0.8481.00
10_Q181_S0.8401.00
62_D67_D0.8351.00
19_T68_P0.8341.00
190_L193_R0.8321.00
141_S207_S0.8251.00
79_T120_R0.8251.00
38_Q101_P0.8171.00
8_A183_L0.8161.00
155_L158_A0.8151.00
191_I203_G0.8151.00
33_A76_W0.8131.00
30_R34_R0.8131.00
206_S209_G0.8071.00
63_L67_D0.8061.00
116_C140_C0.8051.00
133_G137_D0.8041.00
157_S174_M0.8031.00
63_L66_L0.8031.00
6_V205_R0.7991.00
122_R125_T0.7951.00
18_L22_V0.7941.00
114_G131_P0.7931.00
25_H82_A0.7861.00
11_Y46_S0.7851.00
209_G213_D0.7811.00
45_L109_Y0.7771.00
124_I144_T0.7731.00
12_E198_S0.7701.00
22_V69_L0.7691.00
171_A205_R0.7611.00
29_V76_W0.7611.00
118_G121_S0.7611.00
45_L50_C0.7591.00
35_Q200_L0.7571.00
8_A181_S0.7551.00
159_R163_F0.7521.00
192_V203_G0.7391.00
10_Q179_G0.7371.00
58_P61_P0.7361.00
122_R142_L0.7331.00
73_A76_W0.7321.00
171_A210_W0.7271.00
187_Y213_D0.7261.00
66_L70_C0.7251.00
23_A26_L0.7241.00
45_L85_P0.7191.00
4_W122_R0.7181.00
61_P66_L0.7151.00
207_S211_Q0.7121.00
129_E133_G0.7061.00
7_A40_L0.6931.00
27_E30_R0.6911.00
29_V42_F0.6891.00
7_A200_L0.6861.00
145_T172_V0.6841.00
32_A40_L0.6811.00
48_L62_D0.6801.00
14_R21_Q0.6781.00
17_S21_Q0.6731.00
135_D140_C0.6731.00
18_L59_A0.6731.00
122_R127_V0.6721.00
32_A37_C0.6701.00
122_R141_S0.6671.00
34_R76_W0.6641.00
39_L79_T0.6601.00
41_V81_I0.6601.00
148_C177_A0.6571.00
149_L153_D0.6551.00
87_E92_F0.6461.00
38_Q121_S0.6451.00
195_D199_L0.6451.00
143_F172_V0.6441.00
4_W121_S0.6431.00
169_S213_D0.6411.00
122_R207_S0.6401.00
42_F46_S0.6401.00
79_T121_S0.6371.00
14_R24_H0.6371.00
7_A32_A0.6371.00
39_L81_I0.6301.00
65_L68_P0.6301.00
11_Y24_H0.6291.00
134_M137_D0.6281.00
70_C73_A0.6271.00
25_H29_V0.6261.00
182_A193_R0.6261.00
131_P135_D0.6201.00
189_R209_G0.6201.00
171_A209_G0.6201.00
66_L82_A0.6191.00
4_W205_R0.6161.00
105_T109_Y0.6151.00
160_R163_F0.6121.00
103_R107_G0.6111.00
103_R109_Y0.6111.00
22_V65_L0.6101.00
86_V97_A0.6101.00
85_P109_Y0.6101.00
41_V173_L0.6091.00
84_L95_G0.6081.00
48_L57_L0.6081.00
114_G117_L0.6051.00
18_L65_L0.6031.00
114_G135_D0.6031.00
136_M168_Y0.6001.00
117_L124_I0.5941.00
125_T140_C0.5911.00
39_L121_S0.5901.00
162_Q190_L0.5871.00
129_E167_Q0.5861.00
59_A62_D0.5831.00
61_P97_A0.5801.00
54_R57_L0.5731.00
127_V135_D0.5721.00
12_E24_H0.5701.00
151_E178_R0.5701.00
164_F168_Y0.5681.00
114_G134_M0.5681.00
45_L94_R0.5681.00
83_G94_R0.5661.00
4_W39_L0.5641.00
149_L157_S0.5641.00
55_R87_E0.5621.00
31_A200_L0.5571.00
64_S67_D0.5571.00
151_E154_L0.5561.00
19_T22_V0.5551.00
38_Q77_R0.5551.00
28_F198_S0.5541.00
32_A78_M0.5541.00
176_N181_S0.5511.00
155_L159_R0.5501.00
153_D157_S0.5471.00
154_L178_R0.5471.00
61_P64_S0.5441.00
30_R33_A0.5431.00
26_L76_W0.5401.00
88_Y91_R0.5341.00
150_G153_D0.5321.00
37_C78_M0.5311.00
102_W107_G0.5301.00
116_C125_T0.5240.99
22_V72_A0.5230.99
63_L87_E0.5230.99
46_S82_A0.5220.99
47_L69_L0.5220.99
18_L57_L0.5210.99
123_T127_V0.5200.99
132_Q164_F0.5180.99
102_W109_Y0.5170.99
62_D84_L0.5160.99
141_S210_W0.5160.99
162_Q184_W0.5110.99
8_A192_V0.5080.99
183_L192_V0.5060.99
115_A138_P0.5060.99
158_A180_N0.5050.99
153_D156_A0.5050.99
31_A199_L0.5050.99
100_A120_R0.5030.99
48_L85_P0.5020.99
102_W106_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4izuA 2 0.945 100 0.221 Contact Map
2e11A 2 0.9954 100 0.238 Contact Map
2w1vA 2 0.9954 100 0.244 Contact Map
3ivzA 2 0.9725 100 0.244 Contact Map
2vhhA 5 1 100 0.244 Contact Map
3wuyA 2 0.9908 100 0.246 Contact Map
3p8kA 2 1 100 0.246 Contact Map
2dyuA 5 0.9908 100 0.26 Contact Map
3ilvA 2 0.9083 100 0.273 Contact Map
1f89A 2 1 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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