GREMLIN Database
YEBZ - Inner membrane protein YebZ
UniProt: P76278 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14028
Length: 290 (274)
Sequences: 2099 (1591)
Seq/√Len: 96.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_I200_G6.6811.00
237_M274_G4.5351.00
16_S57_S4.5271.00
229_L280_I4.2631.00
228_L232_I4.0471.00
233_L280_I3.8891.00
226_L280_I3.5551.00
16_S50_A3.4021.00
198_V238_V3.3381.00
162_F274_G2.8181.00
150_N208_N2.7011.00
157_C200_G2.6761.00
242_L246_Y2.6721.00
233_L277_V2.6141.00
113_R116_P2.5511.00
225_Q228_L2.1651.00
225_Q229_L2.0431.00
18_M278_L2.0291.00
127_F155_L2.0041.00
218_T224_G1.9641.00
100_L126_Q1.9411.00
195_H199_I1.9371.00
222_Y225_Q1.9341.00
213_T223_W1.9301.00
54_S101_A1.9011.00
277_V281_I1.8941.00
19_L166_L1.8871.00
100_L125_A1.8801.00
23_F167_P1.8731.00
162_F278_L1.8191.00
227_L234_V1.8101.00
209_A227_L1.8041.00
24_A47_Q1.7991.00
14_F281_I1.7871.00
276_V280_I1.7701.00
215_F219_L1.7521.00
236_I240_I1.7151.00
112_P117_R1.6941.00
97_Q129_L1.6821.00
237_M273_I1.6641.00
73_W76_V1.6581.00
247_V251_R1.6551.00
25_M160_A1.6531.00
21_F159_A1.6511.00
187_L263_F1.6411.00
222_Y226_L1.5861.00
11_F278_L1.5781.00
249_V252_M1.5721.00
83_Q86_L1.5651.00
9_L64_V1.5171.00
232_I236_I1.5141.00
194_G241_A1.5121.00
281_I285_A1.5111.00
210_L214_G1.4961.00
191_S245_R1.4751.00
214_G217_P1.4691.00
78_S81_I1.4661.00
106_I273_I1.4641.00
238_V241_A1.4601.00
233_L273_I1.4571.00
154_H230_K1.4471.00
240_I244_N1.4451.00
25_M29_W1.4381.00
240_I273_I1.4241.00
188_M192_W1.4120.99
279_V283_L1.3720.99
243_A247_V1.3690.99
239_V243_A1.3430.99
218_T221_T1.3350.99
236_I273_I1.3280.99
186_A190_F1.3180.99
123_T127_F1.3040.99
80_N84_A1.2950.99
221_T224_G1.2900.99
263_F266_M1.2870.99
28_A120_F1.2750.99
9_L57_S1.2740.99
13_H58_A1.2690.99
201_V285_A1.2680.99
241_A274_G1.2580.99
93_I129_L1.2500.99
209_A221_T1.2470.99
198_V241_A1.2330.99
194_G237_M1.2240.99
75_D78_S1.2170.98
208_N212_I1.2170.98
244_N248_L1.2130.98
157_C201_V1.2030.98
184_I188_M1.2020.98
158_A201_V1.1970.98
66_G81_I1.1950.98
181_H272_A1.1710.98
96_W100_L1.1690.98
104_T122_L1.1590.98
66_G76_V1.1380.98
234_V281_I1.1370.98
249_V263_F1.1370.98
187_L252_M1.1340.98
55_L102_L1.1320.98
198_V201_V1.1280.97
208_N281_I1.1230.97
157_C197_A1.1210.97
165_L271_W1.1210.97
31_A34_T1.1200.97
48_Q52_V1.1170.97
194_G244_N1.1160.97
72_G76_V1.1070.97
16_S53_W1.1040.97
8_A262_W1.0990.97
235_M239_V1.0970.97
26_Y30_L1.0970.97
165_L190_F1.0920.97
202_L234_V1.0900.97
81_I96_W1.0770.97
100_L122_L1.0700.97
31_A171_C1.0640.96
112_P116_P1.0520.96
14_F278_L1.0430.96
95_L99_V1.0400.96
90_F94_W1.0390.96
101_A126_Q1.0390.96
191_S267_T1.0350.96
10_R14_F1.0340.96
17_L21_F1.0320.96
135_H230_K1.0310.96
12_I57_S1.0200.95
24_A119_L1.0150.95
241_A244_N1.0150.95
118_L203_A1.0130.95
187_L248_L1.0100.95
52_V109_L1.0080.95
99_V102_L1.0070.95
241_A245_R1.0040.95
20_V51_A0.9980.95
19_L50_A0.9970.95
111_Q116_P0.9890.95
81_I85_V0.9850.94
7_I282_S0.9840.94
77_F85_V0.9830.94
107_V110_M0.9750.94
57_S61_M0.9730.94
244_N250_P0.9730.94
209_A223_W0.9730.94
187_L249_V0.9690.94
277_V280_I0.9690.94
70_G85_V0.9650.94
77_F81_I0.9640.94
9_L60_A0.9640.94
56_I83_Q0.9600.94
164_G197_A0.9520.93
216_P219_L0.9480.93
226_L284_L0.9460.93
113_R117_R0.9450.93
56_I105_L0.9440.93
194_G285_A0.9400.93
18_M158_A0.9370.93
194_G281_I0.9360.93
136_A208_N0.9330.93
104_T119_L0.9310.93
190_F244_N0.9290.93
54_S58_A0.9220.92
8_A12_I0.9180.92
14_F285_A0.9170.92
51_A101_A0.9170.92
12_I103_V0.9100.92
147_H194_G0.9090.92
15_T106_I0.9050.92
106_I109_L0.9040.92
98_I101_A0.9010.91
183_A263_F0.9000.91
100_L129_L0.8950.91
160_A182_Q0.8880.91
52_V118_L0.8880.91
206_V231_A0.8870.91
77_F84_A0.8850.91
122_L150_N0.8780.90
111_Q115_M0.8760.90
5_T64_V0.8720.90
147_H212_I0.8690.90
80_N83_Q0.8580.89
56_I108_A0.8550.89
58_A101_A0.8530.89
241_A263_F0.8530.89
76_V82_W0.8510.89
106_I110_M0.8470.89
160_A193_C0.8450.89
203_A206_V0.8370.88
58_A97_Q0.8340.88
135_H154_H0.8300.88
261_P265_W0.8280.88
216_P220_T0.8260.87
165_L241_A0.8180.87
132_G136_A0.8150.87
88_T91_G0.8150.87
154_H161_W0.8130.87
42_R45_R0.8100.86
25_M120_F0.8100.86
225_Q276_V0.8010.86
199_I203_A0.7980.86
78_S83_Q0.7970.85
154_H270_E0.7930.85
245_R285_A0.7930.85
154_H205_G0.7880.85
131_A152_A0.7870.85
253_R271_W0.7870.85
164_G194_G0.7860.85
100_L128_I0.7850.85
240_I269_L0.7820.84
72_G75_D0.7820.84
110_M235_M0.7810.84
164_G189_R0.7790.84
227_L231_A0.7780.84
8_A99_V0.7780.84
267_T287_L0.7770.84
121_M125_A0.7760.84
245_R249_V0.7750.84
149_T212_I0.7740.84
104_T288_E0.7730.84
227_L242_L0.7730.84
83_Q99_V0.7720.84
14_F277_V0.7710.84
171_C228_L0.7670.83
136_A148_Q0.7660.83
212_I281_I0.7630.83
149_T152_A0.7610.83
141_G208_N0.7610.83
132_G214_G0.7520.82
48_Q53_W0.7520.82
214_G250_P0.7520.82
44_L55_L0.7500.82
76_V85_V0.7490.82
78_S82_W0.7450.81
172_M263_F0.7390.81
73_W126_Q0.7380.81
44_L49_H0.7370.81
74_T77_F0.7360.81
224_G228_L0.7350.80
148_Q186_A0.7340.80
205_G230_K0.7340.80
204_S208_N0.7340.80
161_W230_K0.7290.80
209_A213_T0.7280.80
245_R274_G0.7260.80
11_F279_V0.7250.80
20_V24_A0.7210.79
76_V79_P0.7180.79
66_G85_V0.7150.79
18_M70_G0.7150.79
144_A208_N0.7140.79
70_G75_D0.7090.78
206_V209_A0.7090.78
230_K270_E0.7040.78
55_L59_T0.7030.77
234_V244_N0.7030.77
46_L162_F0.7020.77
31_A35_I0.7010.77
228_L236_I0.7010.77
54_S126_Q0.6990.77
79_P117_R0.6980.77
10_R136_A0.6980.77
187_L266_M0.6950.77
53_W81_I0.6940.77
249_V266_M0.6910.76
125_A155_L0.6890.76
82_W85_V0.6890.76
60_A102_L0.6790.75
158_A281_I0.6780.75
124_T127_F0.6750.75
234_V250_P0.6740.74
206_V210_L0.6730.74
233_L276_V0.6610.73
272_A276_V0.6600.73
97_Q277_V0.6590.73
15_T166_L0.6590.73
167_P241_A0.6570.73
7_I286_T0.6570.73
13_H57_S0.6470.71
24_A123_T0.6470.71
217_P220_T0.6450.71
13_H130_L0.6440.71
15_T72_G0.6440.71
119_L227_L0.6430.71
160_A216_P0.6420.71
173_Q176_K0.6390.71
6_W65_Q0.6360.70
130_L155_L0.6340.70
130_L285_A0.6340.70
8_A15_T0.6330.70
148_Q275_A0.6330.70
123_T126_Q0.6310.70
12_I34_T0.6300.69
41_K111_Q0.6290.69
59_T118_L0.6290.69
237_M281_I0.6290.69
115_M232_I0.6290.69
208_N211_L0.6250.69
102_L121_M0.6220.68
6_W64_V0.6220.68
77_F86_L0.6210.68
98_I231_A0.6210.68
75_D288_E0.6200.68
10_R281_I0.6180.68
99_V103_V0.6170.68
271_W275_A0.6170.68
111_Q121_M0.6160.68
8_A254_Q0.6160.68
112_P115_M0.6160.68
253_R257_D0.6150.68
190_F212_I0.6150.68
168_V267_T0.6140.67
81_I99_V0.6140.67
93_I285_A0.6120.67
193_C237_M0.6120.67
18_M82_W0.6110.67
112_P256_E0.6110.67
10_R170_W0.6090.67
206_V261_P0.6080.67
49_H60_A0.6070.67
275_A279_V0.6060.66
46_L199_I0.6050.66
23_F35_I0.6050.66
44_L52_V0.6050.66
55_L61_M0.6030.66
164_G241_A0.6020.66
108_A114_N0.6010.66
94_W130_L0.5990.66
232_I287_L0.5990.66
153_I203_A0.5970.65
53_W277_V0.5970.65
55_L72_G0.5950.65
28_A31_A0.5950.65
168_V172_M0.5930.65
219_L225_Q0.5910.65
188_M253_R0.5900.64
18_M21_F0.5890.64
158_A221_T0.5880.64
208_N245_R0.5840.64
191_S281_I0.5790.63
128_I156_I0.5790.63
11_F285_A0.5780.63
51_A105_L0.5770.63
130_L208_N0.5770.63
164_G248_L0.5760.63
23_F47_Q0.5750.62
10_R88_T0.5750.62
120_F203_A0.5740.62
18_M147_H0.5730.62
145_K200_G0.5720.62
249_V284_L0.5720.62
21_F160_A0.5670.61
234_V277_V0.5650.61
63_A73_W0.5650.61
270_E281_I0.5650.61
148_Q164_G0.5640.61
204_S237_M0.5630.61
122_L125_A0.5620.61
58_A164_G0.5620.61
130_L133_V0.5610.61
98_I129_L0.5600.60
62_L86_L0.5600.60
59_T173_Q0.5590.60
241_A266_M0.5580.60
19_L162_F0.5560.60
55_L133_V0.5560.60
83_Q276_V0.5550.60
24_A36_R0.5550.60
44_L48_Q0.5530.59
101_A226_L0.5510.59
207_L213_T0.5500.59
48_Q108_A0.5500.59
57_S69_M0.5500.59
32_P189_R0.5490.59
185_Q236_I0.5490.59
244_N270_E0.5460.58
49_H53_W0.5460.58
158_A264_V0.5460.58
81_I86_L0.5460.58
236_I253_R0.5440.58
136_A151_H0.5430.58
261_P264_V0.5390.58
29_W160_A0.5370.57
59_T137_T0.5350.57
103_V115_M0.5340.57
14_F130_L0.5290.56
19_L236_I0.5270.56
131_A241_A0.5260.56
107_V122_L0.5250.56
160_A197_A0.5240.55
175_I181_H0.5220.55
43_F47_Q0.5210.55
200_G257_D0.5210.55
14_F17_L0.5160.54
8_A20_V0.5160.54
268_K279_V0.5160.54
244_N266_M0.5150.54
226_L268_K0.5130.54
9_L62_L0.5110.54
236_I257_D0.5100.53
157_C271_W0.5100.53
75_D81_I0.5070.53
94_W97_Q0.5060.53
26_Y263_F0.5050.53
241_A286_T0.5050.53
161_W270_E0.5050.53
25_M257_D0.5040.53
209_A284_L0.5020.52
127_F231_A0.5020.52
111_Q114_N0.5010.52
284_L287_L0.5010.52
64_V71_T0.5000.52
78_S85_V0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nv5A 1 0.3207 5.1 0.958 Contact Map
1kqfC 3 0.3793 3.6 0.961 Contact Map
1v54A 1 0.4034 2.9 0.963 Contact Map
3m73A 3 0.3448 2.5 0.964 Contact Map
3h90A 3 0.5655 2 0.966 Contact Map
3wfdB 1 0.3655 2 0.966 Contact Map
3j2wE 1 0.1586 1.6 0.967 Contact Map
4b19A 1 0.1034 1.3 0.969 Contact Map
2nq2A 2 0.3241 1.3 0.969 Contact Map
2l0nA 1 0.1034 1.3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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