GREMLIN Database
RSMF - Ribosomal RNA small subunit methyltransferase F
UniProt: P76273 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14023
Length: 479 (425)
Sequences: 1666 (1339)
Seq/√Len: 65.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_E309_R5.6671.00
241_T309_R4.8901.00
258_C308_L4.8291.00
191_I236_L4.6291.00
270_E311_T4.6151.00
230_D264_T4.2921.00
132_T162_I3.8651.00
132_T147_A3.8301.00
233_F269_V3.7891.00
119_Q190_A3.7841.00
108_V135_I3.6811.00
241_T307_R3.5531.00
290_F304_F3.4861.00
125_A193_L3.2521.00
226_R260_W3.2461.00
26_F30_L3.1951.00
15_Q252_E3.1071.00
10_D14_T3.0801.00
136_S167_I3.0631.00
271_F306_A3.0431.00
15_Q250_N2.8461.00
229_I261_L2.8121.00
273_P289_G2.8111.00
65_T299_D2.6711.00
233_F261_L2.4361.00
25_S296_Q2.4181.00
132_T145_I2.4151.00
91_E446_Q2.3821.00
243_V307_R2.3471.00
111_L115_G2.3211.00
144_A187_M2.3071.00
120_R237_R2.2621.00
175_F179_V2.2441.00
261_L265_Y2.2161.00
31_A35_R2.2071.00
167_I170_V2.1641.00
117_A142_E2.1571.00
200_E248_T2.1181.00
11_A215_P2.0811.00
272_L309_R2.0691.00
110_A305_V2.0521.00
417_T420_E2.0511.00
135_I192_L2.0361.00
189_D237_R2.0071.00
104_S303_F1.9731.00
230_D265_Y1.9511.00
423_E428_R1.9431.00
45_T137_A1.9321.00
293_V298_Y1.9101.00
236_L242_L1.9041.00
110_A274_L1.9021.00
193_L229_I1.8571.00
107_P134_Q1.8261.00
28_D31_A1.8221.00
262_K271_F1.7901.00
32_A35_R1.7821.00
177_G231_S1.7711.00
261_L269_V1.7661.00
251_Q256_A1.7541.00
35_R299_D1.7491.00
363_E389_E1.7270.99
41_I97_F1.7260.99
363_E386_K1.7210.99
114_D135_I1.7110.99
31_A34_Q1.7030.99
43_V53_F1.6950.99
53_F57_T1.6870.99
27_D31_A1.6790.99
180_F235_A1.6660.99
249_L302_G1.6650.99
255_E292_H1.6490.99
272_L307_R1.6410.99
212_N217_S1.6390.99
155_V381_S1.6130.99
178_R227_E1.6080.99
40_S102_A1.6000.99
107_P192_L1.5980.99
115_G139_M1.5790.99
124_V232_A1.5760.99
87_G164_R1.5650.99
280_G283_K1.5650.99
115_G138_R1.5620.99
229_I242_L1.5620.99
162_I167_I1.5510.99
191_I235_A1.5440.99
41_I76_I1.5410.99
339_Q343_A1.5380.99
286_T289_G1.5140.99
236_L310_K1.5120.99
238_P311_T1.5030.99
87_G92_H1.4980.99
29_F296_Q1.4960.99
108_V134_Q1.4850.98
193_L228_L1.4790.98
13_L26_F1.4770.98
277_L280_G1.4680.98
285_L288_E1.4640.98
340_I343_A1.4620.98
287_E290_F1.4560.98
279_P283_K1.4500.98
402_V442_L1.4500.98
42_R133_T1.4430.98
241_T272_L1.4410.98
254_N294_F1.4210.98
106_L293_V1.4100.98
173_T180_F1.4070.98
69_W102_A1.4000.98
92_H164_R1.3980.98
415_E446_Q1.3940.98
134_Q137_A1.3890.98
278_F281_A1.3870.98
111_L192_L1.3650.97
219_Q252_E1.3590.97
177_G228_L1.3520.97
279_P282_N1.3410.97
349_L352_D1.3350.97
388_A395_Y1.3270.97
121_V135_I1.3230.97
115_G119_Q1.3110.97
265_Y269_V1.3100.97
12_F33_C1.3030.96
332_V335_R1.3000.96
41_I99_I1.2970.96
175_F378_V1.2780.96
336_E339_Q1.2780.96
70_C109_A1.2710.96
176_D227_E1.2700.96
110_A291_L1.2690.96
267_D310_K1.2670.96
45_T50_V1.2660.96
230_D260_W1.2580.96
220_E224_T1.2570.96
120_R187_M1.2520.96
233_F267_D1.2490.95
256_A284_A1.2410.95
115_G134_Q1.2390.95
181_G231_S1.2350.95
214_S218_N1.2310.95
231_S234_H1.2300.95
209_A221_I1.2210.95
147_A192_L1.2200.95
259_L263_E1.2120.95
128_P131_K1.2040.94
290_F306_A1.1990.94
233_F265_Y1.1950.94
226_R257_V1.1930.94
114_D241_T1.1880.94
422_E426_R1.1880.94
181_G234_H1.1750.94
122_M146_L1.1700.94
284_A287_E1.1690.94
15_Q19_A1.1640.93
217_S220_E1.1590.93
271_F308_L1.1490.93
146_L188_F1.1490.93
147_A162_I1.1420.93
149_E209_A1.1350.92
271_F289_G1.1310.92
176_D231_S1.1160.92
10_D13_L1.1120.92
38_R299_D1.1060.91
271_F290_F1.1050.91
421_A445_F1.1040.91
19_A252_E1.1000.91
17_R26_F1.0960.91
134_Q138_R1.0910.91
359_Q362_K1.0820.91
103_S300_C1.0820.91
181_G235_A1.0820.91
65_T77_E1.0810.91
252_E256_A1.0720.90
111_L135_I1.0710.90
131_K194_D1.0680.90
385_I404_A1.0600.90
73_G105_M1.0580.90
162_I170_V1.0540.89
105_M125_A1.0530.89
372_E376_G1.0520.89
17_R27_D1.0510.89
160_A164_R1.0460.89
338_G343_A1.0460.89
260_W263_E1.0420.89
333_K340_I1.0350.89
415_E444_T1.0290.88
128_P194_D1.0210.88
202_V301_E1.0170.88
149_E160_A1.0160.88
270_E289_G1.0150.88
16_M26_F1.0090.87
269_V310_K1.0090.87
154_R194_D1.0080.87
49_S52_D1.0060.87
129_G194_D1.0060.87
233_F254_N1.0050.87
218_N221_I1.0040.87
124_V193_L1.0030.87
69_W73_G1.0010.87
257_V260_W0.9990.87
343_A346_G0.9960.87
25_S28_D0.9950.86
256_A259_L0.9930.86
29_F33_C0.9890.86
349_L353_E0.9880.86
212_N224_T0.9860.86
260_W264_T0.9840.86
136_S169_N0.9820.86
121_V190_A0.9790.86
131_K154_R0.9760.85
335_R339_Q0.9760.85
119_Q139_M0.9730.85
11_A14_T0.9720.85
191_I232_A0.9720.85
162_I376_G0.9640.85
114_D307_R0.9610.85
362_K389_E0.9610.85
107_P111_L0.9590.84
155_V172_L0.9590.84
58_A62_W0.9540.84
274_L307_R0.9540.84
92_H149_E0.9540.84
117_A140_N0.9490.84
217_S224_T0.9490.84
69_W97_F0.9480.84
341_R344_A0.9480.84
259_L290_F0.9440.83
238_P313_A0.9420.83
132_T139_M0.9410.83
13_L30_L0.9400.83
91_E96_L0.9370.83
419_Q423_E0.9350.83
243_V305_V0.9340.83
67_I102_A0.9240.82
145_I162_I0.9230.82
98_Y161_N0.9230.82
70_C75_W0.9230.82
388_A398_Q0.9220.82
337_A341_R0.9220.82
44_N47_K0.9180.82
128_P154_R0.9180.82
386_K389_E0.9160.82
157_V224_T0.9110.81
242_L261_L0.9100.81
86_L97_F0.9070.81
101_E204_R0.9040.81
116_N119_Q0.9010.80
155_V174_H0.8980.80
146_L173_T0.8970.80
129_G154_R0.8960.80
105_M213_W0.8900.80
14_T18_E0.8790.79
171_A380_F0.8780.79
342_Q345_T0.8770.79
271_F304_F0.8760.79
133_T162_I0.8690.78
154_R247_C0.8690.78
14_T17_R0.8660.78
126_A174_H0.8650.78
194_D247_C0.8650.78
337_A340_I0.8640.78
47_K73_G0.8620.77
202_V205_K0.8610.77
276_D280_G0.8600.77
43_V74_F0.8570.77
131_K247_C0.8570.77
25_S297_I0.8540.77
233_F310_K0.8520.77
269_V308_L0.8490.76
15_Q251_Q0.8480.76
103_S301_E0.8480.76
229_I260_W0.8460.76
332_V336_E0.8460.76
266_P269_V0.8460.76
150_F176_D0.8450.76
44_N166_G0.8440.76
326_N333_K0.8350.75
50_V54_L0.8350.75
13_L17_R0.8330.75
16_M97_F0.8280.75
124_V177_G0.8280.75
27_D335_R0.8270.74
260_W265_Y0.8230.74
374_L377_K0.8220.74
92_H224_T0.8190.74
356_R369_V0.8190.74
361_D364_L0.8170.74
53_F58_A0.8160.74
109_A243_V0.8160.74
333_K337_A0.8140.73
68_P73_G0.8110.73
128_P247_C0.8100.73
67_I105_M0.8060.73
415_E447_H0.8020.72
412_N437_V0.8010.72
16_M99_I0.7970.72
418_P446_Q0.7960.72
93_L160_A0.7910.71
106_L305_V0.7900.71
444_T449_P0.7900.71
320_P339_Q0.7810.70
96_L448_Q0.7800.70
283_K288_E0.7800.70
391_H396_R0.7790.70
109_A138_R0.7790.70
205_K213_W0.7780.70
20_M26_F0.7770.70
149_E216_E0.7760.70
340_I344_A0.7740.70
341_R347_V0.7730.69
45_T48_I0.7730.69
277_L282_N0.7730.69
181_G228_L0.7720.69
108_V138_R0.7720.69
98_Y133_T0.7710.69
328_P332_V0.7710.69
234_H265_Y0.7690.69
221_I224_T0.7680.69
287_E308_L0.7670.69
180_F188_F0.7620.68
243_V262_K0.7610.68
347_V353_E0.7610.68
329_F333_K0.7580.68
129_G247_C0.7560.68
133_T161_N0.7540.67
224_T228_L0.7540.67
208_D212_N0.7540.67
48_I56_L0.7520.67
87_G205_K0.7520.67
226_R264_T0.7510.67
347_V350_N0.7490.67
278_F282_N0.7490.67
181_G379_R0.7460.67
213_W250_N0.7430.66
202_V303_F0.7360.66
379_R431_Y0.7350.66
20_M25_S0.7340.65
140_N168_S0.7330.65
12_F29_F0.7300.65
274_L291_L0.7270.65
16_M19_A0.7220.64
134_Q165_C0.7220.64
70_C73_G0.7190.64
75_W299_D0.7160.63
174_H381_S0.7160.63
69_W421_A0.7140.63
45_T56_L0.7140.63
204_R301_E0.7120.63
397_W401_A0.7100.63
390_T395_Y0.7070.62
149_E164_R0.7040.62
351_W354_N0.7040.62
332_V343_A0.7020.62
238_P248_T0.7000.62
200_E301_E0.6970.61
18_E27_D0.6940.61
184_V235_A0.6940.61
412_N416_L0.6920.61
327_F330_S0.6920.61
258_C290_F0.6920.61
111_L190_A0.6920.61
355_L358_W0.6900.61
14_T144_A0.6850.60
333_K344_A0.6840.60
321_K326_N0.6830.60
126_A131_K0.6800.59
52_D55_Q0.6800.59
331_P341_R0.6790.59
339_Q344_A0.6780.59
159_H172_L0.6780.59
209_A214_S0.6780.59
262_K266_P0.6780.59
146_L171_A0.6780.59
203_V209_A0.6770.59
312_Q346_G0.6770.59
326_N329_F0.6770.59
160_A165_C0.6730.59
38_R192_L0.6720.59
93_L425_Y0.6720.59
217_S221_I0.6710.58
98_Y166_G0.6690.58
338_G342_Q0.6690.58
69_W402_V0.6660.58
204_R384_G0.6660.58
348_G355_L0.6660.58
346_G349_L0.6650.58
155_V159_H0.6640.58
43_V54_L0.6630.58
382_R385_I0.6630.58
76_I99_I0.6620.57
101_E301_E0.6620.57
69_W101_E0.6620.57
334_D342_Q0.6590.57
135_I190_A0.6570.57
54_L66_P0.6570.57
194_D245_S0.6560.57
214_S221_I0.6540.57
233_F272_L0.6520.56
277_L281_A0.6520.56
158_L245_S0.6510.56
420_E432_P0.6490.56
72_E138_R0.6480.56
321_K356_R0.6470.56
149_E224_T0.6470.56
50_V53_F0.6470.56
158_L247_C0.6470.56
40_S303_F0.6460.56
284_A288_E0.6460.56
171_A371_I0.6440.55
333_K341_R0.6430.55
102_A303_F0.6430.55
108_V115_G0.6420.55
130_S161_N0.6390.55
321_K328_P0.6390.55
223_A227_E0.6370.55
87_G160_A0.6360.54
335_R414_F0.6360.54
97_F130_S0.6360.54
342_Q351_W0.6360.54
388_A401_A0.6350.54
66_P73_G0.6350.54
352_D357_L0.6350.54
334_D337_A0.6340.54
342_Q356_R0.6340.54
28_D338_G0.6330.54
206_D209_A0.6310.54
147_A254_N0.6310.54
160_A293_V0.6260.53
238_P241_T0.6260.53
354_N357_L0.6260.53
264_T419_Q0.6260.53
364_L390_T0.6240.53
400_E403_I0.6240.53
107_P160_A0.6230.53
106_L110_A0.6210.53
276_D279_P0.6200.53
107_P151_S0.6200.53
340_I356_R0.6200.53
424_W427_G0.6190.52
174_H217_S0.6180.52
336_E344_A0.6180.52
146_L180_F0.6180.52
352_D356_R0.6180.52
266_P311_T0.6160.52
251_Q259_L0.6140.52
432_P436_P0.6130.52
193_L224_T0.6130.52
92_H209_A0.6100.51
18_E28_D0.6100.51
67_I73_G0.6090.51
362_K440_D0.6090.51
339_Q342_Q0.6080.51
128_P245_S0.6080.51
131_K245_S0.6070.51
331_P334_D0.6070.51
90_A425_Y0.6060.51
347_V360_R0.6030.51
386_K400_E0.6030.51
16_M200_E0.6020.50
123_D154_R0.6010.50
333_K336_E0.6000.50
157_V160_A0.5990.50
94_S97_F0.5990.50
337_A342_Q0.5990.50
291_L305_V0.5980.50
314_I318_P0.5980.50
177_G229_I0.5970.50
54_L64_L0.5950.50
119_Q140_N0.5940.50
67_I75_W0.5940.50
209_A217_S0.5940.50
47_K169_N0.5940.50
416_L420_E0.5930.49
149_E221_I0.5930.49
130_S202_V0.5930.49
164_R399_H0.5930.49
184_V187_M0.5920.49
284_A289_G0.5920.49
90_A94_S0.5910.49
132_T193_L0.5910.49
431_Y434_A0.5910.49
275_G282_N0.5910.49
104_S194_D0.5890.49
183_A378_V0.5890.49
168_S404_A0.5880.49
148_N196_P0.5870.49
18_E25_S0.5870.49
148_N189_D0.5870.49
180_F308_L0.5860.49
125_A131_K0.5860.49
330_S334_D0.5850.49
320_P430_V0.5840.48
127_A194_D0.5820.48
50_V74_F0.5820.48
155_V224_T0.5820.48
326_N343_A0.5820.48
148_N188_F0.5780.48
16_M41_I0.5780.48
73_G94_S0.5780.48
114_D138_R0.5780.48
334_D348_G0.5780.48
104_S202_V0.5770.48
86_L157_V0.5770.48
413_A444_T0.5760.47
357_L360_R0.5760.47
67_I155_V0.5760.47
149_E157_V0.5750.47
226_R265_Y0.5750.47
46_L167_I0.5740.47
392_N396_R0.5740.47
155_V177_G0.5740.47
196_P240_G0.5730.47
187_M370_G0.5720.47
239_G310_K0.5710.47
412_N443_V0.5690.47
122_M188_F0.5690.47
331_P337_A0.5680.47
101_E303_F0.5670.46
107_P243_V0.5670.46
9_P16_M0.5670.46
230_D433_Q0.5660.46
27_D35_R0.5660.46
104_S131_K0.5660.46
8_F207_P0.5660.46
123_D129_G0.5660.46
337_A344_A0.5650.46
48_I96_L0.5650.46
62_W84_L0.5640.46
186_E310_K0.5640.46
129_G245_S0.5630.46
11_A423_E0.5630.46
118_P141_N0.5630.46
107_P143_G0.5630.46
104_S163_S0.5620.46
120_R371_I0.5600.46
207_P420_E0.5590.45
124_V145_I0.5590.45
75_W102_A0.5570.45
174_H379_R0.5560.45
224_T229_I0.5550.45
264_T308_L0.5550.45
218_N250_N0.5550.45
154_R245_S0.5540.45
126_A245_S0.5540.45
423_E426_R0.5540.45
36_P334_D0.5530.45
92_H160_A0.5520.45
42_R213_W0.5520.45
76_I79_D0.5510.45
343_A347_V0.5490.44
10_D116_N0.5490.44
218_N304_F0.5460.44
148_N205_K0.5460.44
200_E250_N0.5450.44
406_A409_D0.5430.44
256_A287_E0.5430.44
127_A131_K0.5430.44
12_F213_W0.5430.44
116_N190_A0.5430.44
248_T400_E0.5430.44
338_G341_R0.5420.44
222_A226_R0.5420.44
334_D338_G0.5410.43
17_R22_S0.5410.43
192_L307_R0.5400.43
87_G99_I0.5400.43
257_V262_K0.5380.43
160_A214_S0.5380.43
280_G291_L0.5370.43
195_A221_I0.5370.43
38_R303_F0.5370.43
92_H399_H0.5370.43
316_A320_P0.5360.43
295_P302_G0.5360.43
337_A343_A0.5360.43
259_L285_L0.5340.43
124_V132_T0.5340.43
430_V443_V0.5340.43
203_V301_E0.5330.42
108_V111_L0.5330.42
125_A129_G0.5320.42
178_R231_S0.5310.42
76_I86_L0.5310.42
55_Q58_A0.5310.42
224_T227_E0.5300.42
34_Q333_K0.5290.42
237_R310_K0.5290.42
115_G125_A0.5280.42
104_S129_G0.5270.42
41_I64_L0.5260.42
291_L321_K0.5240.41
47_K166_G0.5230.41
238_P314_I0.5230.41
212_N421_A0.5220.41
13_L65_T0.5220.41
92_H107_P0.5200.41
21_P203_V0.5200.41
294_F399_H0.5200.41
421_A425_Y0.5190.41
416_L419_Q0.5190.41
8_F12_F0.5180.41
171_A374_L0.5160.41
101_E300_C0.5160.41
330_S356_R0.5160.41
15_Q18_E0.5130.40
16_M248_T0.5130.40
173_T184_V0.5130.40
335_R338_G0.5130.40
263_E285_L0.5130.40
31_A320_P0.5120.40
97_F105_M0.5120.40
232_A235_A0.5120.40
123_D131_K0.5120.40
331_P336_E0.5110.40
144_A171_A0.5110.40
407_S415_E0.5090.40
111_L243_V0.5090.40
351_W355_L0.5090.40
202_V300_C0.5090.40
86_L89_T0.5080.40
152_A156_K0.5080.40
111_L116_N0.5070.40
246_T253_E0.5070.40
65_T433_Q0.5070.40
104_S128_P0.5060.39
332_V354_N0.5060.39
29_F103_S0.5060.39
87_G221_I0.5050.39
341_R350_N0.5040.39
284_A317_L0.5040.39
114_D190_A0.5030.39
164_R190_A0.5030.39
386_K398_Q0.5030.39
168_S409_D0.5020.39
126_A194_D0.5020.39
258_C447_H0.5020.39
101_E295_P0.5020.39
20_M294_F0.5010.39
136_S165_C0.5010.39
98_Y301_E0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2frxA 1 0.9499 100 0.312 Contact Map
3m4xA 1 0.8956 100 0.361 Contact Map
3m6wA 2 0.9228 100 0.384 Contact Map
1ixkA 1 0.6117 100 0.553 Contact Map
2yxlA 1 0.62 100 0.563 Contact Map
2b9eA 1 0.5282 100 0.58 Contact Map
1sqgA 1 0.6054 100 0.583 Contact Map
3ajdA 1 0.5198 100 0.621 Contact Map
4fzvA 1 0.6326 100 0.636 Contact Map
2vdvE 2 0.4259 99.9 0.829 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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