GREMLIN Database
MSRC - Free methionine-R-sulfoxide reductase
UniProt: P76270 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14020
Length: 165 (153)
Sequences: 14307 (11671)
Seq/√Len: 943.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_R137_E3.5741.00
31_T147_L3.0321.00
83_N113_V3.0161.00
32_S45_A2.8141.00
78_T82_R2.7661.00
23_S26_A2.3371.00
36_Y45_A2.2261.00
85_V141_R2.0491.00
90_D93_V2.0181.00
153_T157_K1.9831.00
89_E131_R1.9781.00
17_L30_N1.9531.00
112_L148_E1.9191.00
114_V152_A1.7741.00
55_L59_P1.7291.00
110_L140_L1.7281.00
74_G77_G1.7081.00
133_T136_D1.7061.00
79_A109_V1.6951.00
13_D34_L1.6841.00
124_I140_L1.6521.00
30_N34_L1.6511.00
43_N127_T1.5961.00
113_V118_I1.5691.00
42_I124_I1.5681.00
34_L37_E1.5611.00
36_Y61_Q1.5481.00
33_A61_Q1.5121.00
29_A33_A1.4931.00
39_L42_I1.4831.00
108_I140_L1.4621.00
134_D137_E1.4511.00
21_E26_A1.4381.00
8_A12_R1.4171.00
137_E141_R1.4081.00
110_L144_V1.3841.00
109_V123_D1.3581.00
80_V118_I1.3511.00
46_G123_D1.3261.00
157_K160_F1.3161.00
85_V110_L1.3151.00
154_T157_K1.3041.00
14_F31_T1.3031.00
52_D55_L1.2941.00
51_E56_V1.2801.00
12_R15_N1.2801.00
22_T157_K1.2791.00
115_K152_A1.2651.00
83_N118_I1.2651.00
141_R145_A1.2621.00
114_V117_Q1.2581.00
92_H105_N1.2541.00
90_D105_N1.2521.00
55_L62_G1.2211.00
42_I132_F1.2071.00
50_L80_V1.2061.00
105_N129_F1.2031.00
49_L119_I1.1871.00
89_E130_G1.1791.00
17_L34_L1.1761.00
79_A86_Q1.1761.00
54_T68_R1.1471.00
85_V137_E1.1201.00
45_A124_I1.1131.00
60_F63_K1.1021.00
78_T96_G1.1021.00
87_R108_I1.0891.00
156_Y160_F1.0831.00
112_L120_G1.0741.00
25_L29_A1.0731.00
126_S130_G1.0511.00
49_L58_G1.0471.00
95_D98_I1.0461.00
50_L71_V1.0451.00
134_D138_Q1.0441.00
107_E123_D1.0431.00
47_F112_L1.0271.00
117_Q152_A1.0271.00
72_G77_G1.0271.00
24_F151_L1.0231.00
48_Y57_L1.0211.00
82_R86_Q1.0191.00
108_I137_E1.0171.00
15_N146_Q1.0121.00
16_A145_A1.0071.00
61_Q64_I0.9951.00
33_A37_E0.9911.00
13_D16_A0.9851.00
142_Q146_Q0.9831.00
108_I132_F0.9751.00
35_L122_L0.9731.00
72_G76_C0.9711.00
114_V119_I0.9681.00
114_V148_E0.9591.00
77_G81_A0.9591.00
14_F143_L0.9561.00
12_R16_A0.9521.00
71_V80_V0.9521.00
34_L38_R0.9411.00
79_A82_R0.9391.00
11_N139_G0.9311.00
44_W125_D0.9281.00
97_H100_C0.9281.00
16_A19_A0.9261.00
125_D128_V0.9241.00
35_L143_L0.9221.00
94_F97_H0.9181.00
130_G136_D0.9171.00
80_V121_V0.9091.00
96_G100_C0.9051.00
59_P62_G0.9051.00
21_E30_N0.8851.00
72_G75_V0.8831.00
78_T81_A0.8751.00
56_V59_P0.8691.00
112_L144_V0.8681.00
35_L38_R0.8631.00
111_P118_I0.8591.00
19_A153_T0.8581.00
55_L60_F0.8571.00
13_D17_L0.8481.00
59_P63_K0.8331.00
35_L45_A0.8311.00
19_A146_Q0.8301.00
70_P73_R0.8221.00
49_L155_D0.8181.00
50_L53_D0.8141.00
125_D130_G0.8131.00
43_N126_S0.8111.00
79_A85_V0.8101.00
122_L144_V0.8071.00
28_L47_F0.8071.00
138_Q141_R0.8021.00
62_G65_A0.8011.00
51_E58_G0.8001.00
67_V71_V0.7951.00
25_L58_G0.7931.00
119_I155_D0.7861.00
76_C121_V0.7861.00
22_T26_A0.7851.00
112_L119_I0.7791.00
22_T154_T0.7781.00
7_Y135_E0.7771.00
155_D158_K0.7771.00
9_D13_D0.7661.00
13_D37_E0.7611.00
78_T86_Q0.7561.00
73_R77_G0.7551.00
150_V154_T0.7481.00
57_L60_F0.7381.00
48_Y123_D0.7311.00
126_S132_F0.7291.00
58_G61_Q0.7241.00
15_N19_A0.7241.00
84_Q141_R0.7161.00
79_A121_V0.7151.00
35_L124_I0.7101.00
153_T156_Y0.7071.00
21_E27_T0.7071.00
30_N33_A0.7051.00
109_V121_V0.7041.00
126_S129_F0.7001.00
24_F28_L0.6991.00
36_Y42_I0.6971.00
152_A155_D0.6951.00
80_V83_N0.6941.00
19_A145_A0.6931.00
72_G81_A0.6891.00
91_V107_E0.6861.00
7_Y138_Q0.6821.00
79_A84_Q0.6811.00
35_L147_L0.6761.00
32_S47_F0.6751.00
10_L38_R0.6751.00
15_N18_M0.6721.00
126_S131_R0.6711.00
155_D159_F0.6591.00
106_S129_F0.6491.00
90_D129_F0.6481.00
79_A83_N0.6471.00
83_N111_P0.6461.00
104_S125_D0.6461.00
106_S132_F0.6451.00
35_L42_I0.6441.00
75_V79_A0.6431.00
138_Q142_Q0.6341.00
39_L136_D0.6291.00
55_L58_G0.6261.00
14_F34_L0.6221.00
68_R71_V0.6211.00
18_M149_K0.6151.00
48_Y121_V0.6101.00
36_Y63_K0.6081.00
88_I94_F0.6061.00
56_V68_R0.6061.00
48_Y76_C0.6051.00
149_K153_T0.5911.00
10_L34_L0.5831.00
44_W104_S0.5831.00
143_L147_L0.5801.00
146_Q149_K0.5761.00
39_L124_I0.5691.00
72_G78_T0.5641.00
50_L118_I0.5641.00
135_E138_Q0.5611.00
76_C123_D0.5531.00
9_D12_R0.5481.00
144_V148_E0.5461.00
31_T35_L0.5431.00
26_A30_N0.5411.00
83_N116_N0.5391.00
39_L140_L0.5291.00
42_I45_A0.5251.00
8_A142_Q0.5251.00
135_E139_G0.5231.00
27_T154_T0.5231.00
67_V70_P0.5211.00
122_L140_L0.5211.00
146_Q150_V0.5181.00
19_A22_T0.5181.00
32_S36_Y0.5151.00
110_L124_I0.5141.00
132_F136_D0.5131.00
113_V148_E0.5111.00
142_Q145_A0.5101.00
12_R142_Q0.5051.00
28_L49_L0.5021.00
43_N128_V0.5011.00
42_I126_S0.5001.00
24_F155_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhmA 2 0.9576 99.9 0.123 Contact Map
3rfbA 2 0.9636 99.9 0.159 Contact Map
2zmfA 2 0.9515 99.9 0.165 Contact Map
3e0yA 2 0.9212 99.9 0.18 Contact Map
1mc0A 4 0.9939 99.8 0.198 Contact Map
3ibjA 2 0.9758 99.8 0.201 Contact Map
1f5mA 3 0.9273 99.8 0.203 Contact Map
1ykdA 2 0.9697 99.8 0.207 Contact Map
3p01A 2 0.9455 99.8 0.207 Contact Map
3bjcA 1 0 99.8 0.209 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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