GREMLIN Database
KDGR - Transcriptional regulator KdgR
UniProt: P76268 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14018
Length: 263 (246)
Sequences: 12791 (9329)
Seq/√Len: 594.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_L244_M3.2231.00
16_V19_V3.1961.00
111_G147_I2.8351.00
17_L58_L2.8191.00
96_Q248_A2.8051.00
189_Q193_Q2.6711.00
24_Q75_K2.5701.00
94_D122_H2.4181.00
149_K186_V2.4121.00
20_F60_Y2.3381.00
161_K184_L2.3321.00
117_S139_R2.1891.00
149_K201_E2.1611.00
96_Q251_K2.1491.00
26_L61_V2.0711.00
98_R124_I2.0561.00
155_R159_E2.0451.00
106_E232_R2.0361.00
21_G58_L2.0031.00
211_V245_L1.9461.00
154_W214_F1.9161.00
113_L142_L1.8851.00
96_Q255_Q1.8681.00
199_N207_R1.8511.00
211_V249_A1.8201.00
207_R230_T1.8141.00
198_D208_C1.8001.00
64_E67_S1.7761.00
99_E251_K1.7691.00
242_V246_H1.7511.00
62_A71_S1.7471.00
22_I37_L1.7361.00
180_T184_L1.7221.00
99_E103_L1.7051.00
24_Q58_L1.6981.00
25_A41_V1.6811.00
179_S182_A1.6711.00
93_A252_I1.6711.00
25_A32_I1.6701.00
25_A40_R1.6581.00
101_S108_I1.6481.00
211_V246_H1.6391.00
52_L61_V1.6331.00
200_E230_T1.6251.00
25_A37_L1.6141.00
228_F233_F1.5911.00
226_I241_Y1.5801.00
32_I40_R1.5701.00
52_L70_Y1.5671.00
195_Y242_V1.5661.00
186_V189_Q1.5541.00
33_G36_E1.5381.00
31_E71_S1.5251.00
160_V184_L1.5201.00
190_V196_G1.5091.00
96_Q99_E1.5061.00
104_T244_M1.5061.00
173_T176_T1.5051.00
200_E205_G1.5001.00
156_D159_E1.4891.00
43_M48_V1.4861.00
37_L48_V1.4601.00
244_M247_T1.4601.00
31_E69_K1.4551.00
118_I151_L1.4361.00
75_K78_E1.4091.00
125_D131_R1.4021.00
161_K180_T1.3971.00
93_A110_L1.3691.00
214_F253_S1.3681.00
90_I122_H1.3681.00
118_I142_L1.3611.00
56_K61_V1.3541.00
100_L244_M1.3521.00
101_S124_I1.3401.00
56_K63_Q1.3321.00
20_F58_L1.3311.00
29_E32_I1.3261.00
24_Q60_Y1.3231.00
249_A253_S1.3161.00
26_L32_I1.3151.00
237_R240_E1.3041.00
116_D166_G1.3031.00
247_T251_K1.2971.00
26_L31_E1.2911.00
64_E71_S1.2881.00
97_M110_L1.2701.00
94_D98_R1.2631.00
177_I186_V1.2501.00
49_Y53_Q1.2451.00
100_L248_A1.2351.00
29_E40_R1.2341.00
44_S47_T1.2311.00
157_R184_L1.2301.00
38_S48_V1.2211.00
187_L190_V1.2091.00
165_E180_T1.2091.00
157_R161_K1.1941.00
37_L52_L1.1911.00
153_A190_V1.1781.00
214_F220_V1.1721.00
113_L155_R1.1431.00
144_S172_S1.1371.00
154_W212_P1.1291.00
154_W220_V1.1281.00
175_R200_E1.1211.00
246_H250_R1.1191.00
111_G118_I1.1171.00
33_G69_K1.1051.00
34_I49_Y1.1041.00
211_V242_V1.1031.00
104_T241_Y1.1001.00
157_R160_V1.0921.00
35_T39_Q1.0891.00
144_S176_T1.0811.00
17_L54_T1.0741.00
17_L57_T1.0691.00
113_L116_D1.0681.00
251_K255_Q1.0671.00
98_R102_R1.0571.00
160_V191_R1.0561.00
110_L222_A1.0561.00
147_I223_G1.0481.00
112_A222_A1.0421.00
164_L180_T1.0371.00
97_M108_I1.0311.00
99_E248_A1.0251.00
110_L213_V1.0221.00
34_I38_S1.0191.00
224_L252_I1.0191.00
104_T226_I1.0151.00
143_Y176_T1.0151.00
243_A247_T1.0141.00
13_V54_T1.0121.00
157_R188_D1.0121.00
76_L83_A1.0101.00
36_E39_Q1.0041.00
60_Y79_L1.0001.00
171_R178_T0.9981.00
159_E162_Q0.9901.00
161_K165_E0.9841.00
215_D219_V0.9791.00
250_R254_A0.9731.00
111_G120_Y0.9721.00
234_S237_R0.9701.00
12_S57_T0.9681.00
114_D139_R0.9631.00
145_T148_G0.9511.00
94_D124_I0.9481.00
103_L247_T0.9461.00
146_A208_C0.9411.00
35_T45_K0.9381.00
31_E64_E0.9361.00
119_V139_R0.9351.00
174_E204_E0.9291.00
190_V193_Q0.9211.00
89_L222_A0.9121.00
108_I226_I0.9111.00
212_P220_V0.9071.00
92_S255_Q0.9051.00
23_L76_L0.9031.00
14_S18_K0.9001.00
188_D192_E0.8921.00
36_E40_R0.8881.00
150_V154_W0.8861.00
159_E163_I0.8841.00
209_I242_V0.8831.00
239_Q243_A0.8821.00
182_A186_V0.8761.00
28_E40_R0.8751.00
199_N230_T0.8751.00
185_P189_Q0.8741.00
160_V187_L0.8711.00
152_L183_L0.8701.00
172_S176_T0.8651.00
150_V220_V0.8651.00
184_L188_D0.8631.00
172_S202_Q0.8631.00
56_K70_Y0.8611.00
185_P188_D0.8601.00
22_I41_V0.8591.00
162_Q166_G0.8551.00
200_E204_E0.8511.00
46_S49_Y0.8511.00
90_I94_D0.8511.00
97_M122_H0.8491.00
215_D221_I0.8461.00
238_L242_V0.8451.00
97_M224_L0.8441.00
109_H227_S0.8431.00
238_L243_A0.8411.00
26_L29_E0.8401.00
193_Q242_V0.8341.00
26_L30_R0.8331.00
147_I225_S0.8251.00
182_A185_P0.8231.00
210_A225_S0.8161.00
150_V190_V0.8151.00
18_K47_T0.8121.00
22_I51_F0.8101.00
245_L249_A0.7961.00
96_Q252_I0.7941.00
12_S17_L0.7921.00
153_A187_L0.7921.00
106_E128_Y0.7871.00
146_A210_A0.7851.00
248_A251_K0.7851.00
113_L159_E0.7831.00
177_I182_A0.7821.00
114_D119_V0.7801.00
63_Q67_S0.7731.00
240_E243_A0.7721.00
43_M47_T0.7681.00
34_I52_L0.7661.00
189_Q192_E0.7571.00
186_V190_V0.7571.00
62_A73_T0.7481.00
53_Q56_K0.7461.00
15_S19_V0.7461.00
128_Y232_R0.7441.00
186_V193_Q0.7431.00
151_L223_G0.7391.00
229_P232_R0.7351.00
209_I238_L0.7331.00
197_E238_L0.7311.00
23_L60_Y0.7301.00
32_I37_L0.7301.00
76_L80_G0.7281.00
76_L79_L0.7271.00
41_V48_V0.7271.00
34_I48_V0.7231.00
208_C227_S0.7221.00
89_L93_A0.7221.00
243_A246_H0.7221.00
163_I167_V0.7191.00
208_C225_S0.7171.00
160_V163_I0.7171.00
109_H123_K0.7141.00
97_M124_I0.7131.00
112_A121_I0.7081.00
144_S202_Q0.7081.00
149_K190_V0.6991.00
214_F221_I0.6981.00
199_N235_E0.6941.00
53_Q57_T0.6931.00
72_L76_L0.6881.00
250_R253_S0.6821.00
116_D163_I0.6811.00
38_S41_V0.6791.00
34_I45_K0.6781.00
99_E102_R0.6751.00
22_I48_V0.6721.00
109_H134_S0.6691.00
247_T250_R0.6671.00
113_L151_L0.6651.00
177_I183_L0.6581.00
100_L226_I0.6521.00
188_D191_R0.6511.00
16_V51_F0.6511.00
251_K254_A0.6511.00
246_H249_A0.6501.00
101_S126_S0.6501.00
34_I70_Y0.6491.00
88_D91_R0.6481.00
62_A74_L0.6461.00
211_V253_S0.6461.00
92_S95_I0.6461.00
152_L187_L0.6451.00
237_R241_Y0.6451.00
100_L108_I0.6431.00
194_G214_F0.6411.00
160_V188_D0.6411.00
224_L249_A0.6391.00
248_A252_I0.6391.00
155_R160_V0.6391.00
157_R191_R0.6371.00
152_L160_V0.6351.00
100_L104_T0.6341.00
80_G83_A0.6331.00
151_L155_R0.6311.00
160_V164_L0.6241.00
178_T182_A0.6221.00
16_V20_F0.6161.00
143_Y169_Y0.6141.00
109_H208_C0.6111.00
200_E207_R0.6111.00
95_I255_Q0.6081.00
224_L248_A0.6081.00
173_T177_I0.6071.00
21_G24_Q0.6071.00
15_S51_F0.6031.00
141_P144_S0.6031.00
53_Q63_Q0.6031.00
240_E244_M0.6021.00
164_L168_E0.6011.00
18_K43_M0.6011.00
102_R127_M0.6011.00
63_Q68_E0.6001.00
105_K127_M0.5991.00
63_Q70_Y0.5981.00
120_Y134_S0.5971.00
36_E69_K0.5961.00
199_N238_L0.5951.00
24_Q78_E0.5941.00
175_R204_E0.5941.00
135_R138_R0.5941.00
21_G25_A0.5901.00
108_I124_I0.5891.00
106_E228_F0.5861.00
150_V210_A0.5831.00
150_V212_P0.5761.00
98_R122_H0.5741.00
27_G79_L0.5741.00
16_V54_T0.5731.00
64_E69_K0.5721.00
13_V51_F0.5711.00
211_V224_L0.5711.00
244_M248_A0.5711.00
19_V51_F0.5691.00
23_L79_L0.5691.00
125_D135_R0.5671.00
145_T208_C0.5621.00
106_E226_I0.5611.00
27_G72_L0.5611.00
38_S45_K0.5570.99
241_Y244_M0.5540.99
59_G75_K0.5530.99
118_I140_N0.5530.99
60_Y75_K0.5520.99
25_A29_E0.5510.99
213_V253_S0.5510.99
169_Y180_T0.5490.99
181_E184_L0.5480.99
81_A84_L0.5480.99
123_K136_I0.5410.99
181_E185_P0.5400.99
120_Y147_I0.5400.99
118_I147_I0.5400.99
151_L222_A0.5370.99
154_W191_R0.5360.99
123_K134_S0.5360.99
195_Y246_H0.5360.99
134_S138_R0.5350.99
213_V222_A0.5330.99
25_A28_E0.5330.99
171_R174_E0.5310.99
77_F84_L0.5260.99
93_A97_M0.5240.99
95_I99_E0.5230.99
18_K51_F0.5220.99
224_L245_L0.5180.99
149_K198_D0.5170.99
183_L187_L0.5160.99
24_Q79_L0.5150.99
33_G45_K0.5140.99
150_V196_G0.5130.99
205_G230_T0.5130.99
14_S54_T0.5110.99
109_H225_S0.5110.99
92_S252_I0.5090.99
19_V55_M0.5090.99
120_Y145_T0.5080.99
130_L231_L0.5080.99
107_T123_K0.5070.99
186_V196_G0.5070.99
118_I145_T0.5060.99
78_E82_R0.5010.99
122_H136_I0.5010.99
236_E240_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mq0A 2 0.9506 100 0.108 Contact Map
2ia2A 4 0.943 100 0.119 Contact Map
2g7uA 6 0.9506 100 0.121 Contact Map
3r4kA 2 0.9544 100 0.128 Contact Map
1mkmA 4 0.9354 100 0.129 Contact Map
2xrnA 3 0.9125 100 0.147 Contact Map
2o0yA 4 0.962 100 0.164 Contact Map
1yspA 1 0.6236 100 0.421 Contact Map
1tf1A 1 0.6996 100 0.425 Contact Map
1ysqA 1 0.6616 100 0.429 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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