GREMLIN Database
MNTP - Probable manganese efflux pump MntP
UniProt: P76264 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14012
Length: 188 (178)
Sequences: 1930 (1555)
Seq/√Len: 116.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_F182_L5.0311.00
86_I90_R3.7061.00
83_R86_I3.6371.00
18_F151_G3.4331.00
48_T141_G3.3661.00
42_I112_A2.9211.00
88_G168_I2.8171.00
48_T137_A2.5151.00
42_I108_L2.5121.00
75_V79_F2.4061.00
172_L176_G2.2921.00
81_G171_G2.2821.00
36_A40_G2.1021.00
52_L137_A2.0771.00
82_G86_I2.0721.00
139_A143_A2.0511.00
38_R105_F1.9641.00
81_G175_I1.9601.00
17_A144_T1.9461.00
22_I151_G1.9271.00
22_I154_V1.9041.00
10_A139_A1.8921.00
154_V158_I1.8551.00
24_K111_T1.8231.00
132_N135_A1.8221.00
7_V139_A1.8041.00
147_M151_G1.8031.00
6_T139_A1.7691.00
85_I171_G1.7651.00
83_R87_E1.7471.00
42_I105_F1.7281.00
13_M118_D1.7261.00
21_S148_S1.7071.00
175_I178_G1.7001.00
32_K35_E1.6981.00
11_F147_M1.6461.00
7_V143_A1.6231.00
6_T136_T1.5571.00
14_S147_M1.5461.00
81_G178_G1.5231.00
79_F83_R1.5001.00
10_A143_A1.4871.00
65_V69_N1.4531.00
31_P36_A1.4461.00
41_L45_A1.4411.00
62_S66_L1.4341.00
46_V50_T1.4031.00
69_N73_A1.3731.00
119_A140_I1.3721.00
78_I82_G1.3701.00
153_M157_F1.3691.00
179_V183_W1.3601.00
14_S143_A1.3571.00
39_T108_L1.3431.00
6_T10_A1.3151.00
154_V162_I1.3061.00
34_S38_R1.2961.00
9_L177_I1.2931.00
31_P35_E1.2520.99
65_V72_I1.2480.99
36_A152_M1.2460.99
14_S43_F1.2310.99
47_E115_T1.2270.99
73_A181_I1.2240.99
40_G145_L1.1720.99
51_P140_I1.1590.99
43_F47_E1.1580.99
18_F125_G1.1460.99
155_G159_G1.1430.99
9_L126_L1.1350.99
123_G155_G1.1250.99
17_A51_P1.1210.99
157_F160_S1.1110.99
39_T103_H1.1110.99
158_I162_I1.1040.98
46_V116_S1.0950.98
14_S144_T1.0890.98
164_K168_I1.0770.98
23_G40_G1.0770.98
74_F78_I1.0770.98
26_A158_I1.0700.98
5_A22_I1.0560.98
47_E119_A1.0550.98
64_F67_E1.0500.98
44_G144_T1.0490.98
85_I168_I1.0410.98
73_A77_L1.0310.98
144_T148_S1.0030.97
35_E38_R1.0030.97
94_D98_E0.9940.97
76_L181_I0.9820.97
45_A49_L0.9750.97
12_G15_M0.9690.97
48_T133_I0.9680.96
53_I113_I0.9540.96
28_L103_H0.9510.96
42_I141_G0.9510.96
78_I178_G0.9430.96
12_G170_G0.9420.96
134_I138_L0.9370.96
24_K103_H0.9320.96
138_L142_C0.9280.96
15_M148_S0.9130.95
47_E140_I0.9130.95
38_R108_L0.9090.95
105_F108_L0.9070.95
43_F140_I0.8980.95
104_G107_L0.8780.94
29_H107_L0.8740.94
23_G144_T0.8720.94
44_G141_G0.8500.93
132_N136_T0.8490.93
24_K107_L0.8490.93
12_G148_S0.8430.93
10_A14_S0.8360.92
138_L180_Q0.8340.92
73_A115_T0.8300.92
86_I89_F0.8290.92
28_L35_E0.8240.92
149_T153_M0.8220.92
133_I137_A0.8130.91
13_M47_E0.8090.91
4_T67_E0.8060.91
162_I165_K0.8000.91
10_A20_A0.7990.91
106_W109_V0.7940.90
89_F168_I0.7870.90
98_E172_L0.7800.89
11_F173_V0.7780.89
24_K124_V0.7770.89
47_E170_G0.7760.89
39_T42_I0.7760.89
47_E144_T0.7670.89
23_G26_A0.7640.88
72_I110_T0.7610.88
43_F115_T0.7580.88
118_D122_V0.7560.88
35_E103_H0.7460.87
56_G60_L0.7370.87
53_I93_D0.7350.86
37_L41_L0.7320.86
43_F119_A0.7300.86
20_A70_H0.7300.86
47_E180_Q0.7270.86
4_T158_I0.7150.85
161_I165_K0.7140.85
24_K127_A0.7120.85
144_T181_I0.7040.84
80_L136_T0.7020.84
63_R66_L0.6980.84
21_S152_M0.6950.83
3_I135_A0.6940.83
32_K63_R0.6940.83
84_M170_G0.6890.83
62_S124_V0.6820.82
3_I53_I0.6810.82
14_S17_A0.6780.82
66_L69_N0.6780.82
115_T119_A0.6770.82
131_V136_T0.6720.81
7_V72_I0.6720.81
47_E50_T0.6680.81
114_A177_I0.6670.81
110_T173_V0.6660.81
15_M19_A0.6660.81
33_F150_L0.6660.81
46_V140_I0.6650.81
82_G89_F0.6610.80
17_A46_V0.6600.80
75_V138_L0.6590.80
70_H76_L0.6570.80
12_G161_I0.6540.79
20_A47_E0.6540.79
47_E118_D0.6510.79
20_A80_L0.6500.79
175_I179_V0.6490.79
17_A119_A0.6470.79
135_A139_A0.6460.79
5_A161_I0.6450.78
136_T140_I0.6450.78
71_W85_I0.6390.78
85_I88_G0.6380.78
4_T8_L0.6380.78
94_D99_P0.6360.78
11_F145_L0.6320.77
17_A44_G0.6320.77
53_I149_T0.6320.77
79_F102_R0.6310.77
112_A137_A0.6240.76
10_A148_S0.6230.76
42_I45_A0.6210.76
13_M17_A0.6200.76
39_T107_L0.6170.75
4_T130_Q0.6170.75
109_V148_S0.6140.75
19_A47_E0.6100.75
107_L114_A0.6100.75
124_V133_I0.6090.74
74_F115_T0.6070.74
130_Q179_V0.6030.74
53_I150_L0.6030.74
71_W182_L0.6020.74
100_R103_H0.6020.74
174_L178_G0.6000.73
40_G149_T0.5990.73
25_G151_G0.5990.73
10_A147_M0.5970.73
13_M46_V0.5950.73
76_L84_M0.5920.72
65_V128_F0.5910.72
74_F178_G0.5850.71
35_E108_L0.5840.71
41_L56_G0.5840.71
19_A165_K0.5810.71
17_A118_D0.5800.71
98_E183_W0.5790.71
21_S36_A0.5780.71
36_A149_T0.5770.70
8_L177_I0.5750.70
14_S118_D0.5700.70
69_N77_L0.5700.70
22_I58_G0.5690.69
47_E148_S0.5690.69
18_F22_I0.5690.69
57_M124_V0.5670.69
120_M124_V0.5590.68
91_G138_L0.5550.67
78_I89_F0.5510.67
42_I109_V0.5500.67
78_I145_L0.5480.67
63_R67_E0.5450.66
47_E84_M0.5430.66
17_A43_F0.5430.66
78_I175_I0.5410.66
7_V153_M0.5400.65
125_G128_F0.5370.65
19_A80_L0.5370.65
37_L49_L0.5360.65
71_W75_V0.5330.64
59_M169_L0.5330.64
61_A117_L0.5310.64
27_T38_R0.5310.64
71_W74_F0.5270.64
176_G183_W0.5270.64
8_L80_L0.5270.64
104_G139_A0.5230.63
50_T115_T0.5230.63
30_K34_S0.5220.63
43_F112_A0.5210.63
29_H101_R0.5200.63
71_W76_L0.5180.62
83_R120_M0.5160.62
129_L181_I0.5150.62
98_E107_L0.5150.62
85_I165_K0.5120.61
12_G119_A0.5110.61
119_A170_G0.5100.61
33_F138_L0.5090.61
91_G117_L0.5070.61
100_R104_G0.5060.60
43_F121_A0.5040.60
65_V121_A0.5030.60
19_A74_F0.5020.60
85_I161_I0.5010.60
38_R104_G0.5010.60
83_R115_T0.5000.60
115_T170_G0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.9681 27.6 0.93 Contact Map
3wdoA 1 0.9468 20.4 0.934 Contact Map
3j1zP 8 0.5 17.5 0.936 Contact Map
2gfpA 2 0.9681 16.9 0.937 Contact Map
1pw4A 1 0.5532 15.7 0.938 Contact Map
4p6vD 1 0.7713 12.1 0.94 Contact Map
4m64A 1 0.9894 12.1 0.941 Contact Map
4j05A 3 0.883 11.6 0.941 Contact Map
3o7qA 1 0.9734 10.9 0.942 Contact Map
4w6vA 1 0.4947 9.9 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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