GREMLIN Database
ADRB - Putative cyclic-di-GMP phosphodiesterase AdrB
UniProt: P76261 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13516
Length: 532 (434)
Sequences: 15952 (12662)
Seq/√Len: 607.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
300_V507_F4.3001.00
292_A493_L3.9761.00
126_E130_P3.8871.00
338_A379_S3.4991.00
333_T363_H3.4671.00
441_K445_A3.3561.00
334_R372_D3.2141.00
499_A502_M3.1491.00
374_N410_K3.1241.00
408_H435_D3.0571.00
286_C343_Q2.9571.00
283_E307_N2.9161.00
265_Y318_V2.8821.00
387_I436_V2.6951.00
291_N294_S2.6241.00
479_Q483_K2.5741.00
253_L256_G2.5441.00
272_E308_N2.5281.00
348_P385_Q2.5071.00
484_Y488_H2.4941.00
345_H349_M2.4931.00
465_Q491_H2.4911.00
256_G259_A2.4381.00
255_V259_A2.3111.00
308_N312_G2.3041.00
476_V493_L2.2871.00
323_A332_L2.1971.00
430_E453_N2.1731.00
304_L336_V2.1511.00
165_E228_V2.1501.00
415_A436_V2.1291.00
343_Q504_L2.1061.00
137_T141_A2.0921.00
482_A498_Y2.0801.00
237_A240_Y2.0701.00
482_A493_L2.0111.00
343_Q347_F1.9961.00
339_E342_R1.9921.00
335_Y339_E1.9681.00
163_V232_G1.9671.00
308_N311_Q1.9641.00
339_E343_Q1.9421.00
146_S238_W1.9161.00
165_E204_D1.8841.00
285_F503_P1.8711.00
266_R325_E1.8701.00
341_I376_Y1.8691.00
284_L336_V1.8481.00
275_L279_Q1.8411.00
344_R381_H1.8401.00
290_L498_Y1.8201.00
253_L259_A1.8171.00
117_N121_V1.8141.00
280_H339_E1.8041.00
478_T481_Q1.8001.00
307_N313_W1.7791.00
404_A414_L1.7561.00
141_A145_G1.7561.00
289_L492_I1.7511.00
283_E313_W1.7411.00
359_V369_L1.7311.00
186_S189_L1.7301.00
454_S484_Y1.7191.00
176_L184_I1.7161.00
458_D466_R1.7091.00
289_L436_V1.7061.00
354_H413_K1.6971.00
458_D488_H1.6941.00
170_D227_N1.6821.00
503_P506_D1.6791.00
382_P385_Q1.6781.00
347_F504_L1.6761.00
448_G454_S1.6691.00
496_Y501_P1.6181.00
281_E308_N1.6161.00
282_F304_L1.6001.00
479_Q497_L1.5951.00
461_I488_H1.5931.00
338_A376_Y1.5891.00
285_F313_W1.5751.00
413_K435_D1.5691.00
448_G480_E1.5621.00
470_E491_H1.5511.00
190_T215_Y1.5461.00
284_L335_Y1.5451.00
482_A486_R1.5421.00
190_T193_K1.5371.00
289_L387_I1.5361.00
377_W412_V1.5321.00
235_A244_Q1.5291.00
482_A497_L1.5191.00
416_I434_P1.5181.00
461_I490_V1.5121.00
436_V472_V1.5001.00
387_I415_A1.4951.00
350_S508_P1.4741.00
430_E446_A1.4731.00
348_P382_P1.4701.00
186_S218_S1.4671.00
359_V388_L1.4571.00
193_K196_L1.4411.00
289_L299_G1.4371.00
502_M510_W1.4351.00
470_E492_I1.4101.00
458_D462_A1.3981.00
216_Q221_R1.3741.00
354_H387_I1.3741.00
123_I127_L1.3691.00
437_L464_G1.3631.00
375_Q379_S1.3631.00
298_I492_I1.3611.00
145_G148_V1.3581.00
126_E135_R1.3511.00
297_C510_W1.3461.00
254_L259_A1.3451.00
309_P312_G1.3441.00
448_G484_Y1.3381.00
109_C113_F1.3291.00
304_L335_Y1.3291.00
272_E311_Q1.3131.00
281_E306_W1.3091.00
374_N406_E1.3041.00
253_L257_Y1.3031.00
275_L281_E1.3001.00
204_D230_G1.2951.00
255_V258_I1.2931.00
311_Q318_V1.2921.00
344_R355_V1.2901.00
117_N120_V1.2901.00
436_V470_E1.2821.00
434_P469_I1.2801.00
506_D509_K1.2751.00
447_I484_Y1.2731.00
205_S209_P1.2681.00
441_K475_G1.2681.00
125_A129_A1.2611.00
347_F508_P1.2591.00
473_A490_V1.2531.00
191_V211_D1.2491.00
118_V121_V1.2491.00
304_L332_L1.2451.00
169_I191_V1.2401.00
340_T355_V1.2311.00
346_V350_S1.2311.00
284_L340_T1.2221.00
110_S113_F1.2201.00
167_I226_I1.2141.00
483_K487_R1.2051.00
86_L90_A1.2031.00
187_A224_F1.2011.00
130_P141_A1.1971.00
464_G471_L1.1931.00
174_A270_S1.1931.00
190_T194_R1.1911.00
361_P393_R1.1821.00
211_D226_I1.1811.00
254_L257_Y1.1671.00
269_F322_I1.1671.00
338_A342_R1.1591.00
123_I126_E1.1561.00
292_A482_A1.1541.00
483_K486_R1.1491.00
147_P238_W1.1431.00
265_Y311_Q1.1421.00
373_L407_L1.1371.00
499_A510_W1.1331.00
231_P244_Q1.1241.00
246_P250_L1.1221.00
450_D453_N1.1221.00
113_F117_N1.1201.00
377_W383_I1.1161.00
107_L110_S1.1151.00
372_D376_Y1.1141.00
282_F335_Y1.1111.00
317_D441_K1.1101.00
244_Q260_W1.1091.00
405_R409_R1.1091.00
344_R348_P1.1061.00
86_L92_K1.1041.00
365_R397_L1.0991.00
343_Q346_V1.0991.00
493_L498_Y1.0981.00
308_N314_I1.0961.00
352_Q385_Q1.0911.00
103_Q106_T1.0911.00
291_N296_Q1.0891.00
233_A241_L1.0771.00
216_Q219_S1.0771.00
171_L174_A1.0741.00
116_R119_P1.0731.00
200_N206_L1.0721.00
149_L162_G1.0701.00
129_A140_R1.0651.00
401_Y405_R1.0631.00
447_I457_T1.0621.00
401_Y431_T1.0591.00
260_W264_A1.0591.00
289_L356_G1.0591.00
186_S190_T1.0521.00
166_M249_V1.0511.00
311_Q314_I1.0501.00
168_N250_L1.0481.00
502_M506_D1.0461.00
330_V366_R1.0461.00
240_Y244_Q1.0451.00
194_R215_Y1.0451.00
387_I413_K1.0441.00
373_L388_L1.0361.00
210_E213_E1.0341.00
436_V492_I1.0331.00
281_E309_P1.0321.00
211_D215_Y1.0311.00
326_H330_V1.0261.00
289_L354_H1.0251.00
173_T250_L1.0241.00
168_N176_L1.0231.00
272_E310_R1.0201.00
370_I403_I1.0181.00
459_I466_R1.0171.00
182_P239_H1.0171.00
374_N378_F1.0161.00
370_I374_N1.0121.00
181_L246_P1.0111.00
121_V125_A1.0111.00
341_I386_L1.0101.00
328_L331_P1.0081.00
254_L258_I1.0071.00
273_I323_A1.0031.00
479_Q482_A1.0011.00
114_G117_N1.0001.00
399_V432_L0.9971.00
171_L270_S0.9911.00
342_R346_V0.9901.00
376_Y379_S0.9891.00
283_E503_P0.9881.00
155_A200_N0.9871.00
289_L472_V0.9871.00
295_Q486_R0.9861.00
356_G387_I0.9841.00
345_H348_P0.9821.00
108_Y111_S0.9791.00
268_S272_E0.9771.00
141_A144_K0.9761.00
147_P151_Q0.9741.00
324_E329_I0.9691.00
208_Q228_V0.9681.00
143_I239_H0.9681.00
299_G354_H0.9651.00
176_L185_S0.9651.00
169_I226_I0.9631.00
290_L510_W0.9621.00
162_G233_A0.9601.00
320_I329_I0.9491.00
371_K406_E0.9461.00
129_A144_K0.9431.00
109_C115_Y0.9431.00
445_A481_Q0.9421.00
343_Q508_P0.9401.00
337_M376_Y0.9371.00
89_Q92_K0.9351.00
145_G149_L0.9351.00
136_L192_D0.9341.00
345_H380_A0.9341.00
203_V206_L0.9331.00
183_Q220_Q0.9311.00
301_E358_N0.9301.00
448_G478_T0.9301.00
448_G481_Q0.9301.00
82_A85_P0.9271.00
331_P334_R0.9261.00
119_P123_I0.9261.00
200_N203_V0.9241.00
284_L304_L0.9211.00
300_V353_F0.9201.00
278_A331_P0.9061.00
291_N298_I0.9051.00
472_V492_I0.9041.00
253_L258_I0.9031.00
217_V222_F0.9021.00
275_L278_A0.9021.00
280_H338_A0.9011.00
316_P319_F0.8991.00
270_S274_N0.8981.00
504_L508_P0.8971.00
172_L188_S0.8971.00
276_G282_F0.8961.00
187_A215_Y0.8931.00
132_P140_R0.8931.00
221_R275_L0.8931.00
370_I406_E0.8931.00
291_N491_H0.8841.00
476_V485_L0.8821.00
273_I282_F0.8771.00
293_R491_H0.8741.00
170_D225_T0.8731.00
396_L428_W0.8731.00
388_L412_V0.8721.00
230_G254_L0.8691.00
340_T357_I0.8671.00
369_L373_L0.8611.00
209_P212_N0.8601.00
461_I471_L0.8591.00
113_F118_V0.8571.00
93_L98_S0.8531.00
204_D208_Q0.8531.00
198_Y206_L0.8521.00
183_Q186_S0.8481.00
194_R214_N0.8471.00
276_G281_E0.8461.00
406_E409_R0.8411.00
108_Y113_F0.8401.00
177_L250_L0.8401.00
122_D125_A0.8391.00
368_V372_D0.8391.00
172_L176_L0.8391.00
293_R486_R0.8391.00
403_I406_E0.8391.00
205_S208_Q0.8381.00
240_Y243_T0.8361.00
386_L412_V0.8361.00
189_L193_K0.8351.00
354_H385_Q0.8321.00
455_T466_R0.8311.00
87_R92_K0.8271.00
198_Y210_E0.8241.00
173_T177_L0.8231.00
401_Y433_R0.8211.00
389_E438_K0.8201.00
144_K148_V0.8181.00
454_S458_D0.8181.00
142_L146_S0.8181.00
198_Y207_P0.8181.00
462_A466_R0.8171.00
179_P220_Q0.8161.00
93_L96_V0.8161.00
461_I465_Q0.8131.00
341_I381_H0.8111.00
168_N172_L0.8101.00
413_K470_E0.8091.00
402_R406_E0.8081.00
260_W263_T0.8061.00
181_L250_L0.8041.00
326_H329_I0.8031.00
124_L127_L0.8001.00
323_A329_I0.7981.00
334_R338_A0.7971.00
280_H335_Y0.7951.00
371_K375_Q0.7941.00
465_Q471_L0.7931.00
290_L297_C0.7931.00
381_H386_L0.7921.00
484_Y487_R0.7911.00
89_Q94_Q0.7901.00
366_R372_D0.7891.00
80_S83_H0.7881.00
86_L89_Q0.7841.00
302_I355_V0.7841.00
430_E456_V0.7811.00
323_A327_H0.7791.00
418_D474_E0.7791.00
330_V363_H0.7781.00
337_M373_L0.7751.00
109_C112_I0.7741.00
129_A137_T0.7721.00
364_F394_D0.7721.00
173_T176_L0.7711.00
92_K98_S0.7701.00
120_V123_I0.7701.00
229_N245_L0.7631.00
150_I233_A0.7631.00
405_R433_R0.7521.00
120_V124_L0.7521.00
391_T418_D0.7521.00
508_P512_A0.7511.00
143_I147_P0.7491.00
234_T244_Q0.7481.00
290_L295_Q0.7461.00
277_L335_Y0.7441.00
485_L490_V0.7411.00
273_I276_G0.7371.00
94_Q98_S0.7361.00
166_M245_L0.7361.00
129_A141_A0.7351.00
307_N312_G0.7331.00
231_P241_L0.7301.00
274_N328_L0.7271.00
191_V215_Y0.7261.00
284_L302_I0.7261.00
346_V349_M0.7231.00
402_R405_R0.7191.00
130_P137_T0.7181.00
453_N481_Q0.7181.00
183_Q217_V0.7171.00
431_T452_V0.7151.00
97_R100_G0.7151.00
461_I485_L0.7141.00
270_S326_H0.7121.00
204_D228_V0.7121.00
171_L325_E0.7121.00
344_R352_Q0.7091.00
229_N248_A0.7081.00
108_Y112_I0.7071.00
285_F307_N0.7071.00
509_K512_A0.7071.00
208_Q226_I0.7061.00
430_E450_D0.7041.00
154_P236_L0.7041.00
175_M184_I0.7031.00
473_A485_L0.7031.00
107_L111_S0.7021.00
197_L210_E0.6981.00
446_A450_D0.6981.00
223_P274_N0.6981.00
391_T474_E0.6981.00
334_R375_Q0.6961.00
372_D375_Q0.6961.00
179_P222_F0.6951.00
446_A449_S0.6941.00
286_C302_I0.6921.00
404_A433_R0.6901.00
133_L185_S0.6891.00
114_G118_V0.6881.00
428_W431_T0.6881.00
507_F510_W0.6871.00
88_K92_K0.6871.00
94_Q100_G0.6871.00
149_L152_W0.6851.00
496_Y500_Q0.6851.00
162_G241_L0.6841.00
270_S322_I0.6821.00
110_S115_Y0.6811.00
167_I228_V0.6801.00
388_L414_L0.6801.00
329_I362_S0.6791.00
462_A465_Q0.6761.00
377_W381_H0.6751.00
183_Q222_F0.6751.00
153_T233_A0.6741.00
370_I410_K0.6731.00
334_R376_Y0.6731.00
373_L412_V0.6721.00
283_E505_R0.6711.00
444_T473_A0.6701.00
364_F403_I0.6701.00
126_E129_A0.6691.00
446_A453_N0.6691.00
172_L184_I0.6691.00
80_S85_P0.6691.00
476_V482_A0.6681.00
304_L319_F0.6681.00
93_L100_G0.6681.00
133_L189_L0.6661.00
456_V463_L0.6661.00
99_I102_V0.6651.00
371_K374_N0.6631.00
471_L491_H0.6621.00
182_P243_T0.6621.00
416_I428_W0.6621.00
153_T162_G0.6601.00
348_P352_Q0.6591.00
317_D321_P0.6581.00
346_V504_L0.6581.00
286_C300_V0.6581.00
421_T442_S0.6581.00
302_I340_T0.6571.00
251_L262_A0.6561.00
314_I321_P0.6551.00
456_V460_I0.6521.00
261_L265_Y0.6511.00
163_V230_G0.6511.00
89_Q93_L0.6491.00
288_P499_A0.6481.00
133_L176_L0.6481.00
274_N331_P0.6471.00
80_S107_L0.6461.00
116_R120_V0.6441.00
508_P511_L0.6431.00
344_R385_Q0.6431.00
502_M507_F0.6421.00
215_Y224_F0.6421.00
95_T112_I0.6421.00
288_P502_M0.6391.00
357_I386_L0.6381.00
353_F385_Q0.6361.00
165_E230_G0.6341.00
109_C114_G0.6341.00
236_L240_Y0.6331.00
347_F507_F0.6321.00
355_V381_H0.6301.00
118_V122_D0.6281.00
373_L376_Y0.6281.00
477_E496_Y0.6271.00
334_R366_R0.6261.00
288_P297_C0.6251.00
98_S109_C0.6251.00
444_T447_I0.6211.00
324_E360_A0.6211.00
191_V195_H0.6211.00
174_A266_R0.6201.00
203_V207_P0.6191.00
176_L188_S0.6191.00
439_I490_V0.6181.00
92_K100_G0.6171.00
421_T443_F0.6161.00
143_I238_W0.6141.00
455_T458_D0.6101.00
107_L113_F0.6101.00
85_P91_A0.6091.00
340_T344_R0.6081.00
358_N417_D0.6051.00
121_V124_L0.6031.00
96_V100_G0.6021.00
100_G103_Q0.6021.00
95_T99_I0.6011.00
193_K197_L0.6001.00
295_Q482_A0.6001.00
88_K93_L0.5981.00
98_S102_V0.5981.00
273_I328_L0.5971.00
247_L259_A0.5971.00
181_L184_I0.5961.00
134_L188_S0.5961.00
361_P394_D0.5951.00
437_L469_I0.5951.00
98_S101_L0.5921.00
150_I162_G0.5911.00
87_R91_A0.5901.00
455_T459_I0.5901.00
451_A454_S0.5901.00
333_T336_V0.5891.00
359_V363_H0.5881.00
153_T159_S0.5871.00
95_T98_S0.5861.00
346_V508_P0.5851.00
171_L257_Y0.5841.00
269_F272_E0.5841.00
413_K436_V0.5821.00
179_P183_Q0.5811.00
358_N438_K0.5811.00
344_R386_L0.5801.00
454_S488_H0.5801.00
285_F501_P0.5801.00
345_H381_H0.5791.00
93_L99_I0.5781.00
86_L94_Q0.5761.00
198_Y203_V0.5751.00
316_P321_P0.5751.00
300_V355_V0.5751.00
363_H369_L0.5741.00
334_R363_H0.5711.00
307_N311_Q0.5701.00
301_E438_K0.5701.00
299_G356_G0.5701.00
381_H385_Q0.5701.00
356_G436_V0.5701.00
85_P93_L0.5691.00
463_L467_L0.5691.00
79_C82_A0.5691.00
110_S114_G0.5671.00
175_M187_A0.5671.00
89_Q98_S0.5641.00
299_G353_F0.5641.00
303_L358_N0.5631.00
146_S162_G0.5631.00
480_E483_K0.5631.00
108_Y115_Y0.5631.00
98_S103_Q0.5601.00
107_L112_I0.5601.00
187_A217_V0.5581.00
115_Y119_P0.5561.00
263_T267_M0.5551.00
498_Y501_P0.5541.00
414_L435_D0.5541.00
286_C340_T0.5531.00
368_V371_K0.5520.99
257_Y261_L0.5510.99
94_Q99_I0.5510.99
444_T457_T0.5500.99
96_V99_I0.5480.99
268_S311_Q0.5460.99
227_N252_S0.5420.99
119_P122_D0.5420.99
277_L332_L0.5420.99
350_S512_A0.5410.99
164_M241_L0.5410.99
209_P213_E0.5410.99
168_N184_I0.5400.99
153_T160_N0.5400.99
338_A372_D0.5390.99
255_V260_W0.5380.99
295_Q479_Q0.5370.99
461_I491_H0.5370.99
86_L91_A0.5370.99
315_S318_V0.5370.99
362_S365_R0.5370.99
407_L412_V0.5340.99
268_S310_R0.5320.99
124_L129_A0.5320.99
195_H199_G0.5320.99
231_P235_A0.5300.99
88_K94_Q0.5290.99
507_F511_L0.5290.99
505_R508_P0.5290.99
120_V127_L0.5290.99
91_A96_V0.5290.99
87_R94_Q0.5280.99
292_A486_R0.5280.99
195_H207_P0.5260.99
301_E417_D0.5260.99
361_P428_W0.5260.99
337_M357_I0.5250.99
314_I318_V0.5240.99
332_L336_V0.5230.99
208_Q225_T0.5230.99
173_T246_P0.5230.99
112_I115_Y0.5230.99
143_I242_P0.5220.99
304_L313_W0.5210.99
320_I324_E0.5210.99
231_P245_L0.5210.99
336_V340_T0.5190.99
287_Q494_Q0.5180.99
334_R368_V0.5180.99
269_F306_W0.5170.99
439_I460_I0.5170.99
460_I464_G0.5170.99
88_K91_A0.5160.99
273_I306_W0.5160.99
86_L93_L0.5140.99
447_I454_S0.5130.99
182_P218_S0.5120.99
94_Q111_S0.5110.99
90_A93_L0.5100.99
115_Y118_V0.5090.99
337_M372_D0.5090.99
337_M341_I0.5090.99
139_D185_S0.5090.99
481_Q497_L0.5080.99
428_W432_L0.5080.99
358_N494_Q0.5060.99
262_A265_Y0.5040.99
272_E306_W0.5040.99
128_P138_I0.5030.99
232_G254_L0.5030.99
272_E275_L0.5020.99
327_H362_S0.5020.99
452_V468_N0.5020.99
252_S259_A0.5010.99
358_N496_Y0.5010.99
168_N246_P0.5000.99
315_S321_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rnhA 2 0.7105 100 0.299 Contact Map
4j40A 2 0.4643 100 0.317 Contact Map
3pjxA 1 0.7274 100 0.324 Contact Map
3gfzA 2 0.656 100 0.422 Contact Map
4hjfA 1 0.4812 100 0.435 Contact Map
4kieA 1 0.4812 100 0.497 Contact Map
2r6oA 2 0.4737 100 0.504 Contact Map
3sy8A 6 0.735 100 0.506 Contact Map
4hu4A 1 0.4549 100 0.51 Contact Map
4rniA 2 0.468 100 0.512 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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