GREMLIN Database
TSAB - tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
UniProt: P76256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13512
Length: 231 (207)
Sequences: 7331 (4877)
Seq/√Len: 339.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_R19_N3.5101.00
60_A198_A3.0951.00
97_T194_M2.8561.00
19_N22_T2.8431.00
43_Q47_T2.8301.00
5_A195_L2.8011.00
53_L85_A2.7371.00
42_V77_I2.5711.00
44_D48_T2.5111.00
130_D134_I2.4901.00
130_D136_H2.4451.00
201_M206_K2.4311.00
2_R51_T2.4121.00
33_E36_Q2.3421.00
61_Y75_I2.2291.00
199_C203_A2.2121.00
56_I87_L2.1951.00
59_L78_A2.1381.00
57_N87_L2.1051.00
58_A202_F2.1031.00
38_I77_I2.1011.00
59_L81_L2.0841.00
82_A89_M2.0651.00
25_A45_I2.0521.00
52_S55_D2.0211.00
61_Y89_M2.0061.00
9_A62_G2.0041.00
76_G80_G2.0001.00
78_A89_M1.9941.00
53_L56_I1.9871.00
17_L45_I1.9761.00
58_A90_I1.9641.00
3_I58_A1.9431.00
80_G84_G1.9431.00
128_Q136_H1.9301.00
27_F44_D1.8891.00
105_K183_D1.8521.00
46_L53_L1.7931.00
27_F48_T1.7141.00
15_V42_V1.6961.00
96_M201_M1.6781.00
2_R57_N1.6691.00
91_G208_V1.6301.00
59_L87_L1.6101.00
45_I49_S1.5991.00
137_G140_T1.5391.00
16_A191_A1.5081.00
96_M135_W1.4721.00
39_L77_I1.4691.00
172_D175_K1.4691.00
14_S191_A1.4571.00
18_W195_L1.4491.00
63_R91_G1.4361.00
3_I60_A1.4361.00
21_G199_C1.4281.00
95_L118_R1.4131.00
17_L49_S1.3601.00
125_A137_G1.3371.00
15_V41_M1.3341.00
148_I151_E1.3241.00
131_E134_I1.2981.00
27_F41_M1.2711.00
56_I85_A1.2591.00
17_L51_T1.2521.00
51_T55_D1.2441.00
114_A129_R1.2281.00
6_I74_G1.2151.00
13_C41_M1.2051.00
90_I202_F1.2051.00
124_W144_L1.1991.00
93_S141_E1.1961.00
110_R113_A1.1881.00
172_D176_E1.1851.00
127_Y137_G1.1801.00
81_L85_A1.1661.00
19_N24_N1.1481.00
144_L149_V1.1371.00
15_V45_I1.1351.00
129_R135_W1.1321.00
8_T74_G1.1281.00
42_V81_L1.1261.00
145_K148_I1.1021.00
5_A198_A1.0951.00
6_I42_V1.0941.00
25_A49_S1.0881.00
7_D62_G1.0791.00
17_L56_I1.0731.00
196_P200_Q1.0711.00
93_S96_M1.0711.00
33_E37_R1.0631.00
202_F207_T1.0391.00
171_P175_K1.0371.00
112_L126_E1.0341.00
44_D47_T1.0211.00
26_H190_A1.0121.00
139_E152_R1.0111.00
80_G83_L1.0101.00
139_E142_A1.0091.00
71_V75_I1.0021.00
124_W149_V1.0001.00
60_A194_M0.9901.00
183_D186_V0.9871.00
137_G141_E0.9861.00
5_A60_A0.9851.00
200_Q203_A0.9841.00
26_H48_T0.9811.00
6_I78_A0.9761.00
54_T85_A0.9741.00
121_E143_V0.9711.00
128_Q158_G0.9611.00
72_R76_G0.9601.00
2_R55_D0.9591.00
99_A116_D0.9541.00
46_L51_T0.9541.00
59_L85_A0.9471.00
58_A88_P0.9451.00
53_L81_L0.9421.00
201_M208_V0.9321.00
174_G177_S0.9321.00
26_H45_I0.9221.00
167_W170_W0.9211.00
97_T197_I0.9131.00
203_A206_K0.9121.00
100_Q196_P0.9121.00
61_Y74_G0.9101.00
170_W174_G0.9011.00
147_E173_L0.8991.00
5_A191_A0.8921.00
23_V26_H0.8891.00
143_V146_P0.8781.00
121_E145_K0.8761.00
64_G93_S0.8751.00
153_M156_L0.8741.00
98_M163_V0.8701.00
110_R126_E0.8661.00
27_F45_I0.8631.00
100_Q103_W0.8521.00
18_W196_P0.8491.00
77_I80_G0.8391.00
63_R208_V0.8381.00
110_R128_Q0.8361.00
39_L43_Q0.8321.00
96_M137_G0.8311.00
59_L82_A0.8271.00
170_W173_L0.8221.00
102_A164_G0.8201.00
58_A198_A0.8201.00
117_A123_Y0.8171.00
113_A124_W0.8121.00
190_A193_D0.8081.00
11_E165_T0.8081.00
17_L46_L0.8071.00
26_H192_E0.8051.00
125_A140_T0.8031.00
150_H153_M0.7991.00
68_F72_R0.7981.00
100_Q135_W0.7971.00
195_L198_A0.7961.00
150_H154_Q0.7941.00
92_V97_T0.7831.00
75_I79_Q0.7831.00
148_I152_R0.7821.00
90_I207_T0.7811.00
9_A94_T0.7791.00
101_G193_D0.7781.00
114_A162_T0.7771.00
142_A152_R0.7751.00
92_V197_I0.7721.00
5_A18_W0.7671.00
37_R40_P0.7671.00
193_D197_I0.7621.00
2_R56_I0.7581.00
151_E155_Q0.7581.00
119_M173_L0.7571.00
171_P174_G0.7561.00
100_Q197_I0.7551.00
111_V163_V0.7511.00
62_G94_T0.7501.00
126_E139_E0.7481.00
79_Q89_M0.7430.99
196_P199_C0.7380.99
110_R138_E0.7300.99
10_T62_G0.7210.99
46_L56_I0.7170.99
47_T50_G0.7130.99
162_T179_L0.7080.99
109_T161_V0.7060.99
120_G173_L0.7020.99
105_K109_T0.7020.99
200_Q204_E0.7000.99
19_N51_T0.7000.99
122_V166_G0.6980.99
35_T69_T0.6960.99
122_V149_V0.6930.99
5_A194_M0.6910.99
166_G170_W0.6860.99
77_I81_L0.6840.99
10_T115_I0.6760.99
128_Q138_E0.6700.99
56_I59_L0.6700.99
34_H74_G0.6680.99
191_A194_M0.6660.99
160_W164_G0.6640.99
75_I91_G0.6640.99
61_Y78_A0.6620.99
95_L125_A0.6610.99
100_Q129_R0.6610.99
18_W199_C0.6610.99
14_S28_E0.6610.99
46_L85_A0.6610.99
114_A167_W0.6590.99
2_R17_L0.6560.99
102_A162_T0.6540.99
2_R5_A0.6530.99
23_V192_E0.6520.99
10_T94_T0.6480.99
10_T189_P0.6440.99
108_A178_G0.6370.98
80_G85_A0.6370.98
38_I42_V0.6340.98
96_M127_Y0.6320.98
104_R193_D0.6310.98
165_T168_Q0.6250.98
150_H174_G0.6220.98
168_Q187_L0.6190.98
26_H185_E0.6190.98
63_R75_I0.6180.98
149_V153_M0.6140.98
96_M100_Q0.6130.98
31_P69_T0.6120.98
194_M198_A0.6080.98
169_A184_G0.6070.98
51_T56_I0.6040.98
152_R155_Q0.6000.98
197_I201_M0.5980.98
92_V194_M0.5960.98
3_I202_F0.5930.98
95_L113_A0.5910.97
103_W200_Q0.5880.97
46_L49_S0.5880.97
98_M113_A0.5860.97
189_P193_D0.5850.97
4_L59_L0.5840.97
165_T169_A0.5830.97
120_G145_K0.5830.97
162_T167_W0.5800.97
118_R125_A0.5800.97
3_I199_C0.5790.97
74_G78_A0.5780.97
147_E151_E0.5770.97
5_A16_A0.5750.97
18_W23_V0.5730.97
103_W129_R0.5720.97
19_N199_C0.5720.97
98_M124_W0.5710.97
98_M101_G0.5700.97
164_G170_W0.5680.97
58_A91_G0.5670.97
40_P43_Q0.5670.97
69_T72_R0.5650.97
68_F76_G0.5640.97
104_R196_P0.5640.97
144_L152_R0.5630.97
17_L25_A0.5610.97
112_L162_T0.5600.97
35_T68_F0.5530.96
201_M207_T0.5530.96
193_D198_A0.5510.96
8_T13_C0.5490.96
28_E31_P0.5460.96
13_C37_R0.5430.96
90_I198_A0.5410.96
118_R123_Y0.5410.96
165_T170_W0.5400.96
9_A71_V0.5370.96
139_E144_L0.5360.96
82_A85_A0.5350.95
162_T174_G0.5330.95
125_A141_E0.5310.95
201_M204_E0.5300.95
143_V147_E0.5280.95
20_D203_A0.5270.95
146_P150_H0.5260.95
91_G201_M0.5260.95
70_G76_G0.5260.95
64_G84_G0.5250.95
130_D133_G0.5240.95
95_L127_Y0.5230.95
63_R141_E0.5220.95
6_I81_L0.5210.95
114_A164_G0.5190.95
173_L177_S0.5190.95
116_D164_G0.5150.94
24_N27_F0.5130.94
41_M44_D0.5130.94
100_Q200_Q0.5120.94
34_H67_S0.5120.94
28_E37_R0.5090.94
99_A102_A0.5050.94
67_S79_Q0.5050.94
128_Q131_E0.5040.94
81_L84_G0.5040.94
70_G99_A0.5030.94
169_A174_G0.5020.94
193_D196_P0.5020.94
195_L199_C0.5020.94
46_L50_G0.5010.94
26_H44_D0.5010.94
97_T189_P0.5010.94
64_G70_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zeuA 1 0.9913 100 0.189 Contact Map
2a6aA 3 0.8355 100 0.247 Contact Map
3r6mA 2 0.9177 100 0.258 Contact Map
5br9A 2 0.9307 100 0.259 Contact Map
3en9A 1 0.9524 100 0.539 Contact Map
3venA 1 0.987 99.9 0.589 Contact Map
4k25A 2 0.9004 99.9 0.601 Contact Map
3enoA 1 0.961 99.9 0.602 Contact Map
2ivnA 1 0.974 99.9 0.606 Contact Map
3zeuB 1 0.8961 99.9 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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