GREMLIN Database
YEAX - Putative dioxygenase subunit beta YeaX
UniProt: P76254 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13510
Length: 321 (308)
Sequences: 5365 (3880)
Seq/√Len: 221.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_M260_N3.9681.00
114_K140_D3.3381.00
76_L89_Q3.1181.00
12_S27_V3.0621.00
17_L23_R3.0421.00
9_V99_I2.8951.00
11_V91_V2.7171.00
259_E271_R2.6771.00
249_P252_M2.6391.00
8_E96_R2.5901.00
14_V22_K2.5281.00
132_A158_E2.5231.00
92_K95_D2.4971.00
24_F87_L2.4821.00
246_F257_V2.4611.00
236_T247_V2.4401.00
280_T307_I2.3111.00
23_R71_Q2.2881.00
255_L268_C2.2851.00
286_E313_K2.2281.00
16_P22_K2.2231.00
284_E318_V2.2121.00
13_Q93_V2.2081.00
236_T245_E2.1681.00
124_I143_L2.1651.00
282_I305_M2.1111.00
147_S153_C2.1021.00
10_Q96_R2.0851.00
8_E98_T2.0751.00
200_E204_E2.0681.00
10_Q27_V2.0671.00
76_L85_R2.0301.00
237_L254_I1.9991.00
45_V72_I1.9961.00
193_H221_H1.9821.00
25_T69_C1.9571.00
87_L91_V1.9461.00
180_E183_R1.9131.00
119_A145_Y1.8921.00
196_T206_V1.8551.00
166_E170_L1.8211.00
150_P175_T1.8001.00
241_R320_D1.7761.00
133_E137_S1.7621.00
118_I202_L1.7371.00
149_N152_S1.6951.00
254_I305_M1.6931.00
13_Q25_T1.6801.00
252_M257_V1.6771.00
14_V93_V1.6531.00
238_V245_E1.6511.00
44_I57_A1.6491.00
114_K142_Q1.6371.00
239_L258_I1.6211.00
282_I287_A1.6021.00
25_T71_Q1.5881.00
23_R155_F1.5831.00
256_Q271_R1.5771.00
156_R160_V1.5771.00
120_G202_L1.5761.00
117_F131_M1.5731.00
146_C202_L1.5571.00
19_E151_E1.5571.00
239_L242_S1.5471.00
173_S178_R1.5391.00
43_V99_I1.5321.00
118_I206_V1.5301.00
147_S172_H1.5231.00
85_R89_Q1.5101.00
46_Q98_T1.5071.00
153_C172_H1.5051.00
181_L185_L1.5031.00
140_D167_K1.4871.00
142_Q169_H1.4831.00
119_A127_F1.4801.00
254_I307_I1.4781.00
297_E301_S1.4701.00
296_D299_R1.4501.00
116_L194_V1.4401.00
15_E23_R1.4361.00
61_L73_A1.4261.00
28_A32_K1.4211.00
246_F262_K1.4201.00
47_M83_G1.4191.00
146_C179_L1.4191.00
146_C173_S1.4101.00
279_E304_S1.4031.00
91_V95_D1.3961.00
11_V26_L1.3851.00
286_E314_G1.3721.00
91_V97_L1.3671.00
114_K192_T1.3571.00
150_P156_R1.3481.00
20_Q152_S1.3411.00
249_P257_V1.3381.00
207_R222_F1.3371.00
266_V307_I1.3341.00
207_R224_Q1.3291.00
119_A143_L1.3241.00
45_V87_L1.3231.00
34_L70_Y1.2961.00
74_V87_L1.2821.00
108_L134_L1.2761.00
259_E268_C1.2301.00
112_A115_H1.2161.00
194_V210_A1.2151.00
204_E208_S1.2041.00
159_L168_V1.2041.00
10_Q29_T1.2011.00
173_S201_A1.2011.00
86_F90_Q1.1991.00
288_D313_K1.1971.00
37_F60_L1.1901.00
14_V92_K1.1871.00
279_E306_L1.1861.00
211_A217_A1.1831.00
21_V154_A1.1831.00
117_F141_W1.1661.00
194_V215_I1.1661.00
33_P67_T1.1611.00
24_F74_V1.1591.00
14_V24_F1.1591.00
29_T96_R1.1571.00
73_A154_A1.1561.00
254_I317_L1.1561.00
49_D86_F1.1441.00
203_I222_F1.1431.00
144_H171_H1.1371.00
17_L155_F1.1361.00
26_L72_I1.1311.00
131_M141_W1.1251.00
196_T203_I1.1201.00
37_F62_S1.1141.00
11_V24_F1.1131.00
9_V26_L1.1131.00
23_R73_A1.1091.00
12_S69_C1.0981.00
75_R152_S1.0961.00
60_L70_Y1.0951.00
149_N174_S1.0941.00
147_S152_S1.0921.00
248_V257_V1.0881.00
287_A310_S1.0821.00
256_Q259_E1.0791.00
207_R211_A1.0751.00
238_V318_V1.0721.00
238_V243_G1.0691.00
153_C156_R1.0591.00
9_V29_T1.0591.00
166_E172_H1.0521.00
115_H139_V1.0521.00
239_L246_F1.0481.00
39_G133_E1.0481.00
24_F91_V1.0321.00
128_L155_F1.0291.00
71_Q158_E1.0211.00
167_K170_L1.0161.00
290_R311_R1.0151.00
253_T256_Q1.0041.00
207_R220_L1.0041.00
15_E25_T0.9961.00
178_R201_A0.9941.00
20_Q75_R0.9921.00
63_S132_A0.9891.00
150_P174_S0.9871.00
182_A209_E0.9851.00
234_A247_V0.9781.00
287_A312_A0.9731.00
258_I266_V0.9711.00
127_F143_L0.9691.00
205_A209_E0.9631.00
185_L188_I0.9541.00
108_L130_H0.9521.00
48_S51_D0.9501.00
150_P160_V0.9481.00
257_V262_K0.9471.00
208_S212_R0.9361.00
210_A220_L0.9301.00
283_L318_V0.9271.00
287_A317_L0.9260.99
45_V97_L0.9230.99
49_D54_Y0.9200.99
281_A304_S0.9200.99
241_R244_K0.9170.99
21_V122_I0.9170.99
183_R186_A0.9150.99
293_Y306_L0.9050.99
240_A318_V0.9020.99
258_I307_I0.9010.99
280_T319_L0.8970.99
196_T207_R0.8930.99
22_K88_H0.8920.99
62_S71_Q0.8920.99
54_Y81_R0.8920.99
147_S170_L0.8900.99
9_V97_L0.8900.99
47_M54_Y0.8860.99
12_S25_T0.8860.99
268_C271_R0.8840.99
77_E80_S0.8800.99
281_A303_Q0.8790.99
299_R302_Q0.8770.99
47_M86_F0.8740.99
196_T220_L0.8720.99
110_P133_E0.8700.99
144_H187_D0.8660.99
9_V28_A0.8660.99
265_K268_C0.8650.99
9_V34_L0.8650.99
118_I184_L0.8640.99
131_M143_L0.8620.99
314_G317_L0.8600.99
145_Y154_A0.8590.99
166_E171_H0.8500.99
171_H176_G0.8500.99
249_P260_N0.8480.99
299_R303_Q0.8470.99
208_S211_A0.8460.99
27_V69_C0.8450.99
300_A303_Q0.8430.99
287_A314_G0.8410.99
236_T315_K0.8370.99
239_L244_K0.8330.99
37_F129_S0.8300.99
117_F127_F0.8260.99
182_A185_L0.8240.99
288_D311_R0.8220.99
205_A208_S0.8140.99
113_R193_H0.8130.99
18_T152_S0.8130.99
58_Y84_S0.8100.99
255_L259_E0.8080.99
110_P137_S0.8060.99
172_H175_T0.8040.99
117_F134_L0.8040.99
188_I192_T0.8030.99
157_D161_Q0.8020.99
46_Q55_S0.8010.99
157_D160_V0.7980.99
229_D232_G0.7980.99
128_L132_A0.7950.98
166_E169_H0.7940.98
117_F130_H0.7930.98
191_G219_T0.7930.98
203_I224_Q0.7930.98
193_H219_T0.7910.98
244_K262_K0.7910.98
259_E265_K0.7880.98
204_E224_Q0.7830.98
61_L71_Q0.7820.98
38_T107_A0.7800.98
113_R191_G0.7780.98
64_P67_T0.7780.98
244_K264_A0.7670.98
144_H184_L0.7660.98
7_F28_A0.7630.98
115_H193_H0.7630.98
44_I103_N0.7570.98
41_S104_N0.7570.98
216_A219_T0.7490.98
43_V60_L0.7480.98
209_E212_R0.7470.98
204_E207_R0.7420.98
108_L115_H0.7410.98
70_Y99_I0.7410.98
19_E152_S0.7400.98
114_K189_E0.7390.98
14_V95_D0.7310.97
77_E85_R0.7310.97
20_Q76_L0.7290.97
146_C171_H0.7230.97
21_V73_A0.7230.97
120_G201_A0.7230.97
291_D294_F0.7230.97
132_A162_H0.7230.97
118_I144_H0.7210.97
283_L320_D0.7180.97
156_R170_L0.7180.97
185_L213_L0.7170.97
188_I215_I0.7160.97
252_M256_Q0.7150.97
28_A34_L0.7140.97
7_F35_P0.7110.97
28_A31_G0.7080.97
233_D315_K0.7070.97
186_A189_E0.7050.97
150_P172_H0.7040.97
196_T222_F0.7020.97
312_A315_K0.7010.97
295_S299_R0.6970.97
269_L277_T0.6950.96
201_A205_A0.6910.96
210_A215_I0.6890.96
47_M87_L0.6890.96
268_C274_V0.6880.96
209_E213_L0.6870.96
44_I55_S0.6840.96
26_L97_L0.6810.96
106_F130_H0.6790.96
54_Y83_G0.6790.96
48_S86_F0.6780.96
35_P101_T0.6770.96
78_E85_R0.6760.96
7_F101_T0.6760.96
255_L266_V0.6750.96
46_Q100_S0.6720.96
38_T104_N0.6700.96
181_L212_R0.6680.96
120_G146_C0.6660.95
158_E161_Q0.6650.95
274_V277_T0.6630.95
59_S127_F0.6610.95
45_V99_I0.6550.95
166_E174_S0.6540.95
33_P68_S0.6530.95
64_P133_E0.6510.95
120_G199_P0.6510.95
160_V170_L0.6470.95
258_I264_A0.6470.95
183_R187_D0.6450.95
43_V72_I0.6420.94
201_A204_E0.6390.94
71_Q132_A0.6390.94
247_V250_E0.6390.94
76_L88_H0.6390.94
297_E300_A0.6370.94
75_R154_A0.6350.94
304_S307_I0.6330.94
174_S178_R0.6330.94
287_A305_M0.6320.94
161_Q164_Q0.6310.94
124_I145_Y0.6300.94
254_I280_T0.6290.94
20_Q78_E0.6290.94
203_I206_V0.6240.94
215_I219_T0.6210.93
44_I100_S0.6210.93
168_V171_H0.6200.93
38_T41_S0.6180.93
153_C170_L0.6180.93
193_H218_D0.6160.93
167_K172_H0.6150.93
235_F314_G0.6120.93
206_V209_E0.6120.93
9_V43_V0.6120.93
240_A320_D0.6110.93
114_K191_G0.6110.93
194_V206_V0.6090.93
160_V164_Q0.6060.93
217_A297_E0.6050.93
135_Q167_K0.6040.93
116_L192_T0.6040.93
116_L188_I0.6030.92
134_L139_V0.6020.92
135_Q141_W0.6020.92
200_E224_Q0.5980.92
295_S303_Q0.5980.92
56_N130_H0.5980.92
51_D54_Y0.5970.92
113_R192_T0.5960.92
220_L223_E0.5960.92
178_R205_A0.5950.92
17_L73_A0.5950.92
171_H174_S0.5950.92
204_E222_F0.5940.92
127_F131_M0.5910.92
240_A283_L0.5900.92
280_T305_M0.5880.92
253_T311_R0.5870.91
24_F72_I0.5850.91
180_E186_A0.5780.91
61_L155_F0.5780.91
272_E292_Q0.5760.91
305_M310_S0.5760.91
257_V260_N0.5750.91
306_L309_C0.5750.91
254_I258_I0.5730.90
288_D310_S0.5720.90
140_D192_T0.5700.90
267_E307_I0.5680.90
289_H293_Y0.5680.90
136_H139_V0.5680.90
238_V284_E0.5670.90
256_Q260_N0.5650.90
50_G54_Y0.5650.90
163_P168_V0.5640.90
142_Q167_K0.5640.90
18_T154_A0.5640.90
38_T110_P0.5630.90
84_S88_H0.5590.89
11_V97_L0.5580.89
116_L144_H0.5560.89
18_T21_V0.5560.89
13_Q183_R0.5560.89
29_T99_I0.5530.89
43_V70_Y0.5520.89
290_R310_S0.5520.89
246_F312_A0.5510.89
182_A212_R0.5500.89
131_M162_H0.5500.89
279_E293_Y0.5500.89
173_S179_L0.5490.89
119_A147_S0.5460.88
130_H195_Y0.5450.88
279_E299_R0.5440.88
36_A67_T0.5440.88
173_S205_A0.5430.88
39_G64_P0.5420.88
144_H169_H0.5420.88
274_V292_Q0.5410.88
115_H195_Y0.5410.88
110_P139_V0.5410.88
109_I193_H0.5400.88
65_H135_Q0.5390.88
143_L159_L0.5380.88
11_V14_V0.5370.87
151_E175_T0.5370.87
108_L195_Y0.5360.87
120_G178_R0.5360.87
287_A302_Q0.5360.87
151_E174_S0.5350.87
109_I221_H0.5340.87
289_H300_A0.5320.87
57_A103_N0.5320.87
131_M168_V0.5320.87
35_P70_Y0.5310.87
90_Q95_D0.5310.87
113_R139_V0.5300.87
301_S304_S0.5300.87
114_K139_V0.5290.87
248_V254_I0.5290.87
73_A155_F0.5270.86
312_A317_L0.5260.86
232_G251_E0.5240.86
65_H68_S0.5240.86
298_E302_Q0.5220.86
16_P20_Q0.5210.86
27_V68_S0.5210.86
294_F299_R0.5200.86
289_H295_S0.5190.86
289_H310_S0.5190.86
237_L246_F0.5170.85
80_S84_S0.5170.85
280_T283_L0.5160.85
202_L205_A0.5150.85
22_K87_L0.5150.85
79_N85_R0.5140.85
133_E136_H0.5100.85
188_I219_T0.5100.85
42_H289_H0.5090.85
49_D83_G0.5090.85
26_L71_Q0.5070.84
253_T309_C0.5060.84
14_V17_L0.5060.84
28_A33_P0.5060.84
129_S132_A0.5040.84
251_E311_R0.5040.84
115_H134_L0.5030.84
246_F258_I0.5030.84
281_A302_Q0.5010.84
169_H172_H0.5000.83
298_E301_S0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2piaA 1 0.9751 100 0.263 Contact Map
1gvhA 3 0.7134 100 0.482 Contact Map
1cqxA 2 0.7165 100 0.487 Contact Map
4g1vA 3 0.7227 100 0.498 Contact Map
1ep3B 2 0.785 100 0.514 Contact Map
4eh1A 2 0.6916 100 0.524 Contact Map
4p6vF 1 0.6978 100 0.528 Contact Map
4ylfA 1 0.7632 100 0.533 Contact Map
1krhA 1 0.6978 100 0.533 Contact Map
1tvcA 1 0.7072 100 0.534 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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