YEAX - ECOLI - GREMLIN Contacts

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YEAX - Putative dioxygenase subunit beta YeaX

UniProt:	P76254	Sequences: MSDYQMFEVQVSQVEPLTEQVKRFTLVATDGKPLPAFTGGSHVIVQMSDGDNQYSNAYSLLSSPHDTSCYQIAVRLEENSRGGSRFLHQQVKVGDRLTISTPNNLFALIPSARKHLFIAGGIGITPFLSHMAELQHSDVDWQLHYCSRNPESCAFRDELVQHPQAEKVHLHHSSTGTRLELARLLADIEPGTHVYTCGPEALIEAVRSEAARLDIAADTLHFEQFAIEDKTGDAFTLVLARSGKEFVVPEEMTILQVIENNKAAKVECLCREGVCGTCETAILEGEADHRDQYFSDEERASQQSMLICCSRAKGKRLVLDL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13510
Length:	321 (308)
Sequences:	5365 (3880)
Seq/√Len:	221.1

ECOLI - YEAX PAAE HCR
BACSU - PYRK HMP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
252_M	260_N	3.968	1.00
114_K	140_D	3.338	1.00
76_L	89_Q	3.118	1.00
12_S	27_V	3.062	1.00
17_L	23_R	3.042	1.00
9_V	99_I	2.895	1.00
11_V	91_V	2.717	1.00
259_E	271_R	2.677	1.00
249_P	252_M	2.639	1.00
8_E	96_R	2.590	1.00
14_V	22_K	2.528	1.00
132_A	158_E	2.523	1.00
92_K	95_D	2.497	1.00
24_F	87_L	2.482	1.00
246_F	257_V	2.461	1.00
236_T	247_V	2.440	1.00
280_T	307_I	2.311	1.00
23_R	71_Q	2.288	1.00
255_L	268_C	2.285	1.00
286_E	313_K	2.228	1.00
16_P	22_K	2.223	1.00
284_E	318_V	2.212	1.00
13_Q	93_V	2.208	1.00
236_T	245_E	2.168	1.00
124_I	143_L	2.165	1.00
282_I	305_M	2.111	1.00
147_S	153_C	2.102	1.00
10_Q	96_R	2.085	1.00
8_E	98_T	2.075	1.00
200_E	204_E	2.068	1.00
10_Q	27_V	2.067	1.00
76_L	85_R	2.030	1.00
237_L	254_I	1.999	1.00
45_V	72_I	1.996	1.00
193_H	221_H	1.982	1.00
25_T	69_C	1.957	1.00
87_L	91_V	1.946	1.00
180_E	183_R	1.913	1.00
119_A	145_Y	1.892	1.00
196_T	206_V	1.855	1.00
166_E	170_L	1.821	1.00
150_P	175_T	1.800	1.00
241_R	320_D	1.776	1.00
133_E	137_S	1.762	1.00
118_I	202_L	1.737	1.00
149_N	152_S	1.695	1.00
254_I	305_M	1.693	1.00
13_Q	25_T	1.680	1.00
252_M	257_V	1.677	1.00
14_V	93_V	1.653	1.00
238_V	245_E	1.651	1.00
44_I	57_A	1.649	1.00
114_K	142_Q	1.637	1.00
239_L	258_I	1.621	1.00
282_I	287_A	1.602	1.00
25_T	71_Q	1.588	1.00
23_R	155_F	1.583	1.00
256_Q	271_R	1.577	1.00
156_R	160_V	1.577	1.00
120_G	202_L	1.576	1.00
117_F	131_M	1.573	1.00
146_C	202_L	1.557	1.00
19_E	151_E	1.557	1.00
239_L	242_S	1.547	1.00
173_S	178_R	1.539	1.00
43_V	99_I	1.532	1.00
118_I	206_V	1.530	1.00
147_S	172_H	1.523	1.00
85_R	89_Q	1.510	1.00
46_Q	98_T	1.507	1.00
153_C	172_H	1.505	1.00
181_L	185_L	1.503	1.00
140_D	167_K	1.487	1.00
142_Q	169_H	1.483	1.00
119_A	127_F	1.480	1.00
254_I	307_I	1.478	1.00
297_E	301_S	1.470	1.00
296_D	299_R	1.450	1.00
116_L	194_V	1.440	1.00
15_E	23_R	1.436	1.00
61_L	73_A	1.426	1.00
28_A	32_K	1.421	1.00
246_F	262_K	1.420	1.00
47_M	83_G	1.419	1.00
146_C	179_L	1.419	1.00
146_C	173_S	1.410	1.00
279_E	304_S	1.403	1.00
91_V	95_D	1.396	1.00
11_V	26_L	1.385	1.00
286_E	314_G	1.372	1.00
91_V	97_L	1.367	1.00
114_K	192_T	1.357	1.00
150_P	156_R	1.348	1.00
20_Q	152_S	1.341	1.00
249_P	257_V	1.338	1.00
207_R	222_F	1.337	1.00
266_V	307_I	1.334	1.00
207_R	224_Q	1.329	1.00
119_A	143_L	1.324	1.00
45_V	87_L	1.323	1.00
34_L	70_Y	1.296	1.00
74_V	87_L	1.282	1.00
108_L	134_L	1.276	1.00
259_E	268_C	1.230	1.00
112_A	115_H	1.216	1.00
194_V	210_A	1.215	1.00
204_E	208_S	1.204	1.00
159_L	168_V	1.204	1.00
10_Q	29_T	1.201	1.00
173_S	201_A	1.201	1.00
86_F	90_Q	1.199	1.00
288_D	313_K	1.197	1.00
37_F	60_L	1.190	1.00
14_V	92_K	1.187	1.00
279_E	306_L	1.186	1.00
211_A	217_A	1.183	1.00
21_V	154_A	1.183	1.00
117_F	141_W	1.166	1.00
194_V	215_I	1.166	1.00
33_P	67_T	1.161	1.00
24_F	74_V	1.159	1.00
14_V	24_F	1.159	1.00
29_T	96_R	1.157	1.00
73_A	154_A	1.156	1.00
254_I	317_L	1.156	1.00
49_D	86_F	1.144	1.00
203_I	222_F	1.143	1.00
144_H	171_H	1.137	1.00
17_L	155_F	1.136	1.00
26_L	72_I	1.131	1.00
131_M	141_W	1.125	1.00
196_T	203_I	1.120	1.00
37_F	62_S	1.114	1.00
11_V	24_F	1.113	1.00
9_V	26_L	1.113	1.00
23_R	73_A	1.109	1.00
12_S	69_C	1.098	1.00
75_R	152_S	1.096	1.00
60_L	70_Y	1.095	1.00
149_N	174_S	1.094	1.00
147_S	152_S	1.092	1.00
248_V	257_V	1.088	1.00
287_A	310_S	1.082	1.00
256_Q	259_E	1.079	1.00
207_R	211_A	1.075	1.00
238_V	318_V	1.072	1.00
238_V	243_G	1.069	1.00
153_C	156_R	1.059	1.00
9_V	29_T	1.059	1.00
166_E	172_H	1.052	1.00
115_H	139_V	1.052	1.00
239_L	246_F	1.048	1.00
39_G	133_E	1.048	1.00
24_F	91_V	1.032	1.00
128_L	155_F	1.029	1.00
71_Q	158_E	1.021	1.00
167_K	170_L	1.016	1.00
290_R	311_R	1.015	1.00
253_T	256_Q	1.004	1.00
207_R	220_L	1.004	1.00
15_E	25_T	0.996	1.00
178_R	201_A	0.994	1.00
20_Q	75_R	0.992	1.00
63_S	132_A	0.989	1.00
150_P	174_S	0.987	1.00
182_A	209_E	0.985	1.00
234_A	247_V	0.978	1.00
287_A	312_A	0.973	1.00
258_I	266_V	0.971	1.00
127_F	143_L	0.969	1.00
205_A	209_E	0.963	1.00
185_L	188_I	0.954	1.00
108_L	130_H	0.952	1.00
48_S	51_D	0.950	1.00
150_P	160_V	0.948	1.00
257_V	262_K	0.947	1.00
208_S	212_R	0.936	1.00
210_A	220_L	0.930	1.00
283_L	318_V	0.927	1.00
287_A	317_L	0.926	0.99
45_V	97_L	0.923	0.99
49_D	54_Y	0.920	0.99
281_A	304_S	0.920	0.99
241_R	244_K	0.917	0.99
21_V	122_I	0.917	0.99
183_R	186_A	0.915	0.99
293_Y	306_L	0.905	0.99
240_A	318_V	0.902	0.99
258_I	307_I	0.901	0.99
280_T	319_L	0.897	0.99
196_T	207_R	0.893	0.99
22_K	88_H	0.892	0.99
62_S	71_Q	0.892	0.99
54_Y	81_R	0.892	0.99
147_S	170_L	0.890	0.99
9_V	97_L	0.890	0.99
47_M	54_Y	0.886	0.99
12_S	25_T	0.886	0.99
268_C	271_R	0.884	0.99
77_E	80_S	0.880	0.99
281_A	303_Q	0.879	0.99
299_R	302_Q	0.877	0.99
47_M	86_F	0.874	0.99
196_T	220_L	0.872	0.99
110_P	133_E	0.870	0.99
144_H	187_D	0.866	0.99
9_V	28_A	0.866	0.99
265_K	268_C	0.865	0.99
9_V	34_L	0.865	0.99
118_I	184_L	0.864	0.99
131_M	143_L	0.862	0.99
314_G	317_L	0.860	0.99
145_Y	154_A	0.859	0.99
166_E	171_H	0.850	0.99
171_H	176_G	0.850	0.99
249_P	260_N	0.848	0.99
299_R	303_Q	0.847	0.99
208_S	211_A	0.846	0.99
27_V	69_C	0.845	0.99
300_A	303_Q	0.843	0.99
287_A	314_G	0.841	0.99
236_T	315_K	0.837	0.99
239_L	244_K	0.833	0.99
37_F	129_S	0.830	0.99
117_F	127_F	0.826	0.99
182_A	185_L	0.824	0.99
288_D	311_R	0.822	0.99
205_A	208_S	0.814	0.99
113_R	193_H	0.813	0.99
18_T	152_S	0.813	0.99
58_Y	84_S	0.810	0.99
255_L	259_E	0.808	0.99
110_P	137_S	0.806	0.99
172_H	175_T	0.804	0.99
117_F	134_L	0.804	0.99
188_I	192_T	0.803	0.99
157_D	161_Q	0.802	0.99
46_Q	55_S	0.801	0.99
157_D	160_V	0.798	0.99
229_D	232_G	0.798	0.99
128_L	132_A	0.795	0.98
166_E	169_H	0.794	0.98
117_F	130_H	0.793	0.98
191_G	219_T	0.793	0.98
203_I	224_Q	0.793	0.98
193_H	219_T	0.791	0.98
244_K	262_K	0.791	0.98
259_E	265_K	0.788	0.98
204_E	224_Q	0.783	0.98
61_L	71_Q	0.782	0.98
38_T	107_A	0.780	0.98
113_R	191_G	0.778	0.98
64_P	67_T	0.778	0.98
244_K	264_A	0.767	0.98
144_H	184_L	0.766	0.98
7_F	28_A	0.763	0.98
115_H	193_H	0.763	0.98
44_I	103_N	0.757	0.98
41_S	104_N	0.757	0.98
216_A	219_T	0.749	0.98
43_V	60_L	0.748	0.98
209_E	212_R	0.747	0.98
204_E	207_R	0.742	0.98
108_L	115_H	0.741	0.98
70_Y	99_I	0.741	0.98
19_E	152_S	0.740	0.98
114_K	189_E	0.739	0.98
14_V	95_D	0.731	0.97
77_E	85_R	0.731	0.97
20_Q	76_L	0.729	0.97
146_C	171_H	0.723	0.97
21_V	73_A	0.723	0.97
120_G	201_A	0.723	0.97
291_D	294_F	0.723	0.97
132_A	162_H	0.723	0.97
118_I	144_H	0.721	0.97
283_L	320_D	0.718	0.97
156_R	170_L	0.718	0.97
185_L	213_L	0.717	0.97
188_I	215_I	0.716	0.97
252_M	256_Q	0.715	0.97
28_A	34_L	0.714	0.97
7_F	35_P	0.711	0.97
28_A	31_G	0.708	0.97
233_D	315_K	0.707	0.97
186_A	189_E	0.705	0.97
150_P	172_H	0.704	0.97
196_T	222_F	0.702	0.97
312_A	315_K	0.701	0.97
295_S	299_R	0.697	0.97
269_L	277_T	0.695	0.96
201_A	205_A	0.691	0.96
210_A	215_I	0.689	0.96
47_M	87_L	0.689	0.96
268_C	274_V	0.688	0.96
209_E	213_L	0.687	0.96
44_I	55_S	0.684	0.96
26_L	97_L	0.681	0.96
106_F	130_H	0.679	0.96
54_Y	83_G	0.679	0.96
48_S	86_F	0.678	0.96
35_P	101_T	0.677	0.96
78_E	85_R	0.676	0.96
7_F	101_T	0.676	0.96
255_L	266_V	0.675	0.96
46_Q	100_S	0.672	0.96
38_T	104_N	0.670	0.96
181_L	212_R	0.668	0.96
120_G	146_C	0.666	0.95
158_E	161_Q	0.665	0.95
274_V	277_T	0.663	0.95
59_S	127_F	0.661	0.95
45_V	99_I	0.655	0.95
166_E	174_S	0.654	0.95
33_P	68_S	0.653	0.95
64_P	133_E	0.651	0.95
120_G	199_P	0.651	0.95
160_V	170_L	0.647	0.95
258_I	264_A	0.647	0.95
183_R	187_D	0.645	0.95
43_V	72_I	0.642	0.94
201_A	204_E	0.639	0.94
71_Q	132_A	0.639	0.94
247_V	250_E	0.639	0.94
76_L	88_H	0.639	0.94
297_E	300_A	0.637	0.94
75_R	154_A	0.635	0.94
304_S	307_I	0.633	0.94
174_S	178_R	0.633	0.94
287_A	305_M	0.632	0.94
161_Q	164_Q	0.631	0.94
124_I	145_Y	0.630	0.94
254_I	280_T	0.629	0.94
20_Q	78_E	0.629	0.94
203_I	206_V	0.624	0.94
215_I	219_T	0.621	0.93
44_I	100_S	0.621	0.93
168_V	171_H	0.620	0.93
38_T	41_S	0.618	0.93
153_C	170_L	0.618	0.93
193_H	218_D	0.616	0.93
167_K	172_H	0.615	0.93
235_F	314_G	0.612	0.93
206_V	209_E	0.612	0.93
9_V	43_V	0.612	0.93
240_A	320_D	0.611	0.93
114_K	191_G	0.611	0.93
194_V	206_V	0.609	0.93
160_V	164_Q	0.606	0.93
217_A	297_E	0.605	0.93
135_Q	167_K	0.604	0.93
116_L	192_T	0.604	0.93
116_L	188_I	0.603	0.92
134_L	139_V	0.602	0.92
135_Q	141_W	0.602	0.92
200_E	224_Q	0.598	0.92
295_S	303_Q	0.598	0.92
56_N	130_H	0.598	0.92
51_D	54_Y	0.597	0.92
113_R	192_T	0.596	0.92
220_L	223_E	0.596	0.92
178_R	205_A	0.595	0.92
17_L	73_A	0.595	0.92
171_H	174_S	0.595	0.92
204_E	222_F	0.594	0.92
127_F	131_M	0.591	0.92
240_A	283_L	0.590	0.92
280_T	305_M	0.588	0.92
253_T	311_R	0.587	0.91
24_F	72_I	0.585	0.91
180_E	186_A	0.578	0.91
61_L	155_F	0.578	0.91
272_E	292_Q	0.576	0.91
305_M	310_S	0.576	0.91
257_V	260_N	0.575	0.91
306_L	309_C	0.575	0.91
254_I	258_I	0.573	0.90
288_D	310_S	0.572	0.90
140_D	192_T	0.570	0.90
267_E	307_I	0.568	0.90
289_H	293_Y	0.568	0.90
136_H	139_V	0.568	0.90
238_V	284_E	0.567	0.90
256_Q	260_N	0.565	0.90
50_G	54_Y	0.565	0.90
163_P	168_V	0.564	0.90
142_Q	167_K	0.564	0.90
18_T	154_A	0.564	0.90
38_T	110_P	0.563	0.90
84_S	88_H	0.559	0.89
11_V	97_L	0.558	0.89
116_L	144_H	0.556	0.89
18_T	21_V	0.556	0.89
13_Q	183_R	0.556	0.89
29_T	99_I	0.553	0.89
43_V	70_Y	0.552	0.89
290_R	310_S	0.552	0.89
246_F	312_A	0.551	0.89
182_A	212_R	0.550	0.89
131_M	162_H	0.550	0.89
279_E	293_Y	0.550	0.89
173_S	179_L	0.549	0.89
119_A	147_S	0.546	0.88
130_H	195_Y	0.545	0.88
279_E	299_R	0.544	0.88
36_A	67_T	0.544	0.88
173_S	205_A	0.543	0.88
39_G	64_P	0.542	0.88
144_H	169_H	0.542	0.88
274_V	292_Q	0.541	0.88
115_H	195_Y	0.541	0.88
110_P	139_V	0.541	0.88
109_I	193_H	0.540	0.88
65_H	135_Q	0.539	0.88
143_L	159_L	0.538	0.88
11_V	14_V	0.537	0.87
151_E	175_T	0.537	0.87
108_L	195_Y	0.536	0.87
120_G	178_R	0.536	0.87
287_A	302_Q	0.536	0.87
151_E	174_S	0.535	0.87
109_I	221_H	0.534	0.87
289_H	300_A	0.532	0.87
57_A	103_N	0.532	0.87
131_M	168_V	0.532	0.87
35_P	70_Y	0.531	0.87
90_Q	95_D	0.531	0.87
113_R	139_V	0.530	0.87
301_S	304_S	0.530	0.87
114_K	139_V	0.529	0.87
248_V	254_I	0.529	0.87
73_A	155_F	0.527	0.86
312_A	317_L	0.526	0.86
232_G	251_E	0.524	0.86
65_H	68_S	0.524	0.86
298_E	302_Q	0.522	0.86
16_P	20_Q	0.521	0.86
27_V	68_S	0.521	0.86
294_F	299_R	0.520	0.86
289_H	295_S	0.519	0.86
289_H	310_S	0.519	0.86
237_L	246_F	0.517	0.85
80_S	84_S	0.517	0.85
280_T	283_L	0.516	0.85
202_L	205_A	0.515	0.85
22_K	87_L	0.515	0.85
79_N	85_R	0.514	0.85
133_E	136_H	0.510	0.85
188_I	219_T	0.510	0.85
42_H	289_H	0.509	0.85
49_D	83_G	0.509	0.85
26_L	71_Q	0.507	0.84
253_T	309_C	0.506	0.84
14_V	17_L	0.506	0.84
28_A	33_P	0.506	0.84
129_S	132_A	0.504	0.84
251_E	311_R	0.504	0.84
115_H	134_L	0.503	0.84
246_F	258_I	0.503	0.84
281_A	302_Q	0.501	0.84
169_H	172_H	0.500	0.83
298_E	301_S	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2piaA	1	0.9751	100	0.263	Contact Map
1gvhA	3	0.7134	100	0.482	Contact Map
1cqxA	2	0.7165	100	0.487	Contact Map
4g1vA	3	0.7227	100	0.498	Contact Map
1ep3B	2	0.785	100	0.514	Contact Map
4eh1A	2	0.6916	100	0.524	Contact Map
4p6vF	1	0.6978	100	0.528	Contact Map
4ylfA	1	0.7632	100	0.533	Contact Map
1krhA	1	0.6978	100	0.533	Contact Map
1tvcA	1	0.7072	100	0.534	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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