GREMLIN Database
DMLA - D-malate dehydrogenase [decarboxylating]
UniProt: P76251 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13507
Length: 361 (336)
Sequences: 6915 (3061)
Seq/√Len: 167.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_Q215_E4.2311.00
172_R212_N3.9291.00
171_L206_V3.1281.00
22_E352_A3.0841.00
172_R176_E2.9061.00
25_R353_D2.7971.00
6_R39_S2.7911.00
309_D326_L2.6921.00
225_I229_R2.6871.00
335_H358_I2.6721.00
60_D64_E2.4241.00
331_E358_I2.4181.00
354_A357_K2.3711.00
164_R168_D2.3661.00
20_L300_T2.3181.00
28_Q40_F2.3171.00
9_A24_I2.2811.00
22_E25_R2.2771.00
187_T219_D2.1381.00
309_D323_N2.1181.00
206_V218_W2.0991.00
185_T219_D2.0811.00
24_I42_Q2.0631.00
56_K60_D2.0551.00
43_M65_Q2.0551.00
8_A65_Q2.0171.00
332_V358_I1.9981.00
130_Y177_L1.9821.00
302_W329_I1.9801.00
298_I355_I1.9681.00
67_S100_F1.9591.00
171_L241_V1.9491.00
168_D205_R1.9491.00
301_I355_I1.9421.00
168_D208_A1.9381.00
293_N347_T1.9021.00
185_T217_R1.8891.00
176_E213_Y1.8801.00
293_N349_P1.8761.00
44_E53_H1.8681.00
233_Q236_R1.8401.00
15_I295_A1.8321.00
164_R208_A1.8151.00
17_K21_P1.8071.00
323_N327_A1.8001.00
50_Y59_P1.7971.00
64_E68_R1.7891.00
207_E220_K1.7621.00
305_A326_L1.7561.00
352_A356_C1.7361.00
189_A226_L1.7081.00
172_R213_Y1.7081.00
110_R330_E1.7001.00
168_D172_R1.6871.00
153_H165_R1.6681.00
337_P354_A1.6671.00
205_R208_A1.6501.00
67_S99_E1.6371.00
353_D357_K1.6121.00
8_A69_F1.5941.00
160_S243_S1.5801.00
279_F311_L1.5711.00
113_P334_A1.5661.00
30_A325_I1.5591.00
106_L130_Y1.5281.00
49_E53_H1.5221.00
146_R204_E1.5211.00
337_P346_A1.5151.00
64_E67_S1.5141.00
23_G304_G1.4981.00
347_T350_Q1.4981.00
63_H99_E1.4971.00
103_Y271_P1.4961.00
95_K99_E1.4901.00
175_F210_A1.4891.00
25_R356_C1.4811.00
4_T39_S1.4781.00
309_D322_H1.4621.00
209_M212_N1.4591.00
172_R209_M1.4571.00
132_V173_Y1.4511.00
231_V253_L1.4511.00
36_F321_A1.4411.00
176_E180_S1.4351.00
188_S206_V1.4321.00
29_A356_C1.4081.00
40_F304_G1.4071.00
41_E68_R1.3971.00
4_T37_A1.3961.00
11_P42_Q1.3961.00
183_R238_D1.3941.00
24_I28_Q1.3811.00
293_N348_T1.3741.00
114_G334_A1.3691.00
294_I340_P1.3441.00
131_V251_S1.3391.00
10_I45_W1.3281.00
23_G73_Y1.3041.00
298_I351_V1.2931.00
8_A43_M1.2881.00
41_E69_F1.2831.00
346_A354_A1.2691.00
227_C250_L1.2691.00
132_V177_L1.2581.00
332_V354_A1.2571.00
79_W82_T1.2561.00
6_R41_E1.2551.00
58_M63_H1.2491.00
201_Y205_R1.2471.00
221_Q229_R1.2451.00
23_G300_T1.2281.00
184_K238_D1.2231.00
158_Q197_I1.2201.00
188_S220_K1.2171.00
154_E164_R1.2141.00
41_E65_Q1.2051.00
327_A331_E1.2011.00
351_V355_I1.1971.00
346_A350_Q1.1971.00
176_E179_Q1.1951.00
308_L321_A1.1951.00
171_L209_M1.1901.00
24_I40_F1.1841.00
160_S197_I1.1801.00
27_L38_L1.1801.00
221_Q225_I1.1791.00
207_E211_E1.1791.00
26_V325_I1.1611.00
50_Y54_H1.1591.00
204_E208_A1.1581.00
230_F240_V1.1571.00
356_C359_I1.1571.00
131_V254_G1.1551.00
221_Q226_L1.1521.00
221_Q237_F1.1521.00
9_A42_Q1.1511.00
168_D209_M1.1461.00
66_L72_I1.1431.00
129_F230_F1.1381.00
164_R205_R1.1231.00
350_Q353_D1.1231.00
175_F213_Y1.1101.00
44_E49_E1.1061.00
101_D169_R1.1041.00
44_E50_Y1.1041.00
8_A66_L1.1041.00
27_L304_G1.0981.00
208_A211_E1.0981.00
167_V171_L1.0961.00
227_C253_L1.0951.00
73_Y304_G1.0851.00
110_R128_D1.0841.00
30_A321_A1.0841.00
293_N350_Q1.0761.00
324_G359_I1.0721.00
106_L132_V1.0691.00
175_F216_I1.0680.99
25_R349_P1.0660.99
289_I295_A1.0610.99
186_L218_W1.0610.99
192_S203_D1.0560.99
181_R238_D1.0550.99
223_I249_I1.0550.99
54_H61_D1.0530.99
331_E335_H1.0510.99
179_Q184_K1.0510.99
177_L181_R1.0440.99
74_F93_L1.0390.99
21_P25_R1.0300.99
314_G321_A1.0260.99
162_F243_S1.0240.99
354_A358_I1.0230.99
126_D235_E1.0210.99
139_E160_S1.0200.99
43_M69_F1.0130.99
189_A223_I1.0130.99
44_E54_H1.0120.99
314_G320_Q1.0050.99
25_R352_A1.0030.99
144_G159_E1.0000.99
139_E243_S0.9980.99
59_P62_W0.9930.99
229_R236_R0.9920.99
179_Q216_I0.9900.99
135_N268_N0.9890.99
298_I333_I0.9880.99
22_E349_P0.9880.99
110_R326_L0.9850.99
61_D64_E0.9750.99
23_G301_I0.9730.99
219_D236_R0.9690.99
294_I345_N0.9680.99
302_W326_L0.9670.99
26_V356_C0.9650.99
174_A186_L0.9630.99
323_N326_L0.9560.99
162_F167_V0.9550.99
206_V241_V0.9520.99
340_P345_N0.9520.99
9_A20_L0.9490.99
50_Y62_W0.9490.99
6_R68_R0.9470.99
321_A324_G0.9460.99
56_K95_K0.9440.99
313_N321_A0.9430.99
298_I329_I0.9420.99
138_G160_S0.9420.99
19_V300_T0.9420.99
118_P123_Q0.9360.99
18_E291_G0.9350.99
186_L239_V0.9330.99
232_M256_A0.9320.99
104_V170_I0.9320.99
113_P125_G0.9300.99
179_Q213_Y0.9290.99
186_L209_M0.9290.99
190_T203_D0.9250.99
129_F254_G0.9230.99
22_E293_N0.9230.99
45_W92_S0.9180.98
114_G330_E0.9140.98
165_R168_D0.9110.98
30_A304_G0.9100.98
11_P21_P0.9100.98
175_F186_L0.9070.98
289_I294_I0.9030.98
26_V359_I0.8990.98
186_L241_V0.8940.98
210_A218_W0.8940.98
281_P300_T0.8920.98
333_I338_K0.8910.98
155_V161_V0.8830.98
229_R233_Q0.8830.98
138_G243_S0.8760.98
52_S81_D0.8760.98
289_I340_P0.8740.98
26_V301_I0.8730.98
307_M312_G0.8720.98
19_V75_G0.8710.98
9_A40_F0.8690.98
106_L173_Y0.8670.98
331_E334_A0.8630.98
343_K346_A0.8570.98
112_F330_E0.8530.98
61_D65_Q0.8510.97
5_M313_N0.8480.97
22_E353_D0.8470.97
305_A309_D0.8460.97
270_N273_R0.8460.97
186_L216_I0.8400.97
186_L210_A0.8390.97
65_Q69_F0.8370.97
155_V163_T0.8350.97
288_D340_P0.8350.97
188_S218_W0.8340.97
145_G157_I0.8320.97
332_V355_I0.8290.97
304_G307_M0.8290.97
52_S79_W0.8270.97
267_A279_F0.8230.97
109_V254_G0.8220.97
36_F314_G0.8210.97
301_I329_I0.8210.97
223_I227_C0.8200.97
328_A332_V0.8130.97
20_L75_G0.8110.97
332_V337_P0.8100.97
113_P330_E0.8080.97
71_A311_L0.8080.97
192_S222_H0.8050.97
101_D136_T0.7950.96
5_M36_F0.7950.96
190_T220_K0.7950.96
51_Y57_M0.7940.96
156_V201_Y0.7910.96
189_A240_V0.7910.96
23_G27_L0.7910.96
210_A214_P0.7910.96
205_R209_M0.7890.96
146_R156_V0.7880.96
104_V173_Y0.7850.96
187_T221_Q0.7850.96
292_K340_P0.7840.96
30_A36_F0.7810.96
148_N155_V0.7760.96
346_A351_V0.7730.96
10_I66_L0.7720.96
43_M62_W0.7700.95
304_G308_L0.7660.95
339_T351_V0.7640.95
226_L240_V0.7600.95
139_E245_L0.7600.95
174_A241_V0.7580.95
131_V250_L0.7580.95
22_E356_C0.7570.95
76_A283_H0.7560.95
171_L218_W0.7560.95
230_F254_G0.7560.95
63_H67_S0.7520.95
160_S245_L0.7520.95
43_M61_D0.7490.95
109_V258_T0.7490.95
327_A330_E0.7490.95
223_I243_S0.7450.95
209_M213_Y0.7450.95
45_W96_F0.7430.95
189_A250_L0.7410.94
48_C52_S0.7410.94
164_R201_Y0.7400.94
27_L308_L0.7390.94
5_M311_L0.7390.94
265_P302_W0.7340.94
105_N282_V0.7330.94
207_E218_W0.7240.94
45_W74_F0.7240.94
349_P353_D0.7220.94
160_S246_F0.7210.94
65_Q68_R0.7210.94
211_E214_P0.7200.94
204_E211_E0.7200.94
265_P306_M0.7190.94
288_D295_A0.7180.93
128_D238_D0.7180.93
21_P349_P0.7160.93
102_Q278_L0.7140.93
132_V170_I0.7130.93
340_P347_T0.7120.93
137_E166_G0.7090.93
123_Q126_D0.7040.93
173_Y177_L0.7030.93
175_F218_W0.7020.93
73_Y300_T0.7000.93
173_Y271_P0.6960.92
116_P338_K0.6930.92
129_F257_C0.6930.92
109_V129_F0.6920.92
20_L23_G0.6860.92
353_D356_C0.6860.92
203_D207_E0.6810.92
116_P342_M0.6810.92
22_E301_I0.6800.92
226_L237_F0.6800.92
87_I91_G0.6790.91
332_V351_V0.6790.91
286_A289_I0.6780.91
225_I261_I0.6770.91
21_P42_Q0.6740.91
38_L304_G0.6740.91
49_E52_S0.6710.91
349_P352_A0.6700.91
167_V205_R0.6670.91
307_M311_L0.6660.91
207_E210_A0.6620.90
144_G157_I0.6570.90
344_G350_Q0.6550.90
48_C79_W0.6540.90
176_E212_N0.6540.90
170_I241_V0.6540.90
190_T222_H0.6510.90
27_L40_F0.6510.90
48_C82_T0.6510.90
111_L127_I0.6510.90
72_I278_L0.6480.89
301_I325_I0.6450.89
146_R149_E0.6450.89
56_K61_D0.6410.89
7_I38_L0.6400.89
60_D95_K0.6400.89
130_Y181_R0.6390.89
330_E334_A0.6380.89
260_T299_A0.6370.89
30_A35_G0.6350.89
229_R232_M0.6330.88
309_D314_G0.6320.88
124_P235_E0.6310.88
339_T342_M0.6300.88
267_A306_M0.6300.88
189_A242_A0.6300.88
184_K215_E0.6260.88
112_F302_W0.6250.88
338_K342_M0.6240.88
25_R28_Q0.6240.88
279_F310_F0.6200.87
308_L325_I0.6190.87
20_L24_I0.6190.87
158_Q200_P0.6190.87
322_H326_L0.6180.87
320_Q323_N0.6180.87
27_L325_I0.6170.87
210_A216_I0.6130.87
130_Y239_V0.6120.87
295_A340_P0.6110.87
167_V243_S0.6110.87
269_L310_F0.6070.86
5_M312_G0.6070.86
92_S95_K0.6070.86
50_Y58_M0.6020.86
188_S202_W0.6010.86
128_D183_R0.6010.86
282_V299_A0.6010.86
131_V240_V0.6000.86
263_I342_M0.6000.86
173_Y176_E0.5980.85
76_A300_T0.5970.85
143_L161_V0.5970.85
58_M96_F0.5950.85
118_P124_P0.5920.85
313_N320_Q0.5910.85
337_P358_I0.5910.85
62_W92_S0.5900.85
75_G300_T0.5870.84
191_K224_D0.5860.84
324_G328_A0.5850.84
144_G147_V0.5840.84
101_D165_R0.5840.84
90_W95_K0.5830.84
308_L322_H0.5810.84
5_M314_G0.5800.84
265_P299_A0.5760.83
195_L198_S0.5760.83
154_E204_E0.5730.83
140_Y280_E0.5690.82
7_I307_M0.5660.82
52_S82_T0.5660.82
36_F313_N0.5650.82
143_L159_E0.5650.82
338_K346_A0.5640.82
7_I40_F0.5640.82
30_A324_G0.5630.82
166_G169_R0.5620.82
146_R196_A0.5620.82
150_G155_V0.5610.82
301_I352_A0.5610.82
231_V257_C0.5600.81
180_S313_N0.5600.81
101_D270_N0.5600.81
17_K49_E0.5590.81
337_P344_G0.5590.81
225_I236_R0.5580.81
158_Q195_L0.5570.81
243_S246_F0.5560.81
66_L100_F0.5560.81
23_G26_V0.5520.81
66_L69_F0.5520.81
58_M95_K0.5500.80
337_P357_K0.5490.80
157_I161_V0.5480.80
50_Y53_H0.5480.80
155_V164_R0.5480.80
101_D137_E0.5480.80
91_G95_K0.5470.80
179_Q210_A0.5440.80
21_P24_I0.5430.79
51_Y87_I0.5430.79
103_Y170_I0.5410.79
171_L205_R0.5410.79
176_E209_M0.5410.79
66_L96_F0.5400.79
20_L73_Y0.5400.79
314_G323_N0.5390.79
320_Q324_G0.5390.79
147_V204_E0.5340.78
27_L30_A0.5330.78
103_Y173_Y0.5330.78
248_D252_D0.5320.78
260_T263_I0.5320.78
47_S50_Y0.5310.78
148_N153_H0.5310.78
58_M62_W0.5290.78
10_I43_M0.5280.78
153_H163_T0.5280.78
127_I235_E0.5270.77
56_K87_I0.5250.77
293_N353_D0.5230.77
333_I342_M0.5220.77
269_L277_S0.5220.77
38_L321_A0.5200.77
226_L250_L0.5200.77
57_M61_D0.5200.77
210_A213_Y0.5190.76
277_S310_F0.5190.76
270_N277_S0.5180.76
74_F96_F0.5180.76
88_S91_G0.5160.76
149_E154_E0.5150.76
145_G155_V0.5150.76
225_I237_F0.5130.76
57_M89_L0.5120.75
132_V174_A0.5100.75
150_G161_V0.5100.75
98_R142_S0.5090.75
137_E163_T0.5070.75
86_H91_G0.5060.75
100_F278_L0.5050.74
248_D283_H0.5040.74
179_Q214_P0.5040.74
337_P345_N0.5030.74
178_A186_L0.5030.74
11_P17_K0.5030.74
328_A355_I0.5020.74
144_G160_S0.5020.74
50_Y56_K0.5010.74
130_Y183_R0.5000.74
132_V251_S0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3flkA 3 0.9889 100 0.021 Contact Map
2y3zA 2 0.9474 100 0.042 Contact Map
1a05A 2 0.9612 100 0.046 Contact Map
1cnzA 2 0.9723 100 0.046 Contact Map
3u1hA 2 0.9418 100 0.047 Contact Map
3r8wA 2 0.964 100 0.048 Contact Map
2e0cA 2 0.9363 100 0.05 Contact Map
3uduA 3 0.9529 100 0.05 Contact Map
1tyoA 2 0.9557 100 0.052 Contact Map
2iv0A 2 0.9584 100 0.055 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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