GREMLIN Database
DMLR - HTH-type transcriptional regulator DmlR
UniProt: P76250 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13506
Length: 307 (288)
Sequences: 79839 (58162)
Seq/√Len: 3427.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_R78_D3.6281.00
19_R28_E3.4221.00
159_R292_R2.7391.00
100_I142_V2.5551.00
71_W85_E2.4401.00
234_C241_A2.3061.00
15_L28_E2.2641.00
116_A294_Y2.2511.00
174_F190_L2.2361.00
163_T269_N2.2231.00
165_Y245_W2.2211.00
160_K163_T2.2111.00
96_M127_R2.1551.00
160_K269_N2.1191.00
24_A27_E2.1121.00
96_M125_E2.1061.00
18_R73_Q2.0781.00
49_V64_E2.0551.00
183_H186_D2.0441.00
12_V39_R2.0391.00
163_T267_P2.0211.00
14_M69_Y1.9911.00
116_A290_F1.9831.00
231_H251_N1.9801.00
71_W78_D1.9761.00
98_R127_R1.9641.00
14_M73_Q1.9521.00
15_L18_R1.9161.00
14_M18_R1.9101.00
235_L256_H1.9081.00
15_L19_R1.8931.00
193_L239_G1.8861.00
12_V36_V1.8761.00
75_I79_V1.8741.00
17_A61_I1.8701.00
167_I245_W1.8691.00
235_L251_N1.8361.00
69_Y73_Q1.8211.00
22_F40_I1.8011.00
170_A260_V1.7601.00
53_H60_T1.7491.00
68_I82_M1.7161.00
191_P221_P1.7121.00
67_R85_E1.6911.00
158_A271_W1.6741.00
179_G186_D1.6411.00
17_A69_Y1.6101.00
136_D141_G1.6081.00
117_L287_T1.6041.00
167_I259_Q1.5801.00
157_I276_S1.5731.00
18_R28_E1.5711.00
14_M72_A1.5711.00
19_R24_A1.5671.00
13_F69_Y1.5431.00
12_V31_V1.5341.00
92_V123_Q1.5151.00
9_D39_R1.4951.00
23_A33_P1.4941.00
9_D46_T1.4871.00
63_E66_E1.4851.00
159_R274_Y1.4771.00
204_V208_R1.4651.00
117_L124_L1.4521.00
50_V53_H1.4461.00
71_W74_R1.4421.00
32_S35_F1.4401.00
21_G24_A1.4391.00
9_D42_L1.4371.00
15_L29_L1.4251.00
288_V292_R1.4161.00
14_M76_L1.4091.00
147_R273_V1.4051.00
6_L9_D1.4041.00
157_I274_Y1.3981.00
149_G271_W1.3911.00
71_W81_Q1.3801.00
280_T284_V1.3771.00
94_Q123_Q1.3641.00
274_Y288_V1.3581.00
75_I82_M1.3571.00
7_L79_V1.3481.00
138_V155_N1.3451.00
107_R228_E1.3451.00
116_A120_A1.3361.00
136_D142_V1.3321.00
272_A288_V1.3261.00
286_I289_E1.3231.00
98_R129_D1.3121.00
55_T60_T1.3031.00
137_L145_D1.3011.00
172_P256_H1.3001.00
164_N246_W1.2961.00
144_L284_V1.2931.00
170_A240_I1.2841.00
144_L272_A1.2801.00
230_V241_A1.2731.00
120_A290_F1.2721.00
190_L240_I1.2641.00
78_D81_Q1.2631.00
118_A221_P1.2571.00
68_I83_M1.2561.00
245_W249_S1.2351.00
70_E74_R1.2251.00
232_Q235_L1.2191.00
71_W82_M1.2101.00
66_E70_E1.2031.00
41_A45_Q1.2031.00
118_A191_P1.2001.00
249_S253_A1.1981.00
115_L119_K1.1951.00
251_N256_H1.1901.00
160_K271_W1.1871.00
67_R70_E1.1801.00
211_E216_I1.1781.00
180_A258_V1.1751.00
13_F52_L1.1701.00
46_T83_M1.1611.00
175_I190_L1.1591.00
116_A119_K1.1561.00
158_A273_V1.1511.00
31_V35_F1.1511.00
245_W259_Q1.1501.00
13_F17_A1.1261.00
38_K41_A1.1251.00
115_L236_D1.1201.00
38_K42_L1.1181.00
259_Q262_P1.1141.00
13_F51_L1.1111.00
131_E135_V1.1101.00
193_L230_V1.1071.00
97_L287_T1.0981.00
289_E292_R1.0971.00
191_P219_T1.0941.00
275_V278_L1.0921.00
121_Y286_I1.0891.00
74_R81_Q1.0891.00
127_R223_S1.0861.00
37_S41_A1.0841.00
290_F294_Y1.0831.00
172_P258_V1.0791.00
10_L72_A1.0781.00
133_R145_D1.0761.00
22_F59_V1.0671.00
75_I78_D1.0671.00
11_R80_G1.0661.00
8_N11_R1.0631.00
117_L290_F1.0611.00
16_V25_V1.0601.00
224_S230_V1.0581.00
15_L25_V1.0531.00
285_R289_E1.0531.00
67_R71_W1.0501.00
106_G130_V1.0441.00
113_A291_L1.0381.00
231_H235_L1.0361.00
39_R42_L1.0341.00
112_P236_D1.0311.00
171_S237_G1.0291.00
159_R288_V1.0261.00
138_V153_A1.0211.00
182_K186_D1.0141.00
61_I65_G1.0131.00
232_Q236_D1.0121.00
165_Y267_P1.0061.00
83_M87_S1.0041.00
80_G83_M0.9851.00
168_L240_I0.9831.00
80_G84_D0.9711.00
31_V36_V0.9691.00
250_E254_S0.9681.00
17_A52_L0.9641.00
169_C248_V0.9621.00
77_Q81_Q0.9621.00
12_V29_L0.9601.00
117_L121_Y0.9571.00
16_V22_F0.9521.00
290_F293_Q0.9501.00
181_P263_E0.9461.00
120_A293_Q0.9391.00
5_P46_T0.9341.00
170_A174_F0.9341.00
194_V220_G0.9331.00
68_I72_A0.9311.00
13_F61_I0.9281.00
136_D139_N0.9271.00
224_S233_W0.9211.00
184_L264_Y0.9171.00
42_L45_Q0.9151.00
169_C259_Q0.9151.00
281_S284_V0.9141.00
129_D136_D0.9101.00
125_E219_T0.9061.00
113_A290_F0.9051.00
25_V36_V0.9001.00
52_L59_V0.8981.00
13_F43_L0.8981.00
49_V86_L0.8971.00
132_D135_V0.8951.00
205_W208_R0.8941.00
24_A28_E0.8881.00
174_F191_P0.8871.00
103_F226_H0.8851.00
17_A65_G0.8841.00
67_R89_V0.8841.00
142_V145_D0.8761.00
174_F177_Q0.8751.00
149_G269_N0.8741.00
70_E73_Q0.8701.00
100_I147_R0.8671.00
155_N276_S0.8641.00
8_N39_R0.8581.00
20_A60_T0.8571.00
289_E293_Q0.8491.00
186_D189_A0.8481.00
170_A175_I0.8471.00
23_A27_E0.8461.00
124_L283_K0.8431.00
74_R77_Q0.8421.00
99_I144_L0.8401.00
135_V139_N0.8391.00
175_I180_A0.8341.00
156_L273_V0.8341.00
169_C241_A0.8281.00
178_H191_P0.8271.00
100_I145_D0.8251.00
191_P220_G0.8241.00
29_L36_V0.8221.00
174_F178_H0.8201.00
55_T58_R0.8181.00
176_A190_L0.8181.00
64_E89_V0.8171.00
205_W209_N0.8151.00
248_V251_N0.8091.00
192_C218_V0.8081.00
157_I160_K0.8041.00
207_L211_E0.8001.00
64_E86_L0.7971.00
7_L76_L0.7951.00
17_A20_A0.7941.00
20_A66_E0.7901.00
115_L238_Q0.7901.00
13_F68_I0.7901.00
95_G283_K0.7881.00
33_P37_S0.7861.00
41_A50_V0.7791.00
280_T285_R0.7771.00
129_D142_V0.7761.00
185_T188_S0.7751.00
210_K214_H0.7751.00
251_N254_S0.7741.00
18_R69_Y0.7671.00
171_S238_Q0.7671.00
19_R25_V0.7651.00
79_V82_M0.7641.00
16_V40_I0.7631.00
16_V52_L0.7631.00
79_V83_M0.7621.00
93_P121_Y0.7611.00
78_D82_M0.7571.00
173_E177_Q0.7531.00
81_Q85_E0.7501.00
64_E67_R0.7491.00
256_H259_Q0.7471.00
120_A286_I0.7471.00
282_A286_I0.7461.00
118_A238_Q0.7461.00
20_A58_R0.7461.00
233_W238_Q0.7391.00
144_L287_T0.7361.00
9_D12_V0.7351.00
116_A293_Q0.7351.00
113_A294_Y0.7331.00
138_V156_L0.7261.00
169_C243_R0.7251.00
11_R15_L0.7221.00
5_P83_M0.7211.00
204_V223_S0.7211.00
188_S216_I0.7181.00
87_S90_R0.7151.00
183_H263_E0.7141.00
185_T214_H0.7141.00
248_V252_I0.7131.00
61_I66_E0.7101.00
72_A75_I0.7101.00
60_T66_E0.7081.00
101_S106_G0.7071.00
209_N212_G0.7061.00
82_M86_L0.7061.00
22_F36_V0.7051.00
117_L286_I0.7031.00
244_S247_D0.7011.00
98_R142_V0.6981.00
53_H62_T0.6971.00
252_I259_Q0.6971.00
53_H58_R0.6931.00
16_V36_V0.6911.00
226_H229_I0.6911.00
171_S174_F0.6901.00
169_C252_I0.6891.00
73_Q77_Q0.6841.00
210_K213_P0.6831.00
170_A176_A0.6811.00
35_F39_R0.6811.00
95_G124_L0.6761.00
64_E68_I0.6741.00
209_N213_P0.6721.00
278_L281_S0.6721.00
189_A219_T0.6711.00
252_I255_G0.6711.00
146_I291_L0.6681.00
66_E69_Y0.6681.00
98_R143_D0.6671.00
63_E67_R0.6661.00
222_L233_W0.6611.00
77_Q80_G0.6601.00
143_D284_V0.6561.00
256_H260_V0.6531.00
196_K223_S0.6521.00
44_E49_V0.6511.00
195_I230_V0.6501.00
140_E275_V0.6491.00
125_E223_S0.6481.00
81_Q84_D0.6451.00
173_E176_A0.6411.00
22_F58_R0.6391.00
286_I290_F0.6391.00
72_A76_L0.6381.00
68_I86_L0.6371.00
8_N42_L0.6361.00
250_E253_A0.6361.00
208_R212_G0.6351.00
44_E54_R0.6311.00
165_Y265_Y0.6301.00
101_S110_V0.6301.00
11_R14_M0.6291.00
170_A258_V0.6261.00
192_C240_I0.6251.00
27_E30_G0.6251.00
97_L283_K0.6221.00
173_E237_G0.6211.00
165_Y261_L0.6201.00
40_I44_E0.6191.00
71_W75_I0.6171.00
107_R232_Q0.6161.00
262_P265_Y0.6151.00
25_V29_L0.6151.00
168_L187_L0.6151.00
211_E218_V0.6031.00
144_L288_V0.5991.00
177_Q258_V0.5991.00
16_V21_G0.5981.00
287_T291_L0.5981.00
282_A285_R0.5971.00
67_R86_L0.5961.00
196_K225_N0.5941.00
162_A270_V0.5921.00
183_H264_Y0.5911.00
206_Q210_K0.5911.00
110_V113_A0.5901.00
134_L145_D0.5901.00
84_D88_D0.5881.00
179_G182_K0.5861.00
137_L273_V0.5821.00
172_P255_G0.5781.00
100_I133_R0.5751.00
148_I268_A0.5731.00
173_E258_V0.5731.00
168_L242_L0.5731.00
233_W239_G0.5711.00
230_V234_C0.5711.00
130_V226_H0.5711.00
61_I69_Y0.5711.00
207_L210_K0.5701.00
97_L144_L0.5691.00
166_R242_L0.5681.00
168_L192_C0.5681.00
35_F38_K0.5661.00
8_N12_V0.5651.00
274_Y285_R0.5651.00
112_P116_A0.5631.00
157_I277_R0.5631.00
175_I178_H0.5601.00
47_L68_I0.5581.00
47_L86_L0.5561.00
34_A38_K0.5561.00
176_A182_K0.5561.00
176_A179_G0.5551.00
112_P115_L0.5551.00
11_R76_L0.5541.00
205_W210_K0.5531.00
164_N268_A0.5531.00
224_S229_I0.5531.00
137_L156_L0.5501.00
47_L50_V0.5491.00
255_G259_Q0.5491.00
130_V225_N0.5491.00
204_V207_L0.5481.00
32_S38_K0.5471.00
175_I179_G0.5471.00
94_Q125_E0.5471.00
161_L272_A0.5461.00
181_P261_L0.5441.00
49_V53_H0.5431.00
174_F240_I0.5411.00
52_L61_I0.5401.00
206_Q209_N0.5361.00
70_E85_E0.5351.00
243_R248_V0.5301.00
76_L80_G0.5271.00
13_F65_G0.5271.00
197_E223_S0.5271.00
76_L79_V0.5181.00
22_F33_P0.5171.00
227_G244_S0.5171.00
12_V40_I0.5171.00
181_P186_D0.5161.00
105_F109_V0.5161.00
185_T216_I0.5101.00
31_V39_R0.5091.00
95_G121_Y0.5091.00
100_I129_D0.5091.00
146_I272_A0.5091.00
208_R211_E0.5071.00
170_A177_Q0.5071.00
50_V64_E0.5061.00
284_V288_V0.5051.00
12_V25_V0.5041.00
6_L42_L0.5041.00
95_G123_Q0.5031.00
40_I52_L0.5011.00
149_G158_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2esnA 3 0.9511 100 0.113 Contact Map
1uthA 2 0.7264 100 0.117 Contact Map
3hhgA 3 0.9577 100 0.123 Contact Map
3fzvA 4 0.9283 100 0.124 Contact Map
1ixcA 4 0.9446 100 0.126 Contact Map
3szpA 3 0.9414 100 0.127 Contact Map
3fxqA 3 0.9414 100 0.128 Contact Map
1al3A 1 0.7003 100 0.133 Contact Map
4x6gA 4 0.9805 100 0.133 Contact Map
2h98A 2 0.684 100 0.138 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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