GREMLIN Database
LEUE - Leucine efflux protein
UniProt: P76249 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13505
Length: 212 (198)
Sequences: 12830 (9162)
Seq/√Len: 651.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_I117_F5.1971.00
91_G201_V3.5521.00
92_S96_Y3.5111.00
10_Y159_T3.1381.00
191_V194_S2.8861.00
77_N80_R2.7501.00
88_L204_A2.6641.00
114_G118_K2.5441.00
190_K194_S2.3401.00
45_L113_Y2.3321.00
56_V121_L2.3071.00
81_Y85_F2.2201.00
89_Y93_K2.2011.00
95_L194_S2.1481.00
84_A208_A2.0531.00
95_L197_G2.0351.00
35_S43_G2.0111.00
30_F46_A1.9941.00
198_L202_G1.8891.00
16_G137_F1.8781.00
93_K96_Y1.8661.00
91_G197_G1.8421.00
53_G125_L1.8371.00
74_I77_N1.8021.00
14_L163_V1.7981.00
88_L201_V1.7931.00
43_G172_I1.7551.00
27_N50_V1.7491.00
42_G116_I1.7351.00
98_T194_S1.6961.00
84_A204_A1.6611.00
179_T183_R1.6611.00
34_N38_S1.6551.00
76_F80_R1.6521.00
28_T171_L1.6451.00
55_A161_E1.5441.00
77_N81_Y1.5321.00
22_L167_Y1.5321.00
118_K122_I1.5221.00
21_V163_V1.4941.00
14_L159_T1.4771.00
99_L194_S1.4741.00
58_M157_A1.4261.00
34_N46_A1.4261.00
88_L92_S1.4231.00
67_T71_T1.3971.00
35_S172_I1.3901.00
47_A172_I1.3841.00
74_I78_I1.3661.00
48_C117_F1.3661.00
46_A120_A1.3401.00
188_L191_V1.3371.00
117_F121_L1.3371.00
43_G47_A1.3311.00
32_L175_G1.3281.00
191_V195_L1.3251.00
44_Y173_I1.3211.00
78_I82_L1.3091.00
112_Q115_A1.3091.00
121_L125_L1.2981.00
187_K191_V1.2751.00
81_Y84_A1.2671.00
164_S168_L1.2561.00
40_M173_I1.2341.00
86_Y90_L1.2341.00
177_F180_Q1.2091.00
185_K188_L1.2091.00
59_F63_A1.2071.00
115_A118_K1.1911.00
134_Y160_L1.1831.00
51_F165_F1.1811.00
41_K45_L1.1721.00
197_G201_V1.1641.00
201_V205_A1.1621.00
40_M176_A1.1441.00
11_W15_V1.1421.00
13_Y156_L1.1401.00
81_Y208_A1.1391.00
9_N12_T1.1391.00
12_T15_V1.1371.00
38_S42_G1.1291.00
34_N119_R1.1281.00
30_F34_N1.1101.00
49_G117_F1.1091.00
30_F123_L1.1061.00
91_G204_A1.0961.00
27_N124_S1.0931.00
147_P151_I1.0911.00
177_F181_Y1.0911.00
13_Y17_A1.0891.00
96_Y99_L1.0741.00
167_Y171_L1.0731.00
44_Y169_S1.0691.00
170_F174_S1.0581.00
56_V125_L1.0521.00
27_N123_L1.0511.00
51_F161_E1.0501.00
21_V164_S1.0451.00
17_A160_L1.0451.00
97_A193_N1.0341.00
37_S41_K1.0271.00
12_T16_G1.0211.00
36_V175_G1.0151.00
194_S198_L1.0141.00
33_K37_S1.0111.00
150_G153_F1.0101.00
31_V168_L0.9981.00
53_G121_L0.9981.00
146_A152_S0.9921.00
31_V35_S0.9911.00
86_Y89_Y0.9891.00
202_G206_R0.9881.00
143_D146_A0.9841.00
115_A119_R0.9821.00
28_T168_L0.9791.00
54_D130_A0.9651.00
27_N164_S0.9611.00
64_G69_I0.9601.00
147_P152_S0.9591.00
54_D124_S0.9431.00
183_R188_L0.9351.00
40_M169_S0.9211.00
122_I126_T0.9211.00
195_L198_L0.9181.00
187_K190_K0.8941.00
111_P115_A0.8941.00
18_I163_V0.8931.00
40_M172_I0.8871.00
41_K113_Y0.8811.00
16_G19_F0.8701.00
14_L18_I0.8681.00
110_E114_G0.8681.00
52_I121_L0.8671.00
57_L131_I0.8611.00
10_Y162_L0.8541.00
64_G71_T0.8511.00
27_N54_D0.8481.00
99_L102_K0.8471.00
93_K97_A0.8441.00
29_L196_I0.8441.00
58_M134_Y0.8341.00
189_A193_N0.8311.00
69_I72_T0.8291.00
165_F169_S0.8261.00
169_S173_I0.8241.00
94_I197_G0.8231.00
29_L33_K0.8131.00
57_L125_L0.8131.00
54_D57_L0.8041.00
72_T75_L0.7991.00
49_G121_L0.7991.00
31_V172_I0.7981.00
174_S177_F0.7971.00
151_I154_F0.7871.00
85_F88_L0.7861.00
28_T32_L0.7851.00
201_V204_A0.7821.00
136_S140_Q0.7811.00
154_F157_A0.7781.00
82_L85_F0.7771.00
42_G45_L0.7741.00
63_A67_T0.7701.00
44_Y172_I0.7691.00
11_W14_L0.7681.00
89_Y92_S0.7681.00
143_D152_S0.7671.00
17_A21_V0.7651.00
96_Y100_K0.7651.00
28_T167_Y0.7611.00
15_V19_F0.7571.00
195_L199_M0.7531.00
57_L130_A0.7511.00
181_Y188_L0.7491.00
66_A70_K0.7351.00
92_S201_V0.7291.00
75_L78_I0.7291.00
62_W153_F0.7241.00
84_A88_L0.7231.00
95_L201_V0.7181.00
126_T135_V0.7111.00
180_Q185_K0.7101.00
73_P77_N0.7081.00
52_I56_V0.7071.00
150_G154_F0.7061.00
116_I119_R0.7051.00
47_A169_S0.7041.00
27_N168_L0.7021.00
179_T182_I0.7011.00
51_F164_S0.6961.00
50_V54_D0.6961.00
192_G196_I0.6951.00
72_T76_F0.6931.00
21_V28_T0.6891.00
19_F23_V0.6891.00
31_V46_A0.6871.00
99_L190_K0.6841.00
35_S175_G0.6821.00
8_L11_W0.6761.00
31_V50_V0.6761.00
38_S116_I0.6751.00
58_M168_L0.6721.00
16_G20_I0.6711.00
44_Y47_A0.6691.00
32_L171_L0.6661.00
173_I177_F0.6651.00
154_F158_A0.6641.00
57_L61_A0.6611.00
47_A51_F0.6611.00
8_L12_T0.6591.00
21_V167_Y0.6591.00
28_T123_L0.6531.00
85_F89_Y0.6481.00
168_L171_L0.6481.00
175_G178_V0.6471.00
205_A209_T0.6451.00
161_E165_F0.6431.00
57_L135_V0.6411.00
53_G124_S0.6401.00
10_Y14_L0.6381.00
82_L126_T0.6321.00
181_Y185_K0.6321.00
54_D161_E0.6311.00
155_I159_T0.6311.00
45_L116_I0.6311.00
46_A116_I0.6291.00
57_L124_S0.6271.00
42_G113_Y0.6211.00
78_I81_Y0.6211.00
174_S178_V0.6191.00
54_D164_S0.6181.00
50_V124_S0.6171.00
18_I22_L0.6141.00
188_L192_G0.6111.00
98_T101_G0.6101.00
34_N37_S0.6091.00
124_S130_A0.6061.00
23_V28_T0.6041.00
67_T70_K0.6041.00
54_D134_Y0.6011.00
62_W157_A0.5991.00
61_A66_A0.5971.00
21_V168_L0.5971.00
48_C51_F0.5931.00
56_V59_F0.5921.00
113_Y117_F0.5881.00
119_R123_L0.5841.00
104_S107_K0.5821.00
61_A131_I0.5801.00
58_M161_E0.5801.00
166_C170_F0.5781.00
114_G117_F0.5731.00
91_G95_L0.5721.00
57_L66_A0.5701.00
83_G132_L0.5671.00
17_A159_T0.5621.00
61_A134_Y0.5601.00
46_A123_L0.5591.00
124_S168_L0.5591.00
162_L166_C0.5581.00
131_I135_V0.5581.00
152_S155_I0.5561.00
33_K193_N0.5561.00
21_V54_D0.5551.00
181_Y186_K0.5541.00
206_R209_T0.5541.00
110_E113_Y0.5511.00
59_F157_A0.5501.00
178_V182_I0.5481.00
23_V193_N0.5461.00
51_F168_L0.5461.00
79_V83_G0.5431.00
167_Y170_F0.5411.00
31_V47_A0.5411.00
158_A162_L0.5381.00
134_Y164_S0.5381.00
106_A109_D0.5351.00
88_L208_A0.5341.00
26_P127_N0.5320.99
202_G205_A0.5310.99
42_G112_Q0.5300.99
24_P129_K0.5300.99
27_N130_A0.5270.99
116_I120_A0.5250.99
166_C169_S0.5240.99
168_L172_I0.5210.99
93_K119_R0.5200.99
171_L175_G0.5190.99
26_P94_I0.5140.99
39_G42_G0.5130.99
182_I186_K0.5110.99
95_L198_L0.5110.99
17_A163_V0.5100.99
130_A135_V0.5090.99
130_A168_L0.5080.99
54_D160_L0.5060.99
20_I137_F0.5000.99
20_I130_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.9009 26.7 0.928 Contact Map
3o7qA 1 0.9387 15.2 0.936 Contact Map
4tphA 2 0.4387 12.2 0.938 Contact Map
2gfpA 2 0.9151 11.6 0.939 Contact Map
3wdoA 1 0.4575 11.4 0.939 Contact Map
4q65A 1 0.4292 10.4 0.94 Contact Map
4ikvA 1 0.5094 9.4 0.942 Contact Map
3j1zP 8 0.816 9.1 0.942 Contact Map
4xnjA 1 0.4575 7.5 0.944 Contact Map
4w6vA 1 0.4858 7.5 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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