LEUE - ECOLI - GREMLIN Contacts

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LEUE - Leucine efflux protein

UniProt:	P76249	Sequences: MFAEYGVLNYWTYLVGAIFIVLVPGPNTLFVLKNSVSSGMKGGYLAACGVFIGDAVLMFLAWAGVATLIKTTPILFNIVRYLGAFYLLYLGSKILYATLKGKNSEAKSDEPQYGAIFKRALILSLTNPKAILFYVSFFVQFIDVNAPHTGISFFILAATLELVSFCYLSFLIISGAFVTQYIRTKKKLAKVGNSLIGLMFVGFAARLATLQS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13505
Length:	212 (198)
Sequences:	12830 (9162)
Seq/√Len:	651.1

ECOLI - LEUE RHTB YAHN RHTC EAMB ARGO
BACSU - YRHP YISU YCGF
SULSO - Q97ZW7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
52_I	117_F	5.197	1.00
91_G	201_V	3.552	1.00
92_S	96_Y	3.511	1.00
10_Y	159_T	3.138	1.00
191_V	194_S	2.886	1.00
77_N	80_R	2.750	1.00
88_L	204_A	2.664	1.00
114_G	118_K	2.544	1.00
190_K	194_S	2.340	1.00
45_L	113_Y	2.332	1.00
56_V	121_L	2.307	1.00
81_Y	85_F	2.220	1.00
89_Y	93_K	2.201	1.00
95_L	194_S	2.148	1.00
84_A	208_A	2.053	1.00
95_L	197_G	2.035	1.00
35_S	43_G	2.011	1.00
30_F	46_A	1.994	1.00
198_L	202_G	1.889	1.00
16_G	137_F	1.878	1.00
93_K	96_Y	1.866	1.00
91_G	197_G	1.842	1.00
53_G	125_L	1.837	1.00
74_I	77_N	1.802	1.00
14_L	163_V	1.798	1.00
88_L	201_V	1.793	1.00
43_G	172_I	1.755	1.00
27_N	50_V	1.749	1.00
42_G	116_I	1.735	1.00
98_T	194_S	1.696	1.00
84_A	204_A	1.661	1.00
179_T	183_R	1.661	1.00
34_N	38_S	1.655	1.00
76_F	80_R	1.652	1.00
28_T	171_L	1.645	1.00
55_A	161_E	1.544	1.00
77_N	81_Y	1.532	1.00
22_L	167_Y	1.532	1.00
118_K	122_I	1.522	1.00
21_V	163_V	1.494	1.00
14_L	159_T	1.477	1.00
99_L	194_S	1.474	1.00
58_M	157_A	1.426	1.00
34_N	46_A	1.426	1.00
88_L	92_S	1.423	1.00
67_T	71_T	1.397	1.00
35_S	172_I	1.390	1.00
47_A	172_I	1.384	1.00
74_I	78_I	1.366	1.00
48_C	117_F	1.366	1.00
46_A	120_A	1.340	1.00
188_L	191_V	1.337	1.00
117_F	121_L	1.337	1.00
43_G	47_A	1.331	1.00
32_L	175_G	1.328	1.00
191_V	195_L	1.325	1.00
44_Y	173_I	1.321	1.00
78_I	82_L	1.309	1.00
112_Q	115_A	1.309	1.00
121_L	125_L	1.298	1.00
187_K	191_V	1.275	1.00
81_Y	84_A	1.267	1.00
164_S	168_L	1.256	1.00
40_M	173_I	1.234	1.00
86_Y	90_L	1.234	1.00
177_F	180_Q	1.209	1.00
185_K	188_L	1.209	1.00
59_F	63_A	1.207	1.00
115_A	118_K	1.191	1.00
134_Y	160_L	1.183	1.00
51_F	165_F	1.181	1.00
41_K	45_L	1.172	1.00
197_G	201_V	1.164	1.00
201_V	205_A	1.162	1.00
40_M	176_A	1.144	1.00
11_W	15_V	1.142	1.00
13_Y	156_L	1.140	1.00
81_Y	208_A	1.139	1.00
9_N	12_T	1.139	1.00
12_T	15_V	1.137	1.00
38_S	42_G	1.129	1.00
34_N	119_R	1.128	1.00
30_F	34_N	1.110	1.00
49_G	117_F	1.109	1.00
30_F	123_L	1.106	1.00
91_G	204_A	1.096	1.00
27_N	124_S	1.093	1.00
147_P	151_I	1.091	1.00
177_F	181_Y	1.091	1.00
13_Y	17_A	1.089	1.00
96_Y	99_L	1.074	1.00
167_Y	171_L	1.073	1.00
44_Y	169_S	1.069	1.00
170_F	174_S	1.058	1.00
56_V	125_L	1.052	1.00
27_N	123_L	1.051	1.00
51_F	161_E	1.050	1.00
21_V	164_S	1.045	1.00
17_A	160_L	1.045	1.00
97_A	193_N	1.034	1.00
37_S	41_K	1.027	1.00
12_T	16_G	1.021	1.00
36_V	175_G	1.015	1.00
194_S	198_L	1.014	1.00
33_K	37_S	1.011	1.00
150_G	153_F	1.010	1.00
31_V	168_L	0.998	1.00
53_G	121_L	0.998	1.00
146_A	152_S	0.992	1.00
31_V	35_S	0.991	1.00
86_Y	89_Y	0.989	1.00
202_G	206_R	0.988	1.00
143_D	146_A	0.984	1.00
115_A	119_R	0.982	1.00
28_T	168_L	0.979	1.00
54_D	130_A	0.965	1.00
27_N	164_S	0.961	1.00
64_G	69_I	0.960	1.00
147_P	152_S	0.959	1.00
54_D	124_S	0.943	1.00
183_R	188_L	0.935	1.00
40_M	169_S	0.921	1.00
122_I	126_T	0.921	1.00
195_L	198_L	0.918	1.00
187_K	190_K	0.894	1.00
111_P	115_A	0.894	1.00
18_I	163_V	0.893	1.00
40_M	172_I	0.887	1.00
41_K	113_Y	0.881	1.00
16_G	19_F	0.870	1.00
14_L	18_I	0.868	1.00
110_E	114_G	0.868	1.00
52_I	121_L	0.867	1.00
57_L	131_I	0.861	1.00
10_Y	162_L	0.854	1.00
64_G	71_T	0.851	1.00
27_N	54_D	0.848	1.00
99_L	102_K	0.847	1.00
93_K	97_A	0.844	1.00
29_L	196_I	0.844	1.00
58_M	134_Y	0.834	1.00
189_A	193_N	0.831	1.00
69_I	72_T	0.829	1.00
165_F	169_S	0.826	1.00
169_S	173_I	0.824	1.00
94_I	197_G	0.823	1.00
29_L	33_K	0.813	1.00
57_L	125_L	0.813	1.00
54_D	57_L	0.804	1.00
72_T	75_L	0.799	1.00
49_G	121_L	0.799	1.00
31_V	172_I	0.798	1.00
174_S	177_F	0.797	1.00
151_I	154_F	0.787	1.00
85_F	88_L	0.786	1.00
28_T	32_L	0.785	1.00
201_V	204_A	0.782	1.00
136_S	140_Q	0.781	1.00
154_F	157_A	0.778	1.00
82_L	85_F	0.777	1.00
42_G	45_L	0.774	1.00
63_A	67_T	0.770	1.00
44_Y	172_I	0.769	1.00
11_W	14_L	0.768	1.00
89_Y	92_S	0.768	1.00
143_D	152_S	0.767	1.00
17_A	21_V	0.765	1.00
96_Y	100_K	0.765	1.00
28_T	167_Y	0.761	1.00
15_V	19_F	0.757	1.00
195_L	199_M	0.753	1.00
57_L	130_A	0.751	1.00
181_Y	188_L	0.749	1.00
66_A	70_K	0.735	1.00
92_S	201_V	0.729	1.00
75_L	78_I	0.729	1.00
62_W	153_F	0.724	1.00
84_A	88_L	0.723	1.00
95_L	201_V	0.718	1.00
126_T	135_V	0.711	1.00
180_Q	185_K	0.710	1.00
73_P	77_N	0.708	1.00
52_I	56_V	0.707	1.00
150_G	154_F	0.706	1.00
116_I	119_R	0.705	1.00
47_A	169_S	0.704	1.00
27_N	168_L	0.702	1.00
179_T	182_I	0.701	1.00
51_F	164_S	0.696	1.00
50_V	54_D	0.696	1.00
192_G	196_I	0.695	1.00
72_T	76_F	0.693	1.00
21_V	28_T	0.689	1.00
19_F	23_V	0.689	1.00
31_V	46_A	0.687	1.00
99_L	190_K	0.684	1.00
35_S	175_G	0.682	1.00
8_L	11_W	0.676	1.00
31_V	50_V	0.676	1.00
38_S	116_I	0.675	1.00
58_M	168_L	0.672	1.00
16_G	20_I	0.671	1.00
44_Y	47_A	0.669	1.00
32_L	171_L	0.666	1.00
173_I	177_F	0.665	1.00
154_F	158_A	0.664	1.00
57_L	61_A	0.661	1.00
47_A	51_F	0.661	1.00
8_L	12_T	0.659	1.00
21_V	167_Y	0.659	1.00
28_T	123_L	0.653	1.00
85_F	89_Y	0.648	1.00
168_L	171_L	0.648	1.00
175_G	178_V	0.647	1.00
205_A	209_T	0.645	1.00
161_E	165_F	0.643	1.00
57_L	135_V	0.641	1.00
53_G	124_S	0.640	1.00
10_Y	14_L	0.638	1.00
82_L	126_T	0.632	1.00
181_Y	185_K	0.632	1.00
54_D	161_E	0.631	1.00
155_I	159_T	0.631	1.00
45_L	116_I	0.631	1.00
46_A	116_I	0.629	1.00
57_L	124_S	0.627	1.00
42_G	113_Y	0.621	1.00
78_I	81_Y	0.621	1.00
174_S	178_V	0.619	1.00
54_D	164_S	0.618	1.00
50_V	124_S	0.617	1.00
18_I	22_L	0.614	1.00
188_L	192_G	0.611	1.00
98_T	101_G	0.610	1.00
34_N	37_S	0.609	1.00
124_S	130_A	0.606	1.00
23_V	28_T	0.604	1.00
67_T	70_K	0.604	1.00
54_D	134_Y	0.601	1.00
62_W	157_A	0.599	1.00
61_A	66_A	0.597	1.00
21_V	168_L	0.597	1.00
48_C	51_F	0.593	1.00
56_V	59_F	0.592	1.00
113_Y	117_F	0.588	1.00
119_R	123_L	0.584	1.00
104_S	107_K	0.582	1.00
61_A	131_I	0.580	1.00
58_M	161_E	0.580	1.00
166_C	170_F	0.578	1.00
114_G	117_F	0.573	1.00
91_G	95_L	0.572	1.00
57_L	66_A	0.570	1.00
83_G	132_L	0.567	1.00
17_A	159_T	0.562	1.00
61_A	134_Y	0.560	1.00
46_A	123_L	0.559	1.00
124_S	168_L	0.559	1.00
162_L	166_C	0.558	1.00
131_I	135_V	0.558	1.00
152_S	155_I	0.556	1.00
33_K	193_N	0.556	1.00
21_V	54_D	0.555	1.00
181_Y	186_K	0.554	1.00
206_R	209_T	0.554	1.00
110_E	113_Y	0.551	1.00
59_F	157_A	0.550	1.00
178_V	182_I	0.548	1.00
23_V	193_N	0.546	1.00
51_F	168_L	0.546	1.00
79_V	83_G	0.543	1.00
167_Y	170_F	0.541	1.00
31_V	47_A	0.541	1.00
158_A	162_L	0.538	1.00
134_Y	164_S	0.538	1.00
106_A	109_D	0.535	1.00
88_L	208_A	0.534	1.00
26_P	127_N	0.532	0.99
202_G	205_A	0.531	0.99
42_G	112_Q	0.530	0.99
24_P	129_K	0.530	0.99
27_N	130_A	0.527	0.99
116_I	120_A	0.525	0.99
166_C	169_S	0.524	0.99
168_L	172_I	0.521	0.99
93_K	119_R	0.520	0.99
171_L	175_G	0.519	0.99
26_P	94_I	0.514	0.99
39_G	42_G	0.513	0.99
182_I	186_K	0.511	0.99
95_L	198_L	0.511	0.99
17_A	163_V	0.510	0.99
130_A	135_V	0.509	0.99
130_A	168_L	0.508	0.99
54_D	160_L	0.506	0.99
20_I	137_F	0.500	0.99
20_I	130_A	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cfqA	1	0.9009	26.7	0.928	Contact Map
3o7qA	1	0.9387	15.2	0.936	Contact Map
4tphA	2	0.4387	12.2	0.938	Contact Map
2gfpA	2	0.9151	11.6	0.939	Contact Map
3wdoA	1	0.4575	11.4	0.939	Contact Map
4q65A	1	0.4292	10.4	0.94	Contact Map
4ikvA	1	0.5094	9.4	0.942	Contact Map
3j1zP	8	0.816	9.1	0.942	Contact Map
4xnjA	1	0.4575	7.5	0.944	Contact Map
4w6vA	1	0.4858	7.5	0.944	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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