GREMLIN Database
YEAP - Probable diguanylate cyclase YeaP
UniProt: P76245 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13502
Length: 341 (306)
Sequences: 9701 (8665)
Seq/√Len: 495.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_A176_T4.3781.00
244_Q247_E3.9621.00
215_N329_Q3.5311.00
209_A298_L3.3321.00
209_A273_R3.2701.00
188_I258_L3.1691.00
207_M302_E2.9621.00
324_E333_F2.8761.00
192_L310_A2.8341.00
183_P187_A2.7811.00
214_D297_S2.5451.00
163_L167_N2.4701.00
309_D312_S2.4091.00
207_M269_I2.3891.00
195_L198_L2.3451.00
188_I250_G2.3281.00
327_H333_F2.3251.00
191_N194_T2.3051.00
281_R330_K2.2921.00
265_E268_D2.2671.00
230_L233_I2.2441.00
304_D307_T2.2211.00
231_F294_P2.1711.00
277_Q332_P2.1621.00
182_L236_G2.0761.00
243_Q249_I2.0401.00
280_I296_A2.0341.00
187_A191_N2.0281.00
213_L235_V2.0271.00
182_L249_I2.0091.00
234_Q237_E1.9941.00
234_Q238_R1.9681.00
171_I175_Y1.9611.00
239_L249_I1.9541.00
274_E277_Q1.9071.00
295_G330_K1.8831.00
210_F321_M1.8211.00
272_L275_R1.8061.00
226_N315_H1.8051.00
219_I231_F1.7921.00
85_C88_S1.7601.00
167_N170_L1.7491.00
211_I296_A1.7481.00
307_T316_A1.7001.00
216_F232_L1.6981.00
315_H319_I1.6921.00
169_A173_Q1.6911.00
252_L258_L1.6451.00
242_L279_Q1.6421.00
323_Q327_H1.6361.00
261_S272_L1.6271.00
323_Q333_F1.6251.00
327_H331_T1.6171.00
237_E240_N1.6121.00
204_H263_N1.6111.00
164_R167_N1.6081.00
195_L262_L1.6041.00
217_K221_D1.5971.00
324_E331_T1.5921.00
85_C89_D1.5891.00
191_N250_G1.5751.00
220_N228_G1.5561.00
213_L296_A1.5401.00
235_V280_I1.5341.00
211_I298_L1.5251.00
209_A261_S1.5041.00
274_E278_Q1.4871.00
175_Y187_A1.4851.00
183_P248_V1.4851.00
191_N248_V1.4721.00
285_H290_D1.4581.00
198_L262_L1.4411.00
187_A190_E1.4341.00
169_A172_A1.4251.00
270_S274_E1.4171.00
188_I260_V1.4061.00
243_Q259_V1.4011.00
300_I332_P1.3961.00
318_D322_Y1.3641.00
323_Q326_K1.3641.00
230_L234_Q1.3581.00
277_Q281_R1.3541.00
187_A248_V1.3521.00
210_F252_L1.3381.00
277_Q330_K1.3181.00
178_S186_R1.3171.00
269_I273_R1.3131.00
167_N171_I1.2991.00
191_N195_L1.2971.00
269_I300_I1.2911.00
90_E93_D1.2881.00
234_Q284_Y1.2871.00
303_V313_A1.2861.00
225_H318_D1.2821.00
209_A259_V1.2751.00
199_A206_I1.2691.00
227_S230_L1.2681.00
210_F314_L1.2611.00
215_N218_L1.2561.00
236_G249_I1.2521.00
202_L263_N1.2511.00
238_R283_E1.2451.00
206_I303_V1.2381.00
175_Y183_P1.2341.00
145_L149_L1.2341.00
273_R298_L1.2251.00
279_Q282_G1.2231.00
242_L275_R1.2201.00
206_I260_V1.2151.00
168_A171_I1.2121.00
324_E328_K1.2061.00
218_L222_R1.2051.00
185_R189_F1.1941.00
221_D322_Y1.1931.00
301_V313_A1.1911.00
256_E318_D1.1901.00
308_T316_A1.1901.00
273_R332_P1.1861.00
175_Y190_E1.1831.00
233_I237_E1.1741.00
201_H244_Q1.1701.00
297_S324_E1.1641.00
180_T232_L1.1641.00
252_L314_L1.1621.00
217_K322_Y1.1611.00
221_D225_H1.1451.00
193_T197_S1.1421.00
243_Q276_I1.1381.00
244_Q275_R1.1371.00
214_D329_Q1.1151.00
300_I334_V1.1151.00
227_S286_L1.1131.00
78_K82_D1.1101.00
273_R300_I1.1061.00
176_T183_P1.1031.00
312_S316_A1.1011.00
270_S332_P1.1011.00
210_F258_L1.0991.00
258_L314_L1.0981.00
192_L260_V1.0981.00
264_N268_D1.0921.00
230_L287_G1.0881.00
244_Q272_L1.0861.00
215_N255_D1.0811.00
189_F311_D1.0811.00
163_L166_A1.0771.00
225_H322_Y1.0761.00
221_D318_D1.0711.00
176_T187_A1.0551.00
211_I239_L1.0541.00
270_S334_V1.0511.00
205_K305_P1.0501.00
199_A303_V1.0501.00
301_V316_A1.0451.00
253_G256_E1.0451.00
213_L232_L1.0381.00
27_L39_T1.0351.00
212_D325_K1.0331.00
301_V317_A1.0331.00
172_A181_G1.0291.00
185_R229_D1.0291.00
179_L232_L1.0251.00
278_Q281_R1.0181.00
173_Q186_R1.0181.00
316_A320_A1.0121.00
87_F91_V1.0111.00
166_A170_L1.0101.00
31_E39_T1.0091.00
195_L206_I1.0081.00
183_P250_G1.0081.00
162_Q165_E1.0041.00
219_I291_L1.0041.00
241_T279_Q1.0011.00
271_S275_R0.9981.00
166_A169_A0.9951.00
88_S92_P0.9931.00
328_K331_T0.9881.00
206_I313_A0.9841.00
86_F90_E0.9821.00
177_D251_R0.9821.00
212_D322_Y0.9801.00
235_V239_L0.9801.00
85_C90_E0.9791.00
193_T310_A0.9791.00
249_I259_V0.9551.00
277_Q298_L0.9551.00
211_I259_V0.9501.00
285_H288_D0.9471.00
207_M300_I0.9471.00
253_G322_Y0.9361.00
79_R83_E0.9341.00
273_R277_Q0.9331.00
175_Y186_R0.9321.00
238_R284_Y0.9191.00
223_F289_V0.9131.00
24_R28_E0.9111.00
238_R279_Q0.9061.00
239_L276_I0.9061.00
240_N249_I0.9061.00
188_I192_L0.9051.00
190_E194_T0.8991.00
243_Q272_L0.8961.00
306_E334_V0.8941.00
212_D255_D0.8921.00
208_I313_A0.8891.00
214_D328_K0.8891.00
27_L31_E0.8851.00
208_I314_L0.8781.00
170_L173_Q0.8721.00
254_G322_Y0.8661.00
227_S289_V0.8651.00
71_S74_Y0.8631.00
231_F284_Y0.8551.00
67_N71_S0.8481.00
40_Y126_C0.8471.00
227_S291_L0.8371.00
268_D271_S0.8361.00
187_A250_G0.8331.00
23_V27_L0.8321.00
243_Q247_E0.8321.00
283_E286_L0.8251.00
55_F58_N0.8211.00
196_F303_V0.8161.00
233_I236_G0.8121.00
74_Y78_K0.8121.00
201_H246_G0.8111.00
85_C93_D0.8071.00
220_N254_G0.8031.00
209_A300_I0.8011.00
247_E272_L0.8001.00
220_N229_D0.7991.00
261_S269_I0.7981.00
50_L54_M0.7981.00
295_G328_K0.7971.00
266_N302_E0.7961.00
165_E169_A0.7961.00
45_D49_R0.7951.00
256_E322_Y0.7921.00
27_L53_I0.7891.00
212_D220_N0.7891.00
214_D330_K0.7871.00
304_D316_A0.7861.00
286_L289_V0.7851.00
188_I314_L0.7771.00
46_V49_R0.7711.00
67_N70_V0.7671.00
269_I302_E0.7631.00
114_I123_G0.7611.00
189_F250_G0.7601.00
255_D295_G0.7561.00
198_L201_H0.7481.00
109_F113_P0.7451.00
310_A314_L0.7401.00
176_T182_L0.7391.00
225_H254_G0.7361.00
217_K225_H0.7351.00
231_F255_D0.7321.00
191_N260_V0.7311.00
37_E130_S0.7311.00
217_K254_G0.7281.00
218_L255_D0.7271.00
250_G258_L0.7251.00
129_S132_K0.7231.00
235_V294_P0.7231.00
38_S128_A0.7231.00
226_N230_L0.7211.00
212_D221_D0.7211.00
26_L150_I0.7181.00
75_S78_K0.7161.00
221_D254_G0.7151.00
255_D329_Q0.7141.00
207_M273_R0.7111.00
217_K256_E0.7011.00
147_A151_A0.7011.00
217_K220_N0.6921.00
213_L295_G0.6911.00
220_N225_H0.6911.00
239_L259_V0.6871.00
123_G126_C0.6871.00
266_N270_S0.6851.00
210_F317_A0.6851.00
253_G318_D0.6851.00
223_F291_L0.6841.00
210_F255_D0.6841.00
95_W99_I0.6821.00
25_Q29_M0.6811.00
219_I227_S0.6801.00
266_N334_V0.6791.00
135_W140_E0.6781.00
198_L202_L0.6781.00
278_Q282_G0.6711.00
188_I252_L0.6711.00
56_A59_S0.6691.00
189_F314_L0.6681.00
235_V296_A0.6681.00
225_H228_G0.6671.00
311_D315_H0.6661.00
29_M32_M0.6651.00
214_D321_M0.6641.00
87_F90_E0.6621.00
220_N325_K0.6621.00
38_S42_T0.6621.00
303_V307_T0.6611.00
30_L33_V0.6611.00
189_F193_T0.6601.00
152_Q156_K0.6601.00
213_L216_F0.6591.00
199_A204_H0.6581.00
239_L243_Q0.6561.00
242_L276_I0.6521.00
217_K318_D0.6491.00
226_N311_D0.6471.00
26_L30_L0.6421.00
81_I84_N0.6421.00
126_C135_W0.6421.00
302_E334_V0.6381.00
283_E292_Y0.6381.00
196_F313_A0.6361.00
89_D93_D0.6331.00
231_F286_L0.6331.00
164_R168_A0.6321.00
221_D256_E0.6301.00
283_E290_D0.6301.00
216_F231_F0.6291.00
99_I102_R0.6281.00
43_K122_Y0.6271.00
273_R296_A0.6271.00
54_M58_N0.6261.00
197_S200_R0.6261.00
301_V320_A0.6241.00
247_E275_R0.6241.00
31_E37_E0.6221.00
54_M60_Q0.6221.00
308_T312_S0.6191.00
89_D92_P0.6191.00
258_L317_A0.6191.00
28_E32_M0.6181.00
200_R303_V0.6181.00
45_D52_H0.6151.00
172_A175_Y0.6151.00
286_L291_L0.6151.00
204_H262_L0.6130.99
306_E316_A0.6120.99
284_Y294_P0.6110.99
226_N287_G0.6100.99
223_F255_D0.6090.99
86_F91_V0.6080.99
168_A172_A0.6070.99
54_M57_R0.6070.99
200_R308_T0.6060.99
199_A202_L0.6060.99
174_S318_D0.6040.99
45_D48_A0.6030.99
320_A324_E0.6030.99
94_R97_D0.6020.99
254_G318_D0.6020.99
84_N115_H0.6020.99
312_S315_H0.6010.99
235_V284_Y0.6000.99
129_S135_W0.5980.99
196_F206_I0.5920.99
216_F255_D0.5910.99
195_L201_H0.5910.99
152_Q155_Q0.5900.99
51_Q54_M0.5890.99
205_K302_E0.5880.99
218_L223_F0.5870.99
228_G254_G0.5820.99
298_L332_P0.5810.99
142_V150_I0.5810.99
280_I294_P0.5790.99
248_V260_V0.5790.99
102_R106_I0.5780.99
140_E144_Q0.5780.99
136_S139_A0.5760.99
237_E241_T0.5750.99
220_N255_D0.5720.99
230_L286_L0.5720.99
242_L272_L0.5680.99
225_H253_G0.5660.99
44_V49_R0.5650.99
231_F234_Q0.5640.99
225_H256_E0.5640.99
198_L246_G0.5630.99
196_F307_T0.5620.99
303_V306_E0.5610.99
212_D253_G0.5600.99
135_W139_A0.5600.99
72_W75_S0.5580.99
319_I323_Q0.5570.99
153_Y156_K0.5570.99
295_G329_Q0.5560.99
304_D308_T0.5550.99
137_E158_A0.5530.99
45_D50_L0.5510.99
49_R53_I0.5500.99
70_V73_D0.5500.99
113_P124_T0.5490.99
214_D295_G0.5480.99
252_L255_D0.5470.99
277_Q324_E0.5470.99
216_F297_S0.5470.99
192_L196_F0.5470.99
196_F310_A0.5470.99
140_E152_Q0.5470.99
88_S91_V0.5460.99
77_C81_I0.5460.99
275_R279_Q0.5450.99
195_L248_V0.5440.99
68_F71_S0.5380.99
137_E163_L0.5380.99
277_Q295_G0.5370.99
307_T312_S0.5370.99
44_V48_A0.5370.99
162_Q166_A0.5360.99
101_A105_G0.5350.99
27_L30_L0.5340.99
40_Y54_M0.5340.99
77_C109_F0.5320.99
238_R242_L0.5320.99
70_V74_Y0.5310.99
190_E193_T0.5300.99
116_L122_Y0.5270.98
212_D318_D0.5270.98
199_A203_N0.5270.98
166_A173_Q0.5260.98
212_D228_G0.5260.98
219_I286_L0.5220.98
29_M33_V0.5200.98
142_V152_Q0.5190.98
205_K265_E0.5190.98
78_K81_I0.5170.98
127_A136_S0.5170.98
277_Q296_A0.5170.98
255_D331_T0.5160.98
185_R256_E0.5150.98
75_S79_R0.5140.98
149_L153_Y0.5130.98
70_V76_L0.5130.98
100_A103_N0.5120.98
189_F310_A0.5120.98
106_I128_A0.5110.98
113_P116_L0.5110.98
212_D217_K0.5100.98
301_V307_T0.5090.98
316_A319_I0.5090.98
111_S126_C0.5090.98
37_E40_Y0.5080.98
115_H121_F0.5080.98
201_H247_E0.5070.98
145_L151_A0.5070.98
223_F227_S0.5070.98
183_P191_N0.5060.98
284_Y291_L0.5040.98
225_H229_D0.5030.98
101_A106_I0.5030.98
229_D254_G0.5030.98
86_F89_D0.5010.98
255_D325_K0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.9501 100 0.356 Contact Map
4j40A 2 0 100 0.389 Contact Map
4h54A 2 0.8094 100 0.393 Contact Map
3ezuA 2 0.9326 100 0.403 Contact Map
4rnhA 2 0.4751 100 0.405 Contact Map
3pjxA 1 0.5191 100 0.409 Contact Map
3mtkA 2 0.4751 100 0.418 Contact Map
3ignA 1 0.4839 100 0.424 Contact Map
3i5cA 2 0.563 100 0.426 Contact Map
3hvaA 1 0.4721 100 0.436 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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