GREMLIN Database
YEAO - Uncharacterized protein YeaO
UniProt: P76243 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13501
Length: 115 (111)
Sequences: 1532 (1172)
Seq/√Len: 111.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_A113_R3.4821.00
8_V94_L3.3301.00
31_K34_D2.6071.00
99_N102_Q2.5431.00
57_E60_D2.4501.00
53_A67_Q2.3531.00
6_K16_D2.3501.00
65_R110_D2.2151.00
69_L107_V2.1611.00
8_V35_L2.1121.00
6_K92_T1.9501.00
65_R69_L1.8951.00
48_T104_H1.8671.00
16_D92_T1.8591.00
73_A111_W1.8361.00
103_N106_L1.8091.00
79_G111_W1.7741.00
95_Y103_N1.7381.00
10_D100_T1.7211.00
4_Q90_P1.7141.00
93_L112_L1.6841.00
48_T52_K1.5961.00
23_D104_H1.5481.00
56_G60_D1.5431.00
61_Y65_R1.5121.00
18_Y39_E1.4551.00
39_E81_R1.4451.00
55_H60_D1.4031.00
45_T104_H1.3891.00
63_T67_Q1.3721.00
61_Y107_V1.3581.00
18_Y38_D1.3201.00
5_C105_A1.3040.99
50_L53_A1.2720.99
31_K35_L1.2180.99
8_V30_I1.2020.99
41_D45_T1.1930.99
95_Y100_T1.1790.99
104_H107_V1.1770.99
17_G92_T1.1710.99
47_S71_E1.1660.99
6_K19_R1.1640.99
18_Y89_Q1.1630.99
53_A60_D1.1610.99
54_F102_Q1.1430.99
53_A59_V1.1420.99
95_Y105_A1.1410.99
78_E81_R1.1340.99
96_S104_H1.1190.98
37_L94_L1.1090.98
97_A103_N1.0990.98
100_T103_N1.0890.98
86_A91_L1.0890.98
80_K83_A1.0650.98
81_R85_I1.0560.98
20_I85_I1.0540.98
16_D19_R1.0320.97
3_I91_L1.0300.97
25_L104_H1.0240.97
41_D44_I1.0140.97
6_K17_G1.0080.97
63_T66_E1.0080.97
70_A74_Q0.9730.96
54_F95_Y0.9730.96
32_K98_K0.9720.96
81_R84_D0.9700.96
23_D96_S0.9530.96
54_F103_N0.9240.95
5_C109_A0.9210.95
18_Y85_I0.9170.95
30_I35_L0.9120.94
56_G97_A0.9040.94
23_D98_K0.8990.94
21_L35_L0.8890.94
95_Y106_L0.8810.93
12_A16_D0.8790.93
20_I39_E0.8690.93
82_L86_A0.8590.92
20_I82_L0.8580.92
3_I86_A0.8520.92
25_L51_R0.8500.92
44_I78_E0.8420.92
85_I89_Q0.8350.91
70_A73_A0.8150.90
58_V99_N0.8100.90
8_V37_L0.7970.89
75_H78_E0.7850.89
52_K98_K0.7680.88
49_E52_K0.7530.86
53_A63_T0.7480.86
45_T56_G0.7450.86
83_A86_A0.7440.86
61_Y106_L0.7420.86
21_L27_P0.7370.85
54_F100_T0.7370.85
56_G59_V0.7340.85
81_R86_A0.7310.85
54_F97_A0.7260.84
4_Q15_S0.7200.84
79_G83_A0.7090.83
69_L110_D0.7070.83
60_D63_T0.7040.83
13_E16_D0.6890.81
80_K84_D0.6830.81
14_Q36_A0.6810.80
16_D90_P0.6740.80
20_I41_D0.6620.79
78_E86_A0.6590.78
34_D77_Q0.6580.78
6_K12_A0.6520.78
95_Y99_N0.6480.77
56_G102_Q0.6450.77
94_L105_A0.6340.76
77_Q80_K0.6310.75
97_A105_A0.6310.75
31_K37_L0.6280.75
20_I81_R0.6270.75
58_V102_Q0.6260.75
24_R48_T0.6250.75
9_Y100_T0.6250.75
35_L38_D0.6230.74
6_K13_E0.6190.74
61_Y103_N0.6160.73
11_P22_V0.6150.73
50_L63_T0.6120.73
33_T36_A0.6120.73
25_L48_T0.6080.73
78_E82_L0.6070.72
66_E70_A0.6050.72
12_A92_T0.6030.72
11_P19_R0.6020.72
19_R37_L0.5970.71
77_Q81_R0.5930.71
106_L109_A0.5890.70
23_D93_L0.5880.70
53_A57_E0.5880.70
62_A76_E0.5870.70
32_K51_R0.5870.70
79_G82_L0.5860.70
61_Y102_Q0.5740.68
107_V111_W0.5700.68
18_Y41_D0.5660.67
82_L91_L0.5630.67
15_S90_P0.5630.67
69_L73_A0.5620.67
86_A90_P0.5620.67
22_V108_L0.5610.66
48_T54_F0.5560.66
100_T106_L0.5560.66
86_A93_L0.5500.65
37_L91_L0.5480.65
21_L37_L0.5470.64
41_D81_R0.5450.64
23_D97_A0.5400.63
32_K52_K0.5380.63
50_L67_Q0.5330.62
22_V105_A0.5310.62
30_I94_L0.5310.62
25_L42_K0.5310.62
20_I91_L0.5310.62
69_L111_W0.5250.61
110_D113_R0.5160.60
75_H111_W0.5140.60
32_K42_K0.5080.59
8_V26_W0.5060.59
15_S92_T0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v54E 1 0.5043 23.3 0.938 Contact Map
2cxnA 2 0.7652 19.4 0.94 Contact Map
2gqrA 2 0.5391 14.7 0.943 Contact Map
2xmoA 1 0.9478 9.1 0.948 Contact Map
4bkyA 1 0.3826 8.3 0.949 Contact Map
3ljkA 2 0.7304 8.2 0.949 Contact Map
3uemA 1 0.5304 7.6 0.95 Contact Map
2ywvA 2 0.5217 6.7 0.951 Contact Map
4l6hA 1 0.9478 6.3 0.952 Contact Map
2y69E 1 0.4957 6.2 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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