GREMLIN Database
YEAM - Uncharacterized HTH-type transcriptional regulator YeaM
UniProt: P76241 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13499
Length: 273 (226)
Sequences: 34425 (28557)
Seq/√Len: 1899.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_L248_L3.2061.00
201_L209_Q3.1161.00
212_L248_L3.0041.00
178_G188_E2.9761.00
168_A210_L2.9421.00
223_D231_T2.8981.00
214_M217_Q2.7731.00
166_M170_G2.7591.00
170_G173_E2.5701.00
209_Q247_G2.5181.00
244_F255_Y2.4231.00
215_A240_F2.3291.00
163_M191_L2.2111.00
218_G231_T2.2001.00
195_I206_W2.1181.00
176_A179_Q2.0211.00
250_Q258_R1.9751.00
218_G232_L1.9491.00
171_P210_L1.9291.00
52_T59_L1.8701.00
166_M183_F1.8651.00
223_D227_K1.8301.00
167_M207_R1.8081.00
218_G223_D1.7981.00
133_R136_Q1.7921.00
212_L247_G1.7821.00
52_T61_M1.7281.00
136_Q140_D1.7161.00
204_R208_Q1.7161.00
190_N194_L1.7111.00
163_M184_F1.6971.00
160_I199_T1.6961.00
164_V199_T1.6891.00
180_W203_F1.6681.00
237_T241_I1.6671.00
54_T59_L1.6631.00
216_L255_Y1.6601.00
177_L192_A1.6551.00
224_T227_K1.6421.00
217_Q221_K1.6201.00
226_Q237_T1.6121.00
243_M246_K1.6001.00
50_A61_M1.5891.00
48_H85_E1.5791.00
165_E169_K1.5771.00
168_A206_W1.5721.00
166_M175_G1.5511.00
214_M218_G1.5351.00
188_E192_A1.5081.00
63_P66_Y1.5081.00
210_L214_M1.5021.00
203_F207_R1.4981.00
186_M190_N1.4971.00
219_L225_V1.4931.00
41_G72_G1.4691.00
227_K231_T1.4551.00
201_L205_Q1.4441.00
239_A243_M1.4441.00
190_N193_R1.4301.00
47_L87_C1.4281.00
171_P214_M1.4221.00
191_L203_F1.4161.00
227_K230_H1.3941.00
234_Y243_M1.3931.00
226_Q230_H1.3821.00
250_Q254_R1.3741.00
172_V231_T1.3651.00
253_G257_A1.3641.00
215_A232_L1.3621.00
157_H198_E1.3611.00
228_V232_L1.3571.00
50_A63_P1.3481.00
52_T79_Q1.3461.00
56_E74_V1.3361.00
164_V168_A1.3311.00
238_T241_I1.3151.00
178_G182_G1.3021.00
214_M232_L1.2871.00
163_M180_W1.2771.00
167_M210_L1.2681.00
192_A203_F1.2681.00
179_Q183_F1.2581.00
173_E179_Q1.2551.00
133_R140_D1.2541.00
208_Q243_M1.2401.00
189_R193_R1.2401.00
241_I251_T1.2301.00
209_Q213_I1.2181.00
54_T77_S1.2111.00
210_L213_I1.1991.00
202_S205_Q1.1941.00
186_M191_L1.1741.00
159_K186_M1.1721.00
71_P74_V1.1691.00
241_I253_G1.1661.00
112_R116_L1.1591.00
42_Q76_H1.1561.00
36_H76_H1.1561.00
187_S190_N1.1561.00
216_L220_V1.1311.00
101_T104_T1.1251.00
117_T121_R1.0901.00
48_H64_P1.0881.00
213_I216_L1.0841.00
251_T254_R1.0721.00
129_P133_R1.0641.00
223_D228_V1.0631.00
194_L197_K1.0561.00
175_G180_W1.0501.00
113_E117_T1.0431.00
38_H76_H1.0311.00
254_R257_A1.0261.00
177_L203_F1.0231.00
132_R139_F1.0201.00
166_M184_F1.0121.00
116_L120_N1.0121.00
159_K194_L1.0101.00
35_V75_E1.0071.00
132_R136_Q1.0031.00
181_A188_E0.9961.00
208_Q246_K0.9911.00
158_P162_T0.9901.00
179_Q182_G0.9851.00
194_L198_E0.9821.00
174_W235_D0.9791.00
242_T246_K0.9741.00
131_T141_E0.9731.00
128_E131_T0.9711.00
171_P175_G0.9681.00
159_K184_F0.9661.00
172_V214_M0.9621.00
161_R165_E0.9521.00
225_V228_V0.9501.00
222_G228_V0.9381.00
105_L108_S0.9371.00
205_Q208_Q0.9351.00
253_G256_I0.9331.00
236_S242_T0.9321.00
104_T108_S0.9291.00
164_V206_W0.9271.00
162_T183_F0.9261.00
180_W183_F0.9261.00
47_L85_E0.9251.00
218_G228_V0.9181.00
129_P132_R0.9091.00
113_E116_L0.9031.00
177_L188_E0.9031.00
100_T104_T0.8981.00
241_I245_K0.8981.00
108_S112_R0.8911.00
243_M247_G0.8811.00
129_P136_Q0.8721.00
248_L255_Y0.8711.00
103_C107_I0.8661.00
254_R258_R0.8641.00
166_M180_W0.8641.00
189_R192_A0.8581.00
51_I84_A0.8541.00
211_Q232_L0.8501.00
140_D144_Q0.8501.00
228_V256_I0.8491.00
46_A51_I0.8461.00
186_M194_L0.8461.00
184_F191_L0.8371.00
206_W210_L0.8331.00
167_M203_F0.8191.00
160_I163_M0.8181.00
135_I141_E0.8151.00
127_A131_T0.8091.00
117_T120_N0.8091.00
162_T165_E0.8071.00
41_G69_W0.8071.00
101_T105_L0.8071.00
174_W179_Q0.8041.00
133_R137_V0.8031.00
195_I199_T0.8001.00
205_Q209_Q0.8001.00
205_Q247_G0.7951.00
239_A242_T0.7951.00
216_L244_F0.7921.00
171_P207_R0.7921.00
38_H42_Q0.7911.00
160_I194_L0.7911.00
52_T81_T0.7891.00
54_T57_N0.7781.00
70_I76_H0.7781.00
219_L228_V0.7751.00
128_E132_R0.7731.00
51_I62_V0.7711.00
53_C68_V0.7711.00
204_R207_R0.7651.00
164_V195_I0.7641.00
212_L240_F0.7631.00
175_G179_Q0.7611.00
195_I203_F0.7601.00
114_L117_T0.7591.00
44_I88_F0.7591.00
208_Q247_G0.7501.00
160_I164_V0.7491.00
55_V58_A0.7491.00
162_T184_F0.7481.00
161_R164_V0.7471.00
54_T79_Q0.7461.00
212_L243_M0.7441.00
122_T125_Q0.7401.00
245_K254_R0.7401.00
204_R239_A0.7371.00
170_G183_F0.7351.00
45_L67_A0.7341.00
135_I139_F0.7331.00
230_H235_D0.7311.00
130_M133_R0.7311.00
35_V77_S0.7301.00
215_A218_G0.7271.00
171_P232_L0.7261.00
160_I198_E0.7251.00
110_L117_T0.7251.00
245_K251_T0.7241.00
219_L256_I0.7201.00
167_M206_W0.7191.00
50_A81_T0.7141.00
192_A196_V0.7121.00
156_S197_K0.7081.00
163_M166_M0.7081.00
250_Q255_Y0.7051.00
192_A202_S0.6941.00
180_W191_L0.6931.00
128_E139_F0.6901.00
42_Q90_F0.6891.00
51_I61_M0.6851.00
220_V255_Y0.6811.00
157_H194_L0.6751.00
46_A49_G0.6741.00
121_R125_Q0.6721.00
128_E137_V0.6671.00
110_L114_L0.6621.00
237_T240_F0.6611.00
229_A237_T0.6581.00
170_G179_Q0.6551.00
163_M167_M0.6511.00
105_L109_P0.6481.00
114_L118_L0.6431.00
235_D239_A0.6411.00
163_M195_I0.6411.00
62_V68_V0.6331.00
37_Q75_E0.6311.00
236_S239_A0.6301.00
84_A88_F0.6301.00
193_R197_K0.6291.00
171_P211_Q0.6271.00
163_M203_F0.6241.00
201_L206_W0.6241.00
159_K162_T0.6221.00
46_A86_L0.6211.00
163_M183_F0.6181.00
224_T228_V0.6181.00
238_T251_T0.6171.00
100_T103_C0.6161.00
196_V202_S0.6161.00
212_L234_Y0.6151.00
167_M175_G0.6101.00
51_I78_N0.6071.00
44_I70_I0.6041.00
137_V142_L0.6041.00
109_P113_E0.6041.00
109_P112_R0.6011.00
238_T242_T0.5991.00
213_I247_G0.5981.00
175_G211_Q0.5971.00
132_R135_I0.5941.00
222_G256_I0.5941.00
119_A123_T0.5911.00
168_A214_M0.5901.00
137_V141_E0.5861.00
130_M134_L0.5811.00
225_V253_G0.5771.00
192_A204_R0.5771.00
170_G175_G0.5761.00
111_C115_I0.5741.00
215_A228_V0.5741.00
134_L139_F0.5741.00
208_Q239_A0.5711.00
207_R211_Q0.5701.00
177_L204_R0.5691.00
156_S198_E0.5651.00
53_C78_N0.5621.00
131_T137_V0.5621.00
41_G44_I0.5601.00
191_L199_T0.5511.00
160_I191_L0.5511.00
44_I86_L0.5511.00
111_C114_L0.5511.00
129_P143_P0.5471.00
104_T107_I0.5471.00
219_L255_Y0.5451.00
130_M140_D0.5451.00
103_C106_K0.5451.00
44_I53_C0.5441.00
207_R210_L0.5441.00
134_L137_V0.5411.00
131_T135_I0.5381.00
234_Y240_F0.5371.00
182_G185_A0.5361.00
110_L113_E0.5351.00
107_I121_R0.5351.00
43_L67_A0.5351.00
174_W211_Q0.5351.00
240_F252_P0.5341.00
43_L69_W0.5321.00
133_R139_F0.5321.00
156_S159_K0.5291.00
229_A234_Y0.5281.00
56_E75_E0.5271.00
244_F250_Q0.5261.00
158_P198_E0.5261.00
181_A184_F0.5261.00
48_H83_N0.5251.00
121_R124_T0.5251.00
218_G221_K0.5241.00
180_W184_F0.5211.00
157_H161_R0.5211.00
236_S246_K0.5171.00
40_K90_F0.5161.00
139_F143_P0.5161.00
46_A84_A0.5141.00
137_V140_D0.5131.00
199_T206_W0.5131.00
240_F244_F0.5121.00
166_M179_Q0.5091.00
80_V84_A0.5081.00
180_W211_Q0.5081.00
102_C106_K0.5061.00
119_A122_T0.5041.00
132_R140_D0.5041.00
165_E168_A0.5031.00
46_A62_V0.5011.00
132_R141_E0.5001.00
213_I248_L0.5001.00
68_V78_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gbgA 1 0.8681 100 0.29 Contact Map
3oioA 1 0.4066 100 0.492 Contact Map
3oouA 1 0.381 100 0.493 Contact Map
3mn2A 1 0.3846 100 0.497 Contact Map
1bl0A 1 0.4212 100 0.498 Contact Map
3w6vA 1 0.4029 100 0.5 Contact Map
3mklA 1 0.4029 99.9 0.505 Contact Map
2k9sA 1 0.3846 99.9 0.509 Contact Map
3lsgA 2 0.37 99.9 0.513 Contact Map
1d5yA 1 0.4322 99.9 0.522 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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