GREMLIN Database
YEAJ - Putative diguanylate cyclase YeaJ
UniProt: P76237 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13496
Length: 496 (426)
Sequences: 2220 (2156)
Seq/√Len: 104.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
414_R417_D6.8401.00
385_K493_N6.6011.00
379_I463_S5.0281.00
379_I443_P4.8751.00
377_M467_A3.9471.00
342_R346_S3.9291.00
333_H337_Y3.8481.00
358_L428_C3.4401.00
444_E447_E3.2841.00
365_R368_K3.2351.00
383_M461_F3.0421.00
352_L406_A3.0301.00
482_D486_Y2.8891.00
362_L474_L2.8861.00
473_T476_D2.8731.00
408_A453_I2.8681.00
396_Q479_K2.8561.00
395_H486_Y2.8481.00
413_I419_A2.7871.00
450_L461_F2.7331.00
358_L420_I2.7111.00
409_I419_A2.7091.00
395_H482_D2.6001.00
425_D460_G2.5771.00
384_D462_S2.5501.00
353_Y418_Y2.5221.00
391_D486_Y2.5161.00
391_D395_H2.4811.00
451_Q494_S2.4631.00
353_Y357_I2.4331.00
431_L442_L2.4211.00
424_G486_Y2.4181.00
479_K483_E2.3621.00
383_M402_I2.3491.00
377_M439_A2.3301.00
401_A459_I2.3201.00
387_K486_Y2.2291.00
371_Q414_R2.2051.00
387_K395_H2.1901.00
380_A478_Y2.1851.00
443_P465_I2.1251.00
389_I401_A2.0961.00
386_L402_I2.0791.00
391_D482_D2.0591.00
471_N480_A2.0431.00
439_A443_P2.0231.00
417_D445_R2.0181.00
383_M405_L2.0031.00
488_N492_K2.0021.00
387_K391_D1.9741.00
334_F337_Y1.9691.00
401_A425_D1.9651.00
352_L419_A1.9391.00
382_D486_Y1.9131.00
422_L478_Y1.8961.00
414_R445_R1.8621.00
357_I361_E1.8541.00
447_E451_Q1.8521.00
387_K482_D1.8491.00
379_I429_I1.8411.00
469_K480_A1.8251.00
380_A485_L1.8041.00
337_Y340_V1.7681.00
423_G486_Y1.7601.00
404_L407_Q1.7581.00
431_L439_A1.7571.00
424_G482_D1.7481.00
385_K485_L1.7451.00
382_D387_K1.7381.00
469_K477_A1.7381.00
361_E364_Q1.7381.00
468_M471_N1.7281.00
406_A419_A1.7271.00
395_H426_E1.7051.00
464_G481_S1.7041.00
384_D492_K1.7031.00
333_H336_L1.6931.00
435_T438_I1.6751.00
361_E418_Y1.6681.00
400_L403_T1.6401.00
425_D485_L1.6271.00
381_I463_S1.6261.00
404_L408_A1.6241.00
296_G334_F1.6181.00
343_E356_K1.6121.00
423_G482_D1.6041.00
460_G494_S1.5991.00
389_I457_K1.5871.00
388_Q425_D1.5821.00
386_L488_N1.5761.00
468_M477_A1.5621.00
420_I428_C1.5581.00
391_D424_G1.5201.00
466_Y477_A1.5191.00
365_R432_V1.5171.00
413_I446_I1.5111.00
379_I465_I1.5061.00
444_E448_K1.5061.00
405_L450_L1.5031.00
426_E486_Y1.4941.00
383_M460_G1.4941.00
395_H424_G1.4821.00
361_E420_I1.4771.00
380_A428_C1.4431.00
357_I360_P1.4431.00
350_T402_I1.4271.00
308_F311_S1.4211.00
409_I446_I1.4161.00
349_M402_I1.4101.00
462_S492_K1.4081.00
348_A356_K1.4011.00
385_K425_D1.3951.00
384_D488_N1.3911.00
447_E494_S1.3881.00
422_L428_C1.3871.00
425_D447_E1.3811.00
382_D424_G1.3781.00
382_D395_H1.3691.00
422_L425_D1.3661.00
380_A422_L1.3570.99
390_N398_G1.3560.99
376_V468_M1.3540.99
401_A485_L1.3480.99
386_L492_K1.3330.99
382_D489_K1.3320.99
382_D482_D1.3280.99
357_I418_Y1.3130.99
393_L425_D1.2780.99
359_T422_L1.2740.99
431_L434_S1.2730.99
462_S488_N1.2720.99
414_R442_L1.2710.99
428_C478_Y1.2650.99
406_A409_I1.2630.99
358_L478_Y1.2580.99
391_D426_E1.2540.99
330_V337_Y1.2490.99
225_P234_G1.2470.99
345_I353_Y1.2380.99
346_S485_L1.2330.99
423_G426_E1.2320.99
409_I413_I1.2240.99
443_P463_S1.2150.99
352_L409_I1.2110.99
381_I429_I1.2090.99
337_Y341_S1.2060.99
345_I357_I1.2050.99
425_D488_N1.1970.99
398_G424_G1.1910.99
374_S433_D1.1910.99
386_L485_L1.1880.99
339_N343_E1.1870.99
382_D421_R1.1710.99
379_I431_L1.1670.98
365_R371_Q1.1660.98
472_D480_A1.1640.98
383_M485_L1.1620.98
434_S439_A1.1550.98
377_M434_S1.1540.98
368_K371_Q1.1530.98
239_D244_N1.1350.98
380_A425_D1.1340.98
413_I417_D1.1290.98
386_L484_R1.1090.98
466_Y480_A1.1040.98
439_A465_I1.1010.98
365_R418_Y1.0990.98
382_D423_G1.0970.98
225_P233_K1.0960.98
161_N164_Y1.0910.98
329_M337_Y1.0770.97
384_D485_L1.0720.97
395_H423_G1.0690.97
338_Q341_S1.0640.97
460_G485_L1.0590.97
357_I420_I1.0460.97
407_Q410_K1.0430.97
425_D486_Y1.0410.97
346_S353_Y1.0400.97
341_S345_I1.0400.97
387_K426_E1.0390.97
487_V490_Q1.0310.97
391_D489_K1.0270.97
382_D399_D1.0260.97
371_Q416_S1.0240.96
401_A420_I1.0130.96
381_I461_F1.0110.96
408_A447_E1.0050.96
377_M443_P1.0040.96
426_E482_D1.0010.96
422_L430_I0.9990.96
358_L430_I0.9980.96
171_V174_E0.9960.96
380_A481_S0.9910.96
369_L376_V0.9900.96
382_D391_D0.9840.96
457_K485_L0.9760.95
355_R399_D0.9720.95
356_K425_D0.9590.95
346_S380_A0.9520.95
334_F338_Q0.9510.95
209_I213_Q0.9480.95
337_Y393_L0.9470.95
365_R376_V0.9470.95
399_D421_R0.9450.95
381_I409_I0.9430.94
485_L493_N0.9400.94
460_G492_K0.9400.94
105_G109_T0.9390.94
386_L425_D0.9380.94
434_S438_I0.9360.94
340_V345_I0.9350.94
466_Y469_K0.9350.94
57_N65_M0.9350.94
385_K388_Q0.9250.94
383_M425_D0.9250.94
440_A444_E0.9210.94
399_D424_G0.9210.94
421_R426_E0.9140.93
263_V302_S0.9120.93
447_E460_G0.9110.93
393_L457_K0.9110.93
393_L401_A0.9090.93
378_F428_C0.9050.93
425_D482_D0.9050.93
106_L109_T0.9040.93
258_W261_L0.8970.93
442_L445_R0.8970.93
312_S322_T0.8920.93
486_Y489_K0.8910.93
436_P439_A0.8900.93
400_L404_L0.8790.92
413_I442_L0.8760.92
436_P467_A0.8720.92
422_L485_L0.8710.92
323_A330_V0.8670.92
353_Y420_I0.8660.92
386_L462_S0.8650.91
225_P232_L0.8640.91
390_N424_G0.8630.91
387_K424_G0.8610.91
70_A73_S0.8560.91
425_D494_S0.8550.91
372_S433_D0.8530.91
329_M332_M0.8500.91
405_L446_I0.8490.91
353_Y361_E0.8450.91
470_E480_A0.8440.90
358_L362_L0.8410.90
390_N399_D0.8390.90
235_I239_D0.8390.90
239_D243_N0.8370.90
388_Q485_L0.8360.90
168_Y173_V0.8350.90
348_A359_T0.8280.90
107_R118_D0.8280.90
345_I356_K0.8270.90
386_L460_G0.8260.89
343_E346_S0.8260.89
162_D167_F0.8260.89
356_K493_N0.8250.89
380_A401_A0.8240.89
432_V439_A0.8220.89
68_L71_E0.8210.89
263_V267_D0.8190.89
384_D482_D0.8190.89
336_L339_N0.8170.89
448_K451_Q0.8170.89
326_L330_V0.8160.89
391_D423_G0.8150.89
382_D398_G0.8130.89
391_D462_S0.8130.89
207_S210_Y0.8100.89
382_D426_E0.8100.89
273_D278_Q0.8090.89
480_A484_R0.8070.88
474_L478_Y0.8040.88
237_L244_N0.8020.88
70_A74_E0.8020.88
371_Q417_D0.8010.88
398_G423_G0.8010.88
439_A467_A0.7990.88
378_F478_Y0.7990.88
476_D480_A0.7980.88
199_V202_G0.7930.88
420_I474_L0.7920.87
169_E174_E0.7910.87
344_N423_G0.7890.87
293_L296_G0.7880.87
366_L477_A0.7870.87
484_R488_N0.7870.87
386_L443_P0.7870.87
346_S352_L0.7840.87
490_Q493_N0.7840.87
129_A134_V0.7810.87
376_V477_A0.7810.87
71_E82_A0.7790.87
63_H67_A0.7790.87
67_A75_V0.7790.87
262_N304_D0.7770.86
68_L72_Q0.7770.86
58_Q61_A0.7760.86
81_R85_E0.7760.86
451_Q460_G0.7760.86
362_L430_I0.7750.86
366_L468_M0.7730.86
254_R329_M0.7730.86
61_A67_A0.7710.86
348_A389_I0.7680.86
67_A71_E0.7670.86
378_F466_Y0.7630.85
417_D434_S0.7590.85
413_I429_I0.7570.85
344_N380_A0.7560.85
382_D425_D0.7560.85
399_D482_D0.7550.85
65_M68_L0.7530.85
326_L329_M0.7520.85
126_L133_A0.7510.85
131_D134_V0.7490.84
209_I212_D0.7470.84
386_L401_A0.7450.84
257_L263_V0.7440.84
206_L225_P0.7430.84
59_S65_M0.7400.84
68_L74_E0.7390.84
366_L471_N0.7390.84
86_A90_A0.7380.83
313_W316_V0.7380.83
387_K423_G0.7370.83
443_P447_E0.7350.83
425_D463_S0.7340.83
66_R72_Q0.7320.83
326_L331_R0.7320.83
100_A103_Y0.7260.82
401_A422_L0.7230.82
60_I64_V0.7220.82
87_F90_A0.7180.82
58_Q65_M0.7180.82
267_D302_S0.7170.82
417_D442_L0.7170.82
378_F477_A0.7170.82
405_L459_I0.7160.82
487_V491_N0.7150.82
319_W329_M0.7130.81
443_P461_F0.7130.81
406_A410_K0.7110.81
466_Y470_E0.7090.81
466_Y481_S0.7080.81
210_Y221_S0.7080.81
142_D145_S0.7060.81
60_I63_H0.7040.81
386_L405_L0.7000.80
83_I86_A0.6990.80
366_L406_A0.6970.80
65_M69_A0.6940.80
315_S320_I0.6940.80
345_I485_L0.6900.79
239_D242_K0.6890.79
195_D198_K0.6890.79
109_T112_T0.6880.79
359_T362_L0.6850.79
196_I200_F0.6830.78
74_E77_P0.6820.78
58_Q64_V0.6810.78
352_L401_A0.6800.78
457_K483_E0.6800.78
421_R424_G0.6780.78
462_S486_Y0.6760.78
349_M390_N0.6760.78
486_Y493_N0.6760.78
387_K489_K0.6760.78
60_I67_A0.6750.78
170_P174_E0.6740.78
395_H399_D0.6730.77
356_K486_Y0.6710.77
329_M333_H0.6690.77
59_S67_A0.6690.77
324_L327_L0.6690.77
164_Y168_Y0.6680.77
439_A442_L0.6670.77
61_A68_L0.6660.77
228_V231_Q0.6660.77
360_P418_Y0.6650.77
397_E400_L0.6650.77
480_A485_L0.6630.76
395_H489_K0.6610.76
359_T474_L0.6600.76
58_Q66_R0.6600.76
403_T407_Q0.6590.76
438_I441_Q0.6590.76
330_V333_H0.6580.76
363_E367_Q0.6570.76
60_I69_A0.6570.76
405_L461_F0.6570.76
480_A483_E0.6560.76
63_H66_R0.6550.76
295_G307_Y0.6540.75
69_A74_E0.6530.75
64_V67_A0.6530.75
360_P364_Q0.6520.75
62_A65_M0.6520.75
319_W322_T0.6500.75
482_D489_K0.6500.75
278_Q281_D0.6490.75
254_R287_V0.6490.75
422_L461_F0.6490.75
62_A67_A0.6470.75
382_D462_S0.6450.74
264_T267_D0.6440.74
401_A453_I0.6440.74
336_L340_V0.6420.74
83_I90_A0.6410.74
80_R84_C0.6390.74
61_A71_E0.6380.74
69_A75_V0.6370.74
330_V334_F0.6360.73
177_A183_F0.6360.73
384_D460_G0.6350.73
61_A65_M0.6340.73
256_L259_R0.6320.73
57_N67_A0.6300.73
355_R359_T0.6300.73
460_G493_N0.6290.73
371_Q438_I0.6290.73
414_R432_V0.6270.72
254_R258_W0.6260.72
369_L469_K0.6260.72
301_L305_I0.6260.72
462_S482_D0.6260.72
335_R339_N0.6250.72
412_S446_I0.6250.72
234_G254_R0.6240.72
299_V307_Y0.6240.72
287_V295_G0.6240.72
283_L300_S0.6230.72
271_G275_I0.6230.72
465_I484_R0.6220.72
58_Q62_A0.6190.71
261_L299_V0.6180.71
233_K237_L0.6180.71
397_E457_K0.6170.71
392_T479_K0.6160.71
110_L131_D0.6150.71
61_A70_A0.6140.71
401_A418_Y0.6140.71
57_N61_A0.6140.71
422_L466_Y0.6130.71
73_S77_P0.6120.71
383_M457_K0.6120.71
353_Y419_A0.6120.71
322_T329_M0.6110.70
293_L323_A0.6100.70
223_L226_V0.6090.70
73_S76_S0.6080.70
257_L309_I0.6060.70
291_H295_G0.6060.70
130_F167_F0.6060.70
275_I278_Q0.6050.70
210_Y219_V0.6050.70
160_L163_R0.6040.70
79_Q82_A0.6030.69
418_Y430_I0.6030.69
203_R210_Y0.6030.69
61_A64_V0.6020.69
227_Y234_G0.6020.69
270_S446_I0.6020.69
276_I282_N0.6010.69
376_V430_I0.6010.69
257_L323_A0.6010.69
61_A69_A0.6010.69
80_R85_E0.6000.69
91_N94_H0.5960.69
461_F485_L0.5950.68
83_I93_T0.5940.68
346_S351_G0.5940.68
322_T328_N0.5920.68
425_D453_I0.5910.68
126_L130_F0.5910.68
424_G462_S0.5900.68
337_Y422_L0.5900.68
414_R434_S0.5900.68
396_Q400_L0.5890.68
325_I330_V0.5890.68
61_A72_Q0.5890.68
62_A70_A0.5880.68
63_H69_A0.5880.68
79_Q91_N0.5880.68
393_L453_I0.5860.67
84_C88_E0.5860.67
61_A66_R0.5860.67
409_I429_I0.5850.67
383_M477_A0.5850.67
123_A134_V0.5830.67
210_Y225_P0.5830.67
396_Q478_Y0.5820.67
253_D261_L0.5810.67
340_V343_E0.5800.66
477_A480_A0.5800.66
344_N386_L0.5780.66
98_L101_H0.5780.66
116_D119_T0.5780.66
278_Q282_N0.5770.66
382_D390_N0.5760.66
80_R83_I0.5750.66
253_D258_W0.5740.66
157_Y169_E0.5730.66
102_K107_R0.5720.65
308_F327_L0.5720.65
258_W271_G0.5710.65
225_P237_L0.5710.65
157_Y164_Y0.5700.65
197_E203_R0.5700.65
118_D122_E0.5700.65
100_A104_P0.5690.65
369_L468_M0.5680.65
72_Q76_S0.5680.65
253_D257_L0.5680.65
368_K433_D0.5660.65
60_I76_S0.5660.65
349_M355_R0.5660.65
174_E180_N0.5660.65
387_K462_S0.5650.64
423_G489_K0.5640.64
346_S389_I0.5640.64
65_M75_V0.5630.64
124_A127_L0.5620.64
64_V72_Q0.5620.64
384_D395_H0.5610.64
323_A326_L0.5600.64
386_L482_D0.5600.64
381_I422_L0.5590.64
395_H398_G0.5580.63
362_L365_R0.5570.63
80_R90_A0.5570.63
412_S445_R0.5560.63
59_S75_V0.5560.63
384_D494_S0.5550.63
160_L172_N0.5540.63
414_R439_A0.5540.63
355_R395_H0.5540.63
62_A73_S0.5530.63
488_N494_S0.5530.63
70_A75_V0.5520.63
65_M81_R0.5520.63
114_S118_D0.5510.63
346_S357_I0.5510.63
202_G212_D0.5480.62
65_M70_A0.5480.62
265_L269_D0.5470.62
257_L279_S0.5470.62
219_V223_L0.5470.62
343_E428_C0.5460.62
394_G398_G0.5450.62
227_Y233_K0.5450.62
391_D399_D0.5450.62
206_L222_L0.5430.61
339_N478_Y0.5430.61
395_H462_S0.5420.61
300_S306_L0.5420.61
434_S467_A0.5420.61
470_E477_A0.5420.61
233_K328_N0.5410.61
223_L227_Y0.5400.61
117_C121_V0.5400.61
162_D172_N0.5390.61
335_R338_Q0.5390.61
377_M465_I0.5390.61
349_M391_D0.5390.61
380_A420_I0.5380.61
210_Y213_Q0.5380.61
344_N354_N0.5370.61
436_P465_I0.5370.61
444_E451_Q0.5350.60
346_S493_N0.5340.60
88_E95_G0.5340.60
398_G426_E0.5340.60
353_Y408_A0.5330.60
107_R111_Q0.5330.60
203_R206_L0.5320.60
464_G486_Y0.5320.60
207_S220_M0.5310.60
220_M223_L0.5310.60
232_L235_I0.5290.59
422_L446_I0.5290.59
468_M480_A0.5290.59
344_N443_P0.5280.59
336_L343_E0.5270.59
261_L268_T0.5270.59
295_G300_S0.5270.59
425_D492_K0.5260.59
154_F158_L0.5260.59
202_G225_P0.5220.58
159_D162_D0.5220.58
450_L459_I0.5220.58
177_A181_W0.5210.58
57_N62_A0.5200.58
243_N254_R0.5200.58
176_F179_N0.5200.58
301_L304_D0.5190.58
359_T381_I0.5190.58
166_Y170_P0.5190.58
169_E173_V0.5180.58
391_D425_D0.5170.58
478_Y481_S0.5170.58
125_A128_P0.5170.58
263_V266_T0.5150.57
361_E365_R0.5150.57
376_V385_K0.5150.57
199_V203_R0.5150.57
283_L286_Y0.5140.57
130_F133_A0.5140.57
174_E177_A0.5140.57
287_V301_L0.5120.57
88_E91_N0.5120.57
167_F178_M0.5120.57
241_N244_N0.5120.57
183_F215_T0.5110.57
344_N485_L0.5110.57
97_N101_H0.5090.57
257_L260_F0.5080.56
195_D199_V0.5080.56
387_K399_D0.5080.56
62_A76_S0.5070.56
120_I132_Q0.5060.56
345_I477_A0.5050.56
210_Y220_M0.5050.56
65_M76_S0.5050.56
231_Q243_N0.5040.56
89_S94_H0.5040.56
221_S239_D0.5040.56
201_T226_V0.5030.56
344_N353_Y0.5030.56
69_A76_S0.5030.56
242_K245_L0.5020.56
230_G235_I0.5010.55
257_L293_L0.5010.55
372_S434_S0.5010.55
64_V73_S0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.7621 100 0.521 Contact Map
3ezuA 2 0.6552 100 0.54 Contact Map
4j40A 2 0 100 0.552 Contact Map
3pjxA 1 0.3407 100 0.556 Contact Map
4h54A 2 0.5202 100 0.567 Contact Map
4rnhA 2 0.2984 100 0.573 Contact Map
3ignA 1 0.3145 100 0.576 Contact Map
3i5cA 2 0.3669 100 0.581 Contact Map
3qyyA 1 0.3024 100 0.581 Contact Map
3breA 4 0.5867 100 0.581 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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