GREMLIN Database
YEAI - Inner membrane protein YeaI
UniProt: P76236 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13495
Length: 491 (408)
Sequences: 4623 (4174)
Seq/√Len: 206.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
396_R399_D7.5561.00
326_K330_H5.6281.00
361_M452_I5.0831.00
346_V464_I4.2041.00
361_M425_A4.1781.00
367_Q483_G3.9211.00
359_C456_F3.6461.00
426_E429_R3.5991.00
337_Y341_Y3.2041.00
342_F410_G3.1851.00
317_I321_L3.0831.00
458_T461_T2.9261.00
413_F424_I2.8901.00
395_I401_L2.8581.00
342_F402_A2.8341.00
359_C421_A2.7651.00
382_K385_V2.7371.00
433_E484_N2.6941.00
404_L410_G2.5941.00
349_L352_R2.5491.00
478_A487_I2.5151.00
371_I383_V2.4871.00
463_N466_L2.4411.00
365_I387_I2.4071.00
417_N420_Q2.3891.00
362_L475_L2.3771.00
321_L324_S2.3721.00
472_D476_R2.3691.00
336_I388_V2.3421.00
390_I435_L2.3241.00
365_I450_I2.3081.00
449_T484_N2.2391.00
363_V450_I2.2371.00
391_I401_L2.2311.00
432_V450_I2.1721.00
345_S400_I2.1321.00
310_V313_L2.1301.00
313_L317_I2.1261.00
386_S389_D2.1121.00
377_H472_D2.1021.00
341_Y345_S2.0541.00
337_Y400_I2.0351.00
306_K313_L2.0241.00
373_A476_R2.0141.00
336_I401_L2.0081.00
429_R486_V1.9531.00
345_S348_S1.9521.00
426_E430_K1.9301.00
369_K476_R1.9211.00
369_K373_A1.8891.00
307_L310_V1.8761.00
481_E487_I1.8641.00
367_Q407_E1.8611.00
389_D392_Q1.8601.00
378_R469_T1.8581.00
454_T486_V1.8491.00
366_N451_S1.8491.00
407_E449_T1.8401.00
377_H476_R1.8311.00
429_R433_E1.8221.00
341_Y400_I1.8171.00
309_V313_L1.8071.00
461_T470_E1.7591.00
478_A485_K1.7411.00
386_S390_I1.7391.00
363_V452_I1.7371.00
386_S436_T1.7301.00
317_I320_E1.6831.00
372_N380_G1.6691.00
405_E408_V1.6631.00
307_L313_L1.6491.00
422_K426_E1.6491.00
390_I436_T1.6341.00
435_L438_F1.6321.00
405_E476_R1.6221.00
306_K315_Y1.6131.00
310_V314_I1.6121.00
477_E480_S1.6031.00
406_G476_R1.5811.00
364_D476_R1.5791.00
425_A452_I1.5711.00
387_I391_I1.5521.00
399_D427_R1.5381.00
210_L214_L1.5371.00
329_V344_N1.5301.00
383_V436_T1.5251.00
474_A478_A1.5241.00
387_I432_V1.5221.00
314_I317_I1.5211.00
306_K310_V1.5181.00
401_L411_L1.5111.00
371_I446_E1.5041.00
318_F321_L1.5021.00
405_E472_D1.5011.00
477_E487_I1.4961.00
383_V448_M1.4941.00
373_A472_D1.4841.00
477_E481_E1.4811.00
361_M411_L1.4761.00
455_V467_V1.4671.00
303_V313_L1.4601.00
325_S329_V1.4561.00
332_V340_R1.4501.00
361_M413_F1.4491.00
421_A425_A1.4401.00
457_S467_V1.4361.00
365_I449_T1.4231.00
364_D479_K1.4181.00
424_I427_R1.4171.00
388_V401_L1.4131.00
410_G468_M1.4081.00
333_L339_R1.4011.00
342_F412_L1.4011.00
382_K386_S1.4001.00
323_L327_L1.4001.00
390_I438_F1.3941.00
163_Y167_Q1.3821.00
481_E485_K1.3731.00
358_F457_S1.3631.00
303_V306_K1.3571.00
344_N348_S1.3521.00
343_F465_S1.3421.00
413_F421_A1.3131.00
306_K314_I1.3011.00
408_V476_R1.2951.00
339_R381_D1.2921.00
346_V412_L1.2871.00
164_I167_Q1.2821.00
377_H408_V1.2761.00
429_R484_N1.2651.00
307_L314_I1.2651.00
404_L468_M1.2601.00
406_G472_D1.2591.00
309_V317_I1.2351.00
430_K434_L1.2341.00
342_F346_V1.2281.00
478_A482_G1.2251.00
408_V472_D1.2241.00
349_L414_T1.2121.00
369_K479_K1.2011.00
383_V407_E1.1931.00
364_D377_H1.1851.00
429_R452_I1.1771.00
449_T482_G1.1771.00
334_T384_L1.1771.00
345_S349_L1.1741.00
369_K472_D1.1711.00
395_I411_L1.1661.00
313_L318_F1.1581.00
67_L71_C1.1571.00
321_L325_S1.1441.00
366_N483_G1.1411.00
407_E429_R1.1351.00
358_F467_V1.1291.00
347_E464_I1.1261.00
369_K408_V1.1121.00
67_L70_F1.1081.00
369_K406_G1.1081.00
349_L358_F1.1061.00
369_K372_N1.0941.00
394_S427_R1.0881.00
394_S431_N1.0851.00
314_I318_F1.0851.00
359_C454_T1.0851.00
337_Y402_A1.0841.00
399_D424_I1.0821.00
402_A410_G1.0781.00
407_E484_N1.0651.00
166_R169_S1.0631.00
431_N434_L1.0581.00
377_H479_K1.0541.00
407_E475_L1.0471.00
364_D372_N1.0391.00
372_N479_K1.0391.00
158_D164_I1.0281.00
357_D459_G1.0261.00
387_I448_M1.0261.00
391_I395_I1.0251.00
395_I399_D1.0241.00
369_K377_H1.0221.00
309_V315_Y1.0221.00
162_F165_F1.0221.00
368_F384_L1.0211.00
373_A405_E1.0171.00
377_H406_G1.0151.00
311_S314_I1.0131.00
396_R427_R1.0081.00
379_V382_K1.0051.00
167_Q170_F1.0021.00
162_F166_R1.0021.00
362_L410_G1.0021.00
367_Q475_L0.9991.00
306_K309_V0.9971.00
176_L180_C0.9961.00
458_T470_E0.9921.00
372_N408_V0.9921.00
373_A377_H0.9891.00
303_V307_L0.9881.00
421_A454_T0.9861.00
469_T473_K0.9811.00
327_L340_R0.9781.00
407_E483_G0.9761.00
380_G408_V0.9761.00
330_H337_Y0.9661.00
365_I475_L0.9651.00
373_A408_V0.9641.00
247_C251_F0.9631.00
372_N407_E0.9560.99
396_R424_I0.9420.99
366_N482_G0.9400.99
367_Q370_R0.9360.99
356_K415_E0.9340.99
316_N319_Q0.9300.99
158_D162_F0.9250.99
140_V143_H0.9240.99
247_C250_A0.9220.99
475_L482_G0.9210.99
343_F347_E0.9160.99
141_I144_K0.9110.99
364_D408_V0.9100.99
373_A406_G0.9080.99
425_A454_T0.9050.99
362_L407_E0.9030.99
353_P457_S0.9000.99
309_V314_I0.8990.99
285_L289_E0.8960.99
311_S315_Y0.8940.99
213_N216_S0.8940.99
475_L483_G0.8920.99
108_M111_K0.8910.99
460_D488_I0.8880.99
336_I391_I0.8840.99
457_S461_T0.8770.99
307_L317_I0.8760.99
313_L321_L0.8730.99
450_I475_L0.8720.99
386_S435_L0.8710.99
159_V162_F0.8690.99
455_V470_E0.8670.99
408_V479_K0.8630.99
425_A482_G0.8630.99
283_L286_T0.8620.99
274_C277_S0.8590.99
476_R479_K0.8570.99
340_R407_E0.8550.99
163_Y166_R0.8540.99
208_P211_A0.8530.99
341_Y344_N0.8530.99
377_H405_E0.8510.99
370_R374_Q0.8460.99
454_T488_I0.8430.99
309_V312_F0.8370.99
162_F175_S0.8360.99
315_Y318_F0.8340.99
407_E435_L0.8340.99
104_I108_M0.8340.99
98_F101_N0.8330.99
364_D380_G0.8300.99
329_V337_Y0.8220.98
68_I72_I0.8200.98
407_E485_K0.8190.98
308_F313_L0.8190.98
316_N320_E0.8160.98
363_V391_I0.8160.98
387_I436_T0.8130.98
371_I374_Q0.8130.98
385_V389_D0.8110.98
399_D413_F0.8110.98
288_D291_N0.8100.98
368_F372_N0.8070.98
425_A486_V0.8070.98
378_R465_S0.8060.98
352_R414_T0.8040.98
369_K405_E0.8020.98
472_D475_L0.8010.98
313_L316_N0.7990.98
382_K442_Y0.7990.98
67_L74_T0.7930.98
325_S344_N0.7930.98
328_A338_N0.7900.98
159_V163_Y0.7890.98
72_I75_L0.7850.98
300_G306_K0.7830.98
206_V209_L0.7830.98
350_L457_S0.7820.98
301_I306_K0.7810.98
175_S178_L0.7800.98
163_Y176_L0.7790.98
422_K486_V0.7780.98
302_E306_K0.7770.98
344_N400_I0.7770.98
380_G479_K0.7760.98
451_S476_R0.7750.98
394_S399_D0.7740.98
166_R175_S0.7730.98
364_D369_K0.7660.98
432_V448_M0.7630.97
364_D406_G0.7620.97
407_E436_T0.7610.97
310_V317_I0.7610.97
383_V438_F0.7610.97
63_L67_L0.7580.97
363_V411_L0.7560.97
364_D373_A0.7550.97
166_R170_F0.7540.97
270_I282_L0.7530.97
329_V341_Y0.7490.97
175_S179_F0.7490.97
408_V451_S0.7490.97
308_F311_S0.7470.97
377_H407_E0.7460.97
250_A253_L0.7460.97
335_N385_V0.7450.97
404_L407_E0.7450.97
371_I407_E0.7420.97
320_E323_L0.7410.97
178_L181_Y0.7400.97
311_S317_I0.7390.97
438_F446_E0.7390.97
302_E305_S0.7390.97
303_V310_V0.7320.97
324_S327_L0.7310.97
64_L68_I0.7310.97
303_V309_V0.7290.97
395_I424_I0.7270.97
120_P123_I0.7240.97
443_D446_E0.7230.97
253_L257_I0.7220.97
323_L326_K0.7210.96
283_L287_L0.7200.96
430_K433_E0.7200.96
322_Q325_S0.7180.96
271_A278_L0.7170.96
129_L138_T0.7170.96
281_N289_E0.7120.96
372_N406_G0.7110.96
330_H341_Y0.7080.96
278_L283_L0.7050.96
242_T249_W0.7020.96
230_P233_H0.6970.96
306_K317_I0.6970.96
451_S482_G0.6930.96
251_F255_F0.6870.95
317_I324_S0.6850.95
394_S428_M0.6850.95
362_L468_M0.6840.95
422_K488_I0.6830.95
330_H335_N0.6820.95
369_K380_G0.6810.95
342_F360_V0.6800.95
432_V436_T0.6800.95
107_F111_K0.6790.95
156_S159_V0.6790.95
362_L404_L0.6790.95
411_L428_M0.6780.95
451_S478_A0.6770.95
375_W444_V0.6750.95
416_L420_Q0.6750.95
70_F74_T0.6740.95
332_V404_L0.6740.95
365_I472_D0.6730.95
461_T466_L0.6730.95
137_E141_I0.6720.95
244_I248_L0.6720.95
284_L287_L0.6700.95
174_T181_Y0.6690.95
300_G303_V0.6690.95
281_N284_L0.6690.95
71_C74_T0.6680.95
173_L180_C0.6670.95
395_I428_M0.6660.95
302_E313_L0.6660.95
368_F479_K0.6650.95
206_V211_A0.6650.95
160_S163_Y0.6630.94
366_N484_N0.6630.94
369_K475_L0.6620.94
137_E140_V0.6620.94
161_I164_I0.6610.94
328_A369_K0.6610.94
308_F314_I0.6590.94
407_E476_R0.6570.94
466_L469_T0.6560.94
388_V391_I0.6520.94
427_R431_N0.6520.94
278_L281_N0.6520.94
274_C283_L0.6510.94
206_V210_L0.6510.94
204_F208_P0.6500.94
345_S402_A0.6500.94
165_F176_L0.6500.94
377_H380_G0.6490.94
230_P237_W0.6490.94
194_T198_L0.6480.94
209_L213_N0.6450.94
170_F178_L0.6440.94
330_H407_E0.6430.93
211_A216_S0.6430.93
365_I368_F0.6430.93
368_F478_A0.6420.93
358_F412_L0.6420.93
375_W383_V0.6410.93
378_R468_M0.6410.93
138_T141_I0.6400.93
170_F173_L0.6400.93
74_T78_E0.6400.93
167_Q171_I0.6390.93
328_A472_D0.6370.93
170_F175_S0.6370.93
245_L248_L0.6350.93
345_S412_L0.6340.93
270_I274_C0.6340.93
75_L79_N0.6340.93
275_L278_L0.6330.93
349_L353_P0.6320.93
163_Y177_A0.6300.93
366_N449_T0.6300.93
426_E486_V0.6280.93
407_E479_K0.6280.93
346_V350_L0.6270.93
390_I446_E0.6250.93
210_L216_S0.6250.93
266_L270_I0.6240.92
220_D223_L0.6230.92
438_F442_Y0.6220.92
407_E486_V0.6220.92
380_G406_G0.6220.92
237_W241_Y0.6190.92
455_V458_T0.6190.92
75_L78_E0.6190.92
64_L67_L0.6180.92
379_V446_E0.6180.92
380_G407_E0.6170.92
327_L338_N0.6170.92
176_L179_F0.6170.92
119_L122_L0.6170.92
165_F170_F0.6160.92
245_L249_W0.6160.92
425_A429_R0.6140.92
174_T180_C0.6130.92
157_N165_F0.6120.92
157_N160_S0.6080.91
307_L312_F0.6070.91
437_G445_P0.6070.91
140_V144_K0.6070.91
310_V320_E0.6060.91
72_I78_E0.6060.91
377_H475_L0.6060.91
314_I321_L0.6050.91
457_S460_D0.6040.91
460_D470_E0.6030.91
350_L464_I0.6020.91
424_I428_M0.6010.91
366_N475_L0.6000.91
361_M454_T0.6000.91
364_D483_G0.5990.91
282_L288_D0.5990.91
339_R343_F0.5970.91
394_S424_I0.5960.91
280_C284_L0.5950.91
350_L358_F0.5950.91
375_W473_K0.5950.91
383_V437_G0.5930.90
370_R407_E0.5920.90
277_S284_L0.5910.90
158_D170_F0.5900.90
235_A238_G0.5900.90
365_I469_T0.5900.90
205_L208_P0.5890.90
175_S182_G0.5890.90
164_I181_Y0.5880.90
127_A130_S0.5880.90
302_E307_L0.5880.90
265_E268_P0.5870.90
380_G476_R0.5870.90
429_R482_G0.5860.90
341_Y349_L0.5830.90
306_K311_S0.5820.90
167_Q177_A0.5810.90
66_T70_F0.5800.89
286_T290_Y0.5800.89
156_S162_F0.5780.89
360_V468_M0.5770.89
451_S479_K0.5760.89
360_V410_G0.5760.89
285_L288_D0.5760.89
278_L284_L0.5750.89
372_N377_H0.5750.89
169_S176_L0.5750.89
428_M484_N0.5750.89
419_A422_K0.5730.89
303_V314_I0.5720.89
228_Y231_D0.5720.89
249_W253_L0.5700.89
283_L290_Y0.5690.89
86_P89_N0.5690.89
272_L276_A0.5690.89
173_L177_A0.5690.89
159_V167_Q0.5670.88
280_C286_T0.5670.88
367_Q449_T0.5660.88
156_S168_L0.5660.88
258_M261_R0.5660.88
208_P212_H0.5650.88
168_L176_L0.5650.88
95_V99_F0.5640.88
253_L256_I0.5620.88
458_T467_V0.5620.88
155_K162_F0.5610.88
475_L478_A0.5610.88
306_K312_F0.5610.88
275_L279_C0.5600.88
138_T144_K0.5590.88
96_A99_F0.5590.88
276_A279_C0.5590.88
210_L213_N0.5580.88
462_R470_E0.5580.88
209_L212_H0.5580.88
437_G443_D0.5560.87
276_A284_L0.5550.87
339_R402_A0.5540.87
237_W240_N0.5530.87
470_E473_K0.5530.87
324_S329_V0.5520.87
198_L216_S0.5510.87
271_A282_L0.5510.87
206_V214_L0.5510.87
277_S280_C0.5510.87
308_F315_Y0.5500.87
167_Q208_P0.5500.87
312_F315_Y0.5500.87
103_V115_N0.5490.87
342_F468_M0.5480.87
248_L252_L0.5480.87
91_L94_V0.5470.87
320_E327_L0.5460.86
349_L412_L0.5460.86
244_I247_C0.5440.86
70_F75_L0.5420.86
195_G206_V0.5420.86
167_Q175_S0.5420.86
343_F402_A0.5410.86
353_P358_F0.5400.86
328_A336_I0.5400.86
420_Q423_I0.5380.86
131_G145_P0.5380.86
279_C282_L0.5380.86
64_L71_C0.5370.86
331_D381_D0.5370.86
332_V337_Y0.5360.85
466_L470_E0.5360.85
407_E482_G0.5360.85
390_I428_M0.5340.85
162_F174_T0.5340.85
387_I450_I0.5330.85
266_L269_L0.5330.85
106_L109_L0.5320.85
164_I175_S0.5320.85
92_M95_V0.5320.85
88_M91_L0.5300.85
234_T238_G0.5280.85
332_V338_N0.5260.84
170_F174_T0.5260.84
178_L183_K0.5250.84
329_V345_S0.5250.84
390_I394_S0.5230.84
371_I401_L0.5230.84
368_F451_S0.5230.84
270_I279_C0.5230.84
304_S311_S0.5220.84
174_T177_A0.5220.84
176_L181_Y0.5200.84
364_D403_R0.5200.84
391_I428_M0.5190.84
364_D381_D0.5180.83
451_S472_D0.5160.83
73_T78_E0.5160.83
248_L255_F0.5160.83
274_C281_N0.5150.83
359_C416_L0.5140.83
250_A254_F0.5140.83
94_V98_F0.5140.83
329_V332_V0.5130.83
231_D235_A0.5130.83
198_L209_L0.5130.83
130_S137_E0.5130.83
396_R416_L0.5130.83
400_I412_L0.5120.83
368_F407_E0.5120.83
250_A256_I0.5110.83
193_K196_I0.5110.83
196_I199_L0.5100.83
205_L214_L0.5100.83
418_S456_F0.5100.83
235_A239_I0.5090.82
194_T197_L0.5080.82
345_S414_T0.5070.82
414_T421_A0.5070.82
123_I127_A0.5070.82
81_N88_M0.5060.82
72_I76_Y0.5060.82
365_I384_L0.5060.82
271_A276_A0.5050.82
331_D339_R0.5050.82
407_E437_G0.5050.82
278_L285_L0.5030.82
212_H215_S0.5030.82
128_F131_G0.5020.82
278_L282_L0.5010.81
330_H404_L0.5010.81
158_D174_T0.5010.81
405_E479_K0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.6701 100 0.494 Contact Map
4j40A 2 0 100 0.494 Contact Map
3pjxA 1 0.3585 100 0.502 Contact Map
4rnhA 2 0.3177 100 0.508 Contact Map
3ezuA 2 0.6721 100 0.517 Contact Map
4h54A 2 0.5519 100 0.521 Contact Map
3mtkA 2 0.3238 100 0.523 Contact Map
3ignA 1 0.334 100 0.523 Contact Map
3i5cA 2 0.3931 100 0.524 Contact Map
3tvkA 1 0.334 100 0.535 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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