GREMLIN Database
YEAH - UPF0229 protein YeaH
UniProt: P76235 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13494
Length: 427 (418)
Sequences: 434 (223)
Seq/√Len: 10.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_S237_K9.1581.00
194_N208_E6.0011.00
209_E213_R4.8211.00
192_E220_R4.7161.00
402_Q416_E4.6641.00
324_M341_A4.4581.00
195_L209_E4.0130.99
254_L324_M3.7370.99
254_L341_A3.6860.98
359_E363_K3.4230.97
140_N370_R3.2950.97
199_S213_R3.2190.96
262_D265_T3.1930.96
111_G312_T3.0930.95
151_H242_R3.0360.95
323_L326_E2.9920.94
13_N16_M2.9280.93
139_Q370_R2.9120.93
318_S349_N2.6860.90
106_S111_G2.6720.90
164_I237_K2.6550.89
133_A170_L2.6260.89
10_N125_L2.3770.83
188_L216_I2.3290.82
274_I403_H2.2530.80
187_E215_E2.2290.79
366_L392_L2.2240.79
4_F124_Y2.1410.76
244_D365_L2.1360.76
302_D305_E2.1330.76
195_L216_I2.1190.75
148_Y392_L2.1110.75
325_D364_K2.0640.73
43_V291_Y2.0460.72
13_N149_K2.0240.72
139_Q413_V1.9140.67
164_I421_Q1.9000.67
138_K273_Y1.8960.66
24_R27_K1.8850.66
287_V328_V1.8630.65
131_D420_K1.8390.64
236_Y372_Y1.8360.64
119_I289_V1.8340.64
292_I324_M1.8240.63
354_S357_C1.7860.62
4_F384_T1.7550.60
341_A369_V1.6970.57
140_N144_Q1.6950.57
128_L263_Q1.6710.56
416_E419_H1.6440.55
197_I201_S1.6240.54
296_T350_W1.6060.53
205_Q209_E1.6020.53
365_L392_L1.5980.53
268_M377_I1.5940.53
105_A111_G1.5910.52
38_I285_K1.5820.52
349_N354_S1.5730.52
299_K305_E1.5630.51
186_R190_A1.5520.51
124_Y310_Q1.5460.50
214_K217_A1.5420.50
377_I404_I1.5410.50
10_N376_E1.5260.49
235_R409_D1.5230.49
51_S118_Q1.5160.49
198_I201_S1.5020.48
31_K377_I1.5010.48
140_N421_Q1.4930.48
31_K308_Y1.4730.47
308_Y316_I1.4730.47
295_H383_Q1.4700.47
46_V122_D1.4550.46
155_Y229_I1.4510.46
181_T223_I1.4380.45
80_D262_D1.4340.45
200_N226_V1.4340.45
4_F226_V1.4320.45
68_R409_D1.4250.45
121_K128_L1.4230.44
46_V274_I1.4180.44
4_F191_L1.4150.44
23_L138_K1.4060.44
194_N326_E1.4010.43
198_I220_R1.4000.43
172_N235_R1.3930.43
125_L403_H1.3820.42
252_F324_M1.3710.42
388_E391_H1.3680.42
211_R214_K1.3680.42
292_I327_V1.3620.42
92_Q327_V1.3610.42
259_G349_N1.3580.41
193_E196_A1.3540.41
4_F365_L1.3500.41
273_Y390_E1.3500.41
358_H362_A1.3500.41
122_D316_I1.3410.41
236_Y310_Q1.3410.41
208_E211_R1.3160.39
24_R259_G1.3150.39
90_R236_Y1.3080.39
119_I316_I1.3040.39
27_K71_L1.3000.39
322_K356_L1.2930.38
164_I287_V1.2920.38
311_E349_N1.2920.38
170_L378_T1.2880.38
27_K127_L1.2870.38
288_E332_Y1.2790.38
344_A414_F1.2780.38
4_F262_D1.2670.37
73_H267_D1.2550.37
248_Q333_N1.2520.37
296_T311_E1.2390.36
26_Y248_Q1.2350.36
296_T319_S1.2340.36
171_Q333_N1.2290.36
411_Y416_E1.2250.35
149_K244_D1.2200.35
169_S350_W1.2180.35
171_Q220_R1.2170.35
106_S109_G1.2160.35
155_Y158_N1.2160.35
17_V399_F1.2140.35
88_I223_I1.2130.35
295_H323_L1.2110.35
189_H193_E1.2110.35
308_Y380_R1.2100.35
221_A225_R1.2070.35
254_L328_V1.2030.34
164_I262_D1.1950.34
175_A262_D1.1910.34
308_Y312_T1.1880.34
263_Q382_H1.1800.33
190_A193_E1.1790.33
157_A235_R1.1700.33
29_Q403_H1.1620.33
377_I409_D1.1550.32
187_E190_A1.1550.32
211_R215_E1.1530.32
234_L319_S1.1460.32
121_K183_G1.1400.32
263_Q316_I1.1320.31
29_Q163_N1.1260.31
128_L380_R1.1230.31
73_H422_N1.1180.31
130_E330_E1.1170.31
378_T404_I1.1110.31
203_P368_V1.1080.30
156_T162_A1.1080.30
57_E202_E1.0980.30
350_W383_Q1.0980.30
197_I203_P1.0960.30
16_M376_E1.0920.30
285_K299_K1.0900.30
164_I351_A1.0900.30
173_S351_A1.0900.30
20_Q231_T1.0800.29
121_K163_N1.0790.29
103_G107_Q1.0760.29
20_Q24_R1.0730.29
404_I409_D1.0640.29
239_Y265_T1.0640.29
130_E236_Y1.0640.29
214_K335_A1.0630.29
12_K357_C1.0610.29
292_I380_R1.0590.28
33_S124_Y1.0550.28
324_M375_I1.0550.28
319_S390_E1.0540.28
296_T383_Q1.0500.28
47_D127_L1.0500.28
370_R403_H1.0490.28
155_Y375_I1.0480.28
20_Q84_Q1.0460.28
400_A416_E1.0450.28
178_T328_V1.0450.28
304_H308_Y1.0430.28
382_H403_H1.0410.28
29_Q297_Q1.0390.28
4_F264_S1.0390.28
34_I37_A1.0350.28
106_S110_E1.0300.27
191_L216_I1.0300.27
119_I128_L1.0270.27
299_K311_E1.0200.27
326_E335_A1.0190.27
175_A312_T1.0180.27
107_Q111_G1.0180.27
13_N58_D1.0180.27
413_V417_L1.0170.27
196_A200_N1.0150.27
43_V288_E1.0130.27
189_H289_V1.0050.26
265_T377_I0.9990.26
104_Q107_Q0.9960.26
42_S289_V0.9940.26
30_I129_F0.9930.26
182_A231_T0.9820.26
173_S384_T0.9810.26
357_C383_Q0.9750.25
48_S240_E0.9710.25
195_L228_F0.9700.25
157_A228_F0.9670.25
182_A295_H0.9660.25
5_I304_H0.9640.25
207_L364_K0.9640.25
192_E196_A0.9630.25
193_E197_I0.9620.25
295_H350_W0.9620.25
110_E288_E0.9600.25
196_A304_H0.9600.25
22_F271_R0.9590.25
126_D420_K0.9570.25
15_S309_S0.9550.25
84_Q308_Y0.9540.25
269_A376_E0.9510.24
308_Y382_H0.9510.24
29_Q120_S0.9490.24
107_Q296_T0.9470.24
139_Q144_Q0.9450.24
53_S355_P0.9420.24
89_E329_K0.9360.24
140_N262_D0.9360.24
300_E331_R0.9350.24
136_N322_K0.9350.24
196_A391_H0.9340.24
186_R197_I0.9320.24
125_L376_E0.9310.24
145_L226_V0.9300.24
220_R224_E0.9250.24
149_K364_K0.9250.24
31_K378_T0.9240.24
194_N197_I0.9230.23
164_I242_R0.9230.23
127_L236_Y0.9190.23
130_E372_Y0.9190.23
202_E288_E0.9190.23
52_V356_L0.9150.23
119_I183_G0.9100.23
30_I166_V0.9060.23
72_R333_N0.9020.23
273_Y332_Y0.8990.23
371_Y413_V0.8980.23
352_D355_P0.8970.23
357_C407_Q0.8960.23
181_T226_V0.8950.23
207_L211_R0.8900.22
200_N211_R0.8880.22
144_Q166_V0.8880.22
179_A271_R0.8880.22
105_A316_I0.8880.22
127_L370_R0.8870.22
188_L220_R0.8860.22
118_Q237_K0.8850.22
29_Q379_R0.8840.22
304_H421_Q0.8830.22
309_S344_A0.8820.22
121_K263_Q0.8810.22
28_A119_I0.8780.22
181_T322_K0.8780.22
357_C377_I0.8760.22
124_Y173_S0.8750.22
268_M407_Q0.8740.22
11_G16_M0.8720.22
17_V382_H0.8690.22
325_D329_K0.8680.22
118_Q139_Q0.8660.22
170_L232_F0.8650.22
84_Q398_N0.8650.22
32_Q236_Y0.8620.21
121_K239_Y0.8620.21
40_K50_E0.8610.21
265_T373_S0.8590.21
52_V289_V0.8590.21
39_N409_D0.8570.21
181_T184_K0.8570.21
65_H90_R0.8530.21
155_Y165_S0.8530.21
20_Q179_A0.8520.21
221_A397_D0.8520.21
12_K148_Y0.8500.21
125_L370_R0.8490.21
11_G160_V0.8460.21
187_E322_K0.8450.21
210_E394_S0.8440.21
234_L323_L0.8410.21
38_I267_D0.8400.21
66_Q240_E0.8400.21
410_I414_F0.8390.21
228_F235_R0.8380.21
74_R193_E0.8360.21
31_K366_L0.8350.21
26_Y185_R0.8340.21
31_K42_S0.8340.21
29_Q316_I0.8310.20
370_R376_E0.8300.20
402_Q421_Q0.8290.20
232_F289_V0.8280.20
16_M265_T0.8280.20
59_I95_G0.8260.20
310_Q421_Q0.8250.20
350_W357_C0.8220.20
231_T283_T0.8210.20
9_L163_N0.8210.20
36_E65_H0.8210.20
191_L199_S0.8200.20
89_E208_E0.8170.20
291_Y370_R0.8160.20
66_Q236_Y0.8130.20
356_L359_E0.8130.20
3_W288_E0.8120.20
22_F115_F0.8110.20
119_I175_A0.8110.20
120_S192_E0.8110.20
112_Q310_Q0.8060.20
128_L239_Y0.8040.20
32_Q247_S0.8030.20
369_V409_D0.8030.20
57_E203_P0.8030.20
46_V285_K0.8030.20
265_T352_D0.8020.20
112_Q224_E0.8020.20
62_P280_L0.8000.20
214_K222_K0.7980.19
52_V327_V0.7970.19
76_H140_N0.7970.19
16_M216_I0.7960.19
32_Q411_Y0.7960.19
268_M369_V0.7950.19
411_Y415_R0.7940.19
54_I194_N0.7940.19
273_Y299_K0.7920.19
92_Q333_N0.7910.19
32_Q36_E0.7870.19
147_E236_Y0.7860.19
210_E214_K0.7850.19
148_Y241_K0.7850.19
375_I387_R0.7850.19
103_G355_P0.7840.19
183_G263_Q0.7830.19
357_C399_F0.7830.19
83_V401_M0.7810.19
100_S336_Q0.7800.19
193_E372_Y0.7800.19
259_G318_S0.7800.19
386_W414_F0.7790.19
26_Y128_L0.7790.19
289_V327_V0.7770.19
31_K44_T0.7760.19
213_R330_E0.7730.19
329_K363_K0.7730.19
52_V333_N0.7720.19
202_E236_Y0.7720.19
288_E392_L0.7700.19
242_R402_Q0.7680.19
126_D387_R0.7670.19
187_E199_S0.7670.19
96_G199_S0.7670.19
316_I382_H0.7590.18
304_H356_L0.7580.18
283_T351_A0.7570.18
42_S382_H0.7530.18
24_R401_M0.7530.18
247_S398_N0.7520.18
170_L387_R0.7500.18
248_Q274_I0.7490.18
87_R330_E0.7480.18
54_I244_D0.7440.18
121_K235_R0.7440.18
120_S324_M0.7400.18
57_E368_V0.7390.18
227_P350_W0.7380.18
128_L316_I0.7360.18
32_Q420_K0.7340.18
121_K236_Y0.7340.18
386_W410_I0.7340.18
36_E409_D0.7320.18
228_F305_E0.7320.18
262_D312_T0.7310.18
162_A381_A0.7300.17
64_F217_A0.7290.17
318_S354_S0.7270.17
235_R360_I0.7250.17
366_L375_I0.7210.17
197_I207_L0.7210.17
333_N368_V0.7190.17
245_P251_M0.7190.17
163_N239_Y0.7180.17
362_A395_T0.7170.17
297_Q351_A0.7160.17
5_I52_V0.7150.17
165_S172_N0.7150.17
199_S209_E0.7140.17
70_G79_N0.7130.17
248_Q409_D0.7130.17
126_D376_E0.7110.17
128_L235_R0.7100.17
13_N366_L0.7090.17
120_S162_A0.7080.17
2_T174_L0.7070.17
105_A109_G0.7070.17
175_A265_T0.7060.17
299_K309_S0.7040.17
65_H82_F0.7030.17
183_G373_S0.6990.17
354_S383_Q0.6990.17
32_Q364_K0.6980.17
182_A323_L0.6980.17
210_E329_K0.6970.17
146_T376_E0.6960.17
122_D281_S0.6960.17
341_A384_T0.6950.17
179_A282_R0.6940.17
140_N143_R0.6940.17
21_R159_G0.6930.16
82_F403_H0.6930.16
63_M322_K0.6930.16
344_A410_I0.6920.16
11_G149_K0.6890.16
333_N402_Q0.6880.16
39_N288_E0.6880.16
4_F44_T0.6860.16
188_L416_E0.6820.16
121_K238_N0.6800.16
53_S335_A0.6790.16
120_S182_A0.6790.16
231_T403_H0.6780.16
4_F120_S0.6780.16
200_N204_A0.6770.16
119_I382_H0.6750.16
16_M130_E0.6750.16
110_E188_L0.6740.16
33_S180_M0.6710.16
165_S171_Q0.6710.16
5_I274_I0.6690.16
119_I308_Y0.6690.16
67_G82_F0.6670.16
47_D202_E0.6650.16
33_S244_D0.6640.16
41_R67_G0.6640.16
211_R363_K0.6610.16
68_R224_E0.6600.16
277_Y350_W0.6600.16
52_V361_L0.6580.16
66_Q310_Q0.6570.16
225_R372_Y0.6550.16
11_G76_H0.6550.16
130_E198_I0.6550.16
185_R189_H0.6520.15
52_V122_D0.6510.15
304_H384_T0.6500.15
52_V351_A0.6500.15
4_F366_L0.6480.15
15_S354_S0.6480.15
156_T180_M0.6480.15
182_A268_M0.6470.15
103_G156_T0.6450.15
365_L419_H0.6430.15
3_W239_Y0.6420.15
125_L212_L0.6420.15
2_T310_Q0.6420.15
263_Q299_K0.6410.15
5_I114_E0.6390.15
119_I265_T0.6380.15
287_V416_E0.6370.15
265_T378_T0.6370.15
124_Y128_L0.6350.15
201_S217_A0.6350.15
90_R141_Q0.6340.15
365_L369_V0.6340.15
31_K304_H0.6330.15
10_N308_Y0.6330.15
333_N421_Q0.6320.15
226_V395_T0.6300.15
276_L290_V0.6280.15
57_E118_Q0.6280.15
310_Q370_R0.6280.15
60_S179_A0.6280.15
27_K90_R0.6270.15
351_A384_T0.6270.15
41_R69_G0.6270.15
88_I214_K0.6270.15
9_L13_N0.6260.15
208_E335_A0.6240.15
302_D327_V0.6230.15
128_L312_T0.6230.15
116_V407_Q0.6220.15
120_S405_R0.6220.15
234_L411_Y0.6210.15
229_I327_V0.6190.15
145_L304_H0.6190.15
172_N334_P0.6170.15
119_I263_Q0.6160.15
169_S241_K0.6150.15
211_R359_E0.6140.15
31_K399_F0.6120.14
117_F342_A0.6120.14
4_F392_L0.6110.14
401_M409_D0.6100.14
174_L421_Q0.6090.14
138_K370_R0.6060.14
100_S190_A0.6000.14
29_Q274_I0.5990.14
130_E309_S0.5970.14
302_D328_V0.5950.14
93_G358_H0.5950.14
379_R403_H0.5940.14
15_S77_P0.5930.14
254_L295_H0.5920.14
173_S310_Q0.5920.14
281_S398_N0.5920.14
114_E334_P0.5890.14
244_D359_E0.5880.14
226_V326_E0.5870.14
385_L418_F0.5870.14
295_H305_E0.5850.14
90_R172_N0.5840.14
204_A362_A0.5840.14
265_T312_T0.5810.14
31_K382_H0.5810.14
74_R155_Y0.5810.14
45_D49_G0.5800.14
31_K229_I0.5790.14
162_A165_S0.5770.14
163_N183_G0.5770.14
190_A221_A0.5750.14
9_L336_Q0.5740.14
16_M378_T0.5720.14
33_S344_A0.5710.14
23_L370_R0.5710.14
54_I111_G0.5700.14
63_M372_Y0.5700.14
32_Q324_M0.5700.14
40_K46_V0.5680.13
329_K379_R0.5670.13
199_S204_A0.5650.13
2_T124_Y0.5650.13
39_N299_K0.5630.13
270_K343_Q0.5630.13
187_E193_E0.5630.13
72_R254_L0.5630.13
17_V170_L0.5630.13
48_S409_D0.5620.13
171_Q237_K0.5610.13
203_P220_R0.5600.13
380_R384_T0.5600.13
183_G244_D0.5570.13
406_D416_E0.5570.13
222_K416_E0.5570.13
50_E379_R0.5560.13
127_L140_N0.5550.13
75_V211_R0.5540.13
46_V406_D0.5530.13
107_Q140_N0.5530.13
208_E218_E0.5520.13
124_Y265_T0.5520.13
201_S214_K0.5520.13
378_T383_Q0.5520.13
274_I354_S0.5500.13
328_V409_D0.5500.13
156_T165_S0.5470.13
195_L213_R0.5460.13
171_Q278_L0.5450.13
191_L236_Y0.5440.13
350_W354_S0.5430.13
348_D417_L0.5430.13
111_G318_S0.5420.13
354_S378_T0.5400.13
2_T229_I0.5400.13
20_Q299_K0.5390.13
105_A259_G0.5390.13
328_V334_P0.5380.13
72_R167_V0.5370.13
129_F377_I0.5360.13
265_T283_T0.5350.13
185_R248_Q0.5350.13
64_F235_R0.5350.13
163_N231_T0.5340.13
360_I400_A0.5330.13
341_A375_I0.5330.13
129_F357_C0.5320.13
124_Y236_Y0.5310.13
79_N245_P0.5300.13
37_A354_S0.5300.13
47_D329_K0.5280.13
3_W148_Y0.5270.13
164_I191_L0.5270.13
126_D378_T0.5270.13
214_K218_E0.5270.13
118_Q235_R0.5270.13
122_D127_L0.5250.13
333_N359_E0.5240.13
333_N397_D0.5240.13
119_I185_R0.5230.12
26_Y263_Q0.5220.12
204_A209_E0.5210.12
7_R317_V0.5210.12
121_K352_D0.5200.12
124_Y138_K0.5190.12
88_I375_I0.5190.12
354_S407_Q0.5180.12
254_L361_L0.5170.12
66_Q358_H0.5170.12
100_S359_E0.5170.12
21_R318_S0.5160.12
169_S403_H0.5150.12
238_N246_S0.5150.12
124_Y140_N0.5150.12
254_L369_V0.5150.12
94_G198_I0.5120.12
136_N139_Q0.5110.12
344_A386_W0.5100.12
91_P96_G0.5100.12
41_R173_S0.5090.12
173_S286_N0.5080.12
186_R399_F0.5050.12
158_N372_Y0.5040.12
384_T400_A0.5020.12
173_S316_I0.5020.12
384_T388_E0.5010.12
128_L274_I0.5010.12
38_I397_D0.5000.12
31_K145_L0.5000.12
179_A401_M0.5000.12
76_H326_E0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q0pA 1 0.3607 97.7 0.958 Contact Map
1ijbA 1 0.4169 97.6 0.96 Contact Map
1atzA 1 0.4005 97.5 0.96 Contact Map
4hqfA 1 0.4215 97.5 0.96 Contact Map
2odpA 1 0.4239 97.4 0.961 Contact Map
2x31A 2 0.3911 97.3 0.962 Contact Map
4f1jA 1 0.4122 97.1 0.962 Contact Map
4okuA 2 0.3747 97 0.963 Contact Map
1n3yA 1 0.4028 97 0.963 Contact Map
4hqoA 1 0.4403 96.9 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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