GREMLIN Database
YEAE - Uncharacterized protein YeaE
UniProt: P76234 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13491
Length: 284 (258)
Sequences: 32384 (20664)
Seq/√Len: 1286.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_A250_Q3.1741.00
96_E135_K2.9641.00
31_R66_E2.8771.00
69_T103_N2.7971.00
219_H264_E2.7271.00
261_S264_E2.5141.00
95_C130_L2.4771.00
92_I129_K2.4241.00
35_V70_G2.4111.00
40_A44_L2.3371.00
92_I133_Q2.3221.00
218_A267_M2.1601.00
128_E132_A2.0741.00
106_Y137_R2.0361.00
233_S265_L2.0231.00
35_V66_E2.0161.00
182_W186_Q2.0131.00
97_A101_R1.9991.00
129_K133_Q1.9801.00
218_A264_E1.9721.00
213_N217_H1.9641.00
246_I250_Q1.9401.00
40_A246_I1.8991.00
183_C190_V1.8771.00
262_S266_A1.8721.00
18_G48_L1.8431.00
214_E267_M1.8191.00
88_G129_K1.8061.00
111_L163_T1.7761.00
44_L250_Q1.7731.00
221_I258_V1.7531.00
189_P238_M1.7271.00
132_A158_G1.7111.00
150_Q154_Q1.7001.00
129_K132_A1.6901.00
39_R71_L1.6891.00
41_G46_L1.6751.00
77_L104_T1.6681.00
150_Q182_W1.6531.00
81_V110_Y1.6411.00
35_V39_R1.6401.00
44_L253_A1.6381.00
88_G92_I1.6301.00
62_K101_R1.6301.00
39_R70_G1.6141.00
229_A258_V1.6071.00
79_S98_S1.5971.00
79_S107_L1.5911.00
92_I96_E1.5891.00
35_V67_A1.5881.00
40_A43_E1.5801.00
95_C110_Y1.5801.00
222_S251_Q1.5751.00
126_A129_K1.5601.00
211_V214_E1.5601.00
78_V111_L1.5381.00
254_A257_E1.5361.00
266_A270_K1.5321.00
81_V91_A1.5241.00
128_E159_N1.4811.00
21_T49_I1.4691.00
93_N97_A1.4651.00
7_Q13_S1.4551.00
12_V138_R1.4461.00
42_I75_V1.4461.00
111_L191_M1.4341.00
53_E94_A1.4311.00
184_Q236_G1.4271.00
31_R35_V1.4181.00
181_P185_Q1.4111.00
96_E100_R1.4051.00
153_W186_Q1.3991.00
38_L67_A1.3781.00
145_D148_D1.3771.00
107_L136_I1.3541.00
221_I225_Q1.3511.00
166_V190_V1.3431.00
229_A233_S1.3411.00
88_G125_A1.3221.00
131_I159_N1.3181.00
221_I226_V1.3171.00
39_R43_E1.3141.00
250_Q254_A1.3101.00
36_A40_A1.3011.00
138_R162_A1.2991.00
12_V76_F1.2971.00
97_A100_R1.2821.00
243_A248_H1.2681.00
267_M270_K1.2661.00
235_Q269_D1.2611.00
211_V267_M1.2581.00
178_D181_P1.2561.00
153_W182_W1.2521.00
92_I126_A1.2491.00
76_F109_L1.2461.00
222_S225_Q1.2361.00
88_G126_A1.2351.00
65_G103_N1.2291.00
102_L107_L1.2281.00
130_L136_I1.2271.00
136_I139_W1.2191.00
72_R104_T1.2181.00
243_A249_V1.2121.00
61_E98_S1.2111.00
121_E155_L1.2081.00
214_E218_A1.2031.00
66_E103_N1.1941.00
49_I64_V1.1851.00
146_Y182_W1.1851.00
33_T36_A1.1801.00
213_N223_A1.1781.00
180_L184_Q1.1741.00
90_K93_N1.1481.00
87_G90_K1.1461.00
115_S148_D1.1411.00
72_R106_Y1.1341.00
48_L78_V1.1331.00
62_K66_E1.1291.00
109_L163_T1.1221.00
122_E125_A1.1181.00
150_Q186_Q1.1161.00
89_Q93_N1.1061.00
131_I162_A1.1031.00
231_V239_A1.0941.00
247_A250_Q1.0931.00
150_Q185_Q1.0831.00
128_E131_I1.0811.00
21_T64_V1.0801.00
127_M139_W1.0791.00
48_L191_M1.0771.00
95_C107_L1.0741.00
170_L268_L1.0671.00
130_L135_K1.0641.00
167_L172_S1.0601.00
215_I226_V1.0591.00
47_T76_F1.0571.00
128_E158_G1.0471.00
173_R272_Y1.0461.00
10_G138_R1.0451.00
37_A249_V1.0441.00
36_A246_I1.0431.00
39_R67_A1.0401.00
212_V223_A1.0401.00
96_E133_Q1.0401.00
146_Y150_Q1.0371.00
210_A214_E1.0361.00
214_E217_H1.0331.00
151_E155_L1.0211.00
15_P47_T1.0101.00
225_Q254_A1.0081.00
9_S162_A1.0071.00
112_L127_M1.0061.00
42_I71_L1.0051.00
61_E101_R0.9901.00
210_A213_N0.9901.00
232_I255_V0.9791.00
108_D137_R0.9691.00
163_T191_M0.9641.00
184_Q235_Q0.9631.00
141_V161_C0.9601.00
170_L227_L0.9481.00
177_Y181_P0.9461.00
225_Q251_Q0.9421.00
121_E151_E0.9381.00
16_A256_L0.9341.00
181_P184_Q0.9331.00
86_A112_L0.9301.00
68_L75_V0.9291.00
125_A129_K0.9281.00
16_A232_I0.9271.00
130_L133_Q0.9151.00
92_I95_C0.9111.00
66_E70_G0.9101.00
251_Q254_A0.9071.00
15_P46_L0.9041.00
53_E90_K0.9011.00
249_V253_A0.8991.00
141_V149_M0.8951.00
245_T248_H0.8931.00
32_K36_A0.8911.00
88_G122_E0.8911.00
78_V191_M0.8881.00
182_W185_Q0.8871.00
126_A130_L0.8841.00
93_N96_E0.8841.00
233_S259_E0.8831.00
139_W161_C0.8831.00
62_K100_R0.8771.00
36_A39_R0.8761.00
266_A269_D0.8731.00
247_A251_Q0.8681.00
38_L49_I0.8671.00
78_V109_L0.8651.00
125_A128_E0.8551.00
85_N90_K0.8491.00
10_G162_A0.8491.00
92_I130_L0.8431.00
263_A267_M0.8421.00
215_I219_H0.8361.00
263_A266_A0.8351.00
53_E101_R0.8341.00
151_E154_Q0.8341.00
164_N183_C0.8231.00
228_L255_V0.8211.00
19_Q41_G0.8131.00
10_G131_I0.8101.00
128_E139_W0.8091.00
143_N193_Y0.8081.00
218_A261_S0.7991.00
229_A255_V0.7951.00
173_R269_D0.7931.00
149_M188_M0.7891.00
53_E97_A0.7871.00
195_P241_P0.7841.00
21_T60_A0.7801.00
53_E85_N0.7781.00
227_L231_V0.7761.00
153_W160_Q0.7701.00
40_A249_V0.7651.00
219_H261_S0.7641.00
99_L135_K0.7631.00
175_I190_V0.7611.00
233_S262_S0.7541.00
171_G209_N0.7541.00
51_T64_V0.7531.00
114_W143_N0.7501.00
79_S110_Y0.7491.00
168_Y180_L0.7471.00
146_Y178_D0.7401.00
33_T246_I0.7381.00
146_Y179_L0.7351.00
34_E63_V0.7341.00
211_V271_A0.7281.00
19_Q24_M0.7251.00
244_A248_H0.7231.00
141_V144_L0.7231.00
180_L190_V0.7191.00
18_G241_P0.7191.00
46_L253_A0.7171.00
179_L183_C0.7171.00
44_L254_A0.7151.00
192_A195_P0.7151.00
42_I49_I0.7131.00
7_Q10_G0.7091.00
124_V139_W0.7091.00
99_L104_T0.7091.00
207_L213_N0.7071.00
17_V232_I0.7051.00
95_C135_K0.7031.00
124_V152_L0.6981.00
230_W269_D0.6971.00
119_A122_E0.6921.00
224_A251_Q0.6831.00
221_I254_A0.6831.00
98_S110_Y0.6831.00
192_A239_A0.6821.00
94_A97_A0.6811.00
91_A123_T0.6761.00
221_I257_E0.6761.00
219_H226_V0.6751.00
260_L265_L0.6711.00
91_A130_L0.6711.00
128_E156_P0.6711.00
124_V161_C0.6701.00
68_L71_L0.6681.00
173_R176_E0.6671.00
168_Y237_V0.6661.00
141_V164_N0.6601.00
23_Y198_Q0.6601.00
37_A246_I0.6591.00
54_M82_Y0.6591.00
111_L140_G0.6581.00
217_H220_N0.6571.00
73_E106_Y0.6561.00
183_C188_M0.6561.00
150_Q153_W0.6551.00
231_V237_V0.6511.00
47_T74_K0.6511.00
123_T126_A0.6481.00
199_A202_L0.6461.00
38_L42_I0.6451.00
212_V268_L0.6381.00
226_V260_L0.6371.00
195_P231_V0.6341.00
173_R177_Y0.6341.00
107_L110_Y0.6311.00
248_H251_Q0.6311.00
125_A158_G0.6301.00
24_M34_E0.6301.00
42_I47_T0.6291.00
216_A226_V0.6251.00
175_I180_L0.6241.00
67_A71_L0.6221.00
86_A123_T0.6201.00
168_Y231_V0.6191.00
212_V227_L0.6191.00
22_W194_S0.6151.00
92_I135_K0.6141.00
71_L74_K0.6141.00
43_E246_I0.6111.00
91_A126_A0.6101.00
12_V137_R0.6091.00
37_A243_A0.6091.00
31_R63_V0.6081.00
44_L249_V0.6061.00
131_I136_I0.6051.00
131_I138_R0.6041.00
148_D151_E0.6031.00
127_M131_I0.5961.00
32_K35_V0.5961.00
168_Y190_V0.5961.00
95_C99_L0.5951.00
264_E267_M0.5951.00
121_E125_A0.5921.00
26_E63_V0.5881.00
50_D165_Q0.5861.00
99_L106_Y0.5861.00
226_V258_V0.5851.00
176_E181_P0.5851.00
215_I264_E0.5851.00
191_M238_M0.5851.00
24_M37_A0.5851.00
99_L107_L0.5811.00
226_V264_E0.5811.00
87_G123_T0.5781.00
194_S198_Q0.5771.00
120_F155_L0.5761.00
207_L210_A0.5761.00
9_S187_Q0.5751.00
42_I74_K0.5751.00
9_S160_Q0.5731.00
260_L264_E0.5721.00
120_F123_T0.5681.00
216_A223_A0.5631.00
205_G208_K0.5611.00
215_I267_M0.5601.00
18_G240_I0.5601.00
53_E82_Y0.5591.00
88_G91_A0.5581.00
192_A237_V0.5581.00
232_I239_A0.5581.00
225_Q258_V0.5571.00
221_I229_A0.5561.00
120_F151_E0.5511.00
168_Y173_R0.5511.00
110_Y127_M0.5501.00
110_Y136_I0.5491.00
25_G60_A0.5491.00
216_A219_H0.5491.00
132_A159_N0.5481.00
119_A123_T0.5481.00
243_A252_N0.5451.00
14_L48_L0.5431.00
43_E71_L0.5411.00
156_P159_N0.5401.00
61_E79_S0.5391.00
180_L235_Q0.5391.00
38_L64_V0.5381.00
19_Q37_A0.5371.00
99_L105_D0.5341.00
124_V156_P0.5331.00
81_V94_A0.5331.00
120_F148_D0.5291.00
95_C126_A0.5251.00
48_L76_F0.5251.00
115_S144_L0.5241.00
226_V268_L0.5231.00
147_A150_Q0.5221.00
17_V256_L0.5221.00
81_V86_A0.5211.00
153_W156_P0.5201.00
112_L123_T0.5201.00
14_L238_M0.5191.00
170_L230_W0.5181.00
80_K113_H0.5171.00
141_V152_L0.5171.00
42_I67_A0.5161.00
215_I271_A0.5131.00
66_E69_T0.5121.00
153_W188_M0.5091.00
41_G49_I0.5091.00
212_V216_A0.5061.00
7_Q189_P0.5061.00
175_I178_D0.5041.00
171_G201_R0.5041.00
64_V67_A0.5021.00
215_I218_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wghA 1 0.993 100 0.094 Contact Map
4xk2A 5 0.9754 100 0.096 Contact Map
1pyfA 1 0.9472 100 0.098 Contact Map
5c7hA 1 0.9789 100 0.102 Contact Map
1pz1A 1 0.9824 100 0.102 Contact Map
3eauA 3 0.9754 100 0.105 Contact Map
3n2tA 1 0.9754 100 0.107 Contact Map
1lqaA 2 0.9754 100 0.107 Contact Map
4r9oA 5 0.9613 100 0.109 Contact Map
3lutA 3 0.9718 100 0.114 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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