YEAE - ECOLI - GREMLIN Contacts

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YEAE - Uncharacterized protein YeaE

UniProt:	P76234	Sequences: MQQKMIQFSGDVSLPAVGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAAMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAIPKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13491
Length:	284 (258)
Sequences:	32384 (20664)
Seq/√Len:	1286.5

ECOLI - YEAE YDHF YDJG YAJO TAS GPR YDBC DKGA DKGB
BACSU - YCCK IOLS YRPG GS69 YTBE YCSN YQKF GR
HALSA - Q9HPH9 Q9HNN3 Q9HQU7 Q9HS02 Q9HSE6 Q9HQT1
SULSO - Q97UV9 Q97UG6 Q97ZZ1 Q97UJ7 Q97V56 Q97U17

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
40_A	250_Q	3.174	1.00
96_E	135_K	2.964	1.00
31_R	66_E	2.877	1.00
69_T	103_N	2.797	1.00
219_H	264_E	2.727	1.00
261_S	264_E	2.514	1.00
95_C	130_L	2.477	1.00
92_I	129_K	2.424	1.00
35_V	70_G	2.411	1.00
40_A	44_L	2.337	1.00
92_I	133_Q	2.322	1.00
218_A	267_M	2.160	1.00
128_E	132_A	2.074	1.00
106_Y	137_R	2.036	1.00
233_S	265_L	2.023	1.00
35_V	66_E	2.016	1.00
182_W	186_Q	2.013	1.00
97_A	101_R	1.999	1.00
129_K	133_Q	1.980	1.00
218_A	264_E	1.972	1.00
213_N	217_H	1.964	1.00
246_I	250_Q	1.940	1.00
40_A	246_I	1.899	1.00
183_C	190_V	1.877	1.00
262_S	266_A	1.872	1.00
18_G	48_L	1.843	1.00
214_E	267_M	1.819	1.00
88_G	129_K	1.806	1.00
111_L	163_T	1.776	1.00
44_L	250_Q	1.773	1.00
221_I	258_V	1.753	1.00
189_P	238_M	1.727	1.00
132_A	158_G	1.711	1.00
150_Q	154_Q	1.700	1.00
129_K	132_A	1.690	1.00
39_R	71_L	1.689	1.00
41_G	46_L	1.675	1.00
77_L	104_T	1.668	1.00
150_Q	182_W	1.653	1.00
81_V	110_Y	1.641	1.00
35_V	39_R	1.640	1.00
44_L	253_A	1.638	1.00
88_G	92_I	1.630	1.00
62_K	101_R	1.630	1.00
39_R	70_G	1.614	1.00
229_A	258_V	1.607	1.00
79_S	98_S	1.597	1.00
79_S	107_L	1.591	1.00
92_I	96_E	1.589	1.00
35_V	67_A	1.588	1.00
40_A	43_E	1.580	1.00
95_C	110_Y	1.580	1.00
222_S	251_Q	1.575	1.00
126_A	129_K	1.560	1.00
211_V	214_E	1.560	1.00
78_V	111_L	1.538	1.00
254_A	257_E	1.536	1.00
266_A	270_K	1.532	1.00
81_V	91_A	1.524	1.00
128_E	159_N	1.481	1.00
21_T	49_I	1.469	1.00
93_N	97_A	1.465	1.00
7_Q	13_S	1.455	1.00
12_V	138_R	1.446	1.00
42_I	75_V	1.446	1.00
111_L	191_M	1.434	1.00
53_E	94_A	1.431	1.00
184_Q	236_G	1.427	1.00
31_R	35_V	1.418	1.00
181_P	185_Q	1.411	1.00
96_E	100_R	1.405	1.00
153_W	186_Q	1.399	1.00
38_L	67_A	1.378	1.00
145_D	148_D	1.377	1.00
107_L	136_I	1.354	1.00
221_I	225_Q	1.351	1.00
166_V	190_V	1.343	1.00
229_A	233_S	1.341	1.00
88_G	125_A	1.322	1.00
131_I	159_N	1.318	1.00
221_I	226_V	1.317	1.00
39_R	43_E	1.314	1.00
250_Q	254_A	1.310	1.00
36_A	40_A	1.301	1.00
138_R	162_A	1.299	1.00
12_V	76_F	1.297	1.00
97_A	100_R	1.282	1.00
243_A	248_H	1.268	1.00
267_M	270_K	1.266	1.00
235_Q	269_D	1.261	1.00
211_V	267_M	1.258	1.00
178_D	181_P	1.256	1.00
153_W	182_W	1.252	1.00
92_I	126_A	1.249	1.00
76_F	109_L	1.246	1.00
222_S	225_Q	1.236	1.00
88_G	126_A	1.235	1.00
65_G	103_N	1.229	1.00
102_L	107_L	1.228	1.00
130_L	136_I	1.227	1.00
136_I	139_W	1.219	1.00
72_R	104_T	1.218	1.00
243_A	249_V	1.212	1.00
61_E	98_S	1.211	1.00
121_E	155_L	1.208	1.00
214_E	218_A	1.203	1.00
66_E	103_N	1.194	1.00
49_I	64_V	1.185	1.00
146_Y	182_W	1.185	1.00
33_T	36_A	1.180	1.00
213_N	223_A	1.178	1.00
180_L	184_Q	1.174	1.00
90_K	93_N	1.148	1.00
87_G	90_K	1.146	1.00
115_S	148_D	1.141	1.00
72_R	106_Y	1.134	1.00
48_L	78_V	1.133	1.00
62_K	66_E	1.129	1.00
109_L	163_T	1.122	1.00
122_E	125_A	1.118	1.00
150_Q	186_Q	1.116	1.00
89_Q	93_N	1.106	1.00
131_I	162_A	1.103	1.00
231_V	239_A	1.094	1.00
247_A	250_Q	1.093	1.00
150_Q	185_Q	1.083	1.00
128_E	131_I	1.081	1.00
21_T	64_V	1.080	1.00
127_M	139_W	1.079	1.00
48_L	191_M	1.077	1.00
95_C	107_L	1.074	1.00
170_L	268_L	1.067	1.00
130_L	135_K	1.064	1.00
167_L	172_S	1.060	1.00
215_I	226_V	1.059	1.00
47_T	76_F	1.057	1.00
128_E	158_G	1.047	1.00
173_R	272_Y	1.046	1.00
10_G	138_R	1.045	1.00
37_A	249_V	1.044	1.00
36_A	246_I	1.043	1.00
39_R	67_A	1.040	1.00
212_V	223_A	1.040	1.00
96_E	133_Q	1.040	1.00
146_Y	150_Q	1.037	1.00
210_A	214_E	1.036	1.00
214_E	217_H	1.033	1.00
151_E	155_L	1.021	1.00
15_P	47_T	1.010	1.00
225_Q	254_A	1.008	1.00
9_S	162_A	1.007	1.00
112_L	127_M	1.006	1.00
42_I	71_L	1.005	1.00
61_E	101_R	0.990	1.00
210_A	213_N	0.990	1.00
232_I	255_V	0.979	1.00
108_D	137_R	0.969	1.00
163_T	191_M	0.964	1.00
184_Q	235_Q	0.963	1.00
141_V	161_C	0.960	1.00
170_L	227_L	0.948	1.00
177_Y	181_P	0.946	1.00
225_Q	251_Q	0.942	1.00
121_E	151_E	0.938	1.00
16_A	256_L	0.934	1.00
181_P	184_Q	0.933	1.00
86_A	112_L	0.930	1.00
68_L	75_V	0.929	1.00
125_A	129_K	0.928	1.00
16_A	232_I	0.927	1.00
130_L	133_Q	0.915	1.00
92_I	95_C	0.911	1.00
66_E	70_G	0.910	1.00
251_Q	254_A	0.907	1.00
15_P	46_L	0.904	1.00
53_E	90_K	0.901	1.00
249_V	253_A	0.899	1.00
141_V	149_M	0.895	1.00
245_T	248_H	0.893	1.00
32_K	36_A	0.891	1.00
88_G	122_E	0.891	1.00
78_V	191_M	0.888	1.00
182_W	185_Q	0.887	1.00
126_A	130_L	0.884	1.00
93_N	96_E	0.884	1.00
233_S	259_E	0.883	1.00
139_W	161_C	0.883	1.00
62_K	100_R	0.877	1.00
36_A	39_R	0.876	1.00
266_A	269_D	0.873	1.00
247_A	251_Q	0.868	1.00
38_L	49_I	0.867	1.00
78_V	109_L	0.865	1.00
125_A	128_E	0.855	1.00
85_N	90_K	0.849	1.00
10_G	162_A	0.849	1.00
92_I	130_L	0.843	1.00
263_A	267_M	0.842	1.00
215_I	219_H	0.836	1.00
263_A	266_A	0.835	1.00
53_E	101_R	0.834	1.00
151_E	154_Q	0.834	1.00
164_N	183_C	0.823	1.00
228_L	255_V	0.821	1.00
19_Q	41_G	0.813	1.00
10_G	131_I	0.810	1.00
128_E	139_W	0.809	1.00
143_N	193_Y	0.808	1.00
218_A	261_S	0.799	1.00
229_A	255_V	0.795	1.00
173_R	269_D	0.793	1.00
149_M	188_M	0.789	1.00
53_E	97_A	0.787	1.00
195_P	241_P	0.784	1.00
21_T	60_A	0.780	1.00
53_E	85_N	0.778	1.00
227_L	231_V	0.776	1.00
153_W	160_Q	0.770	1.00
40_A	249_V	0.765	1.00
219_H	261_S	0.764	1.00
99_L	135_K	0.763	1.00
175_I	190_V	0.761	1.00
233_S	262_S	0.754	1.00
171_G	209_N	0.754	1.00
51_T	64_V	0.753	1.00
114_W	143_N	0.750	1.00
79_S	110_Y	0.749	1.00
168_Y	180_L	0.747	1.00
146_Y	178_D	0.740	1.00
33_T	246_I	0.738	1.00
146_Y	179_L	0.735	1.00
34_E	63_V	0.734	1.00
211_V	271_A	0.728	1.00
19_Q	24_M	0.725	1.00
244_A	248_H	0.723	1.00
141_V	144_L	0.723	1.00
180_L	190_V	0.719	1.00
18_G	241_P	0.719	1.00
46_L	253_A	0.717	1.00
179_L	183_C	0.717	1.00
44_L	254_A	0.715	1.00
192_A	195_P	0.715	1.00
42_I	49_I	0.713	1.00
7_Q	10_G	0.709	1.00
124_V	139_W	0.709	1.00
99_L	104_T	0.709	1.00
207_L	213_N	0.707	1.00
17_V	232_I	0.705	1.00
95_C	135_K	0.703	1.00
124_V	152_L	0.698	1.00
230_W	269_D	0.697	1.00
119_A	122_E	0.692	1.00
224_A	251_Q	0.683	1.00
221_I	254_A	0.683	1.00
98_S	110_Y	0.683	1.00
192_A	239_A	0.682	1.00
94_A	97_A	0.681	1.00
91_A	123_T	0.676	1.00
221_I	257_E	0.676	1.00
219_H	226_V	0.675	1.00
260_L	265_L	0.671	1.00
91_A	130_L	0.671	1.00
128_E	156_P	0.671	1.00
124_V	161_C	0.670	1.00
68_L	71_L	0.668	1.00
173_R	176_E	0.667	1.00
168_Y	237_V	0.666	1.00
141_V	164_N	0.660	1.00
23_Y	198_Q	0.660	1.00
37_A	246_I	0.659	1.00
54_M	82_Y	0.659	1.00
111_L	140_G	0.658	1.00
217_H	220_N	0.657	1.00
73_E	106_Y	0.656	1.00
183_C	188_M	0.656	1.00
150_Q	153_W	0.655	1.00
231_V	237_V	0.651	1.00
47_T	74_K	0.651	1.00
123_T	126_A	0.648	1.00
199_A	202_L	0.646	1.00
38_L	42_I	0.645	1.00
212_V	268_L	0.638	1.00
226_V	260_L	0.637	1.00
195_P	231_V	0.634	1.00
173_R	177_Y	0.634	1.00
107_L	110_Y	0.631	1.00
248_H	251_Q	0.631	1.00
125_A	158_G	0.630	1.00
24_M	34_E	0.630	1.00
42_I	47_T	0.629	1.00
216_A	226_V	0.625	1.00
175_I	180_L	0.624	1.00
67_A	71_L	0.622	1.00
86_A	123_T	0.620	1.00
168_Y	231_V	0.619	1.00
212_V	227_L	0.619	1.00
22_W	194_S	0.615	1.00
92_I	135_K	0.614	1.00
71_L	74_K	0.614	1.00
43_E	246_I	0.611	1.00
91_A	126_A	0.610	1.00
12_V	137_R	0.609	1.00
37_A	243_A	0.609	1.00
31_R	63_V	0.608	1.00
44_L	249_V	0.606	1.00
131_I	136_I	0.605	1.00
131_I	138_R	0.604	1.00
148_D	151_E	0.603	1.00
127_M	131_I	0.596	1.00
32_K	35_V	0.596	1.00
168_Y	190_V	0.596	1.00
95_C	99_L	0.595	1.00
264_E	267_M	0.595	1.00
121_E	125_A	0.592	1.00
26_E	63_V	0.588	1.00
50_D	165_Q	0.586	1.00
99_L	106_Y	0.586	1.00
226_V	258_V	0.585	1.00
176_E	181_P	0.585	1.00
215_I	264_E	0.585	1.00
191_M	238_M	0.585	1.00
24_M	37_A	0.585	1.00
99_L	107_L	0.581	1.00
226_V	264_E	0.581	1.00
87_G	123_T	0.578	1.00
194_S	198_Q	0.577	1.00
120_F	155_L	0.576	1.00
207_L	210_A	0.576	1.00
9_S	187_Q	0.575	1.00
42_I	74_K	0.575	1.00
9_S	160_Q	0.573	1.00
260_L	264_E	0.572	1.00
120_F	123_T	0.568	1.00
216_A	223_A	0.563	1.00
205_G	208_K	0.561	1.00
215_I	267_M	0.560	1.00
18_G	240_I	0.560	1.00
53_E	82_Y	0.559	1.00
88_G	91_A	0.558	1.00
192_A	237_V	0.558	1.00
232_I	239_A	0.558	1.00
225_Q	258_V	0.557	1.00
221_I	229_A	0.556	1.00
120_F	151_E	0.551	1.00
168_Y	173_R	0.551	1.00
110_Y	127_M	0.550	1.00
110_Y	136_I	0.549	1.00
25_G	60_A	0.549	1.00
216_A	219_H	0.549	1.00
132_A	159_N	0.548	1.00
119_A	123_T	0.548	1.00
243_A	252_N	0.545	1.00
14_L	48_L	0.543	1.00
43_E	71_L	0.541	1.00
156_P	159_N	0.540	1.00
61_E	79_S	0.539	1.00
180_L	235_Q	0.539	1.00
38_L	64_V	0.538	1.00
19_Q	37_A	0.537	1.00
99_L	105_D	0.534	1.00
124_V	156_P	0.533	1.00
81_V	94_A	0.533	1.00
120_F	148_D	0.529	1.00
95_C	126_A	0.525	1.00
48_L	76_F	0.525	1.00
115_S	144_L	0.524	1.00
226_V	268_L	0.523	1.00
147_A	150_Q	0.522	1.00
17_V	256_L	0.522	1.00
81_V	86_A	0.521	1.00
153_W	156_P	0.520	1.00
112_L	123_T	0.520	1.00
14_L	238_M	0.519	1.00
170_L	230_W	0.518	1.00
80_K	113_H	0.517	1.00
141_V	152_L	0.517	1.00
42_I	67_A	0.516	1.00
215_I	271_A	0.513	1.00
66_E	69_T	0.512	1.00
153_W	188_M	0.509	1.00
41_G	49_I	0.509	1.00
212_V	216_A	0.506	1.00
7_Q	189_P	0.506	1.00
175_I	178_D	0.504	1.00
171_G	201_R	0.504	1.00
64_V	67_A	0.502	1.00
215_I	218_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wghA	1	0.993	100	0.094	Contact Map
4xk2A	5	0.9754	100	0.096	Contact Map
1pyfA	1	0.9472	100	0.098	Contact Map
5c7hA	1	0.9789	100	0.102	Contact Map
1pz1A	1	0.9824	100	0.102	Contact Map
3eauA	3	0.9754	100	0.105	Contact Map
3n2tA	1	0.9754	100	0.107	Contact Map
1lqaA	2	0.9754	100	0.107	Contact Map
4r9oA	5	0.9613	100	0.109	Contact Map
3lutA	3	0.9718	100	0.114	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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