GREMLIN Database
YEAC - Uncharacterized protein YeaC
UniProt: P76231 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13489
Length: 90 (85)
Sequences: 189 (111)
Seq/√Len: 12.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_D68_V3.4760.98
17_R28_P2.9530.95
35_E39_E2.5490.90
20_T24_L2.5090.89
16_Q19_S2.3110.85
3_L47_L2.2830.84
7_I74_Q2.0490.77
10_M14_V2.0380.76
73_Q77_E2.0000.75
53_N56_A1.9560.73
16_Q36_E1.9410.73
33_L45_V1.7820.66
39_E50_A1.7570.65
24_L63_T1.7250.63
74_Q77_E1.6680.60
18_L79_F1.6570.60
10_M29_D1.5680.55
13_E61_I1.5670.55
51_R79_F1.5450.54
14_V29_D1.4800.51
42_L75_L1.4360.49
58_H75_L1.3980.47
22_V41_C1.3890.46
50_A68_V1.3710.46
75_L79_F1.3380.44
7_I14_V1.3230.43
67_M76_K1.3100.43
4_D7_I1.2940.42
10_M42_L1.2250.38
10_M15_Y1.2020.37
23_E40_N1.1770.36
82_S85_P1.1730.36
2_N5_D1.1670.36
46_M63_T1.1440.35
59_M70_K1.1390.34
23_E58_H1.1180.33
56_A69_M1.0890.32
50_A60_T1.0670.31
29_D39_E1.0580.31
57_Q61_I1.0450.30
40_N44_L1.0180.29
24_L51_R1.0070.29
15_Y70_K0.9920.28
54_I63_T0.9790.28
3_L39_E0.9760.27
22_V58_H0.9680.27
5_D44_L0.9380.26
8_N35_E0.9290.26
3_L86_I0.9260.25
3_L48_W0.9100.25
40_N61_I0.9020.25
26_K51_R0.8850.24
16_Q34_T0.8780.24
72_K79_F0.8650.23
38_K41_C0.8630.23
18_L78_D0.8620.23
76_K79_F0.8570.23
50_A56_A0.8470.23
57_Q82_S0.8440.22
41_C77_E0.8380.22
78_D81_I0.8370.22
10_M59_M0.8270.22
18_L38_K0.8260.22
6_I10_M0.8260.22
11_M59_M0.8220.22
31_V38_K0.8030.21
17_R29_D0.8000.21
45_V71_S0.7860.20
8_N60_T0.7800.20
13_E35_E0.7700.20
3_L62_D0.7690.20
15_Y42_L0.7680.20
46_M61_I0.7680.20
54_I57_Q0.7590.20
60_T80_G0.7490.19
41_C59_M0.7430.19
36_E40_N0.7400.19
11_M47_L0.7310.19
35_E41_C0.7250.19
31_V40_N0.7230.19
14_V40_N0.7160.18
74_Q78_D0.7120.18
21_A42_L0.7060.18
32_A40_N0.7020.18
57_Q76_K0.7000.18
44_L51_R0.6960.18
51_R72_K0.6790.17
14_V47_L0.6760.17
9_S12_P0.6630.17
9_S26_K0.6560.17
44_L87_A0.6560.17
3_L26_K0.6520.16
4_D41_C0.6430.16
9_S44_L0.6420.16
63_T69_M0.6290.16
3_L50_A0.6260.16
7_I50_A0.6240.16
61_I78_D0.6240.16
35_E86_I0.6190.16
66_Q87_A0.6130.15
2_N19_S0.5990.15
75_L78_D0.5980.15
24_L36_E0.5970.15
50_A55_E0.5930.15
1_M4_D0.5880.15
54_I60_T0.5810.15
34_T39_E0.5810.15
20_T23_E0.5810.15
9_S14_V0.5770.14
68_V71_S0.5750.14
36_E85_P0.5720.14
77_E85_P0.5710.14
50_A54_I0.5690.14
62_D69_M0.5680.14
20_T36_E0.5660.14
5_D60_T0.5640.14
33_L38_K0.5600.14
6_I38_K0.5550.14
53_N69_M0.5530.14
10_M21_A0.5500.14
13_E45_V0.5430.14
17_R72_K0.5260.13
39_E57_Q0.5250.13
9_S70_K0.5220.13
47_L58_H0.5200.13
50_A53_N0.5080.13
2_N9_S0.5060.13
71_S74_Q0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sxyA 2 0.7556 25.4 0.93 Contact Map
3o6xA 3 0.8444 24.2 0.931 Contact Map
4p96A 2 0.9111 19.8 0.934 Contact Map
2di3A 2 0.8444 17.3 0.935 Contact Map
1vfrA 2 0.8889 15.8 0.936 Contact Map
2hs5A 1 0.7778 11.7 0.94 Contact Map
1k1xA 2 0.6778 11.5 0.94 Contact Map
1hw1A 2 0.8778 11 0.941 Contact Map
4tv7A 2 0.8556 10.8 0.941 Contact Map
3c7jA 4 0.9111 10.5 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0047 seconds.