GREMLIN Database
YNJF - Inner membrane protein YnjF
UniProt: P76226 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14008
Length: 206 (183)
Sequences: 2399 (1716)
Seq/√Len: 126.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_T30_G5.1591.00
22_D71_L4.1801.00
26_I34_V3.3001.00
20_V24_P3.2051.00
28_P77_L3.1731.00
36_F88_L2.9481.00
91_L186_W2.8831.00
39_G92_F2.6711.00
18_V74_R2.5001.00
80_A197_Y2.4771.00
21_L26_I2.3761.00
45_F57_V2.2871.00
70_A74_R2.2211.00
31_L71_L2.1771.00
46_L168_C2.1141.00
43_L99_G2.0721.00
33_L84_L1.9711.00
167_G177_F1.9631.00
22_D75_R1.9061.00
29_D80_A1.8331.00
125_S186_W1.7831.00
18_V71_L1.7821.00
65_D85_D1.7771.00
19_R74_R1.7631.00
40_V95_L1.7271.00
188_T192_R1.7131.00
129_F133_A1.6821.00
91_L125_S1.6631.00
166_L170_F1.6221.00
130_A133_A1.6191.00
90_F93_Y1.6171.00
163_L177_F1.5791.00
194_W197_Y1.5731.00
82_G135_K1.5721.00
21_L67_L1.5481.00
28_P71_L1.4461.00
130_A136_H1.4421.00
45_F53_A1.4241.00
43_L95_L1.3991.00
46_L99_G1.3881.00
11_K70_A1.3841.00
183_A187_M1.3701.00
131_A134_A1.3441.00
52_L56_V1.3311.00
47_A99_G1.3081.00
18_V70_A1.2931.00
181_F185_C1.2881.00
31_L67_L1.2871.00
155_T184_L1.2821.00
37_A41_L1.2801.00
35_G64_L1.2721.00
16_Q20_V1.2711.00
20_V23_K1.2381.00
115_L118_A1.2321.00
83_F193_V1.2280.99
19_R23_K1.2260.99
27_T71_L1.2140.99
114_W182_G1.2050.99
93_Y160_T1.2000.99
194_W198_L1.1930.99
99_G103_A1.1930.99
86_I160_T1.1890.99
39_G61_N1.1850.99
38_I57_V1.1820.99
155_T163_L1.1780.99
46_L54_A1.1700.99
42_A57_V1.1660.99
41_L57_V1.1480.99
153_G188_T1.1460.99
174_F178_A1.1440.99
14_L70_A1.1410.99
55_L165_V1.1380.99
45_F50_W1.1370.99
44_P47_A1.1290.99
21_L24_P1.1140.99
173_W176_W1.1040.99
33_L37_A1.0990.99
90_F160_T1.0980.99
90_F157_G1.0960.99
42_A96_V1.0960.99
59_L62_R1.0920.99
119_F178_A1.0810.99
67_L70_A1.0720.99
50_W53_A1.0690.99
47_A102_L1.0640.99
116_L119_F1.0480.98
12_P16_Q1.0430.98
101_I112_G1.0420.98
87_S132_L1.0400.98
86_I133_A1.0390.98
163_L167_G1.0280.98
62_R157_G1.0220.98
149_Y152_G1.0050.98
93_Y157_G0.9930.98
180_I184_L0.9860.98
48_L51_Y0.9700.97
179_W183_A0.9680.97
127_L130_A0.9670.97
66_G158_T0.9660.97
187_M191_T0.9610.97
28_P46_L0.9510.97
20_V41_L0.9470.97
46_L103_A0.9390.97
45_F48_L0.9340.97
17_C67_L0.9330.97
38_I64_L0.9230.96
121_G125_S0.9220.96
59_L63_L0.9200.96
176_W179_W0.9200.96
85_D157_G0.9200.96
90_F131_A0.9170.96
41_L45_F0.9160.96
157_G160_T0.9110.96
190_F194_W0.9030.96
153_G192_R0.8980.96
148_F199_T0.8960.96
155_T181_F0.8910.96
62_R66_G0.8910.96
122_T125_S0.8820.95
32_T88_L0.8810.95
131_A135_K0.8780.95
7_H11_K0.8760.95
188_T191_T0.8760.95
38_I61_N0.8720.95
61_N85_D0.8590.95
94_A128_A0.8540.94
182_G186_W0.8520.94
153_G159_E0.8470.94
86_I135_K0.8470.94
16_Q19_R0.8390.94
78_T167_G0.8380.94
91_L128_A0.8240.93
186_W189_T0.8220.93
144_A147_S0.8190.93
192_R196_G0.8180.93
83_F132_L0.8070.93
133_A151_L0.8070.93
7_H18_V0.8060.93
154_L159_E0.8020.92
13_L16_Q0.8010.92
53_A57_V0.7940.92
30_G34_V0.7940.92
82_G147_S0.7910.92
126_F131_A0.7860.92
174_F180_I0.7840.92
175_A178_A0.7810.91
126_F129_F0.7810.91
51_Y103_A0.7630.90
100_F174_F0.7620.90
82_G86_I0.7610.90
101_I114_W0.7570.90
125_S130_A0.7560.90
15_H74_R0.7550.90
10_I158_T0.7530.90
42_A46_L0.7530.90
172_A180_I0.7490.90
112_G115_L0.7470.89
61_N92_F0.7440.89
158_T162_L0.7430.89
100_F103_A0.7410.89
26_I30_G0.7400.89
177_F181_F0.7400.89
175_A179_W0.7390.89
129_F188_T0.7370.89
94_A127_L0.7320.89
61_N65_D0.7300.88
65_D157_G0.7250.88
29_D197_Y0.7200.88
130_A134_A0.7190.88
187_M190_F0.7190.88
84_L88_L0.7190.88
58_I66_G0.7170.87
59_L165_V0.7120.87
129_F135_K0.7110.87
83_F144_A0.7090.87
29_D77_L0.6990.86
172_A175_A0.6980.86
36_F91_L0.6970.86
154_L157_G0.6960.86
24_P75_R0.6930.86
144_A150_Y0.6920.86
91_L189_T0.6900.85
11_K18_V0.6870.85
11_K15_H0.6860.85
54_A168_C0.6790.85
83_F196_G0.6770.84
14_L66_G0.6750.84
61_N157_G0.6670.83
51_Y99_G0.6640.83
126_F133_A0.6590.83
174_F177_F0.6580.83
121_G186_W0.6580.83
114_W118_A0.6550.82
52_L169_L0.6540.82
29_D194_W0.6520.82
91_L131_A0.6470.82
65_D86_I0.6470.82
62_R159_E0.6450.81
163_L181_F0.6390.81
90_F192_R0.6380.81
119_F122_T0.6310.80
85_D154_L0.6310.80
136_H196_G0.6310.80
62_R90_F0.6300.80
62_R165_V0.6300.80
156_E159_E0.6240.79
82_G146_K0.6210.79
42_A58_I0.6210.79
144_A148_F0.6210.79
195_S199_T0.6170.78
173_W182_G0.6160.78
108_N113_G0.6150.78
30_G79_D0.6130.78
179_W190_F0.6090.78
114_W179_W0.6080.77
66_G159_E0.6070.77
9_R12_P0.6060.77
151_L156_E0.6030.77
128_A133_A0.6010.77
182_G185_C0.6000.77
41_L56_V0.5980.76
133_A156_E0.5980.76
115_L119_F0.5960.76
10_I14_L0.5940.76
153_G158_T0.5930.76
64_L67_L0.5890.75
48_L53_A0.5820.74
8_P12_P0.5820.74
167_G170_F0.5810.74
165_V168_C0.5800.74
46_L164_F0.5780.74
185_C188_T0.5770.74
55_L169_L0.5760.74
41_L102_L0.5740.73
42_A45_F0.5720.73
157_G161_I0.5710.73
28_P173_W0.5660.72
172_A179_W0.5640.72
86_I156_E0.5560.71
131_A136_H0.5560.71
15_H19_R0.5530.71
34_V38_I0.5490.70
32_T58_I0.5490.70
61_N86_I0.5440.69
41_L44_P0.5430.69
123_G130_A0.5430.69
64_L78_T0.5400.69
65_D154_L0.5360.68
86_I157_G0.5340.68
130_A154_L0.5330.68
124_S127_L0.5320.68
10_I66_G0.5320.68
51_Y54_A0.5310.67
19_R169_L0.5300.67
80_A83_F0.5290.67
175_A183_A0.5290.67
36_F40_V0.5280.67
56_V60_L0.5270.67
78_T159_E0.5250.67
118_A121_G0.5200.66
10_I70_A0.5180.66
86_I90_F0.5180.66
27_T77_L0.5170.65
54_A100_F0.5150.65
193_V196_G0.5130.65
11_K14_L0.5120.65
146_K150_Y0.5110.65
86_I93_Y0.5100.64
87_S193_V0.5060.64
12_P23_K0.5040.63
177_F180_I0.5040.63
58_I61_N0.5030.63
122_T130_A0.5010.63
7_H35_G0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6mA 2 0.932 100 0.362 Contact Map
4mndA 2 0.8981 99.9 0.453 Contact Map
4tq3A 1 0.8738 15.4 0.94 Contact Map
4od4A 1 0.9175 14.5 0.941 Contact Map
4leuA 1 0.335 10.4 0.944 Contact Map
4bw5A 2 0.5534 4.9 0.952 Contact Map
4twkA 2 0.5728 3.8 0.955 Contact Map
3j1rA 5 0.1262 3.7 0.955 Contact Map
4bwzA 2 0.8932 3.5 0.956 Contact Map
2gfpA 2 0.8058 3.4 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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