GREMLIN Database
YNJC - Inner membrane ABC transporter permease protein YnjC
UniProt: P76224 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14005
Length: 511 (464)
Sequences: 4195 (3024)
Seq/√Len: 140.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
307_Q311_N5.8801.00
15_A23_P5.4211.00
410_A420_I5.3381.00
169_S412_T4.3771.00
67_G140_A4.0991.00
167_L177_C3.9511.00
419_K422_F3.7311.00
63_I136_G3.5421.00
295_V299_V3.3381.00
65_A194_M3.2771.00
175_W179_N3.2231.00
299_V303_I3.2151.00
316_I320_T3.1901.00
398_A432_P3.0871.00
15_A22_A3.0771.00
176_Q180_W3.0761.00
63_I132_G3.0701.00
23_P41_W2.9241.00
15_A19_V2.9061.00
318_S445_I2.7771.00
170_L413_L2.7451.00
328_I384_L2.7281.00
55_L59_V2.7221.00
327_F437_F2.6611.00
72_A147_L2.6161.00
419_K423_Y2.6151.00
173_S176_Q2.5701.00
415_W419_K2.4841.00
415_W423_Y2.4331.00
87_R91_R2.3231.00
300_L303_I2.3031.00
19_V23_P2.2721.00
326_T437_F2.2571.00
416_S419_K2.2471.00
287_A291_P2.2171.00
81_P164_V2.1761.00
165_I408_L2.1601.00
69_L194_M2.1551.00
159_W162_Q2.1531.00
15_A18_A2.1171.00
205_V224_W2.0961.00
172_Y415_W2.0931.00
324_V380_V2.0731.00
147_L197_I2.0691.00
291_P295_V2.0181.00
59_V132_G1.9961.00
176_Q179_N1.9591.00
132_G136_G1.9271.00
180_W423_Y1.9251.00
18_A23_P1.9211.00
492_I496_T1.8971.00
147_L151_L1.8861.00
254_L258_L1.8631.00
171_G414_G1.8531.00
72_A151_L1.8401.00
275_K280_L1.8361.00
51_P55_L1.8151.00
61_T198_V1.8101.00
288_I292_L1.8041.00
474_S477_I1.7941.00
73_L151_L1.7821.00
172_Y180_W1.7691.00
234_Q237_K1.7491.00
299_V302_A1.7341.00
410_A415_W1.7291.00
167_L181_L1.6711.00
166_V409_I1.6451.00
147_L193_A1.6451.00
333_L391_M1.6381.00
325_A444_G1.6361.00
23_P26_P1.6351.00
73_L186_V1.6321.00
320_T324_V1.6111.00
295_V303_I1.6061.00
164_V182_L1.5971.00
52_Q55_L1.5851.00
174_R177_C1.5631.00
282_P295_V1.5621.00
53_A222_I1.5591.00
154_V189_A1.5551.00
289_F293_T1.5451.00
120_Y124_F1.5441.00
41_W243_L1.5301.00
68_A140_A1.5251.00
302_A306_D1.5121.00
284_N299_V1.5061.00
172_Y176_Q1.4911.00
298_V302_A1.4851.00
292_L299_V1.4781.00
300_L483_L1.4771.00
291_P299_V1.4621.00
136_G140_A1.4551.00
168_D411_Q1.4471.00
323_L327_F1.4411.00
107_A138_T1.4411.00
251_A255_L1.4391.00
67_G136_G1.4381.00
57_T202_L1.4321.00
334_L433_V1.4281.00
282_P299_V1.4191.00
15_A26_P1.4141.00
322_G326_T1.4111.00
417_R420_I1.4021.00
60_S132_G1.3891.00
295_V306_D1.3831.00
56_A216_P1.3801.00
320_T323_L1.3761.00
274_R279_P1.3711.00
16_M20_I1.3521.00
273_V279_P1.3481.00
295_V300_L1.3381.00
402_I429_M1.3371.00
489_P492_I1.3321.00
258_L261_R1.3321.00
15_A20_I1.3321.00
288_I300_L1.3321.00
321_M380_V1.3271.00
288_I303_I1.3261.00
164_V177_C1.3191.00
418_A422_F1.3151.00
70_L74_L1.3111.00
288_I291_P1.3081.00
282_P303_I1.3021.00
299_V306_D1.3021.00
132_G216_P1.3001.00
63_I140_A1.2971.00
68_A197_I1.2961.00
20_I23_P1.2901.00
168_D177_C1.2861.00
284_N292_L1.2791.00
133_I137_L1.2761.00
420_I424_V1.2711.00
451_T461_T1.2691.00
296_L299_V1.2641.00
292_L300_L1.2581.00
247_L251_A1.2561.00
15_A21_Y1.2561.00
296_L300_L1.2511.00
342_Q407_I1.2491.00
303_I306_D1.2481.00
447_Q451_T1.2471.00
406_L428_L1.2451.00
407_I425_K1.2441.00
383_H451_T1.2431.00
19_V22_A1.2401.00
345_Q393_F1.2401.00
322_G445_I1.2371.00
223_S241_A1.2371.00
177_C181_L1.2301.00
285_T289_F1.2301.00
337_L399_W1.2301.00
271_D278_T1.2221.00
466_A482_A1.2221.00
295_V302_A1.2181.00
103_F142_K1.2111.00
295_V298_V1.2081.00
186_V189_A1.2011.00
271_D277_A1.1951.00
18_A22_A1.1931.00
300_L304_L1.1911.00
14_W18_A1.1911.00
313_E316_I1.1891.00
59_V136_G1.1891.00
329_A384_L1.1831.00
89_C148_L1.1781.00
284_N288_I1.1751.00
283_G287_A1.1721.00
405_R408_L1.1711.00
291_P302_A1.1670.99
312_S316_I1.1670.99
271_D280_L1.1640.99
129_D134_G1.1580.99
383_H444_G1.1520.99
83_P279_P1.1400.99
59_V63_I1.1380.99
275_K279_P1.1270.99
292_L303_I1.1260.99
287_A292_L1.1230.99
410_A423_Y1.1180.99
298_V303_I1.1150.99
108_L130_R1.1140.99
128_M131_F1.1130.99
15_A24_L1.1100.99
63_I67_G1.0960.99
69_L147_L1.0950.99
292_L302_A1.0950.99
301_L305_A1.0930.99
368_L371_K1.0930.99
79_L148_L1.0880.99
258_L262_S1.0880.99
135_L208_A1.0850.99
288_I299_V1.0790.99
41_W44_L1.0760.99
277_A280_L1.0680.99
479_A482_A1.0660.99
14_W366_L1.0640.99
292_L295_V1.0630.99
394_I436_A1.0590.99
163_Q185_S1.0590.99
167_L172_Y1.0540.99
55_L58_L1.0530.99
382_G450_P1.0510.99
395_L436_A1.0450.99
297_C301_L1.0450.99
151_L190_L1.0450.99
67_G71_I1.0430.99
315_L488_L1.0410.99
455_G464_T1.0330.99
287_A302_A1.0330.99
410_A424_V1.0320.99
202_L245_L1.0290.99
317_N459_F1.0290.99
274_R277_A1.0260.99
64_A139_L1.0250.99
21_Y26_P1.0230.99
327_F331_L1.0210.99
73_L190_L1.0180.99
312_S315_L1.0180.99
284_N291_P1.0160.99
274_R280_L1.0160.99
21_Y25_I1.0150.99
391_M440_G1.0140.99
482_A485_Q1.0120.99
287_A295_V1.0110.99
270_V273_V1.0060.98
179_N183_L1.0050.98
139_L204_V1.0040.98
143_E201_S0.9970.98
60_S64_A0.9960.98
22_A25_I0.9950.98
102_A482_A0.9940.98
325_A384_L0.9900.98
329_A440_G0.9890.98
285_T293_T0.9870.98
164_V168_D0.9800.98
356_A386_W0.9780.98
141_V291_P0.9740.98
281_L292_L0.9710.98
168_D174_R0.9710.98
135_L216_P0.9690.98
315_L462_L0.9680.98
494_A498_L0.9680.98
301_L304_L0.9670.98
302_A305_A0.9670.98
291_P303_I0.9650.98
360_V449_M0.9640.98
284_N287_A0.9530.98
367_A378_A0.9530.98
186_V190_L0.9480.98
485_Q489_P0.9440.98
151_L186_V0.9420.98
75_V92_L0.9420.98
296_L303_I0.9390.98
18_A26_P0.9360.98
243_L247_L0.9360.98
14_W23_P0.9300.97
273_V280_L0.9280.97
296_L306_D0.9250.97
288_I295_V0.9200.97
426_C433_V0.9200.97
465_E468_A0.9190.97
491_I495_L0.9180.97
484_W488_L0.9170.97
18_A21_Y0.9170.97
120_Y123_Y0.9130.97
275_K278_T0.9130.97
316_I319_L0.9030.97
226_W234_Q0.9030.97
289_F294_G0.8970.97
74_L78_A0.8960.97
222_I225_Q0.8960.97
58_L62_T0.8930.97
78_A82_G0.8930.97
429_M432_P0.8920.97
489_P493_F0.8910.97
150_I193_A0.8900.97
270_V278_T0.8880.97
282_P285_T0.8880.97
77_V178_L0.8840.97
490_L494_A0.8840.97
411_Q420_I0.8820.97
89_C152_A0.8810.97
108_L210_I0.8750.96
391_M436_A0.8750.96
265_R268_P0.8700.96
409_I412_T0.8700.96
272_G279_P0.8690.96
23_P243_L0.8680.96
57_T220_A0.8680.96
273_V277_A0.8670.96
395_L429_M0.8670.96
193_A197_I0.8670.96
466_A485_Q0.8660.96
59_V62_T0.8660.96
42_Q46_A0.8640.96
135_L212_G0.8620.96
314_A465_E0.8620.96
173_S177_C0.8610.96
273_V276_P0.8600.96
144_S148_L0.8580.96
281_L299_V0.8580.96
317_N320_T0.8530.96
41_W45_F0.8520.96
281_L291_P0.8480.96
441_F492_I0.8480.96
19_V362_G0.8480.96
271_D279_P0.8460.96
218_T221_V0.8440.96
299_V304_L0.8430.96
287_A299_V0.8410.95
86_Q89_C0.8370.95
469_L481_Q0.8360.95
288_I296_L0.8350.95
402_I428_L0.8340.95
284_N303_I0.8300.95
383_H447_Q0.8270.95
274_R278_T0.8260.95
326_T330_L0.8240.95
62_T194_M0.8230.95
38_L42_Q0.8220.95
192_M393_F0.8210.95
375_S378_A0.8200.95
20_I24_L0.8200.95
75_V144_S0.8180.95
50_L54_L0.8160.95
155_L182_L0.8160.95
271_D274_R0.8150.95
138_T207_V0.8140.95
77_V155_L0.8100.94
206_D356_A0.8090.94
420_I423_Y0.8080.94
19_V24_L0.8080.94
205_V209_I0.8070.94
369_W372_L0.8040.94
460_P468_A0.8040.94
270_V274_R0.8020.94
485_Q492_I0.8020.94
376_W380_V0.8010.94
282_P286_L0.8010.94
204_V356_A0.8010.94
71_I144_S0.7990.94
321_M376_W0.7970.94
271_D276_P0.7930.94
17_V23_P0.7930.94
174_R178_L0.7910.94
399_W429_M0.7880.94
226_W231_D0.7880.94
300_L305_A0.7850.93
217_P222_I0.7850.93
373_D378_A0.7840.93
17_V21_Y0.7840.93
337_L395_L0.7830.93
416_S420_I0.7830.93
336_W348_L0.7820.93
322_G444_G0.7820.93
359_L466_A0.7810.93
398_A429_M0.7810.93
60_S135_L0.7800.93
276_P279_P0.7780.93
282_P289_F0.7770.93
151_L155_L0.7770.93
337_L341_P0.7770.93
14_W24_L0.7750.93
71_I140_A0.7740.93
157_E401_R0.7730.93
122_P125_T0.7710.93
155_L186_V0.7700.93
61_T202_L0.7700.93
333_L392_L0.7690.93
219_L241_A0.7670.93
336_W392_L0.7660.93
281_L284_N0.7660.93
299_V305_A0.7640.93
484_W487_L0.7630.93
89_C156_S0.7630.93
64_A201_S0.7610.92
223_S245_L0.7600.92
116_L120_Y0.7590.92
324_V327_F0.7580.92
303_I483_L0.7580.92
492_I497_A0.7580.92
320_T376_W0.7560.92
117_L120_Y0.7560.92
65_A198_V0.7460.92
158_K186_V0.7460.92
325_A383_H0.7440.92
78_A84_K0.7390.91
72_A148_L0.7390.91
493_F496_T0.7380.91
281_L288_I0.7380.91
101_V204_V0.7380.91
284_N297_C0.7370.91
56_A59_V0.7360.91
209_I467_V0.7340.91
60_S139_L0.7340.91
22_A26_P0.7330.91
318_S463_T0.7330.91
387_V440_G0.7310.91
18_A25_I0.7310.91
321_M379_V0.7290.91
322_G441_F0.7290.91
455_G460_P0.7280.91
41_W240_L0.7270.91
176_Q419_K0.7250.90
379_V383_H0.7230.90
154_V186_V0.7210.90
364_Y373_D0.7200.90
256_S260_W0.7200.90
14_W17_V0.7200.90
152_A156_S0.7190.90
44_L240_L0.7180.90
372_L375_S0.7180.90
68_A147_L0.7150.90
189_A193_A0.7140.90
342_Q404_S0.7090.89
13_L17_V0.7080.89
298_V304_L0.7050.89
119_D122_P0.7040.89
103_F166_V0.7020.89
271_D275_K0.7010.89
285_T288_I0.7000.89
353_L356_A0.7000.89
284_N300_L0.6990.89
79_L82_G0.6970.89
103_F141_V0.6970.89
321_M383_H0.6970.89
166_V169_S0.6960.89
98_I103_F0.6960.89
222_I226_W0.6940.88
54_L248_L0.6920.88
298_V301_L0.6910.88
292_L296_L0.6900.88
270_V279_P0.6890.88
298_V306_D0.6870.88
279_P283_G0.6870.88
421_F425_K0.6840.88
21_Y24_L0.6800.87
60_S218_T0.6800.87
200_W203_S0.6800.87
485_Q488_L0.6790.87
15_A25_I0.6790.87
82_G278_T0.6790.87
16_M25_I0.6780.87
407_I420_I0.6780.87
104_A206_D0.6760.87
348_L392_L0.6750.87
482_A486_L0.6750.87
338_E399_W0.6740.87
291_P294_G0.6740.87
282_P301_L0.6740.87
313_E317_N0.6730.87
324_V328_I0.6720.87
145_A356_A0.6720.87
173_S179_N0.6710.87
65_A69_L0.6710.87
118_Y122_P0.6700.87
416_S422_F0.6690.87
330_L395_L0.6680.87
297_C302_A0.6660.86
218_T461_T0.6650.86
319_L323_L0.6640.86
20_I286_L0.6630.86
53_A57_T0.6620.86
203_S450_P0.6620.86
447_Q461_T0.6610.86
298_V305_A0.6600.86
422_F426_C0.6560.86
332_L384_L0.6550.85
205_V467_V0.6530.85
134_G224_W0.6520.85
292_L306_D0.6520.85
300_L306_D0.6520.85
67_G70_L0.6520.85
379_V450_P0.6510.85
374_G378_A0.6510.85
339_W343_R0.6500.85
272_G278_T0.6490.85
282_P302_A0.6470.85
56_A221_V0.6450.85
19_V25_I0.6450.85
227_L361_A0.6440.84
151_L193_A0.6430.84
218_T462_L0.6430.84
265_R269_R0.6430.84
291_P306_D0.6420.84
283_G286_L0.6420.84
226_W237_K0.6410.84
452_L464_T0.6410.84
283_G295_V0.6400.84
494_A497_A0.6390.84
279_P286_L0.6390.84
287_A293_T0.6390.84
481_Q485_Q0.6380.84
296_L302_A0.6380.84
17_V52_Q0.6370.84
200_W443_V0.6350.84
281_L285_T0.6350.84
51_P54_L0.6350.84
99_P206_D0.6340.84
204_V446_A0.6310.83
158_K182_L0.6310.83
282_P291_P0.6310.83
491_I497_A0.6300.83
282_P292_L0.6300.83
273_V278_T0.6270.83
445_I488_L0.6260.83
16_M24_L0.6260.83
475_N479_A0.6250.83
284_N298_V0.6240.83
75_V211_L0.6240.83
448_Y461_T0.6230.83
337_L396_Q0.6230.83
217_P221_V0.6220.82
294_G297_C0.6210.82
206_D447_Q0.6210.82
238_G446_A0.6210.82
181_L424_V0.6210.82
476_G485_Q0.6200.82
475_N482_A0.6200.82
106_S212_G0.6190.82
73_L147_L0.6190.82
38_L43_A0.6180.82
330_L437_F0.6180.82
328_I380_V0.6170.82
64_A68_A0.6160.82
61_T65_A0.6160.82
286_L290_L0.6160.82
363_Q381_W0.6140.82
291_P491_I0.6130.81
316_I347_W0.6120.81
260_W263_W0.6110.81
287_A300_L0.6110.81
292_L298_V0.6080.81
193_A447_Q0.6080.81
43_A46_A0.6080.81
399_W425_K0.6070.81
330_L433_V0.6070.81
479_A485_Q0.6070.81
142_K446_A0.6050.81
354_L358_P0.6050.81
480_A483_L0.6040.81
17_V70_L0.6030.80
338_E374_G0.6020.80
456_A459_F0.6020.80
251_A323_L0.6020.80
14_W19_V0.6010.80
248_L255_L0.5990.80
204_V449_M0.5990.80
329_A391_M0.5980.80
112_A130_R0.5960.80
421_F426_C0.5960.80
322_G325_A0.5950.80
495_L498_L0.5940.79
107_A448_Y0.5900.79
460_P464_T0.5890.79
432_P436_A0.5880.79
151_L189_A0.5870.79
56_A60_S0.5850.78
364_Y454_L0.5850.78
228_T464_T0.5840.78
283_G288_I0.5840.78
363_Q385_L0.5830.78
129_D145_A0.5830.78
287_A296_L0.5820.78
145_A358_P0.5820.78
72_A76_I0.5820.78
297_C300_L0.5820.78
101_V356_A0.5810.78
282_P288_I0.5810.78
390_W443_V0.5800.78
100_H103_F0.5790.78
92_L144_S0.5780.78
367_A372_L0.5780.78
451_T463_T0.5780.78
288_I293_T0.5780.78
282_P297_C0.5760.77
200_W352_I0.5760.77
395_L433_V0.5760.77
76_I80_W0.5750.77
17_V175_W0.5750.77
386_W447_Q0.5740.77
260_W265_R0.5730.77
446_A463_T0.5720.77
210_I469_L0.5710.77
366_L374_G0.5710.77
73_L178_L0.5700.77
85_W277_A0.5690.76
276_P280_L0.5690.76
83_P86_Q0.5690.76
81_P182_L0.5690.76
452_L467_V0.5690.76
18_A24_L0.5680.76
382_G454_L0.5680.76
285_T300_L0.5670.76
326_T441_F0.5660.76
284_N306_D0.5660.76
282_P298_V0.5650.76
318_S322_G0.5640.76
282_P300_L0.5640.76
119_D123_Y0.5640.76
272_G280_L0.5630.76
48_P52_Q0.5620.76
44_L50_L0.5610.75
318_S444_G0.5600.75
104_A362_G0.5600.75
284_N301_L0.5590.75
14_W22_A0.5590.75
285_T303_I0.5590.75
66_V69_L0.5570.75
337_L392_L0.5570.75
178_L183_L0.5570.75
140_A144_S0.5550.75
336_W388_M0.5540.75
351_P355_P0.5540.75
291_P300_L0.5540.75
330_L436_A0.5520.74
135_L207_V0.5500.74
363_Q426_C0.5490.74
288_I306_D0.5490.74
327_F330_L0.5490.74
190_L257_Y0.5490.74
195_L253_V0.5480.74
321_M459_F0.5480.74
135_L211_L0.5480.74
415_W424_V0.5480.74
283_G297_C0.5480.74
327_F332_L0.5470.74
208_A218_T0.5470.74
146_F193_A0.5460.74
377_T380_V0.5450.73
279_P282_P0.5430.73
242_S358_P0.5420.73
108_L112_A0.5410.73
205_V359_L0.5410.73
293_T297_C0.5410.73
251_A254_L0.5400.73
245_L355_P0.5400.73
14_W26_P0.5400.73
290_L295_V0.5380.72
76_I151_L0.5380.72
101_V449_M0.5360.72
131_F134_G0.5360.72
294_G298_V0.5360.72
320_T491_I0.5350.72
253_V382_G0.5350.72
155_L355_P0.5350.72
60_S220_A0.5340.72
111_F129_D0.5340.72
68_A144_S0.5340.72
489_P496_T0.5310.71
363_Q382_G0.5300.71
238_G493_F0.5290.71
453_W466_A0.5280.71
20_I25_I0.5280.71
200_W449_M0.5280.71
120_Y490_L0.5280.71
53_A219_L0.5270.71
187_A259_L0.5270.71
193_A451_T0.5260.71
463_T470_S0.5250.71
270_V280_L0.5240.70
379_V451_T0.5240.70
266_T269_R0.5240.70
53_A217_P0.5240.70
297_C305_A0.5220.70
48_P70_L0.5210.70
218_T467_V0.5210.70
205_V221_V0.5190.70
70_L422_F0.5180.70
239_A365_T0.5180.70
155_L184_P0.5150.69
251_A283_G0.5150.69
320_T380_V0.5150.69
38_L41_W0.5140.69
287_A301_L0.5140.69
338_E407_I0.5140.69
220_A245_L0.5140.69
349_W389_P0.5140.69
473_G482_A0.5130.69
64_A132_G0.5120.69
139_L208_A0.5120.69
83_P278_T0.5120.69
295_V301_L0.5110.69
409_I415_W0.5100.68
266_T404_S0.5100.68
60_S216_P0.5090.68
106_S298_V0.5070.68
278_T281_L0.5070.68
325_A380_V0.5070.68
440_G444_G0.5040.68
131_F170_L0.5030.67
247_L316_I0.5030.67
315_L319_L0.5020.67
183_L188_P0.5020.67
58_L175_W0.5020.67
114_G120_Y0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.4736 100 0.648 Contact Map
4tquM 1 0.4932 100 0.66 Contact Map
3d31C 2 0.4716 100 0.664 Contact Map
3rlfF 1 0.4873 100 0.686 Contact Map
3rlfG 1 0.5108 100 0.689 Contact Map
4tquN 1 0.4755 100 0.704 Contact Map
4ymuD 2 0.4149 99.9 0.752 Contact Map
3tuiA 2 0.4051 99.9 0.769 Contact Map
2m20A 2 0.0724 9.1 0.975 Contact Map
2kluA 1 0.0802 9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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