GREMLIN Database
YDJZ - TVP38/TMEM64 family inner membrane protein YdjZ
UniProt: P76221 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14002
Length: 235 (183)
Sequences: 6309 (4675)
Seq/√Len: 345.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_A174_F3.9471.00
99_G190_I2.9971.00
173_R176_S2.8071.00
122_R138_D2.7101.00
222_M226_I2.6031.00
146_K180_A2.5711.00
111_A178_F2.5491.00
67_S89_N2.5361.00
94_G98_G2.4211.00
72_I112_L2.3631.00
150_L183_L2.2431.00
107_M182_G2.1791.00
68_F101_L2.1731.00
68_F105_S1.9851.00
90_A196_G1.8841.00
135_D139_G1.8651.00
130_G133_V1.8141.00
210_L214_F1.7721.00
144_Y147_H1.7531.00
121_G124_V1.7411.00
208_T212_I1.7311.00
64_A101_L1.7201.00
103_W186_L1.7111.00
95_A99_G1.6971.00
220_I224_K1.6551.00
115_F174_F1.6481.00
72_I108_A1.6461.00
138_D142_T1.6431.00
146_K176_S1.6281.00
223_A227_W1.6081.00
211_F215_A1.5971.00
174_F178_F1.5961.00
117_A169_L1.5671.00
117_A168_G1.5511.00
56_I63_A1.5501.00
63_A93_F1.5341.00
94_G97_W1.5321.00
175_R179_I1.5251.00
96_F99_G1.5051.00
102_S189_T1.5031.00
54_R57_Q1.4941.00
149_I180_A1.4891.00
217_T221_F1.4711.00
110_A181_T1.4571.00
99_G193_S1.4491.00
217_T220_I1.4491.00
153_R181_T1.4271.00
95_A194_W1.4231.00
97_W100_L1.4051.00
224_K228_L1.3671.00
90_A193_S1.3601.00
115_F119_V1.3551.00
102_S193_S1.3501.00
107_M178_F1.3471.00
96_F100_L1.3361.00
194_W198_M1.3031.00
68_F104_T1.2901.00
223_A226_I1.2581.00
53_E57_Q1.2451.00
138_D171_S1.2351.00
181_T185_Q1.2201.00
203_T207_V1.2191.00
103_W182_G1.2181.00
124_V128_L1.2101.00
111_A115_F1.2041.00
71_M86_T1.1751.00
152_C163_I1.1731.00
67_S102_S1.1701.00
226_I230_R1.1631.00
225_K228_L1.1551.00
68_F72_I1.1441.00
207_V211_F1.1401.00
225_K229_E1.1361.00
213_L217_T1.1281.00
204_F207_V1.1191.00
48_D51_G1.1161.00
97_W101_L1.1111.00
114_F170_T1.1061.00
59_Y66_V1.0961.00
226_I229_E1.0951.00
106_S185_Q1.0931.00
86_T102_S1.0901.00
89_N98_G1.0671.00
50_Q54_R1.0671.00
203_T206_F1.0641.00
146_K179_I1.0631.00
218_V222_M1.0611.00
146_K150_L1.0471.00
93_F98_G1.0441.00
72_I105_S1.0431.00
214_F218_V1.0381.00
219_V223_A1.0321.00
131_K135_D1.0221.00
154_L187_P1.0151.00
205_W208_T1.0061.00
118_R171_S1.0041.00
89_N102_S1.0011.00
99_G103_W0.9881.00
99_G194_W0.9841.00
110_A164_S0.9831.00
122_R126_E0.9771.00
221_F224_K0.9761.00
180_A184_G0.9741.00
126_E138_D0.9621.00
126_E131_K0.9601.00
133_V136_S0.9591.00
202_G205_W0.9491.00
204_F208_T0.9451.00
132_T136_S0.9451.00
51_G55_F0.9441.00
90_A98_G0.9441.00
101_L105_S0.9431.00
176_S180_A0.9381.00
114_F174_F0.9381.00
103_W189_T0.9331.00
86_T193_S0.9321.00
55_F59_Y0.9291.00
151_V155_L0.9261.00
83_F192_Y0.9261.00
122_R125_V0.9171.00
187_P190_I0.9171.00
95_A190_I0.9151.00
141_F167_A0.9091.00
153_R164_S0.9081.00
113_C165_Y0.9061.00
164_S181_T0.9031.00
54_R58_S0.9011.00
179_I183_L0.8881.00
205_W209_G0.8871.00
135_D138_D0.8861.00
202_G206_F0.8681.00
150_L180_A0.8661.00
139_G142_T0.8651.00
147_H151_V0.8561.00
64_A97_W0.8481.00
80_L161_D0.8391.00
100_L103_W0.8351.00
190_I194_W0.8351.00
101_L104_T0.8321.00
185_Q188_A0.8291.00
220_I227_W0.8281.00
207_V210_L0.8281.00
176_S179_I0.8181.00
140_F148_T0.8171.00
71_M85_I0.8131.00
76_I81_P0.8131.00
89_N93_F0.8071.00
114_F177_F0.8021.00
71_M75_A0.8001.00
51_G54_R0.7991.00
71_M74_Q0.7991.00
215_A218_V0.7981.00
64_A68_F0.7951.00
107_M185_Q0.7951.00
108_A112_L0.7941.00
212_I216_L0.7911.00
88_A91_S0.7911.00
73_L78_A0.7901.00
98_G193_S0.7841.00
206_F209_G0.7801.00
149_I172_I0.7791.00
74_Q161_D0.7731.00
216_L220_I0.7731.00
119_V123_E0.7721.00
50_Q53_E0.7691.00
203_T208_T0.7621.00
125_V129_T0.7561.00
138_D170_T0.7561.00
86_T90_A0.7491.00
213_L216_L0.7481.00
175_R178_F0.7471.00
74_Q82_A0.7350.99
79_P82_A0.7330.99
202_G207_V0.7290.99
178_F182_G0.7290.99
103_W185_Q0.7260.99
114_F118_R0.7200.99
86_T189_T0.7150.99
183_L186_L0.7140.99
79_P161_D0.7080.99
123_E127_K0.7070.99
189_T193_S0.7050.99
88_A92_L0.7030.99
159_P164_S0.7030.99
114_F168_G0.7010.99
83_F87_F0.6930.99
61_A65_V0.6890.99
195_A198_M0.6830.99
74_Q109_G0.6820.99
220_I226_I0.6790.99
211_F214_F0.6780.99
150_L184_G0.6760.99
185_Q189_T0.6720.99
78_A113_C0.6700.99
84_L88_A0.6690.99
212_I227_W0.6680.99
95_A193_S0.6590.99
96_F194_W0.6580.99
107_M181_T0.6560.99
55_F63_A0.6550.99
163_I167_A0.6540.99
209_G212_I0.6530.99
218_V221_F0.6510.99
105_S109_G0.6480.99
161_D164_S0.6440.99
103_W107_M0.6440.99
110_A174_F0.6370.99
73_L77_A0.6350.99
191_V194_W0.6340.98
91_S200_T0.6320.98
150_L187_P0.6310.98
152_C167_A0.6250.98
64_A94_G0.6250.98
65_V69_L0.6230.98
204_F209_G0.6230.98
191_V195_A0.6210.98
159_P188_A0.6210.98
139_G143_R0.6210.98
127_K130_G0.6210.98
49_Q53_E0.6170.98
106_S188_A0.6170.98
99_G186_L0.6160.98
110_A153_R0.6160.98
93_F101_L0.6140.98
68_F108_A0.6140.98
71_M82_A0.6090.98
113_C168_G0.6080.98
104_T107_M0.6070.98
197_S200_T0.6000.98
104_T182_G0.5970.98
117_A165_Y0.5930.98
75_A109_G0.5880.98
100_L104_T0.5810.97
82_A188_A0.5810.97
121_G168_G0.5790.97
141_F145_G0.5770.97
74_Q85_I0.5760.97
141_F172_I0.5730.97
71_M105_S0.5720.97
223_A230_R0.5710.97
106_S110_A0.5690.97
182_G186_L0.5680.97
107_M186_L0.5610.97
69_L72_I0.5600.97
227_W230_R0.5600.97
221_F225_K0.5600.97
215_A219_V0.5570.97
126_E135_D0.5560.97
62_L66_V0.5550.97
207_V225_K0.5550.97
121_G128_L0.5490.96
99_G189_T0.5460.96
195_A199_L0.5440.96
115_F118_R0.5430.96
209_G213_L0.5410.96
144_Y148_T0.5410.96
49_Q91_S0.5360.96
62_L65_V0.5340.96
183_L187_P0.5320.96
90_A192_Y0.5210.95
217_T224_K0.5200.95
150_L154_L0.5190.95
53_E56_I0.5180.95
224_K227_W0.5160.95
83_F159_P0.5110.95
71_M78_A0.5100.94
162_P166_A0.5100.94
59_Y63_A0.5090.94
120_M123_E0.5070.94
140_F143_R0.5060.94
47_V50_Q0.5020.94
80_L105_S0.5020.94
71_M152_C0.5010.94
47_V51_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlbA 1 0.6213 62.1 0.915 Contact Map
4huqS 1 0.6766 52.7 0.92 Contact Map
3wajA 1 0.8809 46.4 0.923 Contact Map
4dveA 3 0.6851 38.2 0.927 Contact Map
2m20A 2 0.1617 28.1 0.931 Contact Map
3d31C 2 0.8553 26.1 0.933 Contact Map
2jlnA 1 0.783 22.5 0.935 Contact Map
4tkrA 2 0.634 20.3 0.936 Contact Map
3k3fA 3 0.6681 20.2 0.936 Contact Map
3b5xA 2 0.7362 18.5 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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