GREMLIN Database
YDJX - TVP38/TMEM64 family membrane protein YdjX
UniProt: P76219 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14000
Length: 236 (184)
Sequences: 8155 (6058)
Seq/√Len: 446.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_S158_F3.9971.00
208_Q212_L3.0191.00
82_T174_V2.7321.00
157_A160_P2.6861.00
105_R122_E2.4591.00
90_T166_A2.3291.00
130_I164_I2.3101.00
94_S162_T2.2661.00
77_G80_L2.1601.00
207_V211_K2.1111.00
210_A214_A2.1071.00
134_I167_L2.0711.00
77_G81_G2.0591.00
195_Q199_A2.0531.00
51_Y72_G1.9781.00
209_L213_Y1.9651.00
119_Q123_K1.9561.00
86_L170_L1.9511.00
122_E126_A1.9191.00
194_L198_L1.8811.00
56_I95_C1.8631.00
73_G180_A1.8141.00
130_I160_P1.7871.00
52_I84_L1.7791.00
203_L206_L1.7761.00
206_L210_A1.7651.00
128_N131_D1.7641.00
158_F162_T1.7071.00
104_G107_L1.6971.00
190_L193_I1.6791.00
52_I88_A1.6411.00
208_Q211_K1.6271.00
93_S165_S1.6151.00
213_Y217_K1.6151.00
211_K215_R1.5711.00
90_T162_T1.5601.00
100_A153_L1.5581.00
85_S173_I1.5571.00
78_P82_T1.5501.00
82_T177_T1.5381.00
48_Y84_L1.5351.00
40_I47_G1.5201.00
98_L158_F1.5061.00
198_L202_A1.5001.00
117_T120_A1.4761.00
101_R155_T1.4701.00
56_I91_L1.4641.00
178_V182_D1.4411.00
133_L164_I1.4051.00
159_W163_L1.4051.00
196_L200_G1.4031.00
110_K113_G1.4011.00
78_P178_V1.3941.00
79_L83_L1.3871.00
192_F195_Q1.3811.00
204_F207_V1.3551.00
98_L102_W1.3541.00
37_Q41_R1.3531.00
100_A152_G1.3361.00
94_S98_L1.3261.00
207_V210_A1.3141.00
38_T41_R1.2991.00
211_K214_A1.2861.00
79_L82_T1.2771.00
86_L166_A1.2401.00
55_F58_A1.2361.00
204_F208_Q1.2061.00
52_I56_I1.2061.00
80_L84_L1.2001.00
52_I87_I1.1961.00
72_G81_G1.1931.00
80_L83_L1.1881.00
47_G76_F1.1841.00
85_S177_T1.1831.00
136_T147_Q1.1721.00
105_R109_L1.1641.00
200_G204_F1.1621.00
212_L215_R1.1621.00
165_S169_T1.1581.00
137_R165_S1.1561.00
82_T178_V1.1511.00
38_T42_Q1.1271.00
193_I197_C1.1171.00
113_G117_T1.1161.00
189_T192_F1.1061.00
131_D135_L1.1051.00
119_Q122_E1.0971.00
73_G177_T1.0891.00
69_V177_T1.0881.00
122_E155_T1.0751.00
72_G85_S1.0661.00
189_T193_I1.0481.00
81_G177_T1.0461.00
84_L88_A1.0391.00
51_Y85_S1.0371.00
138_L171_P1.0201.00
171_P174_V1.0191.00
125_I151_Y1.0051.00
212_L216_H0.9901.00
201_L204_F0.9881.00
39_L43_S0.9861.00
144_Y169_T0.9711.00
105_R108_L0.9681.00
144_Y172_G0.9671.00
160_P164_I0.9661.00
69_V85_S0.9621.00
203_L207_V0.9611.00
55_F69_V0.9571.00
130_I163_L0.9541.00
55_F59_T0.9411.00
133_L156_I0.9381.00
167_L170_L0.9351.00
34_P38_T0.9271.00
86_L173_I0.9111.00
76_F81_G0.9091.00
48_Y80_L0.9081.00
137_R148_N0.9011.00
130_I134_I0.8941.00
148_N165_S0.8851.00
159_W162_T0.8841.00
82_T86_L0.8791.00
66_S176_Y0.8751.00
83_L86_L0.8731.00
207_V213_Y0.8721.00
89_A169_T0.8721.00
71_A75_V0.8661.00
72_G76_F0.8461.00
194_L197_C0.8441.00
108_L112_V0.8431.00
124_G132_F0.8321.00
194_L206_L0.8211.00
190_L194_L0.8171.00
162_T166_A0.8151.00
35_H39_L0.8111.00
69_V73_G0.8101.00
122_E154_T0.8091.00
195_Q198_L0.8071.00
58_A145_N0.8071.00
199_A206_L0.8071.00
199_A214_A0.8041.00
69_V173_I0.7911.00
43_S50_L0.7901.00
160_P163_L0.7901.00
58_A92_A0.7881.00
90_T169_T0.7831.00
209_L212_L0.7831.00
97_F158_F0.7811.00
55_F68_L0.7731.00
199_A203_L0.7711.00
63_L145_N0.7701.00
73_G81_G0.7671.00
96_S149_Y0.7631.00
48_Y52_I0.7631.00
206_L213_Y0.7631.00
79_L178_V0.7621.00
97_F154_T0.7591.00
93_S148_N0.7581.00
213_Y216_H0.7521.00
173_I177_T0.7501.00
197_C201_L0.7461.00
83_L87_I0.7461.00
49_S53_L0.7441.00
58_A65_G0.7411.00
66_S144_Y0.7411.00
97_F161_Y0.7391.00
134_I164_I0.7381.00
136_T151_Y0.7301.00
123_K126_A0.7291.00
192_F196_L0.7271.00
58_A63_L0.7261.00
93_S158_F0.7231.00
214_A218_H0.7201.00
60_L96_S0.7181.00
78_P177_T0.7141.00
174_V178_V0.7141.00
164_I168_T0.7131.00
189_T194_L0.7111.00
62_L145_N0.7091.00
34_P37_Q0.7081.00
215_R218_H0.7021.00
125_I129_G0.7021.00
196_L207_V0.7011.00
48_Y77_G0.7011.00
35_H38_T0.6961.00
214_A217_K0.6951.00
135_L139_I0.6941.00
134_I171_P0.6941.00
198_L201_L0.6941.00
195_Q206_L0.6871.00
60_L64_P0.6801.00
116_N120_A0.6761.00
93_S137_R0.6751.00
92_A96_S0.6731.00
114_H119_Q0.6721.00
191_R195_Q0.6701.00
90_T165_S0.6691.00
51_Y55_F0.6671.00
123_K127_R0.6661.00
202_A206_L0.6661.00
205_I208_Q0.6591.00
132_F136_T0.6591.00
84_L87_I0.6591.00
196_L199_A0.6551.00
210_A213_Y0.6531.00
109_L122_E0.6521.00
82_T173_I0.6521.00
86_L90_T0.6511.00
193_I196_L0.6511.00
195_Q203_L0.6360.99
183_L186_E0.6330.99
91_L95_C0.6310.99
96_S145_N0.6310.99
109_L119_Q0.6300.99
106_D109_L0.6290.99
169_T172_G0.6250.99
60_L65_G0.6200.99
199_A202_A0.6180.99
51_Y58_A0.6130.99
151_Y156_I0.6130.99
116_N119_Q0.6130.99
163_L167_L0.6120.99
147_Q151_Y0.6090.99
102_W106_D0.6080.99
194_L199_A0.6040.99
78_P174_V0.6030.99
99_L103_L0.6000.99
44_G47_G0.5980.99
46_F50_L0.5970.99
195_Q210_A0.5960.99
67_I71_A0.5910.99
97_F101_R0.5900.99
201_L205_I0.5890.99
121_I143_P0.5880.99
181_S184_A0.5860.99
190_L195_Q0.5850.99
145_N148_N0.5830.99
206_L217_K0.5810.99
69_V89_A0.5790.99
100_A149_Y0.5780.99
51_Y59_T0.5740.99
50_L53_L0.5710.99
45_F49_S0.5650.99
143_P148_N0.5600.99
134_I168_T0.5550.98
52_I91_L0.5490.98
124_G127_R0.5480.98
200_G207_V0.5460.98
98_L101_R0.5450.98
210_A218_H0.5450.98
103_L106_D0.5420.98
117_T121_I0.5410.98
88_A92_A0.5400.98
99_L133_L0.5400.98
56_I88_A0.5370.98
111_Y114_H0.5360.98
189_T195_Q0.5340.98
107_L111_Y0.5340.98
86_L169_T0.5310.98
87_I91_L0.5300.98
46_F49_S0.5290.98
71_A74_I0.5270.98
113_G116_N0.5250.98
166_A170_L0.5240.98
61_L96_S0.5220.98
33_L36_L0.5200.98
200_G203_L0.5170.98
134_I138_L0.5090.97
196_L206_L0.5080.97
179_M182_D0.5070.97
207_V214_A0.5060.97
194_L201_L0.5060.97
62_L68_L0.5060.97
203_L213_Y0.5020.97
108_L118_F0.5020.97
198_L212_L0.5010.97
199_A210_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.9237 73.3 0.91 Contact Map
4m64A 1 0.9534 60.2 0.918 Contact Map
3giaA 1 0.8136 58.8 0.918 Contact Map
4j05A 3 0.9068 56.5 0.919 Contact Map
4dveA 3 0.7034 54 0.921 Contact Map
4z7fA 2 0.6864 51.6 0.922 Contact Map
4pypA 1 0.8729 49.8 0.922 Contact Map
3wdoA 1 0.9703 49.7 0.922 Contact Map
3w9iA 3 0.7712 46.3 0.924 Contact Map
4dx5A 3 0.8093 44.3 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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