ASTD - ECOLI - GREMLIN Contacts

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ASTD - N-succinylglutamate 5-semialdehyde dehydrogenase

UniProt:	P76217	Sequences: MTLWINGDWITGQGASRVKRNPVSGEVLWQGNDADAAQVEQACRAARAAFPRWARLSFAERHAVVERFAALLESNKAELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHVRTGEQRSEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGEAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHRQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLLLKSGAQGDAFLARLVAVSQRLTPGNWDDEPQPFIGGLISEQAAQQVVTAWQQLEAMGGRPLLAPRLLQAGTSLLTPGIIEMTGVAGVPDEEVFGPLLRVWRYDTFDEAIRMANNTRFGLSCGLVSPEREKFDQLLLEARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYAADYCAWPMASLESDSLTLPATLNPGLDFSDEVVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13997
Length:	492 (453)
Sequences:	36326 (21790)
Seq/√Len:	1023.8

ECOLI - ASTD PUUC BETB ALDB GABD FEAB ABDH ALDA SAD EUTE PUTA PAAZ PROA ADHE
BACSU - ALDH4 ROCA2 ROCA ALDH1 ALDH5 IOLA BETB ALDY GABD ALDH3 ALDH2 PROA
HALSA - Q9HRB5 Q9HQZ2 Q9HMJ6 Q9HR91
SULSO - Q97YT9 GAPN KGSDH Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
287_S	387_D	5.081	1.00
230_R	235_Q	3.454	1.00
287_S	385_R	3.202	1.00
259_D	297_R	3.114	1.00
291_G	385_R	2.996	1.00
18_V	30_Q	2.817	1.00
349_R	359_T	2.801	1.00
47_R	212_D	2.778	1.00
254_E	286_K	2.768	1.00
366_T	369_A	2.674	1.00
324_E	328_Q	2.636	1.00
263_H	301_V	2.594	1.00
336_Q	370_G	2.585	1.00
295_L	383_V	2.556	1.00
179_A	182_R	2.556	1.00
335_Q	339_A	2.506	1.00
254_E	288_G	2.457	1.00
75_N	78_E	2.418	1.00
73_E	106_A	2.410	1.00
409_S	415_F	2.362	1.00
18_V	27_V	2.337	1.00
334_W	358_L	2.264	1.00
47_R	214_D	2.236	1.00
343_R	364_E	2.208	1.00
35_D	38_Q	2.208	1.00
185_Q	191_P	2.205	1.00
76_K	99_T	2.164	1.00
77_A	95_A	2.161	1.00
312_D	315_Q	2.156	1.00
331_V	335_Q	2.153	1.00
68_F	184_W	2.105	1.00
389_F	414_K	2.083	1.00
71_L	186_Q	2.081	1.00
133_R	466_M	2.040	1.00
400_R	447_A	2.034	1.00
205_Q	209_A	2.025	1.00
172_L	323_S	1.998	1.00
209_A	231_Q	1.988	1.00
331_V	350_L	1.981	1.00
336_Q	340_M	1.963	1.00
299_V	303_Q	1.945	1.00
321_L	330_V	1.935	1.00
250_L	265_T	1.934	1.00
417_Q	421_E	1.921	1.00
132_H	460_D	1.919	1.00
331_V	358_L	1.911	1.00
78_E	179_A	1.907	1.00
293_A	297_R	1.899	1.00
64_V	189_L	1.880	1.00
40_E	206_A	1.875	1.00
255_V	414_K	1.818	1.00
226_Y	447_A	1.800	1.00
338_E	344_P	1.800	1.00
44_R	212_D	1.800	1.00
227_Q	230_R	1.787	1.00
71_L	74_S	1.785	1.00
284_L	395_M	1.777	1.00
75_N	186_Q	1.766	1.00
423_R	446_G	1.745	1.00
389_F	417_Q	1.737	1.00
372_P	384_W	1.718	1.00
132_H	463_A	1.710	1.00
71_L	187_A	1.691	1.00
40_E	44_R	1.685	1.00
367_G	395_M	1.677	1.00
286_K	386_Y	1.664	1.00
284_L	392_A	1.658	1.00
302_S	362_I	1.654	1.00
27_V	30_Q	1.650	1.00
66_E	106_A	1.645	1.00
299_V	345_L	1.643	1.00
181_M	196_L	1.621	1.00
71_L	183_L	1.618	1.00
363_I	371_V	1.613	1.00
82_I	179_A	1.605	1.00
391_E	394_R	1.601	1.00
291_G	295_L	1.600	1.00
265_T	294_F	1.592	1.00
370_G	374_E	1.578	1.00
105_I	156_V	1.575	1.00
73_E	102_I	1.572	1.00
91_R	95_A	1.571	1.00
387_D	391_E	1.571	1.00
296_A	300_A	1.567	1.00
270_F	302_S	1.561	1.00
57_S	60_E	1.558	1.00
332_T	370_G	1.542	1.00
70_A	74_S	1.542	1.00
50_F	54_A	1.532	1.00
297_R	300_A	1.526	1.00
324_E	356_S	1.524	1.00
258_I	297_R	1.523	1.00
164_T	193_V	1.514	1.00
67_R	70_A	1.490	1.00
262_V	297_R	1.487	1.00
292_D	385_R	1.481	1.00
283_L	381_L	1.480	1.00
60_E	63_A	1.479	1.00
40_E	210_L	1.469	1.00
16_S	30_Q	1.465	1.00
253_D	414_K	1.463	1.00
182_R	186_Q	1.453	1.00
55_R	421_E	1.446	1.00
81_A	85_R	1.444	1.00
66_E	113_H	1.443	1.00
76_K	95_A	1.440	1.00
264_L	408_V	1.436	1.00
284_L	386_Y	1.436	1.00
344_P	363_I	1.434	1.00
25_G	354_G	1.430	1.00
301_V	304_R	1.424	1.00
390_D	421_E	1.421	1.00
254_E	414_K	1.410	1.00
69_A	106_A	1.409	1.00
293_A	296_A	1.403	1.00
405_C	424_A	1.403	1.00
77_A	81_A	1.402	1.00
265_T	283_L	1.400	1.00
56_L	60_E	1.395	1.00
111_A	114_V	1.395	1.00
335_Q	338_E	1.393	1.00
131_R	420_L	1.384	1.00
391_E	395_M	1.383	1.00
70_A	106_A	1.379	1.00
20_R	27_V	1.374	1.00
105_I	152_N	1.374	1.00
171_E	201_R	1.372	1.00
285_L	294_F	1.370	1.00
38_Q	41_Q	1.367	1.00
75_N	179_A	1.361	1.00
140_V	165_I	1.360	1.00
306_T	315_Q	1.335	1.00
84_A	94_A	1.325	1.00
330_V	378_G	1.325	1.00
229_H	450_N	1.323	1.00
253_D	386_Y	1.320	1.00
205_Q	231_Q	1.320	1.00
327_A	331_V	1.320	1.00
333_A	376_V	1.318	1.00
26_E	354_G	1.317	1.00
15_A	33_D	1.314	1.00
215_G	241_A	1.312	1.00
340_M	370_G	1.306	1.00
328_Q	332_T	1.304	1.00
81_A	311_D	1.304	1.00
386_Y	395_M	1.291	1.00
327_A	350_L	1.284	1.00
151_P	167_F	1.279	1.00
21_N	24_S	1.279	1.00
327_A	358_L	1.278	1.00
181_M	194_L	1.273	1.00
295_L	299_V	1.261	1.00
253_D	418_L	1.259	1.00
50_F	164_T	1.257	1.00
292_D	296_A	1.256	1.00
300_A	303_Q	1.254	1.00
303_Q	346_L	1.248	1.00
393_I	418_L	1.233	1.00
324_E	327_A	1.227	1.00
289_A	293_A	1.221	1.00
36_A	206_A	1.220	1.00
251_I	392_A	1.219	1.00
309_N	312_D	1.218	1.00
43_C	210_L	1.212	1.00
69_A	73_E	1.211	1.00
205_Q	227_Q	1.205	1.00
286_K	388_T	1.202	1.00
368_V	373_D	1.194	1.00
388_T	391_E	1.194	1.00
184_W	194_L	1.193	1.00
457_Y	460_D	1.192	1.00
308_G	316_P	1.191	1.00
44_R	48_A	1.190	1.00
192_G	195_N	1.182	1.00
332_T	336_Q	1.181	1.00
286_K	289_A	1.180	1.00
297_R	301_V	1.179	1.00
306_T	317_F	1.177	1.00
39_V	203_T	1.176	1.00
132_H	465_P	1.161	1.00
456_W	460_D	1.161	1.00
367_G	398_N	1.158	1.00
79_L	179_A	1.157	1.00
56_L	64_V	1.153	1.00
129_S	416_D	1.150	1.00
81_A	91_R	1.148	1.00
390_D	417_Q	1.145	1.00
298_L	381_L	1.144	1.00
43_C	213_L	1.142	1.00
419_L	468_S	1.140	1.00
300_A	304_R	1.136	1.00
84_A	310_W	1.132	1.00
294_F	298_L	1.129	1.00
295_L	345_L	1.128	1.00
405_C	427_V	1.126	1.00
45_A	195_N	1.117	1.00
43_C	212_D	1.115	1.00
227_Q	231_Q	1.112	1.00
373_D	400_R	1.105	1.00
415_F	429_W	1.105	1.00
68_F	189_L	1.105	1.00
17_R	33_D	1.105	1.00
68_F	183_L	1.102	1.00
67_R	71_L	1.098	1.00
224_T	227_Q	1.097	1.00
155_I	194_L	1.096	1.00
135_H	215_G	1.096	1.00
118_E	456_W	1.095	1.00
223_N	227_Q	1.093	1.00
337_L	363_I	1.091	1.00
178_E	198_Q	1.087	1.00
229_H	240_L	1.085	1.00
66_E	110_K	1.085	1.00
373_D	398_N	1.085	1.00
21_N	309_N	1.080	1.00
250_L	280_A	1.078	1.00
140_V	217_L	1.075	1.00
390_D	394_R	1.073	1.00
342_G	363_I	1.072	1.00
251_I	418_L	1.070	1.00
68_F	105_I	1.065	1.00
29_W	175_W	1.065	1.00
257_D	410_P	1.064	1.00
389_F	418_L	1.057	1.00
139_A	207_L	1.054	1.00
23_V	310_W	1.051	1.00
457_Y	465_P	1.049	1.00
303_Q	359_T	1.046	1.00
393_I	421_E	1.045	1.00
351_L	359_T	1.043	1.00
299_V	346_L	1.041	1.00
139_A	213_L	1.041	1.00
251_I	396_A	1.037	1.00
305_L	318_I	1.037	1.00
118_E	457_Y	1.029	1.00
340_M	369_A	1.029	1.00
146_F	276_R	1.028	1.00
155_I	165_I	1.025	1.00
206_A	210_L	1.023	1.00
226_Y	237_E	1.020	1.00
411_E	414_K	1.014	1.00
247_N	281_R	1.012	1.00
386_Y	392_A	1.009	1.00
25_G	356_S	1.005	1.00
327_A	356_S	1.000	1.00
347_A	361_G	0.999	1.00
79_L	183_L	0.994	1.00
49_A	164_T	0.988	1.00
209_A	235_Q	0.985	1.00
62_H	113_H	0.984	1.00
51_P	423_R	0.982	1.00
257_D	260_A	0.981	1.00
131_R	468_S	0.979	1.00
101_M	152_N	0.977	1.00
347_A	359_T	0.973	1.00
443_G	452_R	0.970	1.00
51_P	394_R	0.969	1.00
75_N	183_L	0.968	1.00
330_V	380_L	0.968	1.00
47_R	51_P	0.965	1.00
112_Y	160_L	0.961	1.00
452_R	464_W	0.956	1.00
137_V	164_T	0.956	1.00
74_S	186_Q	0.954	1.00
178_E	196_L	0.951	1.00
445_I	464_W	0.951	1.00
78_E	81_A	0.950	1.00
182_R	185_Q	0.949	1.00
66_E	109_I	0.949	1.00
249_P	405_C	0.949	1.00
21_N	85_R	0.948	1.00
336_Q	339_A	0.946	1.00
259_D	293_A	0.942	1.00
394_R	398_N	0.942	1.00
260_A	264_L	0.935	1.00
75_N	182_R	0.935	1.00
266_I	301_V	0.935	1.00
36_A	40_E	0.921	1.00
54_A	423_R	0.918	1.00
33_D	202_E	0.915	1.00
80_T	95_A	0.914	1.00
229_H	233_S	0.914	1.00
333_A	336_Q	0.913	1.00
292_D	295_L	0.913	1.00
268_S	280_A	0.909	1.00
332_T	335_Q	0.909	1.00
128_A	440_A	0.908	1.00
85_R	311_D	0.907	1.00
137_V	213_L	0.904	1.00
269_A	281_R	0.904	1.00
291_G	383_V	0.903	1.00
63_A	67_R	0.901	1.00
138_L	215_G	0.900	1.00
133_R	420_L	0.899	1.00
214_D	423_R	0.898	1.00
338_E	363_I	0.895	1.00
21_N	26_E	0.894	1.00
133_R	445_I	0.894	1.00
51_P	55_R	0.892	1.00
71_L	75_N	0.892	1.00
364_E	385_R	0.891	1.00
250_L	408_V	0.890	1.00
258_I	262_V	0.887	1.00
58_F	62_H	0.886	1.00
101_M	148_G	0.882	1.00
62_H	66_E	0.880	1.00
239_I	464_W	0.880	1.00
253_D	389_F	0.879	1.00
384_W	395_M	0.878	1.00
87_T	173_T	0.875	1.00
416_D	420_L	0.875	1.00
39_V	139_A	0.873	1.00
20_R	356_S	0.871	1.00
365_M	369_A	0.870	1.00
440_A	467_A	0.866	1.00
333_A	370_G	0.864	1.00
41_Q	45_A	0.862	1.00
221_S	224_T	0.862	1.00
253_D	409_S	0.861	1.00
291_G	364_E	0.861	1.00
69_A	109_I	0.860	1.00
89_K	97_E	0.860	1.00
181_M	185_Q	0.860	1.00
36_A	202_E	0.859	1.00
262_V	298_L	0.858	1.00
262_V	301_V	0.857	1.00
172_L	325_Q	0.857	1.00
135_H	239_I	0.854	1.00
229_H	232_L	0.854	1.00
129_S	470_E	0.851	1.00
226_Y	230_R	0.850	1.00
328_Q	331_V	0.849	1.00
199_G	203_T	0.848	1.00
367_G	384_W	0.846	1.00
342_G	369_A	0.846	1.00
55_R	420_L	0.843	1.00
348_P	361_G	0.842	1.00
341_G	369_A	0.840	1.00
330_V	376_V	0.840	1.00
72_L	101_M	0.839	1.00
392_A	395_M	0.838	1.00
23_V	357_L	0.837	1.00
405_C	422_A	0.837	1.00
62_H	109_I	0.834	1.00
178_E	182_R	0.831	1.00
167_F	177_G	0.820	1.00
95_A	314_P	0.819	1.00
407_L	418_L	0.818	1.00
161_A	463_A	0.817	1.00
37_A	41_Q	0.816	1.00
49_A	193_V	0.816	1.00
261_A	265_T	0.816	1.00
157_P	458_A	0.814	1.00
262_V	294_F	0.814	1.00
216_L	232_L	0.814	1.00
208_S	228_L	0.812	1.00
37_A	40_E	0.808	1.00
225_G	244_M	0.807	1.00
34_A	38_Q	0.807	1.00
386_Y	391_E	0.807	1.00
412_R	415_F	0.806	1.00
201_R	205_Q	0.805	1.00
296_A	299_V	0.804	1.00
252_I	294_F	0.803	1.00
46_A	195_N	0.801	1.00
45_A	192_G	0.799	1.00
158_A	165_I	0.796	1.00
151_P	155_I	0.796	1.00
41_Q	44_R	0.796	1.00
169_P	198_Q	0.794	1.00
135_H	163_N	0.793	1.00
139_A	204_G	0.792	1.00
135_H	464_W	0.791	1.00
334_W	380_L	0.790	1.00
393_I	397_N	0.789	1.00
53_W	193_V	0.788	1.00
424_A	427_V	0.786	1.00
216_L	228_L	0.785	1.00
229_H	237_E	0.781	1.00
92_W	317_F	0.781	1.00
248_N	281_R	0.780	1.00
59_A	113_H	0.779	1.00
48_A	51_P	0.776	1.00
325_Q	328_Q	0.773	1.00
28_L	85_R	0.771	1.00
307_P	351_L	0.770	1.00
66_E	70_A	0.769	1.00
65_V	160_L	0.768	1.00
225_G	242_L	0.768	1.00
189_L	193_V	0.763	1.00
189_L	194_L	0.763	1.00
72_L	102_I	0.762	1.00
48_A	52_R	0.761	1.00
330_V	358_L	0.761	1.00
152_N	180_V	0.758	1.00
84_A	91_R	0.758	1.00
85_R	175_W	0.755	1.00
298_L	362_I	0.755	1.00
148_G	176_S	0.754	1.00
87_T	322_I	0.752	1.00
139_A	216_L	0.751	1.00
337_L	376_V	0.751	1.00
218_F	224_T	0.748	1.00
222_A	447_A	0.747	1.00
73_E	76_K	0.745	1.00
91_R	311_D	0.743	1.00
338_E	349_R	0.742	1.00
34_A	42_A	0.739	1.00
208_S	231_Q	0.739	1.00
262_V	266_I	0.738	1.00
73_E	99_T	0.737	1.00
258_I	289_A	0.737	1.00
249_P	396_A	0.736	1.00
261_A	294_F	0.735	1.00
80_T	84_A	0.734	1.00
286_K	389_F	0.733	1.00
80_T	91_R	0.732	1.00
21_N	311_D	0.730	1.00
51_P	54_A	0.727	1.00
140_V	154_H	0.727	1.00
232_L	240_L	0.726	1.00
67_R	187_A	0.723	1.00
259_D	301_V	0.723	1.00
333_A	374_E	0.721	1.00
226_Y	235_Q	0.720	1.00
305_L	317_F	0.719	1.00
208_S	216_L	0.713	1.00
266_I	298_L	0.713	1.00
52_R	56_L	0.708	1.00
142_G	151_P	0.707	1.00
329_Q	332_T	0.705	1.00
201_R	227_Q	0.703	1.00
302_S	346_L	0.702	1.00
128_A	467_A	0.701	1.00
299_V	302_S	0.700	1.00
285_L	289_A	0.700	1.00
253_D	286_K	0.698	1.00
206_A	209_A	0.698	1.00
167_F	194_L	0.696	1.00
172_L	322_I	0.696	1.00
312_D	316_P	0.695	1.00
77_A	91_R	0.695	1.00
135_H	214_D	0.694	1.00
20_R	25_G	0.692	1.00
151_P	177_G	0.691	1.00
199_G	204_G	0.688	1.00
46_A	164_T	0.688	1.00
204_G	208_S	0.688	1.00
39_V	206_A	0.688	1.00
230_R	233_S	0.687	1.00
284_L	372_P	0.687	1.00
53_W	64_V	0.685	1.00
326_A	329_Q	0.683	1.00
78_E	182_R	0.682	1.00
255_V	409_S	0.680	1.00
40_E	212_D	0.679	1.00
239_I	461_Y	0.679	1.00
25_G	324_E	0.678	1.00
47_R	50_F	0.676	1.00
39_V	43_C	0.676	1.00
345_L	364_E	0.674	1.00
324_E	350_L	0.673	1.00
410_P	413_E	0.673	1.00
265_T	298_L	0.672	1.00
429_W	470_E	0.672	1.00
284_L	367_G	0.672	1.00
163_N	463_A	0.672	1.00
323_S	326_A	0.669	1.00
151_P	180_V	0.668	1.00
412_R	416_D	0.668	1.00
16_S	32_N	0.667	1.00
54_A	421_E	0.667	1.00
83_I	86_E	0.667	1.00
412_R	470_E	0.666	1.00
309_N	316_P	0.666	1.00
171_E	329_Q	0.666	1.00
283_L	294_F	0.664	1.00
423_R	445_I	0.664	1.00
64_V	187_A	0.662	1.00
273_A	318_I	0.662	1.00
82_I	175_W	0.662	1.00
388_T	394_R	0.661	1.00
70_A	73_E	0.661	1.00
202_E	205_Q	0.660	1.00
252_I	261_A	0.657	1.00
15_A	202_E	0.657	1.00
308_G	312_D	0.656	1.00
58_F	112_Y	0.656	1.00
406_G	432_P	0.655	1.00
69_A	102_I	0.654	1.00
367_G	372_P	0.652	1.00
53_W	159_L	0.652	1.00
389_F	393_I	0.650	1.00
419_L	429_W	0.650	1.00
54_A	133_R	0.650	1.00
340_M	368_V	0.650	1.00
302_S	305_L	0.650	1.00
51_P	421_E	0.649	1.00
266_I	305_L	0.648	1.00
231_Q	235_Q	0.645	1.00
258_I	293_A	0.644	1.00
45_A	191_P	0.643	1.00
395_M	398_N	0.643	1.00
89_K	93_E	0.643	1.00
307_P	318_I	0.642	1.00
346_L	362_I	0.642	1.00
365_M	371_V	0.639	1.00
166_I	195_N	0.639	1.00
415_F	419_L	0.638	1.00
348_P	359_T	0.638	1.00
331_V	334_W	0.637	1.00
154_H	453_P	0.637	1.00
128_A	469_L	0.637	1.00
127_A	416_D	0.636	1.00
409_S	414_K	0.635	1.00
358_L	361_G	0.635	1.00
52_R	55_R	0.635	1.00
298_L	383_V	0.632	1.00
241_A	461_Y	0.632	1.00
171_E	227_Q	0.630	1.00
60_E	64_V	0.630	1.00
179_A	183_L	0.629	1.00
32_N	198_Q	0.629	1.00
325_Q	329_Q	0.629	1.00
64_V	188_G	0.629	1.00
79_L	148_G	0.628	1.00
98_V	102_I	0.627	1.00
460_D	465_P	0.627	1.00
460_D	463_A	0.626	1.00
76_K	80_T	0.625	1.00
229_H	242_L	0.624	1.00
34_A	197_V	0.624	1.00
416_D	470_E	0.622	1.00
184_W	189_L	0.619	1.00
154_H	217_L	0.619	1.00
83_I	94_A	0.619	1.00
260_A	263_H	0.618	1.00
19_K	29_W	0.617	1.00
260_A	410_P	0.616	1.00
49_A	52_R	0.616	1.00
115_R	463_A	0.615	1.00
84_A	311_D	0.615	1.00
54_A	134_P	0.614	1.00
89_K	146_F	0.609	1.00
83_I	97_E	0.608	1.00
58_F	160_L	0.606	1.00
129_S	468_S	0.605	1.00
83_I	176_S	0.604	1.00
334_W	363_I	0.603	1.00
148_G	180_V	0.602	1.00
255_V	410_P	0.602	1.00
42_A	197_V	0.602	1.00
44_R	47_R	0.600	1.00
327_A	351_L	0.599	1.00
155_I	167_F	0.597	1.00
131_R	466_M	0.595	1.00
31_G	174_P	0.594	1.00
407_L	415_F	0.594	1.00
19_K	86_E	0.594	1.00
81_A	84_A	0.593	1.00
321_L	326_A	0.593	1.00
413_E	416_D	0.593	1.00
36_A	209_A	0.592	1.00
255_V	411_E	0.591	1.00
350_L	359_T	0.590	1.00
72_L	180_V	0.589	1.00
376_V	380_L	0.588	1.00
393_I	417_Q	0.588	1.00
138_L	163_N	0.588	1.00
268_S	432_P	0.588	1.00
365_M	372_P	0.586	1.00
115_R	459_A	0.586	1.00
413_E	417_Q	0.584	1.00
71_L	188_G	0.582	1.00
72_L	105_I	0.581	1.00
367_G	394_R	0.579	1.00
269_A	381_L	0.579	1.00
98_V	148_G	0.578	1.00
28_L	175_W	0.576	1.00
69_A	105_I	0.576	1.00
344_P	361_G	0.574	1.00
344_P	347_A	0.574	1.00
215_G	461_Y	0.574	1.00
285_L	383_V	0.570	1.00
334_W	361_G	0.568	1.00
164_T	195_N	0.568	1.00
250_L	406_G	0.567	1.00
208_S	236_P	0.566	1.00
407_L	429_W	0.566	1.00
299_V	362_I	0.565	1.00
222_A	226_Y	0.565	1.00
307_P	317_F	0.562	1.00
259_D	300_A	0.561	1.00
250_L	283_L	0.561	1.00
331_V	338_E	0.561	1.00
180_V	184_W	0.561	1.00
278_T	436_A	0.560	1.00
72_L	148_G	0.559	1.00
427_V	466_M	0.558	1.00
45_A	49_A	0.557	1.00
285_L	291_G	0.556	1.00
248_N	404_S	0.554	1.00
80_T	98_V	0.553	1.00
254_E	386_Y	0.553	1.00
393_I	422_A	0.551	1.00
107_I	111_A	0.551	1.00
79_L	98_V	0.551	1.00
396_A	422_A	0.550	1.00
68_F	71_L	0.550	1.00
33_D	200_G	0.550	1.00
428_N	431_K	0.549	1.00
371_V	376_V	0.548	1.00
72_L	79_L	0.548	1.00
159_L	194_L	0.547	1.00
276_R	279_C	0.547	1.00
258_I	294_F	0.544	1.00
240_L	450_N	0.544	1.00
42_A	195_N	0.544	1.00
200_G	204_G	0.544	1.00
287_S	291_G	0.543	1.00
47_R	137_V	0.542	1.00
185_Q	192_G	0.540	1.00
15_A	35_D	0.540	1.00
46_A	137_V	0.539	1.00
137_V	214_D	0.539	1.00
389_F	421_E	0.538	1.00
283_L	383_V	0.537	1.00
258_I	261_A	0.536	1.00
111_A	456_W	0.536	1.00
46_A	166_I	0.536	1.00
171_E	223_N	0.535	1.00
58_F	116_T	0.535	1.00
99_T	102_I	0.535	1.00
392_A	396_A	0.535	1.00
108_S	157_P	0.535	1.00
97_E	146_F	0.535	1.00
223_N	325_Q	0.535	1.00
256_A	261_A	0.534	1.00
423_R	464_W	0.532	1.00
217_L	462_C	0.532	1.00
138_L	165_I	0.532	1.00
59_A	63_A	0.531	1.00
64_V	68_F	0.531	1.00
161_A	459_A	0.531	1.00
110_K	113_H	0.531	1.00
116_T	119_Q	0.530	1.00
76_K	102_I	0.529	1.00
133_R	423_R	0.529	1.00
270_F	305_L	0.528	1.00
149_H	153_G	0.526	1.00
140_V	155_I	0.526	1.00
233_S	237_E	0.526	1.00
426_I	435_G	0.526	1.00
321_L	358_L	0.526	1.00
100_A	149_H	0.525	1.00
329_Q	333_A	0.524	1.00
67_R	188_G	0.523	1.00
19_K	174_P	0.523	1.00
349_R	352_Q	0.522	1.00
340_M	366_T	0.522	1.00
87_T	272_T	0.521	1.00
31_G	175_W	0.519	1.00
63_A	66_E	0.519	1.00
33_D	171_E	0.517	1.00
394_R	421_E	0.517	1.00
280_A	406_G	0.514	1.00
262_V	289_A	0.514	1.00
201_R	223_N	0.512	1.00
418_L	422_A	0.510	1.00
367_G	373_D	0.510	1.00
422_A	427_V	0.509	1.00
272_T	276_R	0.506	1.00
263_H	267_Q	0.505	1.00
344_P	348_P	0.504	1.00
372_P	395_M	0.504	1.00
404_S	428_N	0.504	1.00
342_G	365_M	0.501	1.00
298_L	302_S	0.500	1.00
80_T	94_A	0.500	1.00
34_A	39_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pxlA	4	0.9654	100	0.063	Contact Map
4pz2A	4	0.9634	100	0.063	Contact Map
4yweA	5	0.9533	100	0.064	Contact Map
4lihA	5	0.9533	100	0.064	Contact Map
4o5hA	4	0.9533	100	0.065	Contact Map
4qf6A	4	0.9533	100	0.065	Contact Map
1a4sA	4	0.9654	100	0.068	Contact Map
1wndA	4	0.9492	100	0.069	Contact Map
3ek1A	5	0.9512	100	0.07	Contact Map
4wj9A	4	0.9614	100	0.071	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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