GREMLIN Database
ASTD - N-succinylglutamate 5-semialdehyde dehydrogenase
UniProt: P76217 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13997
Length: 492 (453)
Sequences: 36326 (21790)
Seq/√Len: 1023.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
287_S387_D5.0811.00
230_R235_Q3.4541.00
287_S385_R3.2021.00
259_D297_R3.1141.00
291_G385_R2.9961.00
18_V30_Q2.8171.00
349_R359_T2.8011.00
47_R212_D2.7781.00
254_E286_K2.7681.00
366_T369_A2.6741.00
324_E328_Q2.6361.00
263_H301_V2.5941.00
336_Q370_G2.5851.00
295_L383_V2.5561.00
179_A182_R2.5561.00
335_Q339_A2.5061.00
254_E288_G2.4571.00
75_N78_E2.4181.00
73_E106_A2.4101.00
409_S415_F2.3621.00
18_V27_V2.3371.00
334_W358_L2.2641.00
47_R214_D2.2361.00
343_R364_E2.2081.00
35_D38_Q2.2081.00
185_Q191_P2.2051.00
76_K99_T2.1641.00
77_A95_A2.1611.00
312_D315_Q2.1561.00
331_V335_Q2.1531.00
68_F184_W2.1051.00
389_F414_K2.0831.00
71_L186_Q2.0811.00
133_R466_M2.0401.00
400_R447_A2.0341.00
205_Q209_A2.0251.00
172_L323_S1.9981.00
209_A231_Q1.9881.00
331_V350_L1.9811.00
336_Q340_M1.9631.00
299_V303_Q1.9451.00
321_L330_V1.9351.00
250_L265_T1.9341.00
417_Q421_E1.9211.00
132_H460_D1.9191.00
331_V358_L1.9111.00
78_E179_A1.9071.00
293_A297_R1.8991.00
64_V189_L1.8801.00
40_E206_A1.8751.00
255_V414_K1.8181.00
226_Y447_A1.8001.00
338_E344_P1.8001.00
44_R212_D1.8001.00
227_Q230_R1.7871.00
71_L74_S1.7851.00
284_L395_M1.7771.00
75_N186_Q1.7661.00
423_R446_G1.7451.00
389_F417_Q1.7371.00
372_P384_W1.7181.00
132_H463_A1.7101.00
71_L187_A1.6911.00
40_E44_R1.6851.00
367_G395_M1.6771.00
286_K386_Y1.6641.00
284_L392_A1.6581.00
302_S362_I1.6541.00
27_V30_Q1.6501.00
66_E106_A1.6451.00
299_V345_L1.6431.00
181_M196_L1.6211.00
71_L183_L1.6181.00
363_I371_V1.6131.00
82_I179_A1.6051.00
391_E394_R1.6011.00
291_G295_L1.6001.00
265_T294_F1.5921.00
370_G374_E1.5781.00
105_I156_V1.5751.00
73_E102_I1.5721.00
91_R95_A1.5711.00
387_D391_E1.5711.00
296_A300_A1.5671.00
270_F302_S1.5611.00
57_S60_E1.5581.00
332_T370_G1.5421.00
70_A74_S1.5421.00
50_F54_A1.5321.00
297_R300_A1.5261.00
324_E356_S1.5241.00
258_I297_R1.5231.00
164_T193_V1.5141.00
67_R70_A1.4901.00
262_V297_R1.4871.00
292_D385_R1.4811.00
283_L381_L1.4801.00
60_E63_A1.4791.00
40_E210_L1.4691.00
16_S30_Q1.4651.00
253_D414_K1.4631.00
182_R186_Q1.4531.00
55_R421_E1.4461.00
81_A85_R1.4441.00
66_E113_H1.4431.00
76_K95_A1.4401.00
264_L408_V1.4361.00
284_L386_Y1.4361.00
344_P363_I1.4341.00
25_G354_G1.4301.00
301_V304_R1.4241.00
390_D421_E1.4211.00
254_E414_K1.4101.00
69_A106_A1.4091.00
293_A296_A1.4031.00
405_C424_A1.4031.00
77_A81_A1.4021.00
265_T283_L1.4001.00
56_L60_E1.3951.00
111_A114_V1.3951.00
335_Q338_E1.3931.00
131_R420_L1.3841.00
391_E395_M1.3831.00
70_A106_A1.3791.00
20_R27_V1.3741.00
105_I152_N1.3741.00
171_E201_R1.3721.00
285_L294_F1.3701.00
38_Q41_Q1.3671.00
75_N179_A1.3611.00
140_V165_I1.3601.00
306_T315_Q1.3351.00
84_A94_A1.3251.00
330_V378_G1.3251.00
229_H450_N1.3231.00
253_D386_Y1.3201.00
205_Q231_Q1.3201.00
327_A331_V1.3201.00
333_A376_V1.3181.00
26_E354_G1.3171.00
15_A33_D1.3141.00
215_G241_A1.3121.00
340_M370_G1.3061.00
328_Q332_T1.3041.00
81_A311_D1.3041.00
386_Y395_M1.2911.00
327_A350_L1.2841.00
151_P167_F1.2791.00
21_N24_S1.2791.00
327_A358_L1.2781.00
181_M194_L1.2731.00
295_L299_V1.2611.00
253_D418_L1.2591.00
50_F164_T1.2571.00
292_D296_A1.2561.00
300_A303_Q1.2541.00
303_Q346_L1.2481.00
393_I418_L1.2331.00
324_E327_A1.2271.00
289_A293_A1.2211.00
36_A206_A1.2201.00
251_I392_A1.2191.00
309_N312_D1.2181.00
43_C210_L1.2121.00
69_A73_E1.2111.00
205_Q227_Q1.2051.00
286_K388_T1.2021.00
368_V373_D1.1941.00
388_T391_E1.1941.00
184_W194_L1.1931.00
457_Y460_D1.1921.00
308_G316_P1.1911.00
44_R48_A1.1901.00
192_G195_N1.1821.00
332_T336_Q1.1811.00
286_K289_A1.1801.00
297_R301_V1.1791.00
306_T317_F1.1771.00
39_V203_T1.1761.00
132_H465_P1.1611.00
456_W460_D1.1611.00
367_G398_N1.1581.00
79_L179_A1.1571.00
56_L64_V1.1531.00
129_S416_D1.1501.00
81_A91_R1.1481.00
390_D417_Q1.1451.00
298_L381_L1.1441.00
43_C213_L1.1421.00
419_L468_S1.1401.00
300_A304_R1.1361.00
84_A310_W1.1321.00
294_F298_L1.1291.00
295_L345_L1.1281.00
405_C427_V1.1261.00
45_A195_N1.1171.00
43_C212_D1.1151.00
227_Q231_Q1.1121.00
373_D400_R1.1051.00
415_F429_W1.1051.00
68_F189_L1.1051.00
17_R33_D1.1051.00
68_F183_L1.1021.00
67_R71_L1.0981.00
224_T227_Q1.0971.00
155_I194_L1.0961.00
135_H215_G1.0961.00
118_E456_W1.0951.00
223_N227_Q1.0931.00
337_L363_I1.0911.00
178_E198_Q1.0871.00
229_H240_L1.0851.00
66_E110_K1.0851.00
373_D398_N1.0851.00
21_N309_N1.0801.00
250_L280_A1.0781.00
140_V217_L1.0751.00
390_D394_R1.0731.00
342_G363_I1.0721.00
251_I418_L1.0701.00
68_F105_I1.0651.00
29_W175_W1.0651.00
257_D410_P1.0641.00
389_F418_L1.0571.00
139_A207_L1.0541.00
23_V310_W1.0511.00
457_Y465_P1.0491.00
303_Q359_T1.0461.00
393_I421_E1.0451.00
351_L359_T1.0431.00
299_V346_L1.0411.00
139_A213_L1.0411.00
251_I396_A1.0371.00
305_L318_I1.0371.00
118_E457_Y1.0291.00
340_M369_A1.0291.00
146_F276_R1.0281.00
155_I165_I1.0251.00
206_A210_L1.0231.00
226_Y237_E1.0201.00
411_E414_K1.0141.00
247_N281_R1.0121.00
386_Y392_A1.0091.00
25_G356_S1.0051.00
327_A356_S1.0001.00
347_A361_G0.9991.00
79_L183_L0.9941.00
49_A164_T0.9881.00
209_A235_Q0.9851.00
62_H113_H0.9841.00
51_P423_R0.9821.00
257_D260_A0.9811.00
131_R468_S0.9791.00
101_M152_N0.9771.00
347_A359_T0.9731.00
443_G452_R0.9701.00
51_P394_R0.9691.00
75_N183_L0.9681.00
330_V380_L0.9681.00
47_R51_P0.9651.00
112_Y160_L0.9611.00
452_R464_W0.9561.00
137_V164_T0.9561.00
74_S186_Q0.9541.00
178_E196_L0.9511.00
445_I464_W0.9511.00
78_E81_A0.9501.00
182_R185_Q0.9491.00
66_E109_I0.9491.00
249_P405_C0.9491.00
21_N85_R0.9481.00
336_Q339_A0.9461.00
259_D293_A0.9421.00
394_R398_N0.9421.00
260_A264_L0.9351.00
75_N182_R0.9351.00
266_I301_V0.9351.00
36_A40_E0.9211.00
54_A423_R0.9181.00
33_D202_E0.9151.00
80_T95_A0.9141.00
229_H233_S0.9141.00
333_A336_Q0.9131.00
292_D295_L0.9131.00
268_S280_A0.9091.00
332_T335_Q0.9091.00
128_A440_A0.9081.00
85_R311_D0.9071.00
137_V213_L0.9041.00
269_A281_R0.9041.00
291_G383_V0.9031.00
63_A67_R0.9011.00
138_L215_G0.9001.00
133_R420_L0.8991.00
214_D423_R0.8981.00
338_E363_I0.8951.00
21_N26_E0.8941.00
133_R445_I0.8941.00
51_P55_R0.8921.00
71_L75_N0.8921.00
364_E385_R0.8911.00
250_L408_V0.8901.00
258_I262_V0.8871.00
58_F62_H0.8861.00
101_M148_G0.8821.00
62_H66_E0.8801.00
239_I464_W0.8801.00
253_D389_F0.8791.00
384_W395_M0.8781.00
87_T173_T0.8751.00
416_D420_L0.8751.00
39_V139_A0.8731.00
20_R356_S0.8711.00
365_M369_A0.8701.00
440_A467_A0.8661.00
333_A370_G0.8641.00
41_Q45_A0.8621.00
221_S224_T0.8621.00
253_D409_S0.8611.00
291_G364_E0.8611.00
69_A109_I0.8601.00
89_K97_E0.8601.00
181_M185_Q0.8601.00
36_A202_E0.8591.00
262_V298_L0.8581.00
262_V301_V0.8571.00
172_L325_Q0.8571.00
135_H239_I0.8541.00
229_H232_L0.8541.00
129_S470_E0.8511.00
226_Y230_R0.8501.00
328_Q331_V0.8491.00
199_G203_T0.8481.00
367_G384_W0.8461.00
342_G369_A0.8461.00
55_R420_L0.8431.00
348_P361_G0.8421.00
341_G369_A0.8401.00
330_V376_V0.8401.00
72_L101_M0.8391.00
392_A395_M0.8381.00
23_V357_L0.8371.00
405_C422_A0.8371.00
62_H109_I0.8341.00
178_E182_R0.8311.00
167_F177_G0.8201.00
95_A314_P0.8191.00
407_L418_L0.8181.00
161_A463_A0.8171.00
37_A41_Q0.8161.00
49_A193_V0.8161.00
261_A265_T0.8161.00
157_P458_A0.8141.00
262_V294_F0.8141.00
216_L232_L0.8141.00
208_S228_L0.8121.00
37_A40_E0.8081.00
225_G244_M0.8071.00
34_A38_Q0.8071.00
386_Y391_E0.8071.00
412_R415_F0.8061.00
201_R205_Q0.8051.00
296_A299_V0.8041.00
252_I294_F0.8031.00
46_A195_N0.8011.00
45_A192_G0.7991.00
158_A165_I0.7961.00
151_P155_I0.7961.00
41_Q44_R0.7961.00
169_P198_Q0.7941.00
135_H163_N0.7931.00
139_A204_G0.7921.00
135_H464_W0.7911.00
334_W380_L0.7901.00
393_I397_N0.7891.00
53_W193_V0.7881.00
424_A427_V0.7861.00
216_L228_L0.7851.00
229_H237_E0.7811.00
92_W317_F0.7811.00
248_N281_R0.7801.00
59_A113_H0.7791.00
48_A51_P0.7761.00
325_Q328_Q0.7731.00
28_L85_R0.7711.00
307_P351_L0.7701.00
66_E70_A0.7691.00
65_V160_L0.7681.00
225_G242_L0.7681.00
189_L193_V0.7631.00
189_L194_L0.7631.00
72_L102_I0.7621.00
48_A52_R0.7611.00
330_V358_L0.7611.00
152_N180_V0.7581.00
84_A91_R0.7581.00
85_R175_W0.7551.00
298_L362_I0.7551.00
148_G176_S0.7541.00
87_T322_I0.7521.00
139_A216_L0.7511.00
337_L376_V0.7511.00
218_F224_T0.7481.00
222_A447_A0.7471.00
73_E76_K0.7451.00
91_R311_D0.7431.00
338_E349_R0.7421.00
34_A42_A0.7391.00
208_S231_Q0.7391.00
262_V266_I0.7381.00
73_E99_T0.7371.00
258_I289_A0.7371.00
249_P396_A0.7361.00
261_A294_F0.7351.00
80_T84_A0.7341.00
286_K389_F0.7331.00
80_T91_R0.7321.00
21_N311_D0.7301.00
51_P54_A0.7271.00
140_V154_H0.7271.00
232_L240_L0.7261.00
67_R187_A0.7231.00
259_D301_V0.7231.00
333_A374_E0.7211.00
226_Y235_Q0.7201.00
305_L317_F0.7191.00
208_S216_L0.7131.00
266_I298_L0.7131.00
52_R56_L0.7081.00
142_G151_P0.7071.00
329_Q332_T0.7051.00
201_R227_Q0.7031.00
302_S346_L0.7021.00
128_A467_A0.7011.00
299_V302_S0.7001.00
285_L289_A0.7001.00
253_D286_K0.6981.00
206_A209_A0.6981.00
167_F194_L0.6961.00
172_L322_I0.6961.00
312_D316_P0.6951.00
77_A91_R0.6951.00
135_H214_D0.6941.00
20_R25_G0.6921.00
151_P177_G0.6911.00
199_G204_G0.6881.00
46_A164_T0.6881.00
204_G208_S0.6881.00
39_V206_A0.6881.00
230_R233_S0.6871.00
284_L372_P0.6871.00
53_W64_V0.6851.00
326_A329_Q0.6831.00
78_E182_R0.6821.00
255_V409_S0.6801.00
40_E212_D0.6791.00
239_I461_Y0.6791.00
25_G324_E0.6781.00
47_R50_F0.6761.00
39_V43_C0.6761.00
345_L364_E0.6741.00
324_E350_L0.6731.00
410_P413_E0.6731.00
265_T298_L0.6721.00
429_W470_E0.6721.00
284_L367_G0.6721.00
163_N463_A0.6721.00
323_S326_A0.6691.00
151_P180_V0.6681.00
412_R416_D0.6681.00
16_S32_N0.6671.00
54_A421_E0.6671.00
83_I86_E0.6671.00
412_R470_E0.6661.00
309_N316_P0.6661.00
171_E329_Q0.6661.00
283_L294_F0.6641.00
423_R445_I0.6641.00
64_V187_A0.6621.00
273_A318_I0.6621.00
82_I175_W0.6621.00
388_T394_R0.6611.00
70_A73_E0.6611.00
202_E205_Q0.6601.00
252_I261_A0.6571.00
15_A202_E0.6571.00
308_G312_D0.6561.00
58_F112_Y0.6561.00
406_G432_P0.6551.00
69_A102_I0.6541.00
367_G372_P0.6521.00
53_W159_L0.6521.00
389_F393_I0.6501.00
419_L429_W0.6501.00
54_A133_R0.6501.00
340_M368_V0.6501.00
302_S305_L0.6501.00
51_P421_E0.6491.00
266_I305_L0.6481.00
231_Q235_Q0.6451.00
258_I293_A0.6441.00
45_A191_P0.6431.00
395_M398_N0.6431.00
89_K93_E0.6431.00
307_P318_I0.6421.00
346_L362_I0.6421.00
365_M371_V0.6391.00
166_I195_N0.6391.00
415_F419_L0.6381.00
348_P359_T0.6381.00
331_V334_W0.6371.00
154_H453_P0.6371.00
128_A469_L0.6371.00
127_A416_D0.6361.00
409_S414_K0.6351.00
358_L361_G0.6351.00
52_R55_R0.6351.00
298_L383_V0.6321.00
241_A461_Y0.6321.00
171_E227_Q0.6301.00
60_E64_V0.6301.00
179_A183_L0.6291.00
32_N198_Q0.6291.00
325_Q329_Q0.6291.00
64_V188_G0.6291.00
79_L148_G0.6281.00
98_V102_I0.6271.00
460_D465_P0.6271.00
460_D463_A0.6261.00
76_K80_T0.6251.00
229_H242_L0.6241.00
34_A197_V0.6241.00
416_D470_E0.6221.00
184_W189_L0.6191.00
154_H217_L0.6191.00
83_I94_A0.6191.00
260_A263_H0.6181.00
19_K29_W0.6171.00
260_A410_P0.6161.00
49_A52_R0.6161.00
115_R463_A0.6151.00
84_A311_D0.6151.00
54_A134_P0.6141.00
89_K146_F0.6091.00
83_I97_E0.6081.00
58_F160_L0.6061.00
129_S468_S0.6051.00
83_I176_S0.6041.00
334_W363_I0.6031.00
148_G180_V0.6021.00
255_V410_P0.6021.00
42_A197_V0.6021.00
44_R47_R0.6001.00
327_A351_L0.5991.00
155_I167_F0.5971.00
131_R466_M0.5951.00
31_G174_P0.5941.00
407_L415_F0.5941.00
19_K86_E0.5941.00
81_A84_A0.5931.00
321_L326_A0.5931.00
413_E416_D0.5931.00
36_A209_A0.5921.00
255_V411_E0.5911.00
350_L359_T0.5901.00
72_L180_V0.5891.00
376_V380_L0.5881.00
393_I417_Q0.5881.00
138_L163_N0.5881.00
268_S432_P0.5881.00
365_M372_P0.5861.00
115_R459_A0.5861.00
413_E417_Q0.5841.00
71_L188_G0.5821.00
72_L105_I0.5811.00
367_G394_R0.5791.00
269_A381_L0.5791.00
98_V148_G0.5781.00
28_L175_W0.5761.00
69_A105_I0.5761.00
344_P361_G0.5741.00
344_P347_A0.5741.00
215_G461_Y0.5741.00
285_L383_V0.5701.00
334_W361_G0.5681.00
164_T195_N0.5681.00
250_L406_G0.5671.00
208_S236_P0.5661.00
407_L429_W0.5661.00
299_V362_I0.5651.00
222_A226_Y0.5651.00
307_P317_F0.5621.00
259_D300_A0.5611.00
250_L283_L0.5611.00
331_V338_E0.5611.00
180_V184_W0.5611.00
278_T436_A0.5601.00
72_L148_G0.5591.00
427_V466_M0.5581.00
45_A49_A0.5571.00
285_L291_G0.5561.00
248_N404_S0.5541.00
80_T98_V0.5531.00
254_E386_Y0.5531.00
393_I422_A0.5511.00
107_I111_A0.5511.00
79_L98_V0.5511.00
396_A422_A0.5501.00
68_F71_L0.5501.00
33_D200_G0.5501.00
428_N431_K0.5491.00
371_V376_V0.5481.00
72_L79_L0.5481.00
159_L194_L0.5471.00
276_R279_C0.5471.00
258_I294_F0.5441.00
240_L450_N0.5441.00
42_A195_N0.5441.00
200_G204_G0.5441.00
287_S291_G0.5431.00
47_R137_V0.5421.00
185_Q192_G0.5401.00
15_A35_D0.5401.00
46_A137_V0.5391.00
137_V214_D0.5391.00
389_F421_E0.5381.00
283_L383_V0.5371.00
258_I261_A0.5361.00
111_A456_W0.5361.00
46_A166_I0.5361.00
171_E223_N0.5351.00
58_F116_T0.5351.00
99_T102_I0.5351.00
392_A396_A0.5351.00
108_S157_P0.5351.00
97_E146_F0.5351.00
223_N325_Q0.5351.00
256_A261_A0.5341.00
423_R464_W0.5321.00
217_L462_C0.5321.00
138_L165_I0.5321.00
59_A63_A0.5311.00
64_V68_F0.5311.00
161_A459_A0.5311.00
110_K113_H0.5311.00
116_T119_Q0.5301.00
76_K102_I0.5291.00
133_R423_R0.5291.00
270_F305_L0.5281.00
149_H153_G0.5261.00
140_V155_I0.5261.00
233_S237_E0.5261.00
426_I435_G0.5261.00
321_L358_L0.5261.00
100_A149_H0.5251.00
329_Q333_A0.5241.00
67_R188_G0.5231.00
19_K174_P0.5231.00
349_R352_Q0.5221.00
340_M366_T0.5221.00
87_T272_T0.5211.00
31_G175_W0.5191.00
63_A66_E0.5191.00
33_D171_E0.5171.00
394_R421_E0.5171.00
280_A406_G0.5141.00
262_V289_A0.5141.00
201_R223_N0.5121.00
418_L422_A0.5101.00
367_G373_D0.5101.00
422_A427_V0.5091.00
272_T276_R0.5061.00
263_H267_Q0.5051.00
344_P348_P0.5041.00
372_P395_M0.5041.00
404_S428_N0.5041.00
342_G365_M0.5011.00
298_L302_S0.5001.00
80_T94_A0.5001.00
34_A39_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxlA 4 0.9654 100 0.063 Contact Map
4pz2A 4 0.9634 100 0.063 Contact Map
4yweA 5 0.9533 100 0.064 Contact Map
4lihA 5 0.9533 100 0.064 Contact Map
4o5hA 4 0.9533 100 0.065 Contact Map
4qf6A 4 0.9533 100 0.065 Contact Map
1a4sA 4 0.9654 100 0.068 Contact Map
1wndA 4 0.9492 100 0.069 Contact Map
3ek1A 5 0.9512 100 0.07 Contact Map
4wj9A 4 0.9614 100 0.071 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0145 seconds.