GREMLIN Database
ASTB - N-succinylarginine dihydrolase
UniProt: P76216 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13996
Length: 447 (439)
Sequences: 438 (229)
Seq/√Len: 10.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
215_R219_E5.9111.00
43_K399_D4.9521.00
298_D328_H4.3741.00
120_T192_Q4.3101.00
391_F395_N4.2300.99
180_N255_S4.1410.99
152_I384_V4.0830.99
43_K395_N3.8440.99
241_V296_V3.7450.99
65_H105_P3.5940.98
43_K391_F3.5250.98
321_L348_L3.5000.98
50_K54_D3.4340.97
276_N280_R3.4290.97
66_E421_R3.4180.97
332_W336_N3.4150.97
246_V252_I3.4140.97
42_A398_V3.3830.97
293_Q337_E3.3540.97
332_W350_V3.2980.97
142_A164_A3.2920.97
265_Q291_A3.1710.96
235_A273_L3.0420.95
115_A192_Q2.9880.94
182_L235_A2.9260.93
310_L320_V2.8260.92
259_V317_M2.8020.92
235_A277_L2.7050.90
321_L350_V2.6160.89
257_R311_S2.5610.88
199_E216_E2.5580.88
262_C270_Q2.4910.86
290_P293_Q2.4220.85
302_T328_H2.3090.81
115_A120_T2.2940.81
269_R272_Q2.2390.79
425_D434_G2.2130.79
182_L193_L2.1920.78
72_V136_F2.1590.77
61_V390_L2.1580.77
193_L235_A2.1410.76
74_R85_V2.1400.76
191_M233_I2.1080.75
57_F310_L2.0930.74
395_N399_D2.0790.74
274_L284_F2.0210.72
391_F399_D2.0000.71
241_V244_Q2.0000.71
312_R318_M1.9980.71
51_A351_F1.9900.70
50_K391_F1.9710.70
409_A412_A1.9690.70
125_V372_L1.9660.70
317_M344_P1.9540.69
69_F140_L1.9360.68
218_S234_F1.9290.68
53_A387_N1.9200.68
22_S135_K1.8940.67
428_S434_G1.8640.65
274_L286_A1.8500.65
69_F72_V1.8470.64
262_C286_A1.8450.64
72_V140_L1.7910.62
63_P152_I1.7830.62
117_S376_E1.7730.61
147_S441_R1.7490.60
70_I86_L1.7460.60
17_H98_S1.7400.60
289_V294_V1.7180.59
311_S318_M1.6970.58
116_P192_Q1.6940.57
6_V58_P1.6430.55
343_N346_S1.6190.54
261_F289_V1.6180.54
307_S353_L1.6010.53
199_E215_R1.6010.53
26_E108_V1.5990.53
193_L273_L1.5910.53
334_Y338_L1.5740.52
255_S355_E1.5530.51
146_E161_V1.5340.50
84_Q88_K1.5190.49
323_Q327_E1.5140.49
319_L339_L1.5100.49
323_Q326_R1.5000.48
434_G440_Q1.4930.48
261_F334_Y1.4900.48
256_N317_M1.4880.48
124_K319_L1.4820.47
47_L395_N1.4700.47
434_G439_F1.4690.47
62_I152_I1.4680.47
129_V420_G1.4530.46
221_V396_D1.4510.46
88_K92_Q1.4350.45
123_G226_Q1.4270.45
3_A373_T1.4270.45
232_V277_L1.4160.44
182_L277_L1.4060.44
321_L325_C1.4010.44
116_P371_V1.3850.43
50_K395_N1.3720.42
227_V232_V1.3700.42
425_D428_S1.3600.42
124_K400_R1.3540.41
294_V331_V1.3530.41
100_V136_F1.3530.41
396_D400_R1.3510.41
4_W58_P1.3450.41
37_N405_R1.3440.41
346_S353_L1.3360.41
264_Q288_E1.3350.40
199_E202_N1.3270.40
97_L101_S1.3270.40
142_A167_Q1.3250.40
397_W430_L1.3170.40
390_L430_L1.3050.39
397_W424_L1.2990.39
15_T420_G1.2970.39
57_F313_D1.2960.39
66_E101_S1.2820.38
46_L398_V1.2800.38
428_S439_F1.2640.37
424_L428_S1.2510.37
386_M391_F1.2510.37
294_V334_Y1.2470.36
258_Q285_M1.2430.36
52_L61_V1.2360.36
428_S440_Q1.2340.36
335_L348_L1.2310.36
312_R347_E1.2300.36
115_A227_V1.2300.36
19_A86_L1.2230.35
150_K163_S1.2190.35
270_Q288_E1.2120.35
425_D439_F1.2110.35
206_P239_P1.2080.35
91_R221_V1.2070.35
329_A333_G1.2070.35
70_I417_L1.2070.35
316_S346_S1.2010.34
15_T425_D1.1980.34
425_D440_Q1.1960.34
57_F312_R1.1960.34
233_I273_L1.1930.34
191_M343_N1.1920.34
321_L332_W1.1870.34
120_T156_E1.1860.34
91_R200_E1.1830.34
189_P231_Q1.1770.33
63_P69_F1.1770.33
403_R419_E1.1740.33
78_F89_V1.1660.33
108_V352_D1.1660.33
29_T209_Y1.1620.33
19_A355_E1.1610.33
129_V146_E1.1600.33
262_C288_E1.1590.33
105_P430_L1.1560.33
390_L393_A1.1410.32
288_E382_P1.1400.32
15_T434_G1.1210.31
84_Q87_E1.1160.31
182_L273_L1.1120.31
270_Q286_A1.1080.31
63_P436_V1.1070.30
257_R309_L1.1010.30
63_P148_L1.0990.30
317_M346_S1.0920.30
65_H148_L1.0910.30
115_A225_N1.0860.30
326_R332_W1.0660.29
78_F85_V1.0630.29
273_L277_L1.0620.29
298_D302_T1.0540.28
75_Q142_A1.0510.28
238_N241_V1.0490.28
128_T224_L1.0480.28
8_F60_A1.0470.28
150_K161_V1.0390.28
182_L278_R1.0390.28
261_F294_V1.0340.28
58_P385_M1.0330.28
31_H34_Q1.0320.28
65_H144_V1.0280.27
85_V89_V1.0270.27
43_K241_V1.0240.27
133_N168_V1.0230.27
312_R316_S1.0170.27
424_L437_Y1.0160.27
425_D436_V1.0160.27
120_T262_C1.0150.27
144_V161_V1.0120.27
32_R321_L1.0110.27
23_F40_L1.0040.26
115_A172_G0.9950.26
383_A432_N0.9910.26
89_V100_V0.9900.26
85_V100_V0.9900.26
57_F139_S0.9830.26
69_F101_S0.9760.25
318_M349_K0.9730.25
425_D435_S0.9670.25
232_V235_A0.9540.25
238_N244_Q0.9530.25
74_R82_D0.9490.24
6_V377_R0.9480.24
403_R413_D0.9420.24
172_G221_V0.9410.24
115_A224_L0.9400.24
236_Q268_A0.9380.24
311_S353_L0.9330.24
429_Q435_S0.9330.24
213_Q234_F0.9330.24
155_D158_K0.9300.24
54_D395_N0.9270.24
134_N241_V0.9260.24
202_N234_F0.9250.24
371_V377_R0.9230.24
285_M344_P0.9230.24
286_A320_V0.9210.23
60_A385_M0.9210.23
279_A441_R0.9210.23
180_N193_L0.9120.23
289_V334_Y0.9030.23
40_L133_N0.9000.23
124_K189_P0.9000.23
182_L284_F0.8970.23
114_I368_L0.8970.23
180_N325_C0.8960.23
189_P268_A0.8940.23
239_P268_A0.8940.23
309_L319_L0.8910.22
75_Q163_S0.8890.22
219_E326_R0.8880.22
323_Q353_L0.8870.22
129_V255_S0.8830.22
75_Q129_V0.8800.22
301_S328_H0.8780.22
142_A261_F0.8780.22
258_Q317_M0.8770.22
57_F321_L0.8710.22
17_H180_N0.8710.22
261_F290_P0.8710.22
402_Y419_E0.8700.22
14_L420_G0.8700.22
192_Q226_Q0.8690.22
381_N436_V0.8670.22
66_E417_L0.8670.22
320_V349_K0.8640.22
264_Q330_G0.8630.22
136_F216_E0.8630.22
47_L391_F0.8630.22
54_D388_D0.8610.21
50_K392_N0.8580.21
57_F311_S0.8550.21
253_A262_C0.8540.21
206_P243_D0.8530.21
180_N355_E0.8510.21
22_S134_N0.8480.21
272_Q276_N0.8470.21
186_Y256_N0.8470.21
316_S347_E0.8460.21
216_E220_A0.8430.21
320_V350_V0.8420.21
120_T301_S0.8420.21
296_V393_A0.8410.21
100_V161_V0.8410.21
142_A328_H0.8400.21
317_M343_N0.8390.21
120_T226_Q0.8360.21
167_Q261_F0.8340.21
187_G373_T0.8340.21
321_L335_L0.8310.21
417_L421_R0.8310.21
35_V405_R0.8270.20
221_V392_N0.8250.20
233_I387_N0.8220.20
307_S372_L0.8190.20
12_V325_C0.8180.20
89_V387_N0.8170.20
58_P377_R0.8160.20
275_A278_R0.8150.20
121_L231_Q0.8120.20
183_G192_Q0.8100.20
293_Q336_N0.8090.20
372_L397_W0.8080.20
171_L395_N0.8060.20
318_M353_L0.8060.20
244_Q296_V0.8040.20
50_K145_T0.8030.20
190_G345_I0.7990.20
290_P294_V0.7990.20
232_V386_M0.7970.19
3_A371_V0.7970.19
417_L434_G0.7960.19
403_R424_L0.7950.19
164_A167_Q0.7930.19
323_Q332_W0.7930.19
393_A430_L0.7900.19
222_A234_F0.7870.19
428_S437_Y0.7860.19
302_T390_L0.7850.19
62_I348_L0.7840.19
84_Q354_R0.7830.19
246_V300_V0.7830.19
63_P213_Q0.7790.19
252_I300_V0.7790.19
129_V142_A0.7770.19
6_V144_V0.7740.19
372_L376_E0.7740.19
297_S301_S0.7730.19
397_W417_L0.7720.19
147_S339_L0.7720.19
60_A304_L0.7690.19
7_N10_G0.7670.19
402_Y424_L0.7670.19
239_P243_D0.7650.19
401_Y422_E0.7590.18
351_F386_M0.7580.18
164_A307_S0.7580.18
397_W434_G0.7580.18
277_L286_A0.7570.18
301_S330_G0.7550.18
129_V140_L0.7550.18
297_S415_Q0.7530.18
17_H129_V0.7520.18
54_D391_F0.7490.18
207_S240_D0.7490.18
19_A198_R0.7490.18
70_I76_L0.7490.18
401_Y426_V0.7450.18
128_T225_N0.7440.18
108_V284_F0.7440.18
256_N398_V0.7420.18
86_L101_S0.7410.18
293_Q348_L0.7400.18
262_C317_M0.7380.18
75_Q98_S0.7360.18
158_K188_E0.7350.18
69_F438_P0.7350.18
70_I74_R0.7340.18
36_S409_A0.7340.18
164_A221_V0.7320.18
57_F318_M0.7310.18
88_K264_Q0.7310.18
348_L353_L0.7310.18
219_E330_G0.7280.17
342_D353_L0.7270.17
36_S221_V0.7250.17
135_K334_Y0.7210.17
60_A152_I0.7200.17
397_W428_S0.7190.17
101_S105_P0.7180.17
286_A310_L0.7170.17
120_T355_E0.7140.17
118_A192_Q0.7130.17
281_V353_L0.7120.17
148_L436_V0.7120.17
97_L410_D0.7120.17
252_I325_C0.7110.17
172_G192_Q0.7100.17
191_M277_L0.7100.17
289_V331_V0.7090.17
193_L233_I0.7060.17
325_C331_V0.7040.17
193_L255_S0.7030.17
434_G437_Y0.7010.17
133_N167_Q0.6990.17
228_N231_Q0.6990.17
307_S346_S0.6990.17
253_A256_N0.6990.17
206_P252_I0.6980.17
115_A232_V0.6970.17
55_A328_H0.6970.17
83_E418_R0.6960.17
81_S84_Q0.6960.17
17_H192_Q0.6950.17
31_H184_G0.6950.17
6_V257_R0.6920.17
96_W380_V0.6920.17
81_S336_N0.6910.16
327_E354_R0.6910.16
77_G411_L0.6910.16
323_Q350_V0.6890.16
31_H358_A0.6880.16
60_A373_T0.6880.16
72_V100_V0.6870.16
82_D421_R0.6870.16
259_V344_P0.6860.16
69_F281_V0.6850.16
51_A208_R0.6850.16
26_E31_H0.6840.16
37_N353_L0.6840.16
235_A358_A0.6830.16
274_L310_L0.6830.16
352_D422_E0.6820.16
3_A307_S0.6810.16
6_V60_A0.6810.16
142_A182_L0.6790.16
90_A412_A0.6790.16
435_S440_Q0.6770.16
135_K246_V0.6760.16
17_H401_Y0.6750.16
129_V147_S0.6700.16
151_A381_N0.6690.16
43_K47_L0.6680.16
30_R108_V0.6680.16
384_V390_L0.6680.16
318_M346_S0.6670.16
192_Q224_L0.6660.16
309_L353_L0.6640.16
208_R243_D0.6640.16
354_R436_V0.6640.16
230_Q234_F0.6630.16
63_P354_R0.6620.16
6_V381_N0.6610.16
233_I276_N0.6580.16
191_M405_R0.6580.16
17_H302_T0.6560.16
424_L434_G0.6560.16
37_N404_D0.6560.16
70_I421_R0.6550.16
79_S253_A0.6550.16
6_V387_N0.6540.16
82_D85_V0.6530.16
233_I255_S0.6520.15
379_A412_A0.6490.15
182_L260_L0.6490.15
154_N287_I0.6480.15
11_L78_F0.6460.15
191_M317_M0.6450.15
35_V373_T0.6450.15
53_A385_M0.6450.15
147_S201_G0.6420.15
63_P358_A0.6420.15
319_L335_L0.6410.15
277_L400_R0.6400.15
124_K160_S0.6400.15
39_R285_M0.6390.15
40_L391_F0.6390.15
403_R406_L0.6390.15
47_L54_D0.6370.15
309_L346_S0.6360.15
239_P325_C0.6360.15
286_A420_G0.6350.15
14_L255_S0.6350.15
55_A312_R0.6340.15
26_E355_E0.6320.15
378_R407_T0.6320.15
98_S302_T0.6310.15
88_K238_N0.6300.15
72_V139_S0.6290.15
168_V350_V0.6260.15
89_V379_A0.6260.15
424_L439_F0.6260.15
32_R198_R0.6250.15
274_L420_G0.6250.15
72_V98_S0.6250.15
98_S274_L0.6240.15
397_W425_D0.6240.15
37_N44_Q0.6240.15
256_N259_V0.6230.15
145_T380_V0.6230.15
125_V292_T0.6230.15
135_K300_V0.6190.15
93_A193_L0.6190.15
338_L376_E0.6190.15
62_I108_V0.6180.15
34_Q265_Q0.6180.15
329_A332_W0.6170.15
269_R339_L0.6170.15
27_A45_G0.6160.15
66_E438_P0.6160.15
310_L386_M0.6140.15
40_L355_E0.6120.15
372_L424_L0.6100.14
139_S221_V0.6090.14
164_A310_L0.6090.14
331_V335_L0.6090.14
295_S330_G0.6090.14
101_S417_L0.6090.14
39_R91_R0.6090.14
273_L353_L0.6070.14
76_L256_N0.6070.14
438_P441_R0.6060.14
98_S257_R0.6060.14
17_H60_A0.6050.14
135_K252_I0.6030.14
99_S139_S0.6030.14
26_E255_S0.6020.14
325_C348_L0.6010.14
233_I253_A0.6010.14
139_S142_A0.6010.14
228_N348_L0.6000.14
422_E426_V0.5990.14
326_R432_N0.5990.14
50_K53_A0.5980.14
201_G234_F0.5980.14
336_N348_L0.5980.14
33_F39_R0.5980.14
437_Y440_Q0.5960.14
15_T101_S0.5940.14
257_R302_T0.5930.14
108_V164_A0.5930.14
115_A296_V0.5910.14
30_R301_S0.5910.14
424_L430_L0.5900.14
3_A320_V0.5890.14
293_Q316_S0.5880.14
31_H302_T0.5880.14
19_A293_Q0.5870.14
400_R429_Q0.5870.14
180_N354_R0.5860.14
158_K295_S0.5850.14
47_L125_V0.5850.14
325_C391_F0.5840.14
232_V325_C0.5840.14
397_W402_Y0.5840.14
36_S244_Q0.5820.14
37_N412_A0.5820.14
40_L310_L0.5810.14
208_R310_L0.5800.14
397_W403_R0.5780.14
233_I280_R0.5770.14
55_A318_M0.5760.14
206_P236_Q0.5760.14
397_W437_Y0.5760.14
246_V325_C0.5750.14
100_V312_R0.5750.14
172_G186_Y0.5740.14
259_V398_V0.5740.14
8_F17_H0.5740.14
74_R150_K0.5730.14
261_F335_L0.5730.14
254_V261_F0.5730.14
60_A294_V0.5720.14
77_G80_G0.5720.14
376_E402_Y0.5710.14
301_S319_L0.5710.14
47_L399_D0.5700.14
257_R318_M0.5700.14
196_Y199_E0.5700.14
87_E91_R0.5690.14
307_S323_Q0.5690.14
66_E69_F0.5680.13
8_F380_V0.5680.13
285_M318_M0.5670.13
142_A233_I0.5670.13
50_K101_S0.5670.13
31_H313_D0.5660.13
120_T392_N0.5660.13
403_R437_Y0.5660.13
253_A280_R0.5660.13
53_A391_F0.5630.13
83_E260_L0.5620.13
233_I284_F0.5600.13
52_L277_L0.5590.13
170_L201_G0.5580.13
262_C353_L0.5580.13
209_Y309_L0.5570.13
8_F294_V0.5570.13
256_N311_S0.5560.13
83_E396_D0.5560.13
402_Y413_D0.5550.13
5_E9_D0.5520.13
66_E428_S0.5520.13
313_D420_G0.5510.13
273_L284_F0.5500.13
307_S316_S0.5500.13
196_Y221_V0.5490.13
118_A326_R0.5460.13
5_E10_G0.5460.13
71_P101_S0.5450.13
198_R205_R0.5440.13
232_V280_R0.5440.13
44_Q108_V0.5440.13
22_S267_F0.5440.13
88_K340_A0.5430.13
235_A388_D0.5430.13
170_L202_N0.5420.13
72_V319_L0.5420.13
243_D402_Y0.5410.13
193_L277_L0.5410.13
26_E209_Y0.5390.13
261_F343_N0.5380.13
417_L425_D0.5380.13
302_T405_R0.5370.13
208_R218_S0.5370.13
63_P381_N0.5360.13
274_L288_E0.5350.13
90_A105_P0.5340.13
30_R96_W0.5330.13
383_A393_A0.5330.13
41_A44_Q0.5330.13
209_Y244_Q0.5320.13
259_V343_N0.5320.13
314_D358_A0.5310.13
17_H255_S0.5310.13
167_Q355_E0.5300.13
186_Y319_L0.5300.13
163_S209_Y0.5290.13
243_D252_I0.5290.13
203_D374_E0.5280.13
168_V321_L0.5270.13
206_P246_V0.5270.13
224_L228_N0.5260.13
140_L164_A0.5260.13
284_F387_N0.5240.13
136_F171_L0.5240.13
17_H202_N0.5230.13
284_F325_C0.5230.13
39_R269_R0.5230.13
152_I381_N0.5200.12
311_S390_L0.5200.12
17_H408_A0.5200.12
233_I335_L0.5200.12
36_S317_M0.5190.12
238_N265_Q0.5190.12
124_K358_A0.5190.12
69_F129_V0.5180.12
164_A274_L0.5180.12
88_K226_Q0.5160.12
63_P433_L0.5160.12
22_S261_F0.5160.12
3_A120_T0.5160.12
158_K233_I0.5140.12
11_L77_G0.5140.12
15_T54_D0.5140.12
65_H257_R0.5130.12
343_N353_L0.5130.12
417_L439_F0.5130.12
120_T172_G0.5130.12
230_Q339_L0.5120.12
80_G410_D0.5110.12
46_L394_L0.5110.12
354_R438_P0.5110.12
287_I353_L0.5100.12
275_A280_R0.5100.12
295_S331_V0.5100.12
277_L330_G0.5090.12
54_D101_S0.5070.12
318_M330_G0.5070.12
406_L419_E0.5050.12
105_P349_K0.5050.12
253_A301_S0.5050.12
180_N252_I0.5040.12
122_D126_H0.5040.12
61_V187_G0.5030.12
386_M395_N0.5030.12
31_H429_Q0.5020.12
393_A422_E0.5020.12
300_V351_F0.5010.12
341_A353_L0.5010.12
279_A292_T0.5010.12
144_V436_V0.5000.12
171_L287_I0.5000.12
65_H198_R0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ynfA 2 0.9597 100 0.022 Contact Map
1h70A 1 0.5257 94.6 0.974 Contact Map
3i4aA 1 0.5682 94.5 0.974 Contact Map
1bwdA 1 0.7047 90.3 0.977 Contact Map
2ci1A 1 0.5951 90 0.978 Contact Map
4bofA 4 0.7271 83 0.98 Contact Map
1s9rA 2 0.6242 77 0.981 Contact Map
2a9gA 3 0.7204 76.4 0.981 Contact Map
4e4jA 4 0.7181 71.3 0.982 Contact Map
1jdwA 2 0.7092 58 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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