GREMLIN Database
ASTE - Succinylglutamate desuccinylase
UniProt: P76215 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13995
Length: 322 (317)
Sequences: 447 (289)
Seq/√Len: 16.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_H251_Y5.4891.00
69_A233_A4.5821.00
60_V91_L4.1601.00
152_G273_L3.6861.00
229_A233_A3.1600.99
30_G33_V2.9820.98
8_T88_P2.9140.98
197_F202_F2.8510.98
30_G124_E2.8370.98
69_A229_A2.7660.97
52_I84_I2.7410.97
31_D92_K2.6710.97
3_N64_D2.5760.96
45_A139_S2.5350.95
265_E286_Q2.5310.95
31_D88_P2.5180.95
33_V128_C2.5000.95
144_L172_F2.4650.94
108_G126_E2.4360.94
280_K297_D2.4100.94
255_S295_T2.4030.94
261_S287_D2.3830.93
280_K295_T2.3120.92
268_M278_F2.2510.91
186_F318_L2.2480.91
130_E202_F2.2080.90
221_D224_Q2.1750.90
110_W126_E2.1590.89
283_L291_R2.1590.89
185_V302_L2.1160.88
283_L293_T2.0860.88
161_L207_C2.0720.87
29_L35_E2.0330.86
93_Q98_C2.0290.86
156_P224_Q2.0280.86
47_V133_Y2.0130.86
50_A63_L2.0000.85
236_L257_I1.9850.85
105_M113_F1.9730.84
229_A301_V1.9440.84
214_A302_L1.9210.83
36_L77_L1.9200.83
249_L320_K1.9190.83
144_L207_C1.8790.81
299_E317_M1.8730.81
67_L83_V1.8340.80
100_S105_M1.8140.79
172_F207_C1.8020.78
69_A74_E1.6740.73
50_A85_L1.6370.71
11_G14_P1.6340.71
23_G39_L1.6230.71
87_N121_R1.6060.70
266_M285_A1.5770.68
100_S116_S1.5710.68
45_A80_R1.5680.68
30_G128_C1.5610.68
187_H256_Q1.5600.67
116_S119_T1.5390.66
6_A10_T1.5360.66
262_P310_L1.5350.66
57_T220_N1.5310.66
5_L8_T1.5210.65
109_R191_G1.5170.65
65_A229_A1.5080.65
28_W101_D1.4970.64
101_D312_L1.4830.63
69_A75_I1.4780.63
24_V71_S1.4760.63
130_E197_F1.4750.63
225_F228_T1.4720.63
90_A259_R1.4720.63
300_Y318_L1.4670.63
266_M284_L1.4670.63
48_I270_S1.4600.62
66_L236_L1.4380.61
47_V129_L1.4370.61
36_L83_V1.4060.59
109_R192_G1.3980.59
94_G214_A1.3890.58
88_P194_F1.3760.57
148_T217_F1.3730.57
92_K101_D1.3710.57
3_N70_I1.3580.56
184_L272_T1.3540.56
47_V198_S1.3460.56
100_S113_F1.3450.56
187_H191_G1.3190.54
35_E146_L1.3100.54
255_S299_E1.3020.53
26_W34_L1.3000.53
129_L190_P1.2960.53
64_D68_G1.2960.53
75_I237_S1.2930.53
121_R148_T1.2870.52
81_L133_Y1.2720.51
91_L94_G1.2710.51
272_T276_M1.2660.51
66_L233_A1.2660.51
187_H225_F1.2560.50
133_Y141_R1.2290.49
33_V133_Y1.2280.49
220_N305_N1.2250.49
267_H286_Q1.2250.49
279_E282_T1.2230.49
46_L79_W1.2190.48
47_V82_L1.2170.48
51_G73_G1.2170.48
211_L218_G1.2130.48
60_V159_G1.2110.48
57_T305_N1.2100.48
142_W231_A1.2080.48
156_P251_Y1.2040.47
203_G263_S1.2020.47
36_L67_L1.1930.47
190_P309_A1.1700.45
75_I233_A1.1640.45
83_V257_I1.1590.45
16_I219_Q1.1470.44
91_L255_S1.1470.44
185_V318_L1.1460.44
256_Q287_D1.1450.44
221_D226_A1.1430.44
113_F116_S1.1400.44
264_F308_V1.1360.44
102_M198_S1.1330.43
166_I199_A1.1320.43
57_T212_G1.1220.43
67_L71_S1.1150.42
143_H198_S1.1130.42
86_G148_T1.1050.42
52_I232_I1.1040.42
278_F282_T1.0960.41
251_Y277_P1.0810.40
75_I115_E1.0780.40
187_H196_H1.0720.40
80_R141_R1.0700.40
115_E119_T1.0680.40
150_I213_K1.0560.39
3_N6_A1.0540.39
212_G220_N1.0490.39
26_W36_L1.0490.39
160_V309_A1.0450.38
87_N118_E1.0430.38
19_R26_W1.0420.38
270_S307_L1.0360.38
100_S300_Y1.0330.38
198_S278_F1.0320.38
70_I206_A1.0280.37
75_I94_G1.0250.37
129_L141_R1.0190.37
89_P117_G1.0180.37
169_D191_G1.0100.36
187_H302_L1.0080.36
166_I205_L1.0060.36
260_H287_D1.0060.36
43_Q75_I1.0050.36
129_L306_P1.0030.36
125_L151_R0.9960.36
160_V259_R0.9950.36
80_R299_E0.9880.35
161_L172_F0.9820.35
30_G88_P0.9770.35
55_N217_F0.9720.34
234_A242_G0.9710.34
35_E135_Q0.9700.34
234_A262_P0.9680.34
57_T61_E0.9670.34
185_V207_C0.9660.34
157_Q207_C0.9640.34
124_E128_C0.9620.34
101_D175_W0.9570.34
63_L160_V0.9570.34
33_V84_I0.9550.34
185_V206_A0.9520.33
206_A242_G0.9510.33
169_D205_L0.9500.33
188_Q309_A0.9470.33
11_G50_A0.9440.33
146_L252_R0.9400.33
43_Q240_S0.9350.33
66_L229_A0.9320.32
102_M316_L0.9220.32
268_M317_M0.9210.32
150_I305_N0.9210.32
181_L209_L0.9200.32
25_R284_L0.9190.32
206_A315_G0.9040.31
22_N203_G0.9020.31
69_A237_S0.9020.31
61_E212_G0.8950.31
196_H200_R0.8910.30
70_I77_L0.8900.30
209_L318_L0.8900.30
55_N173_L0.8880.30
47_V235_L0.8840.30
98_C167_P0.8820.30
105_M300_Y0.8820.30
57_T150_I0.8800.30
115_E226_A0.8790.30
87_N148_T0.8740.29
28_W31_D0.8730.29
4_F8_T0.8710.29
87_N196_H0.8710.29
68_G72_H0.8680.29
150_I220_N0.8670.29
55_N164_R0.8590.29
163_Q172_F0.8580.29
241_V287_D0.8570.29
130_E201_H0.8570.29
51_G91_L0.8520.28
301_V315_G0.8490.28
61_E220_N0.8490.28
36_L70_I0.8490.28
73_G77_L0.8460.28
11_G31_D0.8400.28
287_D302_L0.8390.28
144_L164_R0.8390.28
52_I115_E0.8370.28
125_L184_L0.8350.28
278_F284_L0.8340.28
160_V202_F0.8240.27
255_S266_M0.8230.27
195_T270_S0.8230.27
212_G305_N0.8220.27
215_L251_Y0.8220.27
51_G222_L0.8180.27
35_E82_L0.8180.27
73_G82_L0.8170.27
84_I194_F0.8170.27
142_W199_A0.8170.27
246_T249_L0.8150.27
164_R187_H0.8130.27
168_W191_G0.8120.27
80_R136_G0.7980.26
129_L133_Y0.7980.26
100_S309_A0.7940.26
278_F316_L0.7900.26
296_H319_E0.7880.25
199_A228_T0.7880.25
101_D185_V0.7870.25
160_V278_F0.7820.25
58_A217_F0.7810.25
101_D302_L0.7810.25
181_L185_V0.7740.25
44_G79_W0.7730.25
148_T218_G0.7710.25
111_Q115_E0.7700.25
159_G283_L0.7660.25
8_T14_P0.7650.24
76_P93_Q0.7630.24
35_E252_R0.7620.24
29_L128_C0.7620.24
4_F10_T0.7610.24
29_L50_A0.7600.24
309_A312_L0.7600.24
284_L294_V0.7590.24
186_F192_G0.7490.24
101_D300_Y0.7450.24
25_R179_A0.7420.24
235_L276_M0.7380.23
9_L93_Q0.7360.23
77_L83_V0.7360.23
99_H117_G0.7360.23
27_R131_D0.7350.23
62_M228_T0.7340.23
268_M306_P0.7330.23
152_G317_M0.7330.23
209_L312_L0.7330.23
189_E256_Q0.7310.23
3_N292_F0.7300.23
40_T135_Q0.7280.23
149_A176_L0.7270.23
148_T305_N0.7230.23
97_Y310_L0.7190.23
31_D266_M0.7180.23
31_D101_D0.7180.23
111_Q237_S0.7160.22
14_P28_W0.7150.22
182_E287_D0.7120.22
184_L315_G0.7100.22
300_Y312_L0.7080.22
58_A216_P0.7040.22
73_G219_Q0.7040.22
206_A228_T0.7030.22
126_E213_K0.7000.22
31_D182_E0.6970.22
23_G89_P0.6960.22
175_W266_M0.6960.22
246_T258_T0.6920.21
154_L297_D0.6920.21
79_W191_G0.6910.21
87_N94_G0.6900.21
30_G89_P0.6870.21
175_W255_S0.6860.21
129_L202_F0.6840.21
55_N267_H0.6830.21
182_E241_V0.6830.21
178_A269_A0.6810.21
128_C197_F0.6800.21
13_K16_I0.6790.21
164_R168_W0.6780.21
61_E305_N0.6780.21
159_G185_V0.6770.21
7_L51_G0.6760.21
91_L256_Q0.6760.21
159_G318_L0.6750.21
90_A176_L0.6740.21
261_S288_G0.6740.21
29_L131_D0.6740.21
243_I265_E0.6730.21
180_G228_T0.6730.21
286_Q291_R0.6720.21
67_L278_F0.6710.21
67_L301_V0.6690.21
85_L91_L0.6680.21
58_A305_N0.6650.20
223_R226_A0.6560.20
52_I102_M0.6530.20
154_L300_Y0.6480.20
182_E289_E0.6480.20
168_W199_A0.6450.20
266_M314_A0.6450.20
46_L116_S0.6380.19
51_G259_R0.6380.19
257_I285_A0.6370.19
97_Y209_L0.6370.19
167_P289_E0.6350.19
285_A306_P0.6350.19
287_D308_V0.6350.19
58_A220_N0.6340.19
154_L273_L0.6310.19
45_A63_L0.6300.19
151_R221_D0.6280.19
258_T317_M0.6280.19
51_G90_A0.6270.19
107_G191_G0.6260.19
47_V202_F0.6250.19
101_D192_G0.6250.19
189_E261_S0.6250.19
133_Y146_L0.6250.19
121_R126_E0.6210.19
55_N172_F0.6210.19
115_E120_C0.6190.19
8_T204_A0.6180.19
148_T216_P0.6180.19
305_N313_R0.6170.19
64_D284_L0.6170.19
85_L236_L0.6160.19
268_M301_V0.6160.19
241_V262_P0.6160.19
192_G309_A0.6160.19
27_R33_V0.6150.19
150_I212_G0.6150.19
187_H205_L0.6140.19
85_L191_G0.6130.19
60_V150_I0.6130.19
46_L268_M0.6120.18
102_M105_M0.6110.18
127_Q197_F0.6100.18
100_S119_T0.6090.18
258_T278_F0.6080.18
102_M273_L0.6070.18
133_Y206_A0.6030.18
55_N199_A0.6030.18
130_E141_R0.6030.18
5_L178_A0.6020.18
24_V70_I0.5990.18
199_A205_L0.5970.18
101_D268_M0.5970.18
120_C134_D0.5950.18
185_V300_Y0.5920.18
48_I113_F0.5900.18
50_A170_E0.5860.18
98_C244_V0.5860.18
141_R285_A0.5850.18
11_G92_K0.5850.18
9_L63_L0.5840.18
8_T11_G0.5830.17
252_R301_V0.5820.17
161_L183_A0.5810.17
192_G312_L0.5790.17
83_V140_V0.5790.17
64_D70_I0.5770.17
231_A248_P0.5740.17
57_T148_T0.5730.17
183_A314_A0.5720.17
169_D236_L0.5680.17
88_P262_P0.5670.17
12_K16_I0.5660.17
138_E203_G0.5650.17
177_G248_P0.5650.17
46_L186_F0.5650.17
97_Y309_A0.5640.17
251_Y268_M0.5630.17
46_L81_L0.5620.17
216_P219_Q0.5620.17
82_L204_A0.5620.17
21_I24_V0.5620.17
131_D242_G0.5610.17
121_R207_C0.5590.17
129_L194_F0.5590.17
22_N248_P0.5570.17
144_L161_L0.5560.17
86_G218_G0.5560.17
47_V114_A0.5560.17
222_L229_A0.5560.17
7_L14_P0.5560.17
297_D319_E0.5540.17
41_P289_E0.5540.17
278_F299_E0.5530.16
55_N213_K0.5530.16
58_A212_G0.5520.16
155_H182_E0.5510.16
101_D309_A0.5500.16
90_A260_H0.5490.16
180_G255_S0.5480.16
155_H198_S0.5480.16
187_H209_L0.5470.16
164_R199_A0.5460.16
25_R249_L0.5460.16
47_V84_I0.5450.16
160_V315_G0.5440.16
119_T128_C0.5430.16
167_P309_A0.5430.16
23_G186_F0.5420.16
185_V192_G0.5400.16
148_T220_N0.5400.16
298_V320_K0.5400.16
102_M181_L0.5390.16
164_R205_L0.5390.16
133_Y301_V0.5360.16
146_L311_G0.5340.16
65_A182_E0.5330.16
9_L294_V0.5320.16
195_T285_A0.5320.16
276_M289_E0.5320.16
155_H273_L0.5310.16
188_Q294_V0.5290.16
148_T196_H0.5280.16
167_P259_R0.5270.16
95_K105_M0.5270.16
277_P288_G0.5270.16
187_H318_L0.5270.16
198_S284_L0.5250.16
121_R196_H0.5240.16
148_T180_G0.5230.16
185_V214_A0.5220.16
3_N89_P0.5210.15
37_T252_R0.5210.15
255_S268_M0.5180.15
72_H282_T0.5180.15
292_F299_E0.5170.15
27_R37_T0.5160.15
62_M191_G0.5160.15
23_G241_V0.5150.15
43_Q70_I0.5140.15
60_V186_F0.5140.15
18_E48_I0.5140.15
102_M116_S0.5130.15
101_D207_C0.5130.15
14_P50_A0.5130.15
131_D269_A0.5120.15
181_L222_L0.5110.15
221_D262_P0.5090.15
63_L300_Y0.5090.15
100_S225_F0.5090.15
67_L186_F0.5090.15
159_G184_L0.5080.15
148_T207_C0.5060.15
142_W183_A0.5050.15
28_W92_K0.5040.15
249_L290_E0.5030.15
48_I144_L0.5010.15
144_L192_G0.5010.15
88_P155_H0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yw4A 1 0.9596 100 0.476 Contact Map
1yw6A 4 0.9814 100 0.498 Contact Map
2bcoA 1 0.9907 100 0.512 Contact Map
2gu2A 3 0.8385 100 0.707 Contact Map
3nh4A 2 0.823 100 0.728 Contact Map
4wckA 1 0.8758 100 0.754 Contact Map
2qj8A 2 0.913 100 0.755 Contact Map
3cdxA 4 0.9224 100 0.766 Contact Map
3na6A 4 0.9255 100 0.782 Contact Map
3fmcA 4 0.913 99.9 0.807 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.