ASTE - ECOLI - GREMLIN Contacts

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ASTE - Succinylglutamate desuccinylase

UniProt:	P76215	Sequences: MDNFLALTLTGKKPVITEREINGVRWRWLGDGVLELTPLTPPQGALVISAGIHGNETAPVEMLDALLGAISHGEIPLRWRLLVILGNPPALKQGKRYCHSDMNRMFGGRWQLFAESGETCRARELEQCLEDFYDQGKESVRWHLDLHTAIRGSLHPQFGVLPQRDIPWDEKFLTWLGAAGLEALVFHQEPGGTFTHFSARHFGALACTLELGKALPFGQNDLRQFAVTASAIAALLSGESVGIVRTPPLRYRVVSQITRHSPSFEMHMASDTLNFMPFEKGTLLAQDGEERFTVTHDVEYVLFPNPLVALGLRAGLMLEKIS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13995
Length:	322 (317)
Sequences:	447 (289)
Seq/√Len:	16.2

ECOLI - ASTE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_H	251_Y	5.489	1.00
69_A	233_A	4.582	1.00
60_V	91_L	4.160	1.00
152_G	273_L	3.686	1.00
229_A	233_A	3.160	0.99
30_G	33_V	2.982	0.98
8_T	88_P	2.914	0.98
197_F	202_F	2.851	0.98
30_G	124_E	2.837	0.98
69_A	229_A	2.766	0.97
52_I	84_I	2.741	0.97
31_D	92_K	2.671	0.97
3_N	64_D	2.576	0.96
45_A	139_S	2.535	0.95
265_E	286_Q	2.531	0.95
31_D	88_P	2.518	0.95
33_V	128_C	2.500	0.95
144_L	172_F	2.465	0.94
108_G	126_E	2.436	0.94
280_K	297_D	2.410	0.94
255_S	295_T	2.403	0.94
261_S	287_D	2.383	0.93
280_K	295_T	2.312	0.92
268_M	278_F	2.251	0.91
186_F	318_L	2.248	0.91
130_E	202_F	2.208	0.90
221_D	224_Q	2.175	0.90
110_W	126_E	2.159	0.89
283_L	291_R	2.159	0.89
185_V	302_L	2.116	0.88
283_L	293_T	2.086	0.88
161_L	207_C	2.072	0.87
29_L	35_E	2.033	0.86
93_Q	98_C	2.029	0.86
156_P	224_Q	2.028	0.86
47_V	133_Y	2.013	0.86
50_A	63_L	2.000	0.85
236_L	257_I	1.985	0.85
105_M	113_F	1.973	0.84
229_A	301_V	1.944	0.84
214_A	302_L	1.921	0.83
36_L	77_L	1.920	0.83
249_L	320_K	1.919	0.83
144_L	207_C	1.879	0.81
299_E	317_M	1.873	0.81
67_L	83_V	1.834	0.80
100_S	105_M	1.814	0.79
172_F	207_C	1.802	0.78
69_A	74_E	1.674	0.73
50_A	85_L	1.637	0.71
11_G	14_P	1.634	0.71
23_G	39_L	1.623	0.71
87_N	121_R	1.606	0.70
266_M	285_A	1.577	0.68
100_S	116_S	1.571	0.68
45_A	80_R	1.568	0.68
30_G	128_C	1.561	0.68
187_H	256_Q	1.560	0.67
116_S	119_T	1.539	0.66
6_A	10_T	1.536	0.66
262_P	310_L	1.535	0.66
57_T	220_N	1.531	0.66
5_L	8_T	1.521	0.65
109_R	191_G	1.517	0.65
65_A	229_A	1.508	0.65
28_W	101_D	1.497	0.64
101_D	312_L	1.483	0.63
69_A	75_I	1.478	0.63
24_V	71_S	1.476	0.63
130_E	197_F	1.475	0.63
225_F	228_T	1.472	0.63
90_A	259_R	1.472	0.63
300_Y	318_L	1.467	0.63
266_M	284_L	1.467	0.63
48_I	270_S	1.460	0.62
66_L	236_L	1.438	0.61
47_V	129_L	1.437	0.61
36_L	83_V	1.406	0.59
109_R	192_G	1.398	0.59
94_G	214_A	1.389	0.58
88_P	194_F	1.376	0.57
148_T	217_F	1.373	0.57
92_K	101_D	1.371	0.57
3_N	70_I	1.358	0.56
184_L	272_T	1.354	0.56
47_V	198_S	1.346	0.56
100_S	113_F	1.345	0.56
187_H	191_G	1.319	0.54
35_E	146_L	1.310	0.54
255_S	299_E	1.302	0.53
26_W	34_L	1.300	0.53
129_L	190_P	1.296	0.53
64_D	68_G	1.296	0.53
75_I	237_S	1.293	0.53
121_R	148_T	1.287	0.52
81_L	133_Y	1.272	0.51
91_L	94_G	1.271	0.51
272_T	276_M	1.266	0.51
66_L	233_A	1.266	0.51
187_H	225_F	1.256	0.50
133_Y	141_R	1.229	0.49
33_V	133_Y	1.228	0.49
220_N	305_N	1.225	0.49
267_H	286_Q	1.225	0.49
279_E	282_T	1.223	0.49
46_L	79_W	1.219	0.48
47_V	82_L	1.217	0.48
51_G	73_G	1.217	0.48
211_L	218_G	1.213	0.48
60_V	159_G	1.211	0.48
57_T	305_N	1.210	0.48
142_W	231_A	1.208	0.48
156_P	251_Y	1.204	0.47
203_G	263_S	1.202	0.47
36_L	67_L	1.193	0.47
190_P	309_A	1.170	0.45
75_I	233_A	1.164	0.45
83_V	257_I	1.159	0.45
16_I	219_Q	1.147	0.44
91_L	255_S	1.147	0.44
185_V	318_L	1.146	0.44
256_Q	287_D	1.145	0.44
221_D	226_A	1.143	0.44
113_F	116_S	1.140	0.44
264_F	308_V	1.136	0.44
102_M	198_S	1.133	0.43
166_I	199_A	1.132	0.43
57_T	212_G	1.122	0.43
67_L	71_S	1.115	0.42
143_H	198_S	1.113	0.42
86_G	148_T	1.105	0.42
52_I	232_I	1.104	0.42
278_F	282_T	1.096	0.41
251_Y	277_P	1.081	0.40
75_I	115_E	1.078	0.40
187_H	196_H	1.072	0.40
80_R	141_R	1.070	0.40
115_E	119_T	1.068	0.40
150_I	213_K	1.056	0.39
3_N	6_A	1.054	0.39
212_G	220_N	1.049	0.39
26_W	36_L	1.049	0.39
160_V	309_A	1.045	0.38
87_N	118_E	1.043	0.38
19_R	26_W	1.042	0.38
270_S	307_L	1.036	0.38
100_S	300_Y	1.033	0.38
198_S	278_F	1.032	0.38
70_I	206_A	1.028	0.37
75_I	94_G	1.025	0.37
129_L	141_R	1.019	0.37
89_P	117_G	1.018	0.37
169_D	191_G	1.010	0.36
187_H	302_L	1.008	0.36
166_I	205_L	1.006	0.36
260_H	287_D	1.006	0.36
43_Q	75_I	1.005	0.36
129_L	306_P	1.003	0.36
125_L	151_R	0.996	0.36
160_V	259_R	0.995	0.36
80_R	299_E	0.988	0.35
161_L	172_F	0.982	0.35
30_G	88_P	0.977	0.35
55_N	217_F	0.972	0.34
234_A	242_G	0.971	0.34
35_E	135_Q	0.970	0.34
234_A	262_P	0.968	0.34
57_T	61_E	0.967	0.34
185_V	207_C	0.966	0.34
157_Q	207_C	0.964	0.34
124_E	128_C	0.962	0.34
101_D	175_W	0.957	0.34
63_L	160_V	0.957	0.34
33_V	84_I	0.955	0.34
185_V	206_A	0.952	0.33
206_A	242_G	0.951	0.33
169_D	205_L	0.950	0.33
188_Q	309_A	0.947	0.33
11_G	50_A	0.944	0.33
146_L	252_R	0.940	0.33
43_Q	240_S	0.935	0.33
66_L	229_A	0.932	0.32
102_M	316_L	0.922	0.32
268_M	317_M	0.921	0.32
150_I	305_N	0.921	0.32
181_L	209_L	0.920	0.32
25_R	284_L	0.919	0.32
206_A	315_G	0.904	0.31
22_N	203_G	0.902	0.31
69_A	237_S	0.902	0.31
61_E	212_G	0.895	0.31
196_H	200_R	0.891	0.30
70_I	77_L	0.890	0.30
209_L	318_L	0.890	0.30
55_N	173_L	0.888	0.30
47_V	235_L	0.884	0.30
98_C	167_P	0.882	0.30
105_M	300_Y	0.882	0.30
57_T	150_I	0.880	0.30
115_E	226_A	0.879	0.30
87_N	148_T	0.874	0.29
28_W	31_D	0.873	0.29
4_F	8_T	0.871	0.29
87_N	196_H	0.871	0.29
68_G	72_H	0.868	0.29
150_I	220_N	0.867	0.29
55_N	164_R	0.859	0.29
163_Q	172_F	0.858	0.29
241_V	287_D	0.857	0.29
130_E	201_H	0.857	0.29
51_G	91_L	0.852	0.28
301_V	315_G	0.849	0.28
61_E	220_N	0.849	0.28
36_L	70_I	0.849	0.28
73_G	77_L	0.846	0.28
11_G	31_D	0.840	0.28
287_D	302_L	0.839	0.28
144_L	164_R	0.839	0.28
52_I	115_E	0.837	0.28
125_L	184_L	0.835	0.28
278_F	284_L	0.834	0.28
160_V	202_F	0.824	0.27
255_S	266_M	0.823	0.27
195_T	270_S	0.823	0.27
212_G	305_N	0.822	0.27
215_L	251_Y	0.822	0.27
51_G	222_L	0.818	0.27
35_E	82_L	0.818	0.27
73_G	82_L	0.817	0.27
84_I	194_F	0.817	0.27
142_W	199_A	0.817	0.27
246_T	249_L	0.815	0.27
164_R	187_H	0.813	0.27
168_W	191_G	0.812	0.27
80_R	136_G	0.798	0.26
129_L	133_Y	0.798	0.26
100_S	309_A	0.794	0.26
278_F	316_L	0.790	0.26
296_H	319_E	0.788	0.25
199_A	228_T	0.788	0.25
101_D	185_V	0.787	0.25
160_V	278_F	0.782	0.25
58_A	217_F	0.781	0.25
101_D	302_L	0.781	0.25
181_L	185_V	0.774	0.25
44_G	79_W	0.773	0.25
148_T	218_G	0.771	0.25
111_Q	115_E	0.770	0.25
159_G	283_L	0.766	0.25
8_T	14_P	0.765	0.24
76_P	93_Q	0.763	0.24
35_E	252_R	0.762	0.24
29_L	128_C	0.762	0.24
4_F	10_T	0.761	0.24
29_L	50_A	0.760	0.24
309_A	312_L	0.760	0.24
284_L	294_V	0.759	0.24
186_F	192_G	0.749	0.24
101_D	300_Y	0.745	0.24
25_R	179_A	0.742	0.24
235_L	276_M	0.738	0.23
9_L	93_Q	0.736	0.23
77_L	83_V	0.736	0.23
99_H	117_G	0.736	0.23
27_R	131_D	0.735	0.23
62_M	228_T	0.734	0.23
268_M	306_P	0.733	0.23
152_G	317_M	0.733	0.23
209_L	312_L	0.733	0.23
189_E	256_Q	0.731	0.23
3_N	292_F	0.730	0.23
40_T	135_Q	0.728	0.23
149_A	176_L	0.727	0.23
148_T	305_N	0.723	0.23
97_Y	310_L	0.719	0.23
31_D	266_M	0.718	0.23
31_D	101_D	0.718	0.23
111_Q	237_S	0.716	0.22
14_P	28_W	0.715	0.22
182_E	287_D	0.712	0.22
184_L	315_G	0.710	0.22
300_Y	312_L	0.708	0.22
58_A	216_P	0.704	0.22
73_G	219_Q	0.704	0.22
206_A	228_T	0.703	0.22
126_E	213_K	0.700	0.22
31_D	182_E	0.697	0.22
23_G	89_P	0.696	0.22
175_W	266_M	0.696	0.22
246_T	258_T	0.692	0.21
154_L	297_D	0.692	0.21
79_W	191_G	0.691	0.21
87_N	94_G	0.690	0.21
30_G	89_P	0.687	0.21
175_W	255_S	0.686	0.21
129_L	202_F	0.684	0.21
55_N	267_H	0.683	0.21
182_E	241_V	0.683	0.21
178_A	269_A	0.681	0.21
128_C	197_F	0.680	0.21
13_K	16_I	0.679	0.21
164_R	168_W	0.678	0.21
61_E	305_N	0.678	0.21
159_G	185_V	0.677	0.21
7_L	51_G	0.676	0.21
91_L	256_Q	0.676	0.21
159_G	318_L	0.675	0.21
90_A	176_L	0.674	0.21
261_S	288_G	0.674	0.21
29_L	131_D	0.674	0.21
243_I	265_E	0.673	0.21
180_G	228_T	0.673	0.21
286_Q	291_R	0.672	0.21
67_L	278_F	0.671	0.21
67_L	301_V	0.669	0.21
85_L	91_L	0.668	0.21
58_A	305_N	0.665	0.20
223_R	226_A	0.656	0.20
52_I	102_M	0.653	0.20
154_L	300_Y	0.648	0.20
182_E	289_E	0.648	0.20
168_W	199_A	0.645	0.20
266_M	314_A	0.645	0.20
46_L	116_S	0.638	0.19
51_G	259_R	0.638	0.19
257_I	285_A	0.637	0.19
97_Y	209_L	0.637	0.19
167_P	289_E	0.635	0.19
285_A	306_P	0.635	0.19
287_D	308_V	0.635	0.19
58_A	220_N	0.634	0.19
154_L	273_L	0.631	0.19
45_A	63_L	0.630	0.19
151_R	221_D	0.628	0.19
258_T	317_M	0.628	0.19
51_G	90_A	0.627	0.19
107_G	191_G	0.626	0.19
47_V	202_F	0.625	0.19
101_D	192_G	0.625	0.19
189_E	261_S	0.625	0.19
133_Y	146_L	0.625	0.19
121_R	126_E	0.621	0.19
55_N	172_F	0.621	0.19
115_E	120_C	0.619	0.19
8_T	204_A	0.618	0.19
148_T	216_P	0.618	0.19
305_N	313_R	0.617	0.19
64_D	284_L	0.617	0.19
85_L	236_L	0.616	0.19
268_M	301_V	0.616	0.19
241_V	262_P	0.616	0.19
192_G	309_A	0.616	0.19
27_R	33_V	0.615	0.19
150_I	212_G	0.615	0.19
187_H	205_L	0.614	0.19
85_L	191_G	0.613	0.19
60_V	150_I	0.613	0.19
46_L	268_M	0.612	0.18
102_M	105_M	0.611	0.18
127_Q	197_F	0.610	0.18
100_S	119_T	0.609	0.18
258_T	278_F	0.608	0.18
102_M	273_L	0.607	0.18
133_Y	206_A	0.603	0.18
55_N	199_A	0.603	0.18
130_E	141_R	0.603	0.18
5_L	178_A	0.602	0.18
24_V	70_I	0.599	0.18
199_A	205_L	0.597	0.18
101_D	268_M	0.597	0.18
120_C	134_D	0.595	0.18
185_V	300_Y	0.592	0.18
48_I	113_F	0.590	0.18
50_A	170_E	0.586	0.18
98_C	244_V	0.586	0.18
141_R	285_A	0.585	0.18
11_G	92_K	0.585	0.18
9_L	63_L	0.584	0.18
8_T	11_G	0.583	0.17
252_R	301_V	0.582	0.17
161_L	183_A	0.581	0.17
192_G	312_L	0.579	0.17
83_V	140_V	0.579	0.17
64_D	70_I	0.577	0.17
231_A	248_P	0.574	0.17
57_T	148_T	0.573	0.17
183_A	314_A	0.572	0.17
169_D	236_L	0.568	0.17
88_P	262_P	0.567	0.17
12_K	16_I	0.566	0.17
138_E	203_G	0.565	0.17
177_G	248_P	0.565	0.17
46_L	186_F	0.565	0.17
97_Y	309_A	0.564	0.17
251_Y	268_M	0.563	0.17
46_L	81_L	0.562	0.17
216_P	219_Q	0.562	0.17
82_L	204_A	0.562	0.17
21_I	24_V	0.562	0.17
131_D	242_G	0.561	0.17
121_R	207_C	0.559	0.17
129_L	194_F	0.559	0.17
22_N	248_P	0.557	0.17
144_L	161_L	0.556	0.17
86_G	218_G	0.556	0.17
47_V	114_A	0.556	0.17
222_L	229_A	0.556	0.17
7_L	14_P	0.556	0.17
297_D	319_E	0.554	0.17
41_P	289_E	0.554	0.17
278_F	299_E	0.553	0.16
55_N	213_K	0.553	0.16
58_A	212_G	0.552	0.16
155_H	182_E	0.551	0.16
101_D	309_A	0.550	0.16
90_A	260_H	0.549	0.16
180_G	255_S	0.548	0.16
155_H	198_S	0.548	0.16
187_H	209_L	0.547	0.16
164_R	199_A	0.546	0.16
25_R	249_L	0.546	0.16
47_V	84_I	0.545	0.16
160_V	315_G	0.544	0.16
119_T	128_C	0.543	0.16
167_P	309_A	0.543	0.16
23_G	186_F	0.542	0.16
185_V	192_G	0.540	0.16
148_T	220_N	0.540	0.16
298_V	320_K	0.540	0.16
102_M	181_L	0.539	0.16
164_R	205_L	0.539	0.16
133_Y	301_V	0.536	0.16
146_L	311_G	0.534	0.16
65_A	182_E	0.533	0.16
9_L	294_V	0.532	0.16
195_T	285_A	0.532	0.16
276_M	289_E	0.532	0.16
155_H	273_L	0.531	0.16
188_Q	294_V	0.529	0.16
148_T	196_H	0.528	0.16
167_P	259_R	0.527	0.16
95_K	105_M	0.527	0.16
277_P	288_G	0.527	0.16
187_H	318_L	0.527	0.16
198_S	284_L	0.525	0.16
121_R	196_H	0.524	0.16
148_T	180_G	0.523	0.16
185_V	214_A	0.522	0.16
3_N	89_P	0.521	0.15
37_T	252_R	0.521	0.15
255_S	268_M	0.518	0.15
72_H	282_T	0.518	0.15
292_F	299_E	0.517	0.15
27_R	37_T	0.516	0.15
62_M	191_G	0.516	0.15
23_G	241_V	0.515	0.15
43_Q	70_I	0.514	0.15
60_V	186_F	0.514	0.15
18_E	48_I	0.514	0.15
102_M	116_S	0.513	0.15
101_D	207_C	0.513	0.15
14_P	50_A	0.513	0.15
131_D	269_A	0.512	0.15
181_L	222_L	0.511	0.15
221_D	262_P	0.509	0.15
63_L	300_Y	0.509	0.15
100_S	225_F	0.509	0.15
67_L	186_F	0.509	0.15
159_G	184_L	0.508	0.15
148_T	207_C	0.506	0.15
142_W	183_A	0.505	0.15
28_W	92_K	0.504	0.15
249_L	290_E	0.503	0.15
48_I	144_L	0.501	0.15
144_L	192_G	0.501	0.15
88_P	155_H	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1yw4A	1	0.9596	100	0.476	Contact Map
1yw6A	4	0.9814	100	0.498	Contact Map
2bcoA	1	0.9907	100	0.512	Contact Map
2gu2A	3	0.8385	100	0.707	Contact Map
3nh4A	2	0.823	100	0.728	Contact Map
4wckA	1	0.8758	100	0.754	Contact Map
2qj8A	2	0.913	100	0.755	Contact Map
3cdxA	4	0.9224	100	0.766	Contact Map
3na6A	4	0.9255	100	0.782	Contact Map
3fmcA	4	0.913	99.9	0.807	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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