GREMLIN Database
VES - Protein Ves
UniProt: P76214 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13994
Length: 191 (174)
Sequences: 893 (643)
Seq/√Len: 48.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_E112_L4.2831.00
55_M109_M4.1941.00
108_I117_A3.9171.00
5_D154_Q3.7051.00
42_S104_M3.2181.00
25_C36_W3.2011.00
138_V141_G2.8191.00
65_G99_A2.7771.00
137_F153_D2.5111.00
24_I155_G2.4221.00
71_S93_V2.2831.00
59_V85_F2.2521.00
60_T119_V2.2031.00
5_D8_K2.1901.00
66_E97_L2.1671.00
28_P34_F2.0571.00
38_A135_V1.9990.99
110_T117_A1.9960.99
108_I119_V1.9950.99
43_I105_D1.9630.99
43_I67_M1.9460.99
67_M103_S1.9450.99
59_V105_D1.9440.99
15_R52_F1.8760.99
106_F137_F1.8410.99
90_D112_L1.7720.99
72_A91_Q1.7320.99
49_F105_D1.7050.98
46_N97_L1.7040.98
35_Y115_C1.6840.98
38_A108_I1.6700.98
35_Y114_V1.6670.98
4_F9_M1.6640.98
58_I117_A1.6430.98
11_V20_E1.6260.98
67_M95_A1.6180.98
28_P31_K1.6100.98
82_F121_I1.5850.97
97_L100_G1.5690.97
40_I62_L1.5460.97
9_M155_G1.5460.97
71_S85_F1.5440.97
40_I59_V1.5410.97
60_T175_L1.5290.97
164_T168_L1.4910.96
170_P174_L1.4810.96
168_L172_G1.3930.94
11_V22_R1.3740.94
169_Q172_G1.3700.94
61_L103_S1.3630.94
55_M112_L1.3450.93
55_M110_T1.3290.93
27_F35_Y1.3220.93
18_A47_G1.2930.92
168_L171_Q1.2920.92
6_M154_Q1.2870.92
34_F105_D1.2280.90
71_S91_Q1.2080.89
30_A33_D1.2010.89
68_L98_T1.1970.88
20_E42_S1.1900.88
88_A112_L1.1690.87
4_F155_G1.1460.86
12_N106_F1.1430.86
47_G95_A1.1380.86
28_P111_R1.1350.86
24_I154_Q1.1080.84
34_F59_V1.1060.84
145_L156_A1.1010.84
150_L154_Q1.0940.83
67_M76_N1.0920.83
23_E37_R1.0880.83
167_L172_G1.0830.83
68_L96_K1.0740.82
90_D93_V1.0660.82
56_E109_M1.0480.81
109_M112_L1.0370.80
58_I110_T1.0270.79
16_N50_S1.0230.79
60_T117_A1.0200.79
23_E34_F1.0140.78
32_R53_P1.0050.78
46_N96_K0.9930.77
151_T154_Q0.9880.77
18_A44_A0.9880.77
26_T31_K0.9820.76
167_L176_F0.9760.76
15_R47_G0.9680.75
57_R107_N0.9660.75
2_E29_P0.9590.74
169_Q173_K0.9560.74
4_F166_R0.9470.73
21_T39_S0.9430.73
57_R87_F0.9320.72
134_G158_W0.9160.71
95_A175_L0.8980.69
88_A91_Q0.8970.69
58_I86_A0.8930.69
62_L79_L0.8910.69
81_P95_A0.8880.69
68_L76_N0.8830.68
49_F59_V0.8780.68
34_F55_M0.8780.68
15_R34_F0.8750.67
39_S105_D0.8460.65
167_L170_P0.8440.65
8_K63_E0.8440.65
124_R148_K0.8430.64
43_I59_V0.8320.63
6_M9_M0.8310.63
66_E98_T0.8300.63
80_K118_K0.8300.63
70_E73_D0.8160.62
109_M113_D0.8100.61
59_V67_M0.8070.61
47_G64_G0.8060.61
56_E110_T0.7930.60
66_E100_G0.7900.59
53_P72_A0.7850.59
10_S23_E0.7720.58
13_L16_N0.7680.57
62_L105_D0.7630.57
49_F79_L0.7570.56
70_E76_N0.7540.56
22_R40_I0.7510.56
122_A126_F0.7510.56
15_R50_S0.7510.56
21_T41_A0.7470.55
56_E88_A0.7460.55
87_F107_N0.7440.55
139_I175_L0.7440.55
135_V157_C0.7430.55
123_E165_L0.7400.54
40_I67_M0.7350.54
17_A47_G0.7340.54
36_W61_L0.7340.54
41_A57_R0.7300.53
17_A32_R0.7280.53
148_K168_L0.7250.53
45_A93_V0.7240.53
58_I121_I0.7180.52
76_N139_I0.7170.52
12_N34_F0.7130.52
101_Q131_S0.7120.52
3_Y148_K0.7100.51
22_R89_A0.7090.51
142_A149_L0.7090.51
114_V151_T0.7080.51
82_F93_V0.7050.51
66_E99_A0.7020.51
168_L176_F0.7020.51
62_L150_L0.6970.50
58_I84_P0.6970.50
165_L168_L0.6960.50
168_L174_L0.6950.50
58_I119_V0.6920.50
59_V95_A0.6920.50
72_A92_V0.6910.49
159_F162_R0.6850.49
140_N153_D0.6850.49
56_E111_R0.6830.49
173_K176_F0.6800.48
21_T105_D0.6760.48
70_E96_K0.6720.48
14_W19_G0.6700.47
41_A105_D0.6690.47
60_T82_F0.6680.47
30_A38_A0.6660.47
40_I105_D0.6590.46
97_L103_S0.6570.46
3_Y156_A0.6570.46
15_R117_A0.6530.46
15_R26_T0.6480.45
35_Y111_R0.6460.45
13_L92_V0.6450.45
10_S59_V0.6400.44
5_D155_G0.6380.44
59_V87_F0.6370.44
49_F103_S0.6340.44
5_D151_T0.6330.44
140_N158_W0.6310.43
79_L113_D0.6300.43
6_M40_I0.6270.43
80_K136_V0.6270.43
7_R116_K0.6240.43
26_T30_A0.6200.42
12_N22_R0.6190.42
110_T115_C0.6150.42
172_G176_F0.6140.42
49_F87_F0.6130.42
61_L106_F0.6100.41
23_E105_D0.6090.41
106_F111_R0.6090.41
43_I117_A0.6070.41
86_A116_K0.6050.41
166_R172_G0.6020.41
12_N23_E0.6020.41
34_F79_L0.6000.40
50_S54_G0.5990.40
21_T37_R0.5980.40
165_L169_Q0.5960.40
13_L131_S0.5920.40
33_D82_F0.5890.39
40_I106_F0.5860.39
10_S22_R0.5860.39
58_I111_R0.5820.39
81_P139_I0.5810.39
51_L90_D0.5800.38
106_F175_L0.5800.38
145_L151_T0.5750.38
64_G97_L0.5750.38
9_M24_I0.5740.38
38_A95_A0.5700.38
89_A117_A0.5700.38
67_M105_D0.5700.38
82_F139_I0.5660.37
23_E106_F0.5640.37
58_I106_F0.5630.37
18_A97_L0.5610.37
25_C31_K0.5610.37
71_S103_S0.5590.36
90_D106_F0.5590.36
93_V174_L0.5590.36
38_A115_C0.5580.36
48_E94_K0.5570.36
41_A107_N0.5570.36
87_F105_D0.5560.36
17_A50_S0.5530.36
22_R42_S0.5530.36
78_T135_V0.5510.36
168_L175_L0.5460.35
26_T33_D0.5460.35
13_L50_S0.5450.35
147_D158_W0.5420.35
89_A175_L0.5410.35
60_T121_I0.5410.35
24_I67_M0.5410.35
34_F61_L0.5400.35
12_N105_D0.5390.35
67_M162_R0.5380.35
44_A95_A0.5380.35
41_A49_F0.5370.34
11_V40_I0.5340.34
149_L159_F0.5320.34
115_C132_R0.5300.34
167_L171_Q0.5260.33
33_D150_L0.5240.33
26_T40_I0.5220.33
24_I89_A0.5220.33
40_I104_M0.5220.33
93_V137_F0.5190.33
56_E90_D0.5160.33
68_L78_T0.5160.33
167_L173_K0.5140.32
65_G123_E0.5130.32
88_A109_M0.5120.32
77_H85_F0.5080.32
164_T167_L0.5030.31
18_A60_T0.5020.31
74_R156_A0.5010.31
61_L77_H0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3esgA 3 0.9476 100 0.131 Contact Map
1yllA 3 0.9529 100 0.142 Contact Map
1rc6A 4 0.9424 96.5 0.878 Contact Map
1sefA 5 0.9581 96.2 0.883 Contact Map
1sq4A 5 0.9738 96.1 0.884 Contact Map
1sfnA 5 0.9424 95.7 0.887 Contact Map
4e2qA 6 0.9372 95.2 0.891 Contact Map
3rnsA 1 0.8743 94.9 0.893 Contact Map
4axoA 2 0.6178 92.5 0.903 Contact Map
2pytA 2 0.5602 89.5 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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