GREMLIN Database
CHO - Excinuclease cho
UniProt: P76213 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13993
Length: 295 (235)
Sequences: 3931 (2452)
Seq/√Len: 160.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_T56_N5.4451.00
31_L61_V4.5371.00
125_R199_H3.9951.00
198_S201_E3.5071.00
42_G46_T3.3591.00
141_N210_L2.9611.00
27_F79_R2.8511.00
45_D79_R2.8001.00
74_L77_S2.6471.00
227_K238_I2.6361.00
34_R84_C2.3561.00
41_H81_S2.3541.00
47_M102_Q2.3471.00
225_A246_G2.3201.00
43_E78_R2.3011.00
120_Q140_P2.2851.00
33_T58_R2.2331.00
211_E216_V2.1411.00
40_F77_S2.0981.00
70_E73_M2.0871.00
131_A153_L2.0241.00
225_A229_Q2.0211.00
221_Q242_W1.9891.00
86_A253_E1.9681.00
224_V242_W1.9521.00
49_L105_L1.9501.00
221_Q246_G1.9301.00
88_E92_L1.9011.00
190_A197_E1.8861.00
199_H203_A1.8791.00
121_L210_L1.8581.00
231_P238_I1.8231.00
180_A194_C1.8091.00
33_T59_S1.7331.00
229_Q232_E1.7291.00
56_N59_S1.7011.00
41_H79_R1.7001.00
227_K234_T1.6621.00
234_T237_H1.6591.00
236_Y240_Q1.6521.00
164_K190_A1.6441.00
121_L129_V1.6381.00
184_S191_G1.6261.00
208_Q223_A1.6051.00
141_N214_R1.5951.00
181_C189_C1.5901.00
41_H47_M1.5871.00
42_G76_Q1.5731.00
31_L57_I1.5671.00
227_K230_H1.5651.00
181_C193_C1.5501.00
226_L230_H1.5341.00
165_L209_S1.5211.00
203_A207_R1.5051.00
39_L83_I1.4661.00
164_K205_R1.4621.00
236_Y239_I1.4491.00
126_V173_E1.4471.00
59_S62_L1.4411.00
167_Y183_R1.4111.00
49_L69_D1.4091.00
42_G49_L1.4061.00
197_E201_E1.4051.00
160_A167_Y1.3991.00
27_F30_D1.3781.00
218_W222_G1.3681.00
47_M51_I1.3661.00
197_E205_R1.3561.00
161_D188_R1.3501.00
73_M77_S1.3481.00
76_Q106_F1.3471.00
201_E204_L1.3411.00
223_A227_K1.3361.00
234_T238_I1.3331.00
190_A205_R1.3141.00
39_L98_L1.2761.00
183_R188_R1.2731.00
120_Q138_R1.2701.00
59_S67_T1.2661.00
49_L70_E1.2581.00
189_C193_C1.2521.00
69_D73_M1.2511.00
143_F210_L1.2461.00
124_K128_V1.2431.00
191_G196_K1.2221.00
123_E140_P1.2141.00
122_N130_Y1.2081.00
96_A110_L1.2081.00
138_R142_L1.2011.00
243_L246_G1.1961.00
40_F80_I1.1951.00
72_A76_Q1.1951.00
221_Q225_A1.1941.00
31_L80_I1.1711.00
63_S66_R1.1701.00
124_K170_L1.1601.00
64_H70_E1.1511.00
207_R211_E1.1431.00
32_P82_W1.1371.00
26_S29_N1.1371.00
164_K209_S1.1341.00
39_L81_S1.1151.00
222_G226_L1.1101.00
126_V199_H1.1091.00
207_R210_L1.1061.00
28_L31_L1.1041.00
58_R62_L1.0850.99
164_K187_K1.0840.99
231_P234_T1.0830.99
120_Q142_L1.0820.99
170_L173_E1.0740.99
132_K135_D1.0630.99
41_H45_D1.0510.99
222_G225_A1.0440.99
119_L152_A1.0370.99
158_T162_E1.0370.99
211_E219_P1.0310.99
96_A115_Q1.0250.99
205_R208_Q1.0200.99
120_Q130_Y1.0060.99
154_Q244_W1.0040.99
204_L207_R1.0000.99
149_R153_L0.9960.99
184_S187_K0.9950.99
114_R133_E0.9890.99
224_V238_I0.9870.99
129_V209_S0.9750.99
223_A226_L0.9540.99
226_L229_Q0.9470.99
97_R255_T0.9360.98
24_L28_L0.9340.98
131_A152_A0.9270.98
165_L206_L0.9170.98
228_E239_I0.9140.98
156_L160_A0.9090.98
132_K140_P0.9070.98
53_K99_I0.8860.98
70_E108_K0.8810.98
39_L102_Q0.8810.98
160_A183_R0.8790.98
90_G252_E0.8760.98
42_G78_R0.8740.98
136_F140_P0.8720.98
53_K92_L0.8710.98
69_D108_K0.8620.97
228_E242_W0.8600.97
159_I209_S0.8590.97
39_L47_M0.8570.97
123_E139_A0.8560.97
28_L62_L0.8560.97
152_A156_L0.8540.97
119_L156_L0.8520.97
100_K113_N0.8520.97
96_A100_K0.8520.97
121_L206_L0.8480.97
127_D133_E0.8450.97
137_S140_P0.8440.97
62_L65_L0.8400.97
32_P56_N0.8390.97
51_I102_Q0.8370.97
211_E223_A0.8360.97
208_Q219_P0.8330.97
124_K130_Y0.8290.97
25_R29_N0.8240.97
39_L51_I0.8220.96
26_S30_D0.8190.96
165_L205_R0.8190.96
130_Y169_L0.8110.96
112_R133_E0.8110.96
152_A248_V0.8060.96
159_I212_R0.7980.96
173_E176_S0.7920.96
238_I242_W0.7880.96
135_D138_R0.7880.96
23_H28_L0.7830.95
31_L58_R0.7810.95
38_Y52_G0.7780.95
85_T94_L0.7670.95
25_R28_L0.7600.95
100_K110_L0.7570.94
27_F80_I0.7510.94
70_E77_S0.7510.94
166_C192_A0.7500.94
85_T155_A0.7490.94
247_A250_S0.7490.94
72_A105_L0.7420.94
168_G189_C0.7410.94
97_R101_E0.7380.94
129_V156_L0.7350.94
33_T62_L0.7310.93
182_F185_A0.7300.93
42_G45_D0.7260.93
89_I96_A0.7230.93
95_E107_N0.7150.93
54_S59_S0.7130.92
173_E177_R0.7130.92
96_A105_L0.7120.92
46_T105_L0.7120.92
32_P36_G0.7030.92
49_L76_Q0.6980.92
98_L102_Q0.6970.92
131_A149_R0.6970.92
97_R252_E0.6960.92
181_C191_G0.6960.92
100_K114_R0.6950.92
128_V133_E0.6940.91
164_K167_Y0.6880.91
211_E220_W0.6870.91
52_G99_I0.6870.91
160_A165_L0.6870.91
184_S196_K0.6860.91
146_F213_L0.6830.91
239_I243_L0.6820.91
45_D78_R0.6810.91
38_Y50_Y0.6800.91
171_G174_P0.6790.91
151_A247_A0.6750.90
126_V190_A0.6750.90
206_L209_S0.6710.90
68_P71_A0.6700.90
23_H27_F0.6550.89
135_D142_L0.6530.89
212_R215_V0.6520.89
242_W246_G0.6500.89
131_A156_L0.6480.88
32_P84_C0.6440.88
104_P107_N0.6440.88
155_A248_V0.6410.88
28_L65_L0.6390.88
72_A75_R0.6390.88
52_G107_N0.6380.88
145_L215_V0.6360.88
126_V133_E0.6360.88
125_R203_A0.6350.87
27_F31_L0.6320.87
210_L214_R0.6290.87
40_F63_S0.6290.87
99_I107_N0.6280.87
182_F186_L0.6260.87
35_P85_T0.6250.87
90_G253_E0.6210.86
35_P57_I0.6200.86
126_V195_G0.6160.86
40_F61_V0.6160.86
69_D72_A0.6160.86
87_G90_G0.6110.85
206_L210_L0.6090.85
170_L178_G0.6090.85
204_L208_Q0.6070.85
111_R147_A0.6050.85
62_L66_R0.6050.85
70_E74_L0.6040.85
132_K136_F0.6030.85
170_L177_R0.5970.84
32_P61_V0.5950.84
38_Y99_I0.5950.84
237_H241_N0.5950.84
163_Q212_R0.5950.84
53_K100_K0.5930.84
185_A214_R0.5920.84
166_C193_C0.5920.84
219_P223_A0.5920.84
89_I250_S0.5900.83
23_H78_R0.5890.83
205_R209_S0.5890.83
167_Y173_E0.5880.83
183_R190_A0.5880.83
72_A106_F0.5880.83
61_V80_I0.5850.83
60_R107_N0.5820.82
40_F85_T0.5820.82
83_I94_L0.5790.82
208_Q227_K0.5770.82
177_R194_C0.5760.82
172_L176_S0.5760.82
43_E46_T0.5740.82
124_K174_P0.5710.81
163_Q209_S0.5710.81
246_G249_N0.5700.81
120_Q139_A0.5680.81
61_V82_W0.5670.81
65_L74_L0.5670.81
37_V98_L0.5660.81
89_I152_A0.5640.81
34_R56_N0.5620.80
95_E104_P0.5610.80
122_N138_R0.5580.80
124_K166_C0.5580.80
212_R217_C0.5570.80
208_Q241_N0.5570.80
103_Q111_R0.5550.79
168_G193_C0.5530.79
136_F139_A0.5520.79
216_V219_P0.5520.79
51_I99_I0.5510.79
225_A242_W0.5460.78
24_L27_F0.5450.78
218_W223_A0.5440.78
157_Q160_A0.5440.78
180_A191_G0.5440.78
218_W246_G0.5430.78
85_T91_A0.5430.78
109_R150_R0.5430.78
154_Q157_Q0.5410.78
166_C191_G0.5410.78
50_Y53_K0.5400.78
117_C133_E0.5400.78
61_V65_L0.5390.77
54_S105_L0.5390.77
251_L254_A0.5360.77
63_S68_P0.5350.77
83_I98_L0.5330.77
134_V138_R0.5330.77
73_M106_F0.5330.77
159_I163_Q0.5330.77
158_T241_N0.5320.77
169_L172_L0.5320.77
27_F82_W0.5320.77
217_C249_N0.5320.77
200_E203_A0.5300.76
145_L235_Q0.5290.76
160_A164_K0.5280.76
184_S194_C0.5270.76
168_G181_C0.5270.76
172_L183_R0.5270.76
77_S80_I0.5260.76
39_L73_M0.5260.76
250_S255_T0.5260.76
157_Q186_L0.5240.75
166_C181_C0.5220.75
90_G254_A0.5210.75
224_V245_L0.5200.75
66_R72_A0.5180.75
227_K241_N0.5180.75
150_R153_L0.5180.75
222_G259_R0.5170.75
38_Y64_H0.5160.74
123_E138_R0.5150.74
155_A159_I0.5130.74
161_D245_L0.5120.74
93_L101_E0.5100.74
82_W119_L0.5090.73
145_L239_I0.5090.73
55_V217_C0.5080.73
166_C189_C0.5060.73
111_R115_Q0.5060.73
167_Y188_R0.5050.73
125_R130_Y0.5040.73
122_N128_V0.5030.73
211_E214_R0.5020.72
53_K88_E0.5020.72
56_N254_A0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yd6A 5 0.3186 100 0.634 Contact Map
1yd0A 1 0.2949 100 0.646 Contact Map
2wshA 4 0.3492 100 0.67 Contact Map
1mk0A 1 0.2847 99.4 0.826 Contact Map
3mx1A 2 0.5254 97 0.914 Contact Map
2lwfA 1 0.3763 94.6 0.93 Contact Map
1zg2A 1 0.3119 88.9 0.941 Contact Map
1ywlA 1 0.3085 78.4 0.948 Contact Map
1e52A 2 0.1695 28.7 0.963 Contact Map
4csoA 1 0.3424 8.6 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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