GREMLIN Database
YDIY - Uncharacterized protein YdiY
UniProt: P76206 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13984
Length: 252 (217)
Sequences: 956 (716)
Seq/√Len: 48.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_H180_Y4.2371.00
150_F178_G4.2071.00
113_Y139_G3.9411.00
57_N241_D3.7991.00
191_T209_A3.7921.00
226_V240_T3.6111.00
148_H182_W2.9841.00
78_W102_G2.9631.00
50_G64_T2.7791.00
141_Q151_R2.6211.00
192_Q206_S2.5731.00
158_V170_T2.5671.00
223_A245_T2.5581.00
142_F152_F2.4941.00
112_D140_R2.4511.00
115_F137_G2.3801.00
143_L148_H2.3641.00
222_V246_L2.3191.00
113_Y153_E2.2981.00
55_S242_R2.2661.00
76_T104_S2.2641.00
196_V202_T2.2591.00
93_R96_E2.1601.00
55_S61_S2.1431.00
77_A105_R2.1231.00
56_G241_D2.1151.00
222_V244_T2.0621.00
43_F71_W2.0621.00
153_E175_Y2.0411.00
192_Q208_S1.9870.99
36_P40_K1.9410.99
150_F180_Y1.8770.99
45_G69_M1.8750.99
157_G173_L1.7870.99
103_R153_E1.7090.98
77_A107_N1.6930.98
34_D37_A1.6340.98
48_N221_K1.6290.98
84_A96_E1.6290.98
34_D38_S1.6140.98
114_L136_A1.5680.97
84_A98_Y1.5670.97
72_Y107_N1.5650.97
145_G148_H1.5630.97
108_L114_L1.5450.97
50_G247_S1.5260.97
224_Y242_R1.5120.96
64_T247_S1.4860.96
120_W132_D1.4800.96
114_L248_L1.4770.96
48_N249_G1.4600.96
226_V242_R1.4490.95
185_T188_A1.4430.95
54_Q60_S1.4380.95
201_D232_P1.4120.95
120_W130_E1.3910.94
112_D138_Y1.3770.94
190_F208_S1.3680.94
92_E235_S1.3620.94
151_R184_L1.3410.93
183_Q189_K1.3270.93
47_L67_T1.3140.92
36_P39_A1.3140.92
62_S87_T1.2880.92
43_F69_M1.2790.91
207_E223_A1.2790.91
103_R115_F1.2760.91
221_K249_G1.2670.91
96_E124_R1.2610.91
156_P176_A1.2540.90
56_G155_G1.2530.90
118_A134_L1.1890.88
213_A219_G1.1730.87
56_G125_Y1.1710.87
35_D39_A1.1630.87
128_Y159_R1.1490.86
186_D230_S1.1270.85
34_D39_A1.1240.85
153_E177_S1.1220.85
115_F135_T1.0970.83
53_A244_T1.0900.83
90_N167_A1.0890.83
77_A151_R1.0880.83
58_T89_S1.0800.82
201_D229_N1.0740.82
154_F174_G1.0740.82
56_G242_R1.0740.82
35_D38_S1.0670.82
135_T173_L1.0410.80
64_T245_T1.0340.80
161_D232_P1.0300.79
127_G233_P1.0300.79
159_R173_L1.0290.79
139_G153_E1.0240.79
81_W101_G1.0200.79
83_N99_A1.0110.78
47_L121_L1.0000.77
78_W104_S0.9890.77
53_A224_Y0.9870.76
45_G121_L0.9870.76
156_P172_P0.9700.75
175_Y195_S0.9690.75
188_A214_I0.9640.75
143_L150_F0.9620.74
62_S85_S0.9570.74
126_N130_E0.9490.73
181_A190_F0.9420.73
203_T229_N0.9410.73
228_W239_H0.9410.73
131_R229_N0.9330.72
161_D229_N0.9280.72
48_N66_D0.9260.72
220_L248_L0.9230.71
54_Q87_T0.9220.71
85_S97_K0.9190.71
114_L138_Y0.9190.71
187_N214_I0.9180.71
40_K248_L0.9170.71
43_F123_D0.9150.71
211_N219_G0.9130.71
200_E235_S0.9110.70
128_Y161_D0.9100.70
57_N155_G0.9070.70
78_W100_A0.9010.70
57_N238_E0.8980.69
121_L229_N0.8950.69
232_P239_H0.8830.68
134_L158_V0.8800.68
178_G206_S0.8800.68
45_G250_Y0.8730.67
184_L188_A0.8680.67
196_V228_W0.8610.66
198_G232_P0.8610.66
131_R161_D0.8600.66
207_E225_N0.8580.66
212_V220_L0.8550.65
159_R203_T0.8550.65
59_K238_E0.8540.65
111_Y144_N0.8520.65
103_R113_Y0.8380.64
76_T106_F0.8350.64
188_A238_E0.8320.63
162_K168_S0.8310.63
86_N93_R0.8300.63
146_P187_N0.8270.63
106_F110_D0.8220.62
46_N68_T0.8150.62
94_S125_Y0.8050.61
174_G224_Y0.7980.60
150_F194_V0.7970.60
135_T157_G0.7960.60
244_T247_S0.7960.60
90_N248_L0.7930.60
59_K91_D0.7900.59
102_G149_S0.7820.59
50_G222_V0.7790.58
65_A84_A0.7730.58
229_N237_P0.7730.58
53_A102_G0.7690.57
209_A223_A0.7610.56
113_Y173_L0.7610.56
88_S149_S0.7610.56
135_T156_P0.7600.56
34_D40_K0.7580.56
59_K106_F0.7510.55
109_T114_L0.7510.55
72_Y77_A0.7500.55
116_G243_R0.7470.55
89_S239_H0.7460.55
181_A189_K0.7460.55
126_N157_G0.7380.54
101_G195_S0.7350.54
88_S176_A0.7330.54
48_N247_S0.7320.54
113_Y117_Q0.7290.53
142_F178_G0.7280.53
138_Y188_A0.7260.53
39_A186_D0.7210.52
139_G195_S0.7150.52
152_F178_G0.7120.52
103_R177_S0.7110.51
117_Q195_S0.7110.51
52_L85_S0.7050.51
158_V247_S0.7030.51
66_D247_S0.7030.51
184_L214_I0.7010.50
58_T126_N0.6990.50
44_E69_M0.6940.50
48_N125_Y0.6920.50
60_S218_F0.6910.49
147_V248_L0.6890.49
76_T212_V0.6850.49
61_S86_N0.6840.49
82_G100_A0.6840.49
34_D100_A0.6830.49
129_R162_K0.6830.49
60_S89_S0.6800.48
185_T210_L0.6770.48
35_D40_K0.6760.48
171_Q198_G0.6740.48
144_N186_D0.6730.48
93_R179_A0.6730.48
231_E234_E0.6720.47
91_D170_T0.6680.47
121_L131_R0.6670.47
38_S184_L0.6670.47
159_R171_Q0.6630.47
180_Y208_S0.6590.46
99_A130_E0.6580.46
95_S220_L0.6560.46
99_A119_S0.6550.46
197_F203_T0.6540.46
68_T162_K0.6500.45
181_A193_G0.6490.45
107_N175_Y0.6490.45
155_G241_D0.6480.45
43_F151_R0.6460.45
160_Y170_T0.6460.45
151_R183_Q0.6430.45
43_F160_Y0.6420.44
99_A205_N0.6410.44
118_A132_D0.6400.44
198_G230_S0.6340.44
113_Y179_A0.6340.44
173_L198_G0.6330.44
136_A239_H0.6290.43
49_A136_A0.6290.43
115_F153_E0.6280.43
90_N235_S0.6260.43
202_T230_S0.6240.43
115_F139_G0.6220.42
46_N143_L0.6210.42
58_T123_D0.6200.42
135_T140_R0.6190.42
111_Y140_R0.6170.42
205_N225_N0.6150.42
177_S195_S0.6150.42
55_S244_T0.6140.42
192_Q212_V0.6130.42
44_E121_L0.6130.42
187_N213_A0.6080.41
75_T106_F0.6060.41
88_S96_E0.6050.41
86_N208_S0.6040.41
167_A196_V0.6040.41
191_T211_N0.5980.40
47_L219_G0.5960.40
219_G249_G0.5960.40
139_G151_R0.5950.40
82_G98_Y0.5890.39
172_P194_V0.5890.39
167_A234_E0.5890.39
228_W231_E0.5880.39
43_F76_T0.5850.39
119_S151_R0.5840.39
162_K172_P0.5830.39
103_R117_Q0.5830.39
45_G223_A0.5820.39
57_N232_P0.5770.38
158_V187_N0.5720.38
81_W113_Y0.5720.38
179_A193_G0.5720.38
45_G135_T0.5710.38
80_L216_E0.5690.37
133_V150_F0.5650.37
184_L218_F0.5640.37
44_E68_T0.5630.37
51_Y175_Y0.5630.37
197_F202_T0.5630.37
54_Q89_S0.5600.36
62_S95_S0.5600.36
57_N113_Y0.5540.36
63_L108_L0.5530.36
118_A210_L0.5520.36
42_P71_W0.5510.36
36_P152_F0.5500.36
78_W233_P0.5500.36
56_G124_R0.5490.35
49_A217_H0.5490.35
124_R159_R0.5490.35
113_Y163_Y0.5490.35
55_S147_V0.5490.35
224_Y244_T0.5480.35
194_V204_L0.5470.35
41_K88_S0.5460.35
142_F146_P0.5460.35
68_T193_G0.5450.35
73_G80_L0.5400.35
70_T77_A0.5390.35
198_G202_T0.5380.34
37_A40_K0.5370.34
75_T83_N0.5370.34
151_R179_A0.5360.34
90_N205_N0.5350.34
60_S196_V0.5340.34
222_V228_W0.5300.34
240_T243_R0.5290.34
67_T102_G0.5260.33
78_W123_D0.5260.33
90_N222_V0.5250.33
165_D170_T0.5240.33
115_F155_G0.5240.33
119_S193_G0.5240.33
47_L198_G0.5230.33
113_Y140_R0.5220.33
71_W171_Q0.5220.33
76_T95_S0.5210.33
185_T230_S0.5210.33
133_V156_P0.5210.33
67_T90_N0.5200.33
80_L111_Y0.5190.33
75_T116_G0.5180.33
92_E210_L0.5160.32
182_W185_T0.5150.32
115_F173_L0.5140.32
88_S93_R0.5130.32
154_F231_E0.5120.32
185_T204_L0.5080.32
102_G213_A0.5070.32
60_S95_S0.5060.32
59_K200_E0.5040.31
151_R216_E0.5030.31
209_A248_L0.5020.31
97_K227_T0.5010.31
139_G157_G0.5010.31
48_N65_A0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nb3A 2 0.5198 98.1 0.837 Contact Map
2x9kA 1 0.7024 97 0.87 Contact Map
4rlcA 1 0.5317 96.2 0.881 Contact Map
2k0lA 1 0.7222 95.5 0.888 Contact Map
2jmmA 1 0.5794 95.4 0.888 Contact Map
1ormA 1 0.5595 95.2 0.89 Contact Map
3qraA 1 0.5794 94.7 0.893 Contact Map
1i78A 2 0.8373 93.9 0.897 Contact Map
1p4tA 2 0.6071 93.8 0.897 Contact Map
2lhfA 1 0.6548 92.7 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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