GREMLIN Database
YDIV - Putative anti-FlhC(2)FlhD(4) factor YdiV
UniProt: P76204 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13981
Length: 237 (225)
Sequences: 24483 (19245)
Seq/√Len: 1283.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_N218_L3.9741.00
28_V231_I3.7031.00
111_E161_R2.8901.00
166_K170_Q2.8391.00
101_A136_V2.7941.00
134_S160_T2.6901.00
12_D35_S2.5601.00
209_Q213_F2.5271.00
62_S106_K2.3361.00
15_F67_L2.3301.00
190_S216_H2.2971.00
204_A208_A2.2721.00
72_Q109_F2.2271.00
207_L223_W2.2211.00
140_V161_R2.1881.00
36_S40_T2.1601.00
183_R191_P2.0771.00
203_T206_I1.9991.00
18_I217_A1.9621.00
69_K73_H1.9331.00
155_F178_F1.9251.00
36_S39_G1.8831.00
166_K200_G1.8681.00
207_L218_L1.8671.00
111_E140_V1.8331.00
179_E209_Q1.7961.00
18_I161_R1.7831.00
67_L228_I1.7611.00
59_Q63_E1.7301.00
161_R197_I1.7271.00
201_I218_L1.7161.00
4_F8_L1.7041.00
35_S42_R1.6931.00
14_Y227_P1.6851.00
183_R213_F1.6671.00
81_F138_P1.6311.00
12_D42_R1.6281.00
19_R223_W1.6171.00
130_L139_L1.6121.00
162_V189_I1.6121.00
207_L211_T1.6061.00
67_L71_C1.6011.00
138_P160_T1.5941.00
63_E67_L1.5721.00
207_L222_L1.5411.00
18_I111_E1.5301.00
227_P230_Q1.5241.00
173_I179_E1.5171.00
81_F111_E1.5121.00
103_E107_Y1.5011.00
221_C225_A1.4951.00
65_L103_E1.4931.00
183_R187_A1.4911.00
11_S32_T1.4861.00
204_A222_L1.4751.00
14_Y42_R1.4691.00
26_V217_A1.4521.00
173_I205_E1.4421.00
32_T60_L1.4421.00
63_E66_E1.4401.00
186_Q213_F1.4391.00
186_Q215_F1.4211.00
104_L137_Y1.4181.00
195_C216_H1.4131.00
10_H36_S1.4091.00
198_A215_F1.3991.00
195_C217_A1.3971.00
9_Y63_E1.3561.00
13_C60_L1.3351.00
86_L96_E1.3301.00
86_L112_L1.2971.00
18_I27_G1.2861.00
218_L223_W1.2771.00
173_I206_I1.2751.00
67_L70_S1.2521.00
161_R195_C1.2501.00
172_Q209_Q1.2461.00
62_S103_E1.2411.00
71_C228_I1.2331.00
187_A191_P1.2301.00
62_S107_Y1.2291.00
127_N156_D1.2211.00
99_N103_E1.2031.00
155_F171_Q1.1961.00
10_H34_F1.1911.00
172_Q182_I1.1801.00
141_L159_F1.1741.00
127_N131_L1.1721.00
173_I209_Q1.1641.00
102_G106_K1.1591.00
79_K109_F1.1561.00
112_L137_Y1.1511.00
111_E138_P1.1461.00
83_W111_E1.1361.00
27_G81_F1.1321.00
60_L64_Q1.1291.00
18_I83_W1.1281.00
20_D26_V1.1231.00
70_S74_F1.1191.00
189_I196_I1.1181.00
208_A211_T1.1161.00
68_L72_Q1.1141.00
101_A105_L1.1061.00
173_I203_T1.0861.00
37_E40_T1.0831.00
186_Q196_I1.0691.00
175_H178_F1.0681.00
97_R101_A1.0641.00
131_L135_Q1.0611.00
159_F194_N1.0601.00
180_P191_P1.0601.00
101_A132_S1.0551.00
4_F10_H1.0541.00
21_N207_L1.0541.00
92_T121_L1.0531.00
20_D24_V1.0471.00
28_V80_L1.0471.00
23_Q211_T1.0371.00
226_V230_Q1.0321.00
18_I81_F1.0321.00
184_A191_P1.0261.00
100_Y133_L1.0251.00
100_Y112_L1.0251.00
29_E85_N1.0191.00
30_L82_A1.0171.00
204_A207_L1.0041.00
13_C59_Q1.0021.00
132_S135_Q0.9981.00
125_K129_G0.9891.00
122_N125_K0.9841.00
68_L82_A0.9821.00
208_A212_P0.9761.00
97_R129_G0.9711.00
161_R217_A0.9651.00
66_E107_Y0.9641.00
209_Q212_P0.9641.00
66_E70_S0.9631.00
15_F30_L0.9581.00
97_R132_S0.9521.00
39_G47_R0.9441.00
64_Q82_A0.9391.00
129_G132_S0.9331.00
123_E157_G0.9261.00
69_K72_Q0.9221.00
15_F28_V0.9201.00
171_Q178_F0.9061.00
180_P183_R0.9051.00
12_D227_P0.8961.00
197_I217_A0.8911.00
198_A210_I0.8871.00
46_S166_K0.8871.00
52_L58_W0.8791.00
62_S66_E0.8731.00
98_D132_S0.8691.00
53_T58_W0.8681.00
15_F228_I0.8621.00
13_C30_L0.8581.00
81_F109_F0.8541.00
128_R131_L0.8541.00
170_Q206_I0.8541.00
13_C32_T0.8501.00
20_D216_H0.8481.00
178_F206_I0.8411.00
143_N199_G0.8401.00
72_Q75_F0.8401.00
10_H37_E0.8351.00
186_Q190_S0.8331.00
49_I58_W0.8331.00
138_P195_C0.8331.00
201_I210_I0.8261.00
120_H153_A0.8251.00
32_T59_Q0.8221.00
103_E106_K0.8191.00
17_P224_P0.8181.00
128_R132_S0.8171.00
36_S43_I0.8061.00
69_K107_Y0.8041.00
187_A190_S0.7941.00
113_L163_M0.7931.00
98_D102_G0.7871.00
88_P117_N0.7831.00
210_I215_F0.7761.00
179_E183_R0.7721.00
19_R25_L0.7711.00
131_L158_L0.7621.00
4_F7_N0.7621.00
70_S73_H0.7571.00
17_P226_V0.7541.00
11_S59_Q0.7531.00
99_N102_G0.7461.00
169_I172_Q0.7461.00
60_L65_L0.7451.00
18_I197_I0.7451.00
5_L11_S0.7431.00
125_K128_R0.7421.00
201_I207_L0.7411.00
95_L99_N0.7381.00
46_S50_A0.7321.00
155_F181_F0.7281.00
169_I198_A0.7271.00
171_Q174_T0.7261.00
44_P47_R0.7241.00
144_L185_I0.7241.00
70_S228_I0.7231.00
52_L56_Q0.7171.00
65_L110_I0.7161.00
123_E127_N0.7131.00
210_I218_L0.7121.00
226_V231_I0.7071.00
115_N143_N0.7071.00
39_G42_R0.7041.00
61_F103_E0.7011.00
104_L107_Y0.7001.00
98_D101_A0.6981.00
127_N158_L0.6971.00
96_E100_Y0.6961.00
55_E58_W0.6931.00
32_T48_V0.6921.00
80_L109_F0.6921.00
83_W161_R0.6911.00
5_L34_F0.6911.00
172_Q210_I0.6891.00
72_Q79_K0.6851.00
129_G133_L0.6841.00
176_R179_E0.6831.00
23_Q207_L0.6781.00
39_G43_I0.6781.00
202_D221_C0.6751.00
196_I216_H0.6741.00
85_N142_G0.6731.00
17_P25_L0.6721.00
138_P161_R0.6711.00
171_Q175_H0.6681.00
91_A129_G0.6651.00
27_G83_W0.6641.00
132_S136_V0.6601.00
72_Q76_I0.6571.00
188_Q192_C0.6561.00
45_T48_V0.6531.00
35_S39_G0.6531.00
53_T117_N0.6511.00
164_L215_F0.6491.00
190_S196_I0.6431.00
11_S34_F0.6421.00
14_Y35_S0.6401.00
13_C64_Q0.6401.00
85_N163_M0.6391.00
59_Q64_Q0.6361.00
120_H126_D0.6321.00
110_I137_Y0.6321.00
58_W89_Q0.6281.00
180_P184_A0.6261.00
93_L99_N0.6251.00
23_Q204_A0.6231.00
68_L79_K0.6211.00
184_A188_Q0.6201.00
146_A168_F0.6131.00
25_L224_P0.6111.00
22_Q218_L0.6061.00
40_T43_I0.6061.00
9_Y62_S0.6031.00
64_Q84_L0.6011.00
35_S40_T0.5971.00
14_Y225_A0.5971.00
184_A187_A0.5961.00
179_E213_F0.5951.00
146_A167_S0.5951.00
156_D177_S0.5931.00
29_E142_G0.5921.00
189_I194_N0.5921.00
89_Q118_Y0.5911.00
61_F65_L0.5911.00
65_L107_Y0.5911.00
123_E156_D0.5891.00
100_Y103_E0.5881.00
76_I80_L0.5881.00
115_N199_G0.5881.00
123_E126_D0.5861.00
34_F48_V0.5851.00
176_R180_P0.5841.00
31_I85_N0.5841.00
94_L125_K0.5831.00
116_E145_G0.5821.00
5_L10_H0.5821.00
29_E163_M0.5811.00
91_A118_Y0.5771.00
186_Q210_I0.5741.00
61_F100_Y0.5681.00
141_L153_A0.5631.00
21_N211_T0.5621.00
179_E212_P0.5601.00
112_L139_L0.5591.00
88_P118_Y0.5581.00
9_Y59_Q0.5561.00
102_G105_L0.5561.00
155_F175_H0.5561.00
96_E99_N0.5561.00
120_H123_E0.5541.00
162_V194_N0.5521.00
19_R23_Q0.5521.00
28_V82_A0.5501.00
97_R136_V0.5491.00
12_D229_N0.5471.00
202_D206_I0.5461.00
26_V81_F0.5461.00
53_T87_T0.5441.00
205_E208_A0.5421.00
124_G128_R0.5371.00
56_Q89_Q0.5371.00
164_L182_I0.5361.00
185_I189_I0.5361.00
131_L134_S0.5351.00
105_L136_V0.5321.00
16_L31_I0.5271.00
87_T90_V0.5231.00
211_T218_L0.5231.00
86_L90_V0.5181.00
19_R224_P0.5171.00
152_K167_S0.5171.00
100_Y137_Y0.5161.00
43_I47_R0.5121.00
9_Y66_E0.5111.00
169_I210_I0.5111.00
25_L28_V0.5111.00
133_L137_Y0.5081.00
124_G156_D0.5081.00
89_Q92_T0.5081.00
130_L158_L0.5061.00
172_Q179_E0.5061.00
152_K156_D0.5061.00
68_L110_I0.5051.00
53_T118_Y0.5031.00
28_V226_V0.5021.00
139_L160_T0.5011.00
88_P153_A0.5011.00
85_N221_C0.5001.00
88_P120_H0.5001.00
51_Q54_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hjfA 1 0.9958 100 0.058 Contact Map
4kieA 1 0.9916 100 0.067 Contact Map
4rnhA 2 0.9873 100 0.074 Contact Map
2r6oA 2 0.9958 100 0.093 Contact Map
3sy8A 6 0.9873 100 0.1 Contact Map
4rniA 2 0.9916 100 0.104 Contact Map
4hu4A 1 0.9451 100 0.107 Contact Map
4j40A 2 0.9705 100 0.112 Contact Map
3tlqA 1 0.9873 100 0.115 Contact Map
3s83A 1 0.9831 100 0.128 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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