GREMLIN Database
SUFE - Cysteine desulfuration protein SufE
UniProt: P76194 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13961
Length: 138 (128)
Sequences: 1886 (1048)
Seq/√Len: 92.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_M96_D3.8241.00
95_Q99_N3.5741.00
72_D79_K3.5701.00
107_E112_T3.1251.00
43_S46_N2.5461.00
68_E91_Q2.4171.00
6_D92_M2.3941.00
68_E90_D2.3811.00
38_R41_D2.2981.00
47_S54_Q2.2261.00
13_N87_I2.1171.00
101_D104_P2.0981.00
41_D58_V2.0401.00
41_D70_Q1.9291.00
10_L87_I1.9231.00
11_L108_K1.8031.00
93_T96_D1.7911.00
26_Y29_E1.7011.00
59_M133_K1.6861.00
39_D42_R1.6821.00
89_Y130_I1.6821.00
129_A133_K1.6541.00
60_R63_A1.6411.00
52_Q118_S1.5901.00
60_R70_Q1.5891.00
44_P49_Q1.5621.00
27_I84_V1.5531.00
8_E12_R1.5251.00
61_Q94_P1.5191.00
71_G82_I1.4731.00
53_S75_A1.4681.00
15_L108_K1.4671.00
42_R72_D1.4661.00
28_I31_G1.4631.00
7_K88_L1.4471.00
88_L105_W1.4360.99
88_L100_F1.4140.99
89_Y102_V1.3970.99
63_A68_E1.3920.99
59_M69_L1.3850.99
37_L70_Q1.3790.99
37_L42_R1.3090.99
7_K48_I1.2920.99
17_C22_E1.2750.99
20_W114_H1.2540.99
20_W24_Y1.2260.98
54_Q74_D1.2240.98
69_L97_I1.2240.98
69_L130_I1.1940.98
46_N59_M1.1910.98
37_L41_D1.1770.98
22_E25_L1.1610.98
77_I114_H1.1580.98
128_R132_A1.1580.98
102_V127_I1.1280.97
8_E104_P1.0910.97
78_V81_L1.0780.96
27_I32_Q1.0770.96
50_G73_S1.0600.96
58_V70_Q1.0580.96
25_L76_A1.0420.95
94_P98_V1.0350.95
128_R135_A1.0170.95
76_A79_K1.0030.94
67_I94_P0.9990.94
78_V125_A0.9920.94
24_Y114_H0.9850.94
41_D46_N0.9830.94
26_Y30_L0.9830.94
38_R70_Q0.9820.94
66_I93_T0.9640.93
100_F105_W0.9330.92
82_I126_M0.9330.92
14_F109_M0.9210.92
63_A66_I0.9140.91
13_N26_Y0.9130.91
71_G86_F0.9050.91
129_A132_A0.9000.91
60_R68_E0.8970.90
37_L58_V0.8940.90
59_M67_I0.8910.90
19_N22_E0.8880.90
46_N58_V0.8810.90
85_V123_L0.8780.89
35_P70_Q0.8700.89
57_I69_L0.8680.89
98_V135_A0.8630.89
11_L15_L0.8550.88
85_V130_I0.8550.88
48_I129_A0.8430.87
7_K100_F0.8350.87
55_V83_A0.8120.85
44_P47_S0.8060.85
61_Q64_Q0.8050.85
24_Y28_I0.7980.84
52_Q117_P0.7950.84
14_F17_C0.7870.84
61_Q97_I0.7840.83
94_P97_I0.7840.83
96_D99_N0.7780.83
16_R26_Y0.7760.83
24_Y77_I0.7550.81
131_R135_A0.7510.81
81_L123_L0.7340.79
13_N17_C0.7110.77
89_Y100_F0.7050.76
55_V82_I0.7010.76
132_A135_A0.7000.76
50_G56_W0.6980.76
56_W73_S0.6940.75
116_T133_K0.6920.75
10_L30_L0.6910.75
21_E25_L0.6910.75
52_Q76_A0.6890.75
20_W125_A0.6880.75
28_I75_A0.6830.74
83_A87_I0.6760.73
18_A29_E0.6720.73
7_K104_P0.6710.73
92_M100_F0.6700.73
45_Q63_A0.6680.72
29_E32_Q0.6670.72
25_L29_E0.6650.72
65_G95_Q0.6630.72
104_P108_K0.6560.71
37_L43_S0.6560.71
30_L87_I0.6510.70
34_L80_G0.6510.70
85_V102_V0.6440.70
18_A118_S0.6430.70
35_P91_Q0.6360.69
104_P107_E0.6340.68
17_C26_Y0.6290.68
40_E45_Q0.6200.67
24_Y115_L0.6160.66
78_V126_M0.6130.66
128_R131_R0.6120.66
25_L32_Q0.6080.65
14_F46_N0.6060.65
114_H121_Q0.5990.64
115_L122_G0.5990.64
22_E28_I0.5960.64
86_F90_D0.5940.63
6_D87_I0.5890.63
105_W108_K0.5880.63
29_E52_Q0.5860.62
17_C118_S0.5850.62
10_L84_V0.5840.62
61_Q65_G0.5840.62
14_F85_V0.5750.61
121_Q124_E0.5700.60
118_S121_Q0.5690.60
114_H123_L0.5690.60
24_Y78_V0.5670.60
120_S127_I0.5650.60
61_Q68_E0.5580.59
14_F120_S0.5580.59
36_E79_K0.5550.58
84_V126_M0.5540.58
110_A113_Q0.5530.58
27_I54_Q0.5530.58
55_V125_A0.5520.58
110_A114_H0.5520.58
53_S74_D0.5470.57
57_I109_M0.5470.57
61_Q91_Q0.5460.57
71_G78_V0.5450.57
105_W109_M0.5440.57
101_D131_R0.5430.57
73_S121_Q0.5420.56
66_I96_D0.5410.56
16_R91_Q0.5380.56
38_R43_S0.5350.56
67_I98_V0.5290.55
93_T98_V0.5280.55
29_E78_V0.5280.55
112_T120_S0.5270.54
82_I100_F0.5270.54
7_K52_Q0.5260.54
57_I105_W0.5240.54
57_I120_S0.5220.54
7_K105_W0.5180.53
69_L79_K0.5170.53
7_K92_M0.5120.52
37_L57_I0.5110.52
88_L92_M0.5100.52
47_S74_D0.5100.52
74_D121_Q0.5050.51
114_H127_I0.5040.51
86_F130_I0.5030.51
25_L52_Q0.5030.51
92_M105_W0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3g0mA 1 1 100 0.037 Contact Map
4lw4C 1 0.9783 100 0.05 Contact Map
1wloA 1 0.9565 100 0.109 Contact Map
3lvlA 1 0.8043 37.5 0.927 Contact Map
2qq4A 5 0.8406 26.7 0.932 Contact Map
2z7eA 5 0.8333 25.6 0.933 Contact Map
4eb5C 1 0.7971 20.5 0.936 Contact Map
4k51A 1 0.5 15.3 0.94 Contact Map
4xaiA 2 0.7536 8.4 0.946 Contact Map
4u1dC 1 0.5 6.9 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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