GREMLIN Database
MEPH - Murein DD-endopeptidase MepH
UniProt: P76190 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13949
Length: 271 (229)
Sequences: 2726 (2476)
Seq/√Len: 163.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_V246_I3.6001.00
151_Q154_K3.3641.00
206_L261_A2.8851.00
160_G166_G2.8291.00
242_Q245_Q2.7591.00
238_P243_E2.7131.00
149_M235_I2.6921.00
258_Y261_A2.6641.00
145_M229_V2.6191.00
152_I235_I2.4931.00
202_E205_E2.4791.00
161_S187_R2.3711.00
149_M246_I2.3531.00
173_V227_V2.2711.00
186_P195_L2.1901.00
173_V211_L2.1351.00
188_T191_E2.1031.00
200_P262_R2.0511.00
89_K93_K1.9471.00
147_K175_Y1.9421.00
174_Y187_R1.9301.00
154_K167_F1.9251.00
147_K179_D1.8821.00
167_F175_Y1.8131.00
162_S166_G1.7891.00
189_A193_Y1.7881.00
214_F234_F1.7751.00
214_F226_G1.7441.00
173_V192_M1.7391.00
107_K110_K1.6971.00
198_A262_R1.6891.00
239_R242_Q1.6881.00
91_R95_A1.6811.00
93_K97_N1.6661.00
148_L235_I1.6581.00
155_P166_G1.6481.00
142_K146_N1.6481.00
92_S96_V1.6431.00
236_Q247_T1.6371.00
172_L176_A1.6211.00
203_R258_Y1.6211.00
215_R223_D1.6111.00
213_F225_V1.6051.00
87_N91_R1.5851.00
147_K167_F1.5711.00
238_P241_G1.5471.00
233_K246_I1.5471.00
211_L225_V1.5221.00
214_F258_Y1.4841.00
141_T145_M1.4841.00
95_A99_T1.4691.00
175_Y179_D1.4371.00
154_K160_G1.4101.00
173_V185_I1.4011.00
154_K162_S1.3941.00
238_P245_Q1.3621.00
147_K150_Q1.3601.00
68_T72_K1.3591.00
174_Y178_K1.3501.00
72_K76_S1.3371.00
37_T41_T1.3291.00
240_T243_E1.3251.00
51_A54_K1.3231.00
57_Q60_A1.3171.00
71_S74_A1.3151.00
154_K166_G1.3121.00
152_I243_E1.3121.00
88_A92_S1.3051.00
103_S107_K1.2981.00
238_P242_Q1.2961.00
193_Y222_A1.2931.00
29_K32_R1.2891.00
103_S106_E1.2841.00
147_K151_Q1.2821.00
215_R257_H1.2781.00
51_A55_K1.2661.00
216_T223_D1.2651.00
203_R206_L1.2581.00
193_Y260_G1.2461.00
99_T103_S1.2271.00
100_A103_S1.2161.00
203_R250_S1.2051.00
104_F108_C1.2011.00
82_I85_S1.2001.00
86_K90_T1.1941.00
36_A39_H1.1881.00
115_K118_C1.1851.00
152_I246_I1.1841.00
47_K50_T1.1691.00
186_P191_E1.1641.00
111_R114_Y1.1611.00
67_S71_S1.1601.00
83_T87_N1.1591.00
74_A78_K1.1541.00
234_F249_L1.1521.00
85_S89_K1.1471.00
102_A106_E1.1471.00
58_K62_K1.1341.00
206_L212_V1.1231.00
114_Y118_C1.1181.00
190_N222_A1.1101.00
112_K116_S1.1101.00
177_Y264_V1.1061.00
67_S70_K1.0971.00
226_G234_F1.0951.00
144_A181_V1.0881.00
61_K65_S1.0790.99
146_N149_M1.0770.99
82_I86_K1.0760.99
215_R221_T1.0760.99
75_S79_K1.0740.99
100_A104_F1.0670.99
239_R243_E1.0650.99
96_V100_A1.0610.99
157_R160_G1.0550.99
75_S78_K1.0470.99
88_A91_R1.0210.99
39_H43_K1.0130.99
206_L249_L1.0030.99
147_K176_A1.0010.99
85_S88_A1.0000.99
161_S174_Y0.9970.99
110_K114_Y0.9970.99
106_E110_K0.9960.99
201_I205_E0.9870.99
106_E109_T0.9790.99
56_T60_A0.9790.99
127_G131_D0.9780.99
233_K248_S0.9760.99
189_A222_A0.9680.99
33_E37_T0.9670.99
163_P167_F0.9660.99
145_M149_M0.9650.99
193_Y259_V0.9570.99
96_V99_T0.9540.99
47_K51_A0.9520.99
193_Y198_A0.9510.99
43_K46_K0.9450.99
191_E194_H0.9430.99
26_H30_Q0.9380.99
98_K102_A0.9370.99
176_A181_V0.9350.99
187_R190_N0.9340.99
141_T208_N0.9330.99
214_F223_D0.9170.98
148_L227_V0.9080.98
157_R240_T0.9070.98
213_F222_A0.9060.98
116_S119_V0.9060.98
92_S95_A0.9020.98
104_F107_K0.8980.98
81_S84_A0.8970.98
157_R166_G0.8960.98
52_T55_K0.8960.98
124_A128_T0.8910.98
145_M235_I0.8900.98
236_Q245_Q0.8900.98
167_F244_I0.8890.98
114_Y117_H0.8820.98
151_Q162_S0.8770.98
111_R115_K0.8760.98
90_T94_H0.8750.98
186_P189_A0.8750.98
76_S79_K0.8680.98
26_H29_K0.8650.98
24_M28_S0.8630.98
102_A105_T0.8620.98
74_A77_V0.8590.97
161_S188_T0.8540.97
149_M229_V0.8530.97
142_K208_N0.8500.97
70_K74_A0.8470.97
147_K181_V0.8460.97
174_Y192_M0.8440.97
69_T72_K0.8440.97
27_A31_A0.8410.97
91_R94_H0.8370.97
42_K46_K0.8360.97
193_Y213_F0.8340.97
122_K125_A0.8290.97
194_H200_P0.8210.97
32_R36_A0.8090.96
108_C112_K0.8070.96
124_A130_A0.8070.96
151_Q176_A0.8030.96
94_H97_N0.7970.96
81_S85_S0.7950.96
140_A143_V0.7910.96
105_T109_T0.7900.96
101_S105_T0.7890.96
208_N229_V0.7860.96
174_Y188_T0.7780.95
86_K89_K0.7780.95
190_N193_Y0.7770.95
203_R212_V0.7730.95
236_Q250_S0.7710.95
187_R191_E0.7690.95
25_A29_K0.7630.95
127_G130_A0.7590.95
175_Y178_K0.7540.95
226_G236_Q0.7540.95
89_K92_S0.7500.95
143_V181_V0.7490.94
242_Q247_T0.7430.94
24_M27_A0.7420.94
53_T57_Q0.7410.94
151_Q175_Y0.7410.94
83_T86_K0.7410.94
47_K54_K0.7380.94
206_L258_Y0.7360.94
97_N100_A0.7360.94
194_H198_A0.7340.94
203_R261_A0.7320.94
154_K164_R0.7230.93
60_A64_A0.7200.93
26_H33_E0.7190.93
151_Q172_L0.7160.93
122_K128_T0.7150.93
84_A88_A0.7100.93
149_M152_I0.7100.93
238_P244_I0.7070.93
68_T71_S0.7040.92
216_T221_T0.7030.92
212_V226_G0.7020.92
105_T108_C0.7020.92
43_K54_K0.7010.92
144_A176_A0.6980.92
50_T53_T0.6960.92
120_K123_N0.6940.92
64_A67_S0.6900.92
214_F250_S0.6890.92
134_K137_V0.6870.92
90_T93_K0.6850.91
143_V146_N0.6840.91
202_E206_L0.6830.91
57_Q61_K0.6780.91
107_K114_Y0.6770.91
151_Q181_V0.6720.91
158_W166_G0.6700.90
123_N128_T0.6670.90
157_R161_S0.6670.90
33_E36_A0.6650.90
222_A259_V0.6640.90
110_K113_G0.6640.90
125_A129_L0.6640.90
44_A48_K0.6620.90
41_T45_D0.6620.90
31_A34_S0.6580.90
235_I246_I0.6530.89
195_L264_V0.6490.89
84_A87_N0.6460.89
48_K51_A0.6450.89
45_D49_S0.6440.89
40_I44_A0.6420.89
177_Y181_V0.6390.88
255_Q258_Y0.6380.88
97_N101_S0.6330.88
141_T229_V0.6320.88
150_Q175_Y0.6310.88
155_P243_E0.6310.88
95_A98_K0.6290.88
76_S80_S0.6270.87
177_Y185_I0.6240.87
162_S167_F0.6220.87
232_G249_L0.6200.87
46_K50_T0.6190.87
72_K75_S0.6180.87
40_I47_K0.6170.87
189_A192_M0.6170.87
201_I262_R0.6150.86
193_Y261_A0.6150.86
229_V233_K0.6110.86
115_K120_K0.6100.86
48_K52_T0.6100.86
161_S167_F0.6090.86
249_L261_A0.6080.86
158_W171_G0.6070.86
201_I261_A0.6070.86
28_S31_A0.6030.85
144_A177_Y0.6030.85
187_R195_L0.6020.85
32_R35_S0.5930.84
60_A67_S0.5930.84
70_K73_T0.5870.84
44_A55_K0.5860.84
113_G121_V0.5840.83
223_D240_T0.5830.83
127_G133_H0.5820.83
192_M225_V0.5820.83
87_N90_T0.5810.83
159_G187_R0.5800.83
189_A213_F0.5790.83
108_C111_R0.5780.83
107_K111_R0.5760.83
25_A28_S0.5740.82
73_T77_V0.5690.82
35_S39_H0.5670.82
154_K244_I0.5660.81
112_K115_K0.5620.81
151_Q167_F0.5610.81
28_S32_R0.5610.81
66_K70_K0.5600.81
173_V225_V0.5580.81
229_V235_I0.5580.81
115_K119_V0.5540.80
62_K65_S0.5540.80
163_P175_Y0.5540.80
34_S37_T0.5520.80
92_S98_K0.5500.80
101_S109_T0.5490.79
44_A50_T0.5480.79
73_T76_S0.5470.79
65_S69_T0.5450.79
45_D48_K0.5430.79
93_K96_V0.5430.79
185_I198_A0.5420.79
178_K184_R0.5380.78
212_V249_L0.5340.78
174_Y185_I0.5340.78
48_K54_K0.5340.78
101_S104_F0.5310.77
227_V235_I0.5280.77
172_L181_V0.5270.77
150_Q154_K0.5270.77
60_A63_A0.5250.76
113_G119_V0.5250.76
155_P158_W0.5230.76
121_V125_A0.5230.76
189_A225_V0.5220.76
38_T41_T0.5210.76
193_Y221_T0.5200.76
26_H51_A0.5200.76
88_A98_K0.5180.75
113_G116_S0.5180.75
118_C121_V0.5140.75
99_T106_E0.5140.75
126_S129_L0.5140.75
122_K129_L0.5130.75
31_A35_S0.5090.74
212_V258_Y0.5070.74
99_T102_A0.5030.73
41_T54_K0.5030.73
64_A72_K0.5010.73
69_T73_T0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4gX 1 0.5424 100 0.318 Contact Map
2k1gA 1 0.476 100 0.443 Contact Map
3pbiA 1 0.679 100 0.461 Contact Map
4hpeA 1 0.631 100 0.461 Contact Map
3h41A 1 0.7897 100 0.462 Contact Map
4xcmA 2 0.786 100 0.463 Contact Map
4fdyA 1 0.9004 100 0.47 Contact Map
4lj1A 1 0.4354 100 0.471 Contact Map
3npfA 2 0.6531 100 0.476 Contact Map
2hbwA 1 0.7638 100 0.493 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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