GREMLIN Database
YDHF - Oxidoreductase YdhF
UniProt: P76187 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13420
Length: 298 (262)
Sequences: 32590 (20665)
Seq/√Len: 1276.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_E270_R3.2551.00
111_E151_K2.9621.00
31_A66_E2.9211.00
69_K118_A2.8501.00
237_L284_Q2.7501.00
281_T284_Q2.5131.00
35_V70_L2.4941.00
110_A146_L2.4541.00
107_I145_H2.4521.00
40_E44_L2.3881.00
107_I149_S2.3351.00
144_K148_Q2.1461.00
236_E287_R2.1261.00
35_V66_E2.0781.00
121_H153_R2.0481.00
112_Q116_N2.0351.00
252_R285_W2.0161.00
145_H149_S2.0061.00
198_Q202_L1.9921.00
231_A235_E1.9871.00
266_I270_R1.9861.00
199_L206_P1.9351.00
40_E266_I1.9351.00
236_E284_Q1.9121.00
74_L77_R1.9081.00
103_R145_H1.8801.00
282_R286_F1.8681.00
232_V287_R1.8641.00
44_L270_R1.8631.00
18_V48_T1.8601.00
59_Q62_A1.8211.00
253_L289_R1.7371.00
126_L178_T1.7031.00
166_A170_S1.6961.00
145_H148_Q1.6951.00
166_A198_Q1.6931.00
103_R107_I1.6771.00
41_H46_V1.6601.00
229_E232_V1.6561.00
62_A116_N1.6461.00
239_A278_L1.6361.00
44_L273_V1.6281.00
84_C125_L1.6241.00
35_V39_E1.6191.00
40_E43_D1.6161.00
142_A145_H1.6041.00
30_S33_Q1.6031.00
107_I111_E1.5981.00
205_R258_L1.5981.00
274_E277_T1.5921.00
82_S113_S1.5921.00
241_S271_A1.5911.00
39_E70_L1.5911.00
80_I119_T1.5851.00
110_A125_L1.5691.00
35_V67_A1.5681.00
248_A278_L1.5661.00
286_F290_K1.5651.00
82_S122_L1.5581.00
84_C106_I1.5521.00
31_A35_V1.5511.00
144_K174_F1.5381.00
81_V126_L1.5021.00
108_K112_Q1.4931.00
21_Y49_V1.4641.00
12_P154_H1.4501.00
42_L78_M1.4391.00
53_D109_S1.4241.00
161_T164_Q1.4231.00
197_D201_Q1.4101.00
200_Q254_P1.4061.00
111_E115_I1.4031.00
194_G197_D1.3951.00
169_Q202_L1.3921.00
126_L207_M1.3851.00
147_H174_F1.3781.00
181_V206_P1.3691.00
33_Q36_S1.3671.00
239_A244_Q1.3521.00
38_I67_A1.3481.00
270_R274_E1.3311.00
248_A252_R1.3161.00
36_S40_E1.3141.00
12_P79_E1.3071.00
122_L152_V1.3041.00
103_R141_D1.3021.00
39_E43_D1.3011.00
287_R290_K1.2921.00
112_Q115_I1.2901.00
154_H177_A1.2811.00
229_E287_R1.2751.00
239_A245_V1.2711.00
169_Q198_Q1.2611.00
107_I142_A1.2571.00
146_L152_V1.2401.00
263_S268_R1.2381.00
79_E124_L1.2371.00
117_L122_L1.2371.00
65_G118_A1.2341.00
103_R142_A1.2341.00
152_V155_F1.2221.00
162_P198_Q1.2211.00
231_A242_I1.2211.00
232_V236_E1.2191.00
241_S244_Q1.2121.00
263_S269_V1.2101.00
66_E118_A1.2031.00
75_R119_T1.1921.00
196_L200_Q1.1901.00
61_E113_S1.1841.00
137_D171_R1.1791.00
32_R36_S1.1761.00
105_H108_K1.1711.00
130_P164_Q1.1621.00
183_I253_L1.1531.00
62_A66_E1.1481.00
124_L178_T1.1361.00
104_D108_K1.1351.00
48_T81_V1.1291.00
49_V64_F1.1251.00
148_Q173_P1.1211.00
166_A202_L1.1191.00
267_E270_R1.1121.00
102_D105_H1.1111.00
144_K147_H1.0991.00
147_H177_A1.0931.00
250_V259_P1.0911.00
186_V227_R1.0901.00
48_T207_M1.0891.00
21_Y64_F1.0891.00
111_E149_S1.0881.00
182_E187_H1.0751.00
143_F155_F1.0751.00
75_R121_H1.0711.00
138_E141_D1.0621.00
166_A201_Q1.0601.00
127_I143_F1.0591.00
36_S266_I1.0551.00
228_D232_V1.0541.00
10_Q154_H1.0501.00
47_T79_E1.0481.00
110_A122_L1.0381.00
146_L151_K1.0291.00
233_V245_V1.0281.00
167_L171_R1.0271.00
37_F269_V1.0191.00
162_P166_A1.0181.00
185_P288_I1.0131.00
232_V235_E1.0081.00
39_E67_A1.0041.00
244_Q274_E1.0001.00
228_D231_A0.9981.00
230_L242_I0.9971.00
9_P177_A0.9961.00
61_E116_N0.9781.00
15_S47_T0.9751.00
157_V176_L0.9741.00
123_D153_R0.9681.00
66_E70_L0.9631.00
16_R251_L0.9571.00
244_Q271_A0.9531.00
193_D197_D0.9531.00
185_P246_V0.9481.00
141_D145_H0.9441.00
251_L275_A0.9441.00
207_M258_L0.9431.00
142_A146_L0.9411.00
178_T207_M0.9331.00
16_R276_E0.9321.00
68_L78_M0.9271.00
36_S39_E0.9241.00
108_K111_E0.9241.00
197_D200_Q0.9181.00
271_A274_E0.9161.00
107_I110_A0.9101.00
146_L149_S0.9001.00
53_D88_T0.8991.00
15_S46_V0.8971.00
265_K268_R0.8891.00
267_E271_A0.8891.00
107_I146_L0.8881.00
10_Q177_A0.8881.00
286_F289_R0.8871.00
198_Q201_Q0.8861.00
137_D167_L0.8851.00
269_V273_V0.8841.00
200_Q256_Q0.8711.00
155_F176_L0.8701.00
252_R279_K0.8681.00
38_I49_V0.8681.00
165_F204_V0.8681.00
179_N199_L0.8651.00
157_V165_F0.8631.00
42_L74_L0.8611.00
141_D144_K0.8601.00
167_L170_S0.8571.00
53_D105_H0.8491.00
283_Q287_R0.8451.00
103_R138_E0.8441.00
81_V124_L0.8411.00
53_D116_N0.8361.00
144_K173_P0.8361.00
62_A115_I0.8301.00
81_V207_M0.8301.00
188_Q289_R0.8261.00
31_A63_A0.8251.00
283_Q286_F0.8241.00
144_K155_F0.8231.00
233_V237_L0.8191.00
253_L285_W0.8101.00
19_M41_H0.8001.00
237_L281_T0.7991.00
31_A59_Q0.7981.00
40_E269_V0.7931.00
53_D112_Q0.7891.00
247_Y275_A0.7881.00
32_R35_V0.7711.00
196_L206_P0.7711.00
162_P195_T0.7681.00
159_N209_W0.7621.00
44_L274_E0.7621.00
10_Q147_H0.7611.00
183_I196_L0.7601.00
114_L151_K0.7551.00
246_V250_V0.7531.00
82_S125_L0.7521.00
211_C261_I0.7461.00
236_E281_T0.7431.00
169_Q175_T0.7411.00
264_G268_R0.7391.00
51_H64_F0.7381.00
252_R282_R0.7381.00
229_E291_A0.7371.00
39_E74_L0.7311.00
34_L63_A0.7301.00
129_R159_N0.7261.00
46_V273_V0.7231.00
17_F251_L0.7201.00
114_L119_T0.7171.00
21_Y60_C0.7161.00
162_P194_G0.7151.00
208_A211_C0.7141.00
195_T199_L0.7131.00
70_L74_L0.7121.00
140_A155_F0.7101.00
42_L49_V0.7071.00
196_L253_L0.7071.00
140_A168_L0.7021.00
221_D225_P0.6991.00
135_D138_E0.6971.00
109_S112_Q0.6971.00
126_L156_G0.6921.00
208_A259_P0.6921.00
106_I146_L0.6901.00
188_Q192_L0.6881.00
249_W289_R0.6871.00
188_Q193_D0.6861.00
110_A151_K0.6811.00
113_S125_L0.6791.00
224_Q228_D0.6751.00
19_M24_L0.6721.00
18_V261_I0.6701.00
243_E271_A0.6681.00
205_R257_P0.6681.00
134_M138_E0.6651.00
37_F266_I0.6621.00
157_V160_F0.6571.00
192_L197_D0.6561.00
144_K172_L0.6531.00
248_A275_A0.6531.00
86_I89_T0.6511.00
227_R231_A0.6511.00
47_T77_R0.6501.00
18_V258_L0.6501.00
250_V257_P0.6491.00
14_F258_L0.6461.00
199_L204_V0.6461.00
233_V284_Q0.6451.00
54_I85_G0.6451.00
280_M285_W0.6421.00
140_A176_L0.6421.00
101_T127_I0.6401.00
183_I250_V0.6401.00
225_P228_D0.6401.00
23_R214_G0.6391.00
76_E121_H0.6381.00
131_D134_M0.6371.00
106_I142_A0.6361.00
12_P153_R0.6351.00
268_R271_A0.6281.00
230_L288_I0.6251.00
237_L245_V0.6231.00
42_L47_T0.6211.00
157_V179_N0.6211.00
106_I139_V0.6211.00
122_L125_L0.6201.00
245_V280_M0.6201.00
59_Q63_A0.6161.00
73_H78_M0.6151.00
42_L77_R0.6141.00
211_C250_V0.6131.00
88_T105_H0.6131.00
234_A245_V0.6131.00
43_D266_I0.6121.00
143_F147_H0.6111.00
44_L269_V0.6071.00
230_L246_V0.6061.00
9_P203_R0.6031.00
139_V142_A0.6001.00
183_I206_P0.5991.00
235_E238_N0.5991.00
50_D180_Q0.5981.00
166_A169_Q0.5951.00
164_Q167_L0.5941.00
210_S214_G0.5931.00
74_L78_M0.5901.00
147_H152_V0.5901.00
24_L34_L0.5881.00
37_F263_S0.5881.00
114_L121_H0.5881.00
223_F226_L0.5881.00
220_D223_F0.5871.00
284_Q287_R0.5851.00
224_Q227_R0.5841.00
26_D63_A0.5821.00
253_L257_P0.5821.00
38_I42_L0.5811.00
147_H154_H0.5811.00
33_Q266_I0.5801.00
239_A277_T0.5791.00
107_I151_K0.5781.00
136_A171_R0.5771.00
183_I257_P0.5751.00
245_V284_Q0.5751.00
22_W210_S0.5751.00
114_L122_L0.5751.00
38_I64_F0.5721.00
110_A114_L0.5721.00
9_P175_T0.5711.00
234_A237_L0.5711.00
24_L37_F0.5701.00
234_A242_I0.5691.00
84_C101_T0.5661.00
244_Q278_L0.5641.00
102_D139_V0.5631.00
25_M60_C0.5601.00
251_L259_P0.5591.00
186_V216_R0.5591.00
280_M284_Q0.5561.00
18_V260_I0.5521.00
8_A205_R0.5491.00
225_P229_E0.5491.00
125_L152_V0.5481.00
137_D141_D0.5481.00
239_A274_E0.5451.00
245_V288_I0.5441.00
233_V287_R0.5421.00
136_A164_Q0.5401.00
245_V278_L0.5381.00
263_S272_A0.5381.00
66_E69_K0.5371.00
148_Q174_F0.5371.00
114_L120_D0.5361.00
125_L143_F0.5361.00
84_C109_S0.5351.00
216_R227_R0.5311.00
19_M37_F0.5291.00
248_A279_K0.5281.00
110_A142_A0.5251.00
51_H60_C0.5241.00
136_A167_L0.5241.00
56_G59_Q0.5231.00
135_D139_V0.5211.00
53_D85_G0.5201.00
208_A256_Q0.5201.00
14_F48_T0.5181.00
130_P160_F0.5181.00
136_A139_V0.5171.00
42_L67_A0.5141.00
49_V68_L0.5121.00
86_I129_R0.5121.00
41_H49_V0.5111.00
239_A248_A0.5101.00
64_F67_A0.5091.00
169_Q204_V0.5081.00
8_A14_F0.5081.00
147_H175_T0.5071.00
157_V168_L0.5071.00
127_I139_V0.5061.00
183_I188_Q0.5051.00
226_L231_A0.5021.00
208_A250_V0.5011.00
17_F276_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r9oA 5 0.9866 100 0.039 Contact Map
4xk2A 5 0.9497 100 0.071 Contact Map
1pyfA 1 0.9497 100 0.071 Contact Map
1lqaA 2 0.9832 100 0.073 Contact Map
3eauA 3 0.9799 100 0.074 Contact Map
1pz1A 1 0.9664 100 0.075 Contact Map
3v0sA 1 0.8993 100 0.076 Contact Map
3lutA 3 0.9765 100 0.078 Contact Map
3n6qA 5 0.9799 100 0.079 Contact Map
3n2tA 1 0.9732 100 0.082 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.