GREMLIN Database
CLCB - Voltage-gated ClC-type chloride channel ClcB
UniProt: P76175 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13848
Length: 418 (389)
Sequences: 5319 (3681)
Seq/√Len: 186.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
361_T393_A4.3641.00
299_A335_L3.6451.00
110_V115_S3.4861.00
240_T244_A3.4111.00
116_A309_V3.3961.00
115_S312_S3.3251.00
117_I312_S3.3221.00
61_G65_G3.1821.00
357_T393_A3.1631.00
116_A305_K3.1381.00
127_A151_G2.9901.00
230_L332_I2.9791.00
60_G113_S2.8671.00
20_A200_I2.8601.00
18_A130_A2.8481.00
66_L70_G2.6441.00
24_H28_L2.6291.00
227_T336_Y2.6051.00
244_A248_G2.5481.00
270_L308_A2.5331.00
224_I357_T2.4881.00
28_L32_L2.4711.00
374_T391_L2.3181.00
364_A394_C2.3081.00
234_C362_L2.3061.00
8_A12_G2.3011.00
241_L310_L2.2901.00
228_G232_G2.2781.00
302_F335_L2.2331.00
168_L375_L2.2251.00
220_D354_L2.2071.00
244_A247_R2.1411.00
232_G400_I2.1301.00
271_S278_W2.1231.00
285_V330_L2.1171.00
234_C332_I2.1141.00
57_P61_G2.0991.00
249_F315_S2.0891.00
302_F332_I2.0031.00
110_V317_A1.9871.00
222_A226_S1.9801.00
11_V15_A1.9761.00
233_L237_L1.9691.00
110_V117_I1.9581.00
16_A20_A1.9411.00
245_C314_G1.9371.00
325_T366_T1.9111.00
65_G68_L1.9011.00
13_I196_V1.8931.00
100_S129_L1.8931.00
25_A108_L1.8921.00
189_S193_A1.8661.00
266_I311_A1.8621.00
67_L71_W1.8601.00
235_G365_A1.8221.00
306_L328_I1.8181.00
135_A144_W1.8071.00
225_I396_I1.7961.00
54_L57_P1.7881.00
295_L335_L1.7811.00
29_L112_T1.7371.00
17_F200_I1.7311.00
22_F26_M1.7071.00
9_T192_V1.7051.00
228_G397_A1.6831.00
238_L309_V1.6831.00
85_Y128_A1.6661.00
231_A332_I1.6661.00
263_G315_S1.6611.00
302_F328_I1.6471.00
368_H402_R1.6471.00
360_A394_C1.6261.00
15_A127_A1.6261.00
110_V312_S1.5961.00
19_V123_M1.5951.00
325_T362_L1.5821.00
169_F173_V1.5801.00
225_I229_V1.5691.00
284_T327_F1.5681.00
57_P60_G1.5641.00
133_C137_R1.5591.00
288_F331_A1.5501.00
298_I334_M1.5391.00
8_A11_V1.5221.00
228_G396_I1.4971.00
53_R57_P1.4911.00
63_A109_L1.4861.00
302_F331_A1.4851.00
264_G268_G1.4841.00
223_L340_L1.4841.00
294_L297_I1.4841.00
227_T231_A1.4671.00
378_C387_L1.4651.00
218_A222_A1.4571.00
132_S144_W1.4571.00
149_A186_V1.4521.00
231_A361_T1.4481.00
231_A362_L1.4431.00
356_L381_T1.4391.00
154_A189_S1.4381.00
229_V400_I1.4271.00
224_I393_A1.4221.00
248_G252_L1.4201.00
153_A157_A1.4161.00
23_R26_M1.3961.00
28_L31_W1.3891.00
140_P143_E1.3721.00
269_L273_F1.3661.00
66_L71_W1.3561.00
247_R251_S1.3541.00
72_Q75_T1.3461.00
326_L359_M1.3461.00
398_S402_R1.3461.00
11_V147_W1.3451.00
104_S126_L1.3411.00
336_Y340_L1.3281.00
229_V233_L1.3271.00
103_K318_P1.3181.00
223_L336_Y1.3141.00
77_Q102_V1.3091.00
106_A318_P1.3071.00
255_A258_W1.3041.00
153_A170_I1.2991.00
363_L367_T1.2911.00
61_G64_A1.2901.00
338_R342_L1.2881.00
298_I331_A1.2871.00
68_L72_Q1.2861.00
330_L355_G1.2811.00
68_L71_W1.2791.00
245_C310_L1.2781.00
58_A261_A1.2771.00
101_L105_L1.2761.00
277_V308_A1.2751.00
72_Q102_V1.2741.00
20_A24_H1.2691.00
377_I390_L1.2571.00
72_Q77_Q1.2541.00
149_A175_F1.2511.00
363_L373_S1.2501.00
157_A190_A1.2451.00
164_L375_L1.2351.00
17_F21_G1.2351.00
334_M355_G1.2331.00
9_T188_I1.2301.00
150_C189_S1.2291.00
23_R27_L1.2191.00
365_A397_A1.2051.00
298_I335_L1.2051.00
337_G351_T1.1971.00
19_V158_A1.1821.00
27_L31_W1.1671.00
232_G401_S1.1661.00
286_Q290_T1.1621.00
93_G132_S1.1591.00
152_A174_L1.1591.00
136_Q144_W1.1531.00
196_V200_I1.1471.00
267_V312_S1.1461.00
300_G304_C1.1421.00
50_P53_R1.1371.00
219_R223_L1.1311.00
360_A377_I1.1301.00
122_A160_Y1.1271.00
56_T60_G1.1261.00
393_A397_A1.1261.00
54_L272_L1.1181.00
353_L386_L1.1141.00
249_F263_G1.1141.00
296_M300_G1.1121.00
299_A303_L1.1121.00
86_M89_L1.1051.00
368_H401_S1.1011.00
25_A28_L1.0971.00
8_A23_R1.0941.00
386_L390_L1.0861.00
220_D224_I1.0861.00
20_A26_M1.0861.00
14_L18_A1.0791.00
236_P401_S1.0781.00
310_L314_G1.0651.00
351_T355_G1.0621.00
157_A194_L1.0501.00
15_A154_A1.0461.00
97_Y133_C1.0441.00
332_I362_L1.0401.00
32_L36_N1.0371.00
33_F113_S1.0371.00
281_G327_F1.0261.00
287_S292_P1.0191.00
374_T394_C1.0131.00
13_I17_F1.0131.00
64_A68_L1.0131.00
267_V308_A1.0020.99
288_F334_M1.0010.99
18_A22_F0.9990.99
62_L261_A0.9910.99
183_L187_I0.9900.99
29_L33_F0.9890.99
234_C237_L0.9870.99
277_V280_N0.9850.99
161_R198_N0.9830.99
276_A301_I0.9720.99
306_L310_L0.9680.99
21_G24_H0.9670.99
235_G366_T0.9640.99
79_P103_K0.9630.99
89_L174_L0.9580.99
56_T59_L0.9550.99
108_L112_T0.9540.99
65_G69_M0.9540.99
167_S187_I0.9520.99
336_Y354_L0.9520.99
232_G397_A0.9450.99
52_R56_T0.9450.99
196_V199_L0.9430.99
22_F107_S0.9410.99
153_A186_V0.9400.99
117_I319_G0.9400.99
256_P259_Q0.9380.99
276_A279_G0.9370.99
26_M30_E0.9350.99
241_L306_L0.9320.99
82_P124_I0.9230.99
337_G354_L0.9230.99
228_G361_T0.9180.99
19_V23_R0.9160.99
238_L312_S0.9160.99
166_G170_I0.9130.99
81_A121_G0.9120.99
327_F331_A0.9080.99
63_A67_L0.9050.99
349_E354_L0.9040.99
159_A173_V0.8980.99
116_A267_V0.8970.99
99_A125_L0.8960.99
281_G285_V0.8930.99
301_I331_A0.8900.99
48_L52_R0.8840.99
352_L355_G0.8840.99
21_G25_A0.8790.99
21_G104_S0.8770.99
20_A23_R0.8730.99
72_Q76_Q0.8730.99
96_D133_C0.8730.99
274_T304_C0.8660.98
83_T86_M0.8640.98
236_P240_T0.8640.98
166_G373_S0.8620.98
45_A49_S0.8540.98
248_G251_S0.8520.98
258_W262_L0.8470.98
233_L400_I0.8450.98
276_A287_S0.8410.98
370_P373_S0.8400.98
60_G66_L0.8380.98
65_G261_A0.8260.98
237_L306_L0.8250.98
67_L70_G0.8250.98
322_F380_M0.8180.98
187_I371_I0.8170.98
18_A100_S0.8160.98
49_S52_R0.8150.98
354_L358_G0.8140.98
246_H250_V0.8140.98
226_S336_Y0.8130.98
30_E34_L0.8130.98
228_G392_I0.8090.98
236_P404_L0.8090.98
58_A61_G0.8070.98
341_G351_T0.8070.98
120_E159_A0.8060.98
194_L198_N0.8060.98
123_M323_T0.8040.98
224_I228_G0.8030.97
277_V304_C0.8030.97
80_H84_D0.7980.97
80_H83_T0.7970.97
103_K155_G0.7970.97
15_A20_A0.7950.97
81_A86_M0.7940.97
136_Q139_T0.7900.97
229_V396_I0.7870.97
62_L65_G0.7850.97
115_S317_A0.7830.97
295_L338_R0.7770.97
224_I353_L0.7770.97
217_Q220_D0.7750.97
267_V270_L0.7720.97
188_I192_V0.7710.97
263_G308_A0.7700.97
193_A197_S0.7680.97
117_I313_S0.7670.97
165_A372_M0.7670.97
82_P85_Y0.7670.97
190_A194_L0.7660.97
29_L108_L0.7650.97
15_A23_R0.7650.97
367_T380_M0.7640.97
57_P264_G0.7610.97
288_F355_G0.7610.97
237_L241_L0.7580.96
353_L357_T0.7560.96
205_A208_Y0.7550.96
94_Q136_Q0.7550.96
80_H103_K0.7540.96
231_A365_A0.7540.96
124_I169_F0.7530.96
269_L272_L0.7530.96
282_Y323_T0.7520.96
235_G362_L0.7450.96
87_E90_Q0.7430.96
153_A190_A0.7410.96
20_A30_E0.7400.96
357_T361_T0.7370.96
20_A196_V0.7360.96
249_F259_Q0.7340.96
22_F126_L0.7310.96
146_L185_P0.7290.96
334_M351_T0.7290.96
61_G257_P0.7290.96
127_A131_A0.7280.96
51_W55_L0.7280.96
8_A20_A0.7270.95
103_K121_G0.7270.95
235_G364_A0.7260.95
144_W148_I0.7260.95
367_T370_P0.7250.95
372_M376_M0.7240.95
79_P318_P0.7230.95
22_F27_L0.7220.95
8_A26_M0.7210.95
12_G23_R0.7180.95
88_A132_S0.7170.95
395_V399_V0.7160.95
173_V313_S0.7160.95
29_L36_N0.7160.95
300_G303_L0.7100.95
162_A202_H0.7030.95
377_I386_L0.7020.95
48_L51_W0.7020.95
281_G305_K0.7010.95
232_G365_A0.7010.95
162_A322_F0.6990.94
152_A326_L0.6980.94
396_I400_I0.6960.94
60_G109_L0.6940.94
26_M119_R0.6920.94
390_L394_C0.6880.94
258_W261_A0.6870.94
204_D209_N0.6870.94
284_T287_S0.6840.94
329_G358_G0.6800.94
335_L339_S0.6790.94
65_G257_P0.6780.93
187_I391_L0.6780.93
334_M337_G0.6760.93
14_L130_A0.6750.93
57_P65_G0.6750.93
198_N203_S0.6740.93
166_G169_F0.6710.93
355_G358_G0.6710.93
103_K122_A0.6710.93
26_M111_V0.6700.93
50_P54_L0.6670.93
123_M372_M0.6650.93
254_L262_L0.6640.93
265_L269_L0.6630.93
68_L77_Q0.6630.93
8_A15_A0.6630.93
165_A369_A0.6630.93
33_F36_N0.6620.93
20_A33_F0.6610.93
283_S287_S0.6580.92
67_L72_Q0.6580.92
116_A312_S0.6570.92
169_F410_Y0.6560.92
215_T218_A0.6550.92
61_G261_A0.6550.92
318_P321_V0.6540.92
245_C249_F0.6540.92
23_R159_A0.6540.92
375_L378_C0.6520.92
69_M256_P0.6500.92
59_L62_L0.6500.92
103_K106_A0.6490.92
165_A321_V0.6480.92
145_K148_I0.6470.92
55_L59_L0.6470.92
362_L366_T0.6470.92
11_V18_A0.6460.92
48_L54_L0.6440.92
90_Q93_G0.6430.92
231_A366_T0.6430.92
253_K262_L0.6410.91
135_A151_G0.6410.91
182_S186_V0.6410.91
326_L362_L0.6400.91
329_G333_G0.6390.91
228_G231_A0.6370.91
186_V190_A0.6360.91
8_A188_I0.6340.91
168_L185_P0.6340.91
111_V123_M0.6320.91
46_T49_S0.6300.91
12_G15_A0.6290.91
111_V122_A0.6280.91
24_H27_L0.6270.91
50_P57_P0.6260.90
367_T410_Y0.6230.90
327_F330_L0.6220.90
10_V14_L0.6210.90
54_L269_L0.6210.90
235_G239_L0.6200.90
165_A375_L0.6190.90
152_A156_M0.6190.90
338_R351_T0.6170.90
157_A384_Y0.6150.90
53_R56_T0.6150.90
65_G71_W0.6140.90
274_T300_G0.6130.90
97_Y136_Q0.6120.89
102_V106_A0.6120.89
369_A372_M0.6110.89
27_L30_E0.6100.89
242_M245_C0.6100.89
65_G70_G0.6090.89
187_I395_V0.6090.89
121_G379_E0.6070.89
61_G264_G0.6070.89
227_T358_G0.6060.89
150_C185_P0.6060.89
134_F138_F0.6050.89
11_V20_A0.6050.89
284_T331_A0.6020.89
53_R60_G0.6010.89
303_L307_C0.6000.89
96_D99_A0.6000.89
84_D89_L0.6000.89
61_G268_G0.5990.88
79_P83_T0.5990.88
143_E146_L0.5980.88
185_P314_G0.5970.88
58_A264_G0.5950.88
86_M411_R0.5940.88
297_I300_G0.5930.88
265_L270_L0.5930.88
8_A22_F0.5920.88
15_A19_V0.5900.88
367_T376_M0.5900.88
285_V289_L0.5900.88
111_V321_V0.5900.88
125_L318_P0.5870.87
45_A48_L0.5870.87
121_G318_P0.5870.87
141_R144_W0.5870.87
305_K316_G0.5860.87
173_V369_A0.5860.87
161_R202_H0.5860.87
270_L273_F0.5850.87
240_T243_N0.5830.87
130_A138_F0.5820.87
378_C384_Y0.5800.87
119_R125_L0.5800.87
168_L384_Y0.5790.87
309_V328_I0.5790.87
266_I270_L0.5790.87
77_Q99_A0.5770.87
107_S367_T0.5760.86
335_L338_R0.5760.86
149_A170_I0.5760.86
224_I227_T0.5730.86
117_I323_T0.5720.86
35_N55_L0.5710.86
54_L58_A0.5690.86
400_I403_T0.5690.86
7_I147_W0.5690.86
248_G311_A0.5680.86
58_A265_L0.5680.86
192_V267_V0.5670.86
195_L218_A0.5660.86
287_S293_P0.5660.86
321_V409_I0.5650.85
110_V318_P0.5650.85
56_T65_G0.5640.85
369_A373_S0.5630.85
103_K125_L0.5600.85
15_A22_F0.5590.85
31_W192_V0.5580.85
146_L182_S0.5570.85
294_L342_L0.5570.85
227_T354_L0.5560.85
166_G232_G0.5560.85
219_R222_A0.5540.84
159_A313_S0.5540.84
24_H200_I0.5540.84
47_N51_W0.5530.84
146_L153_A0.5530.84
274_T308_A0.5520.84
216_V389_G0.5510.84
384_Y387_L0.5510.84
22_F121_G0.5510.84
8_A189_S0.5490.84
194_L388_P0.5480.84
155_G228_G0.5470.84
22_F119_R0.5460.83
21_G58_A0.5460.83
155_G369_A0.5460.83
95_F129_L0.5450.83
51_W54_L0.5450.83
218_A221_Y0.5450.83
238_L328_I0.5450.83
396_I405_H0.5450.83
246_H318_P0.5440.83
80_H86_M0.5440.83
131_A135_A0.5420.83
174_L177_T0.5410.83
133_C136_Q0.5410.83
30_E33_F0.5410.83
239_L243_N0.5410.83
47_N52_R0.5400.83
9_T196_V0.5390.83
171_A183_L0.5390.83
12_G192_V0.5390.83
12_G65_G0.5380.83
81_A122_A0.5360.82
23_R119_R0.5360.82
201_N205_A0.5360.82
339_S342_L0.5360.82
341_G349_E0.5350.82
167_S171_A0.5350.82
92_D96_D0.5340.82
287_S291_A0.5320.82
159_A326_L0.5320.82
337_G349_E0.5300.82
47_N50_P0.5290.82
155_G232_G0.5290.82
157_A193_A0.5290.82
276_A280_N0.5290.82
121_G160_Y0.5290.82
71_W76_Q0.5290.82
401_S406_R0.5290.82
23_R30_E0.5280.81
116_A308_A0.5280.81
158_A193_A0.5270.81
260_L264_G0.5270.81
295_L339_S0.5260.81
84_D88_A0.5250.81
71_W75_T0.5250.81
235_G310_L0.5250.81
282_Y286_Q0.5240.81
132_S148_I0.5230.81
152_A235_G0.5230.81
16_A26_M0.5230.81
191_V371_I0.5230.81
243_N247_R0.5220.81
57_P64_A0.5200.80
11_V131_A0.5180.80
32_L63_A0.5180.80
16_A196_V0.5180.80
232_G366_T0.5170.80
230_L336_Y0.5140.80
171_A174_L0.5140.80
107_S119_R0.5140.80
123_M159_A0.5130.80
319_G323_T0.5120.79
106_A126_L0.5120.79
263_G311_A0.5110.79
80_H87_E0.5090.79
64_A109_L0.5060.79
45_A56_T0.5060.79
307_C339_S0.5060.79
89_L175_F0.5050.78
69_M228_G0.5050.78
58_A268_G0.5050.78
156_M322_F0.5040.78
326_L363_L0.5030.78
67_L102_V0.5030.78
127_A278_W0.5030.78
89_L148_I0.5020.78
62_L255_A0.5010.78
55_L60_G0.5010.78
72_Q96_D0.5000.78
111_V373_S0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nd0A 2 0.988 100 0.107 Contact Map
4eneA 2 0.988 100 0.117 Contact Map
3orgA 2 0.9211 100 0.184 Contact Map
1jcnA 6 0.201 98.7 0.877 Contact Map
3usbA 4 0.177 75.4 0.951 Contact Map
3k3fA 3 0.6531 18.9 0.967 Contact Map
3llqA 3 0.1699 18.4 0.967 Contact Map
2ksfA 1 0.2464 15.8 0.968 Contact Map
1ldfA 3 0.1818 12.6 0.969 Contact Map
2f2bA 4 0.1746 7.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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