GREMLIN Database
YNFH - Anaerobic dimethyl sulfoxide reductase chain YnfH
UniProt: P76173 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13846
Length: 284 (264)
Sequences: 896 (739)
Seq/√Len: 45.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_V124_L8.6241.00
20_V93_F4.8301.00
21_V125_G4.4241.00
82_G85_N3.9681.00
234_G238_W3.9001.00
98_G102_L3.7811.00
231_L235_L3.6661.00
67_S70_R3.4081.00
86_E136_Y3.0651.00
61_S86_E2.8841.00
24_L121_S2.8571.00
89_A131_M2.6761.00
78_I84_S2.6391.00
55_G94_F2.5991.00
20_V50_L2.5601.00
14_T136_Y2.5571.00
14_T86_E2.4411.00
19_C53_L2.3751.00
26_V162_P2.3551.00
64_H86_E2.3351.00
54_M94_F2.1561.00
235_L238_W2.1311.00
89_A127_I2.1081.00
86_E131_M2.0710.99
223_L234_G2.0630.99
129_V157_V2.0610.99
28_G118_L1.9560.99
53_L164_L1.9390.99
61_S136_Y1.8640.99
149_T271_F1.7910.98
224_Q227_R1.7620.98
18_Q132_M1.7440.98
13_F136_Y1.7410.98
230_L235_L1.7160.98
197_V258_I1.6940.98
79_G85_N1.6690.98
14_T61_S1.6640.98
23_A165_A1.6540.97
13_F86_E1.6510.97
232_C236_G1.6390.97
51_W97_G1.6390.97
28_G122_M1.6370.97
54_M128_F1.6320.97
70_R73_N1.6270.97
61_S131_M1.6080.97
258_I262_G1.6010.97
64_H136_Y1.5620.96
19_C164_L1.5560.96
19_C160_S1.5530.96
186_V190_I1.5410.96
7_E13_F1.5210.96
71_A84_S1.5130.96
22_G153_F1.5070.96
64_H85_N1.5050.96
18_Q21_V1.4840.95
61_S83_L1.4700.95
163_I257_L1.4510.95
7_E14_T1.4300.94
122_M127_I1.4210.94
82_G134_C1.3960.93
216_L219_D1.3940.93
267_G272_Y1.3830.93
137_Q150_T1.3810.93
117_W166_A1.3530.92
23_A50_L1.3510.92
160_S164_L1.3480.92
152_A156_T1.3470.92
85_N272_Y1.3190.91
223_L238_W1.3150.91
58_F90_G1.3120.91
262_G265_M1.2980.90
21_V157_V1.2980.90
238_W241_P1.2820.90
27_S164_L1.2570.89
227_R267_G1.2520.89
58_F94_F1.2470.89
61_S64_H1.2400.88
61_S74_S1.2360.88
86_E149_T1.2260.88
77_R80_A1.2230.88
11_V270_L1.2110.87
10_L18_Q1.2110.87
120_F191_A1.2040.87
120_F194_G1.2030.87
82_G135_V1.1980.87
102_L106_I1.1880.86
21_V87_I1.1860.86
90_G128_F1.1840.86
229_V246_R1.1750.85
13_F131_M1.1710.85
179_T183_I1.1700.85
13_F17_G1.1630.85
185_S192_C1.1570.85
84_S268_R1.1570.85
74_S82_G1.1500.84
18_Q267_G1.1410.84
12_I33_A1.1180.82
227_R238_W1.1100.82
90_G132_M1.1000.81
73_N85_N1.0780.80
79_G272_Y1.0750.80
99_L265_M1.0740.80
7_E10_L1.0730.80
222_S226_W1.0660.79
14_T131_M1.0660.79
128_F132_M1.0640.79
8_W19_C1.0630.79
31_W104_A1.0590.79
83_L86_E1.0570.79
18_Q264_E1.0550.79
147_G151_L1.0450.78
41_Q45_R1.0450.78
190_I194_G1.0430.78
231_L234_G1.0350.77
238_W242_L1.0310.77
142_P267_G1.0280.77
14_T271_F1.0220.76
14_T64_H1.0220.76
62_V75_L1.0200.76
119_L123_A1.0150.76
64_H71_A1.0140.76
16_L53_L1.0110.76
187_L190_I0.9980.75
56_V123_A0.9950.74
203_L206_I0.9930.74
15_V264_E0.9920.74
56_V254_I0.9920.74
238_W256_G0.9800.73
96_V121_S0.9790.73
10_L61_S0.9760.73
222_S225_V0.9650.72
100_W118_L0.9640.72
80_A148_Y0.9570.71
83_L143_T0.9560.71
86_E267_G0.9540.71
7_E18_Q0.9530.71
264_E267_G0.9520.71
122_M126_V0.9470.71
83_L131_M0.9420.70
234_G260_I0.9360.70
225_V236_G0.9350.70
220_Y226_W0.9330.70
58_F82_G0.9300.69
225_V229_V0.9280.69
57_G127_I0.9200.68
18_Q153_F0.9150.68
12_I60_A0.8960.66
86_E129_V0.8920.66
133_T150_T0.8880.66
183_I189_L0.8880.66
220_Y224_Q0.8860.65
11_V269_V0.8860.65
97_G100_W0.8860.65
156_T160_S0.8830.65
229_V263_G0.8810.65
37_D255_L0.8770.65
17_G135_V0.8750.65
112_A167_A0.8680.64
92_I121_S0.8630.63
196_I200_G0.8580.63
13_F90_G0.8560.63
227_R264_E0.8550.63
101_W206_I0.8520.62
8_W121_S0.8410.61
199_Q275_H0.8370.61
230_L238_W0.8350.61
137_Q145_H0.8340.61
251_A254_I0.8340.61
84_S203_L0.8280.60
24_L27_S0.8260.60
131_M136_Y0.8250.60
220_Y227_R0.8220.60
123_A251_A0.8190.59
152_A267_G0.8180.59
95_A266_I0.8170.59
85_N132_M0.8140.59
26_V57_G0.8100.58
24_L29_I0.8090.58
15_V156_T0.8050.58
171_A258_I0.7930.57
64_H135_V0.7930.57
14_T143_T0.7910.57
245_R258_I0.7880.56
18_Q50_L0.7870.56
47_M100_W0.7870.56
75_L91_S0.7860.56
128_F140_T0.7850.56
83_L153_F0.7830.56
13_F61_S0.7830.56
224_Q232_C0.7800.56
18_Q84_S0.7780.55
99_L201_L0.7770.55
193_A196_I0.7760.55
234_G256_G0.7740.55
66_G71_A0.7740.55
221_A225_V0.7740.55
56_V116_L0.7730.55
74_S77_R0.7700.55
194_G233_A0.7690.55
68_P71_A0.7670.54
156_T264_E0.7670.54
232_C244_R0.7640.54
214_S219_D0.7620.54
16_L261_L0.7620.54
114_G239_L0.7570.53
186_V194_G0.7550.53
169_L181_F0.7540.53
101_W165_A0.7510.53
16_L65_L0.7410.52
183_I187_L0.7400.52
199_Q203_L0.7370.51
62_V98_G0.7360.51
227_R236_G0.7350.51
14_T138_I0.7350.51
16_L130_W0.7330.51
127_I181_F0.7310.51
24_L28_G0.7300.51
45_R244_R0.7300.51
9_P18_Q0.7290.51
125_G156_T0.7280.51
62_V68_P0.7280.51
125_G157_V0.7260.50
74_S132_M0.7240.50
20_V57_G0.7240.50
91_S125_G0.7240.50
66_G70_R0.7230.50
200_G206_I0.7200.50
200_G204_A0.7180.50
16_L228_V0.7170.49
58_F71_A0.7160.49
209_S214_S0.7100.49
269_V272_Y0.7050.48
220_Y238_W0.7040.48
82_G125_G0.7020.48
7_E132_M0.7000.48
34_A254_I0.7000.48
10_L91_S0.6990.48
77_R82_G0.6960.47
230_L266_I0.6960.47
242_L245_R0.6890.47
10_L13_F0.6880.47
50_L93_F0.6870.47
224_Q228_V0.6860.46
7_E272_Y0.6850.46
8_W164_L0.6820.46
224_Q236_G0.6820.46
197_V233_A0.6800.46
190_I208_S0.6790.46
45_R189_L0.6790.46
21_V153_F0.6750.45
158_L261_L0.6720.45
232_C258_I0.6710.45
50_L120_F0.6680.45
31_W44_V0.6660.45
65_L144_W0.6640.44
187_L204_A0.6630.44
54_M60_A0.6610.44
137_Q272_Y0.6600.44
157_V203_L0.6600.44
151_L259_L0.6590.44
86_E143_T0.6580.44
217_V224_Q0.6580.44
270_L275_H0.6570.44
24_L100_W0.6520.43
18_Q125_G0.6520.43
136_Y161_G0.6510.43
210_V216_L0.6490.43
16_L57_G0.6480.43
170_R191_A0.6480.43
59_I63_M0.6470.43
183_I186_V0.6470.43
95_A151_L0.6460.43
65_L253_L0.6440.42
10_L136_Y0.6380.42
61_S65_L0.6380.42
189_L260_I0.6370.42
53_L77_R0.6360.42
121_S150_T0.6290.41
220_Y223_L0.6290.41
25_I218_P0.6280.41
255_L259_L0.6280.41
97_G257_L0.6260.41
13_F267_G0.6250.41
20_V76_N0.6210.40
178_T256_G0.6200.40
73_N76_N0.6190.40
56_V59_I0.6170.40
231_L238_W0.6130.39
18_Q272_Y0.6130.39
18_Q156_T0.6120.39
222_S262_G0.6110.39
92_I96_V0.6100.39
80_A195_V0.6090.39
81_S144_W0.6070.39
26_V181_F0.6040.39
86_E161_G0.6030.39
17_G67_S0.6030.39
50_L261_L0.6020.38
6_H274_L0.6010.38
77_R140_T0.6000.38
80_A275_H0.5990.38
155_L192_C0.5980.38
11_V209_S0.5980.38
54_M273_G0.5980.38
128_F270_L0.5970.38
104_A121_S0.5950.38
135_V264_E0.5940.38
7_E274_L0.5940.38
85_N134_C0.5900.37
92_I124_L0.5880.37
240_C256_G0.5870.37
86_E128_F0.5870.37
45_R167_A0.5870.37
58_F269_V0.5860.37
87_I132_M0.5850.37
9_P63_M0.5850.37
171_A232_C0.5840.37
63_M130_W0.5820.37
18_Q135_V0.5790.36
158_L183_I0.5780.36
74_S86_E0.5770.36
153_F227_R0.5770.36
62_V90_G0.5760.36
87_I93_F0.5740.36
187_L194_G0.5730.36
141_V275_H0.5730.36
255_L261_L0.5720.36
197_V201_L0.5710.36
54_M152_A0.5710.36
10_L86_E0.5710.36
228_V233_A0.5710.36
167_A171_A0.5700.36
56_V223_L0.5700.36
99_L102_L0.5690.35
226_W251_A0.5670.35
227_R232_C0.5660.35
125_G132_M0.5660.35
188_A252_G0.5660.35
116_L127_I0.5660.35
191_A194_G0.5660.35
13_F153_F0.5630.35
259_L265_M0.5620.35
160_S264_E0.5610.35
36_N124_L0.5610.35
234_G264_E0.5600.35
27_S50_L0.5570.34
162_P166_A0.5570.34
134_C267_G0.5560.34
171_A191_A0.5550.34
31_W121_S0.5540.34
198_L201_L0.5510.34
46_G250_V0.5490.34
219_D225_V0.5480.34
80_A139_D0.5460.33
153_F196_I0.5440.33
195_V199_Q0.5430.33
160_S216_L0.5410.33
186_V258_I0.5400.33
71_A86_E0.5400.33
117_W212_Q0.5400.33
83_L133_T0.5400.33
83_L101_W0.5380.33
8_W94_F0.5360.33
24_L44_V0.5330.32
21_V82_G0.5310.32
66_G271_F0.5290.32
181_F207_H0.5270.32
70_R128_F0.5270.32
91_S98_G0.5250.32
18_Q87_I0.5240.32
246_R251_A0.5230.31
209_S215_A0.5210.31
187_L262_G0.5210.31
120_F254_I0.5210.31
210_V214_S0.5210.31
124_L176_F0.5190.31
18_Q85_N0.5190.31
90_G275_H0.5190.31
226_W239_L0.5180.31
230_L234_G0.5180.31
73_N275_H0.5170.31
136_Y149_T0.5170.31
166_A178_T0.5150.31
52_L56_V0.5140.31
20_V132_M0.5140.31
49_F59_I0.5130.31
15_V160_S0.5100.30
155_L188_A0.5080.30
142_P153_F0.5060.30
74_S85_N0.5050.30
29_I120_F0.5050.30
74_S89_A0.5040.30
50_L185_S0.5020.30
29_I33_A0.5010.30
17_G90_G0.5010.30
85_N136_Y0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vpzC 2 0.838 100 0.543 Contact Map
4gc0A 1 0.6127 7.4 0.96 Contact Map
1pw4A 1 0.9085 4.3 0.964 Contact Map
3wdoA 1 0.8838 3.9 0.965 Contact Map
1dc1A 2 0.2113 3.7 0.965 Contact Map
3wt9A 1 0.257 3.3 0.966 Contact Map
3ne5A 3 0.3732 2.9 0.967 Contact Map
3am6A 3 0.243 2.6 0.968 Contact Map
3dh4A 3 0.6268 2 0.97 Contact Map
3iynN 3 0 2 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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