GREMLIN Database
INTQ - Putative lambdoid prophage Qin defective integrase (Fragment)
UniProt: P76168 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13188
Length: 385 (300)
Sequences: 18569 (15390)
Seq/√Len: 888.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
322_A339_M4.7851.00
198_W246_M3.2561.00
84_N87_K3.2201.00
77_K87_K2.8751.00
313_K316_Q2.7701.00
206_G239_I2.7431.00
187_G321_Y2.7321.00
230_R340_G2.7311.00
321_Y338_Q2.6641.00
183_S314_S2.5271.00
209_M231_V2.4751.00
190_P315_Y2.3391.00
95_L121_Y2.3211.00
41_K71_L2.2291.00
178_N245_Q2.2231.00
44_A67_I2.2171.00
207_T231_V2.1841.00
73_I94_E2.1711.00
183_S193_L2.1561.00
319_H353_K2.1401.00
202_D205_N2.1091.00
92_R122_M2.0881.00
197_G273_T2.0561.00
64_R68_K2.0191.00
239_I243_R1.9581.00
131_F135_N1.9521.00
331_N334_F1.9421.00
44_A128_V1.9231.00
321_Y325_S1.9091.00
185_Y235_I1.8501.00
332_P348_F1.8301.00
188_V193_L1.8141.00
66_V124_N1.7761.00
88_L143_F1.7551.00
43_L132_G1.7491.00
160_S163_E1.7431.00
41_K45_E1.7401.00
198_W275_V1.7301.00
116_V120_N1.7291.00
48_L64_R1.7211.00
326_L335_I1.7151.00
345_Q349_Q1.7051.00
326_L352_G1.7041.00
29_E32_G1.6861.00
164_F184_V1.6761.00
228_T342_A1.6531.00
59_S63_Y1.6431.00
45_E71_L1.6371.00
56_A221_V1.6351.00
233_H338_Q1.6301.00
136_G140_D1.6051.00
197_G274_F1.5711.00
179_L296_I1.5661.00
200_D211_R1.5491.00
24_S27_N1.5461.00
130_Q144_K1.5331.00
190_P194_C1.5281.00
43_L131_F1.5241.00
83_I129_F1.5221.00
178_N244_S1.5131.00
343_D349_Q1.5091.00
203_L243_R1.4921.00
206_G236_K1.4821.00
163_E166_R1.4671.00
234_L239_I1.4611.00
341_H347_V1.4521.00
39_T42_E1.4501.00
177_K181_C1.4121.00
346_M350_V1.4081.00
333_A336_A1.4061.00
48_L60_L1.3821.00
179_L193_L1.3761.00
41_K76_E1.3741.00
333_A337_N1.3731.00
330_A365_L1.3731.00
178_N241_A1.3601.00
184_V317_S1.3571.00
202_D207_T1.3481.00
325_S330_A1.3431.00
128_V132_G1.3361.00
69_N121_Y1.3351.00
159_L312_R1.3221.00
325_S335_I1.3131.00
327_T358_N1.3131.00
196_L208_M1.3081.00
159_L320_T1.3031.00
197_G200_D1.3031.00
78_N82_S1.2971.00
122_M126_N1.2921.00
185_Y238_A1.2921.00
199_E273_T1.2911.00
188_V210_I1.2851.00
181_C241_A1.2851.00
89_L135_N1.2841.00
322_A335_I1.2831.00
21_Q25_S1.2801.00
164_F324_W1.2781.00
192_E230_R1.2761.00
336_A344_A1.2721.00
297_R301_D1.2671.00
62_T65_A1.2661.00
52_E60_L1.2541.00
133_V138_L1.2471.00
166_R170_A1.2331.00
46_K50_L1.2221.00
43_L79_L1.2121.00
159_L167_L1.2071.00
161_R324_W1.2011.00
126_N130_Q1.2001.00
56_A220_T1.1981.00
334_F362_Q1.1941.00
91_V121_Y1.1791.00
176_A299_M1.1781.00
196_L201_I1.1761.00
21_Q24_S1.1721.00
91_V95_L1.1671.00
134_D147_S1.1621.00
68_K71_L1.1561.00
69_N72_S1.1541.00
339_M347_V1.1541.00
236_K240_D1.1531.00
237_P367_N1.1531.00
337_N359_N1.1521.00
96_L118_V1.1481.00
224_T228_T1.1411.00
234_L238_A1.1371.00
172_R177_K1.1301.00
74_I91_V1.1231.00
26_R29_E1.1111.00
66_V120_N1.1071.00
361_A365_L1.1041.00
245_Q249_T1.1021.00
236_K364_A1.1021.00
85_K134_D1.1011.00
182_V238_A1.1001.00
63_Y124_N1.0991.00
37_D81_S1.0861.00
301_D311_H1.0861.00
67_I71_L1.0801.00
40_I128_V1.0781.00
235_I238_A1.0751.00
299_M302_A1.0721.00
130_Q141_N1.0701.00
57_K61_N1.0661.00
330_A362_Q1.0661.00
61_N65_A1.0661.00
168_I181_C1.0651.00
179_L276_F1.0641.00
274_F290_H1.0631.00
343_D346_M1.0621.00
55_V63_Y1.0601.00
134_D145_G1.0581.00
55_V60_L1.0501.00
165_I169_D1.0491.00
300_W304_I1.0461.00
56_A59_S1.0441.00
23_P27_N1.0431.00
323_C353_K1.0341.00
197_G290_H1.0341.00
89_L93_K1.0341.00
129_F142_P1.0301.00
320_T324_W1.0281.00
120_N123_T1.0151.00
60_L64_R1.0151.00
129_F138_L1.0111.00
129_F143_F1.0031.00
364_A368_T1.0021.00
336_A347_V1.0001.00
24_S28_L0.9981.00
25_S29_E0.9941.00
324_W327_T0.9911.00
182_V208_M0.9881.00
358_N361_A0.9871.00
58_T61_N0.9711.00
92_R96_L0.9701.00
21_Q26_R0.9701.00
190_P293_V0.9681.00
171_C303_A0.9661.00
96_L115_A0.9621.00
170_A306_R0.9591.00
323_C352_G0.9531.00
190_P314_S0.9491.00
41_K75_G0.9491.00
170_A307_A0.9481.00
78_N81_S0.9471.00
47_F127_A0.9411.00
45_E64_R0.9411.00
203_L239_I0.9331.00
194_C293_V0.9301.00
330_A334_F0.9291.00
327_T355_M0.9251.00
119_N149_L0.9181.00
73_I91_V0.9161.00
191_G195_A0.9151.00
86_E135_N0.9121.00
85_K136_G0.9121.00
95_L118_V0.9121.00
167_L180_W0.9061.00
181_C237_P0.9051.00
185_Y237_P0.9041.00
114_S117_T0.9041.00
199_E272_C0.9001.00
182_V276_F0.9001.00
222_P229_N0.8941.00
62_T66_V0.8931.00
344_A348_F0.8901.00
233_H360_N0.8891.00
133_V145_G0.8841.00
338_Q359_N0.8771.00
360_N364_A0.8771.00
43_L128_V0.8751.00
237_P240_D0.8741.00
246_M249_T0.8681.00
117_T121_Y0.8681.00
322_A352_G0.8661.00
88_L125_L0.8651.00
158_P320_T0.8631.00
301_D305_K0.8601.00
90_E94_E0.8511.00
321_Y339_M0.8511.00
77_K82_S0.8511.00
200_D212_R0.8431.00
182_V193_L0.8381.00
246_M250_R0.8371.00
26_R30_K0.8361.00
40_I125_L0.8331.00
95_L113_R0.8331.00
86_E90_E0.8321.00
209_M229_N0.8301.00
122_M143_F0.8301.00
43_L135_N0.8241.00
198_W249_T0.8191.00
163_E310_R0.8171.00
44_A71_L0.8141.00
328_A365_L0.8141.00
322_A326_L0.8121.00
44_A48_L0.8111.00
116_V119_N0.8101.00
278_P289_D0.8081.00
243_R246_M0.8071.00
21_Q29_E0.8061.00
208_M212_R0.8051.00
37_D78_N0.8041.00
113_R117_T0.8031.00
161_R165_I0.8011.00
133_V140_D0.7991.00
235_I367_N0.7981.00
161_R327_T0.7981.00
211_R229_N0.7971.00
238_A241_A0.7961.00
46_K137_Y0.7961.00
171_C177_K0.7911.00
70_I125_L0.7901.00
184_V324_W0.7861.00
292_T295_S0.7851.00
58_T62_T0.7831.00
331_N358_N0.7821.00
336_A349_Q0.7811.00
45_E49_A0.7791.00
196_L275_V0.7771.00
38_L137_Y0.7661.00
200_D221_V0.7661.00
295_S298_Q0.7611.00
300_W317_S0.7571.00
136_G145_G0.7571.00
319_H350_V0.7541.00
133_V141_N0.7521.00
298_Q302_A0.7461.00
62_T120_N0.7421.00
190_P297_R0.7401.00
159_L163_E0.7391.00
38_L42_E0.7391.00
297_R314_S0.7361.00
132_G138_L0.7351.00
66_V121_Y0.7341.00
47_F131_F0.7281.00
172_R181_C0.7241.00
186_T232_I0.7231.00
73_I90_E0.7221.00
188_V208_M0.7211.00
167_L300_W0.7211.00
38_L46_K0.7211.00
326_L355_M0.7201.00
119_N123_T0.7171.00
83_I88_L0.7131.00
70_I75_G0.7131.00
40_I83_I0.7111.00
87_K90_E0.7071.00
322_A347_V0.7071.00
166_R169_D0.7051.00
208_M234_L0.7051.00
184_V320_T0.7051.00
122_M146_I0.7041.00
180_W317_S0.7031.00
126_N143_F0.7001.00
51_K55_V0.6981.00
201_I242_L0.6961.00
177_K241_A0.6921.00
40_I44_A0.6921.00
141_N144_K0.6921.00
294_D297_R0.6911.00
50_L93_K0.6911.00
312_R316_Q0.6891.00
161_R328_A0.6881.00
92_R118_V0.6881.00
296_I314_S0.6851.00
156_P313_K0.6851.00
197_G212_R0.6851.00
326_L332_P0.6841.00
295_S299_M0.6811.00
93_K96_L0.6801.00
240_D243_R0.6801.00
178_N276_F0.6791.00
22_F26_R0.6781.00
233_H359_N0.6751.00
26_R32_G0.6751.00
22_F31_F0.6741.00
236_K367_N0.6741.00
49_A52_E0.6741.00
51_K54_E0.6711.00
171_C180_W0.6701.00
57_K60_L0.6701.00
175_Q245_Q0.6681.00
42_E45_E0.6661.00
133_V144_K0.6661.00
334_F358_N0.6651.00
187_G339_M0.6651.00
126_N144_K0.6631.00
21_Q28_L0.6601.00
113_R118_V0.6581.00
244_S247_T0.6581.00
85_K89_L0.6581.00
357_E361_A0.6521.00
79_L129_F0.6491.00
304_I312_R0.6461.00
67_I128_V0.6451.00
362_Q365_L0.6441.00
361_A364_A0.6431.00
357_E360_N0.6421.00
51_K127_A0.6401.00
299_M303_A0.6391.00
280_V289_D0.6371.00
170_A303_A0.6371.00
129_F133_V0.6341.00
355_M358_N0.6321.00
132_G137_Y0.6301.00
84_N139_A0.6301.00
133_V139_A0.6291.00
198_W242_L0.6281.00
274_F277_Q0.6281.00
46_K131_F0.6281.00
323_C354_W0.6271.00
27_N31_F0.6251.00
65_A68_K0.6241.00
207_T360_N0.6231.00
91_V125_L0.6211.00
222_P228_T0.6191.00
38_L81_S0.6181.00
333_A349_Q0.6131.00
152_S225_Q0.6131.00
203_L234_L0.6131.00
245_Q248_L0.6121.00
326_L333_A0.6091.00
43_L137_Y0.6071.00
28_L31_F0.6071.00
129_F141_N0.6061.00
21_Q31_F0.6061.00
332_P344_A0.6041.00
157_D316_Q0.6031.00
69_N113_R0.6021.00
300_W314_S0.6021.00
188_V196_L0.6001.00
28_L32_G0.6001.00
55_V59_S0.5991.00
331_N362_Q0.5971.00
278_P281_S0.5971.00
182_V242_L0.5931.00
22_F25_S0.5911.00
175_Q178_N0.5821.00
204_K243_R0.5811.00
201_I208_M0.5801.00
22_F28_L0.5781.00
42_E46_K0.5781.00
127_A131_F0.5761.00
203_L206_G0.5761.00
125_L143_F0.5741.00
130_Q133_V0.5741.00
210_I222_P0.5731.00
293_V297_R0.5711.00
63_Y66_V0.5691.00
348_F352_G0.5681.00
333_A348_F0.5671.00
93_K97_T0.5661.00
327_T357_E0.5631.00
164_F320_T0.5631.00
327_T354_W0.5631.00
338_Q363_V0.5621.00
69_N95_L0.5591.00
86_E136_G0.5581.00
23_P26_R0.5581.00
25_S28_L0.5571.00
67_I124_N0.5571.00
241_A244_S0.5561.00
26_R31_F0.5521.00
243_R247_T0.5491.00
301_D304_I0.5481.00
224_T340_G0.5461.00
302_A306_R0.5451.00
304_I307_A0.5421.00
180_W300_W0.5411.00
115_A119_N0.5411.00
303_A307_A0.5411.00
188_V192_E0.5401.00
202_D209_M0.5401.00
336_A346_M0.5381.00
130_Q145_G0.5381.00
158_P353_K0.5361.00
197_G272_C0.5361.00
181_C238_A0.5361.00
202_D206_G0.5341.00
46_K90_E0.5331.00
75_G78_N0.5321.00
162_E166_R0.5301.00
140_D145_G0.5301.00
77_K83_I0.5301.00
188_V232_I0.5271.00
183_S190_P0.5261.00
41_K67_I0.5261.00
240_D244_S0.5241.00
332_P336_A0.5241.00
128_V131_F0.5241.00
193_L314_S0.5221.00
164_F168_I0.5211.00
84_N136_G0.5191.00
326_L354_W0.5191.00
186_T238_A0.5181.00
138_L142_P0.5181.00
91_V94_E0.5171.00
21_Q27_N0.5161.00
364_A367_N0.5161.00
69_N112_G0.5161.00
38_L43_L0.5121.00
330_A335_I0.5101.00
157_D310_R0.5101.00
178_N238_A0.5041.00
74_I83_I0.5031.00
23_P29_E0.5031.00
67_I70_I0.5021.00
298_Q301_D0.5011.00
359_N363_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1bA 3 0.8 100 0.315 Contact Map
1a0pA 1 0.6753 100 0.315 Contact Map
2a3vA 3 0.787 100 0.329 Contact Map
1z19A 3 0.7169 100 0.333 Contact Map
4a8eA 2 0.6883 100 0.364 Contact Map
1xo0A 3 0.7532 100 0.379 Contact Map
3nkhA 2 0.5247 100 0.467 Contact Map
1ae9A 4 0.4312 100 0.559 Contact Map
1aihA 2 0.426 99.9 0.593 Contact Map
4e0gA 2 0.6831 99.9 0.617 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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