GREMLIN Database
LYSQ - Probable lysozyme from lambdoid prophage Qin
UniProt: P76159 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13829
Length: 177 (142)
Sequences: 1557 (1105)
Seq/√Len: 92.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_D134_G3.6151.00
55_A81_E3.5181.00
99_E103_A2.8771.00
138_A141_W2.6851.00
49_W65_P2.4721.00
24_P103_A2.4331.00
98_T101_Q2.3071.00
92_N119_F2.2601.00
143_I161_V2.2531.00
108_F113_I2.1831.00
126_R138_A2.1241.00
88_W115_P2.1101.00
136_C171_T2.0201.00
24_P99_E1.9811.00
31_L107_S1.8981.00
48_I56_T1.8861.00
32_D75_D1.8571.00
37_N53_R1.8321.00
143_I149_D1.8311.00
43_R49_W1.8221.00
168_S172_C1.7281.00
34_K166_Q1.7161.00
46_S145_D1.6861.00
126_R134_G1.6831.00
34_K162_I1.6231.00
94_K128_N1.6091.00
52_C74_C1.5811.00
43_R47_G1.5801.00
107_S167_E1.5621.00
123_F138_A1.5451.00
55_A111_Y1.5371.00
101_Q132_R1.5191.00
137_E168_S1.4811.00
41_A66_N1.4761.00
64_F67_M1.4150.99
85_A109_C1.4130.99
147_G150_C1.3710.99
140_R165_D1.3650.99
144_K149_D1.3540.99
89_V106_A1.3430.99
140_R168_S1.3380.99
37_N71_K1.3170.99
25_Q29_Q1.3080.99
55_A77_V1.3050.99
51_I69_L1.2990.99
151_R162_I1.2940.99
93_I97_L1.2810.99
126_R131_D1.2650.99
85_A89_V1.2420.98
43_R48_I1.2390.98
90_E102_K1.2270.98
23_A86_L1.2130.98
97_L127_L1.2070.98
30_F34_K1.2030.98
71_K75_D1.1990.98
70_S73_K1.1940.98
69_L77_V1.1810.98
121_S142_W1.1720.98
41_A68_K1.1680.98
69_L74_C1.1430.97
113_I118_C1.1380.97
45_G150_C1.1290.97
52_C69_L1.1170.97
127_L135_A1.1120.97
108_F139_I1.1110.97
41_A67_M1.1080.97
146_G149_D1.0950.97
40_M68_K1.0780.96
89_V109_C1.0770.96
32_D53_R1.0750.96
39_T71_K1.0730.96
127_L171_T1.0730.96
23_A27_L1.0490.96
108_F118_C1.0270.95
93_I124_Y1.0190.95
164_R167_E1.0180.95
63_V67_M1.0080.95
92_N124_Y1.0020.94
39_T74_C1.0010.94
72_E76_Q0.9850.94
37_N74_C0.9840.94
124_Y128_N0.9670.93
73_K77_V0.9620.93
44_D48_I0.9520.93
28_D79_A0.9500.93
137_E172_C0.9420.92
99_E102_K0.9300.92
53_R74_C0.9220.92
81_E85_A0.9220.92
95_V127_L0.9180.91
56_T63_V0.9180.91
27_L103_A0.8710.89
41_A51_I0.8690.89
126_R129_A0.8690.89
122_T141_W0.8410.87
86_L102_K0.8390.87
37_N75_D0.8360.87
109_C118_C0.8360.87
162_I166_Q0.8320.87
86_L106_A0.8210.86
125_K129_A0.8150.86
133_K137_E0.8120.85
146_G151_R0.8010.85
41_A63_V0.7940.84
138_A142_W0.7940.84
151_R161_V0.7920.84
149_D161_V0.7840.83
53_R71_K0.7800.83
121_S124_Y0.7760.83
169_A173_W0.7640.82
139_I171_T0.7620.82
105_I127_L0.7620.82
41_A64_F0.7610.82
33_E166_Q0.7580.81
62_T67_M0.7460.80
24_P27_L0.7460.80
97_L105_I0.7430.80
123_F141_W0.7390.80
144_K161_V0.7370.79
108_F142_W0.7360.79
122_T125_K0.7240.78
28_D82_R0.7210.78
123_F139_I0.7210.78
122_T142_W0.7200.78
93_I127_L0.7160.77
41_A49_W0.7140.77
136_C172_C0.7140.77
73_K76_Q0.7130.77
122_T126_R0.7130.77
122_T138_A0.7090.77
92_N118_C0.7090.77
53_R75_D0.7060.76
31_L82_R0.7030.76
23_A31_L0.7020.76
118_C124_Y0.7000.76
108_F124_Y0.6960.75
53_R78_N0.6890.75
55_A62_T0.6820.74
43_R65_P0.6780.74
42_Y50_T0.6770.73
102_K106_A0.6770.73
38_H42_Y0.6760.73
140_R143_I0.6740.73
146_G150_C0.6730.73
56_T60_G0.6710.73
93_I128_N0.6680.72
147_G151_R0.6650.72
22_S86_L0.6640.72
100_P170_L0.6560.71
24_P102_K0.6510.71
112_N164_R0.6490.70
50_T159_G0.6490.70
126_R141_W0.6470.70
60_G63_V0.6460.70
101_Q105_I0.6420.69
32_D71_K0.6420.69
135_A168_S0.6360.69
28_D78_N0.6340.69
121_S138_A0.6330.68
95_V128_N0.6300.68
136_C168_S0.6250.67
117_K142_W0.6200.67
46_S146_G0.6190.67
135_A171_T0.6180.67
165_D169_A0.6100.66
23_A82_R0.6050.65
36_G78_N0.6020.65
105_I123_F0.6010.64
53_R111_Y0.6010.64
87_A91_R0.5950.64
45_G145_D0.5940.63
150_C161_V0.5910.63
145_D150_C0.5910.63
113_I121_S0.5860.62
26_I103_A0.5860.62
133_K172_C0.5850.62
45_G48_I0.5850.62
140_R161_V0.5840.62
89_V102_K0.5830.62
113_I139_I0.5810.62
94_K124_Y0.5790.62
93_I105_I0.5790.62
61_K67_M0.5780.61
137_E140_R0.5760.61
39_T69_L0.5730.61
49_W63_V0.5730.61
30_F170_L0.5700.60
86_L89_V0.5690.60
42_Y112_N0.5660.60
121_S141_W0.5600.59
35_E112_N0.5570.59
100_P173_W0.5560.58
119_F124_Y0.5450.57
91_R119_F0.5430.57
127_L132_R0.5410.56
168_S171_T0.5410.56
55_A61_K0.5400.56
67_M73_K0.5360.56
85_A106_A0.5350.56
97_L101_Q0.5310.55
116_G120_P0.5300.55
31_L53_R0.5290.55
51_I77_V0.5210.54
150_C160_Q0.5200.53
56_T65_P0.5190.53
75_D79_A0.5170.53
27_L86_L0.5160.53
41_A56_T0.5070.52
26_I29_Q0.5070.52
44_D47_G0.5030.51
51_I67_M0.5020.51
113_I117_K0.5010.51
44_D56_T0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hdeA 2 0.9153 100 0.182 Contact Map
1xjtA 1 0.8983 100 0.191 Contact Map
1xjuA 2 0.8023 100 0.2 Contact Map
2anvA 4 0.8192 100 0.201 Contact Map
3hdfA 1 0.7514 100 0.204 Contact Map
4zwjA 1 0.7853 100 0.307 Contact Map
4yx7C 1 0.9209 100 0.309 Contact Map
4httA 1 0.0056 100 0.313 Contact Map
4e97A 1 0.8701 100 0.319 Contact Map
4iapA 2 0.8701 100 0.338 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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