GREMLIN Database
TFAQ - Tail fiber assembly protein homolog from lambdoid prophage Qin
UniProt: P76155 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13825
Length: 191 (184)
Sequences: 436 (302)
Seq/√Len: 22.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_D171_R5.2991.00
132_T136_L4.2891.00
45_I58_F3.1181.00
122_K126_I2.7820.99
152_D168_K2.7420.99
6_S10_R2.6430.99
69_E92_P2.6350.99
150_A176_R2.5870.99
150_A172_V2.5310.98
104_G107_Q2.4870.98
93_L97_V2.2370.96
156_A160_E2.1130.95
43_T58_F2.0680.94
156_A172_V2.0380.94
17_L43_T2.0270.93
172_V176_R2.0200.93
30_A36_T1.8990.91
147_L156_A1.8710.90
89_E94_P1.8440.90
76_V97_V1.8430.90
151_A156_A1.8180.89
152_D171_R1.7740.88
51_P67_L1.7660.87
168_K171_R1.7360.87
156_A176_R1.7260.86
156_A168_K1.7180.86
173_L176_R1.6780.85
168_K176_R1.6690.84
147_L150_A1.6090.82
150_A168_K1.6050.82
108_K117_D1.6050.82
150_A156_A1.5920.81
104_G116_K1.5860.81
149_D168_K1.5800.81
147_L168_K1.5740.81
155_I172_V1.5530.80
10_R35_H1.5040.77
71_H74_K1.4700.76
149_D156_A1.4660.75
74_K93_L1.4610.75
160_E176_R1.4450.74
116_K121_E1.4450.74
95_E119_E1.4400.74
168_K172_V1.4390.74
147_L172_V1.4370.74
150_A175_N1.4150.73
178_D181_T1.4070.72
75_T84_A1.4020.72
110_N113_A1.3990.72
51_P54_F1.3750.71
160_E175_N1.3710.70
147_L176_R1.3570.70
140_A167_W1.3510.69
149_D152_D1.3370.68
172_V175_N1.3340.68
151_A176_R1.3330.68
160_E172_V1.3120.67
155_I169_K1.2920.66
128_E132_T1.2710.64
137_M145_A1.2650.64
165_E169_K1.2620.64
141_S171_R1.2410.62
14_I24_F1.2380.62
147_L175_N1.2310.62
147_L160_E1.2100.60
147_L151_A1.2050.60
16_N33_P1.1950.59
149_D176_R1.1890.59
33_P37_G1.1770.58
158_E161_I1.1760.58
151_A171_R1.1750.58
10_R30_A1.1750.58
11_T48_P1.1720.58
55_V90_L1.1600.57
60_S79_V1.1540.57
147_L171_R1.1400.56
152_D156_A1.1350.55
150_A171_R1.1020.53
102_P107_Q1.1000.53
10_R36_T1.1000.53
148_Q152_D1.0970.53
56_A67_L1.0900.52
150_A160_E1.0820.52
152_D176_R1.0740.51
6_S35_H1.0520.50
167_W191_P1.0500.50
168_K174_L1.0480.50
9_P31_Y1.0420.49
30_A35_H1.0400.49
133_K148_Q1.0380.49
94_P97_V1.0310.48
31_Y37_G1.0150.47
18_L38_L1.0140.47
16_N28_G1.0020.46
166_A169_K1.0020.46
28_G39_P0.9910.46
120_A124_F0.9900.46
182_A185_I0.9880.45
26_G57_V0.9840.45
107_Q116_K0.9820.45
11_T17_L0.9750.45
32_I36_T0.9710.44
151_A160_E0.9700.44
71_H97_V0.9580.43
76_V93_L0.9430.42
41_N161_I0.9400.42
11_T43_T0.9380.42
155_I165_E0.9320.42
45_I56_A0.9260.41
106_F124_F0.9240.41
57_V66_H0.9200.41
17_L26_G0.9150.41
149_D172_V0.9100.40
141_S150_A0.8930.39
141_S149_D0.8920.39
78_D97_V0.8880.39
84_A99_W0.8850.39
43_T57_V0.8840.39
37_G40_A0.8840.39
130_E133_K0.8790.38
35_H42_S0.8750.38
32_I37_G0.8670.37
78_D82_G0.8620.37
79_V96_N0.8610.37
151_A172_V0.8590.37
148_Q163_L0.8510.36
169_K173_L0.8490.36
39_P48_P0.8400.36
50_I56_A0.8300.35
26_G29_D0.8290.35
160_E163_L0.8270.35
147_L164_L0.8240.35
111_G183_Q0.8230.35
143_H146_P0.8220.35
169_K172_V0.8200.34
174_L177_V0.8190.34
47_P65_W0.8110.34
157_T171_R0.8050.34
133_K144_I0.8050.34
146_P175_N0.8040.33
20_G42_S0.8030.33
162_S186_E0.7980.33
147_L152_D0.7970.33
146_P171_R0.7800.32
148_Q168_K0.7730.32
16_N37_G0.7730.32
70_D91_G0.7680.31
68_V90_L0.7640.31
153_L167_W0.7630.31
141_S144_I0.7600.31
154_E173_L0.7580.31
147_L167_W0.7580.31
10_R58_F0.7570.31
23_E47_P0.7570.31
32_I38_L0.7530.30
89_E96_N0.7520.30
77_Y93_L0.7510.30
148_Q169_K0.7480.30
144_I150_A0.7480.30
147_L153_L0.7460.30
150_A165_E0.7450.30
14_I25_I0.7450.30
38_L55_V0.7410.30
171_R176_R0.7340.29
8_Q20_G0.7340.29
167_W170_Y0.7330.29
151_A173_L0.7250.29
156_A173_L0.7160.28
152_D172_V0.7120.28
17_L39_P0.7100.28
145_A152_D0.7090.28
122_K125_R0.7090.28
133_K155_I0.7080.28
163_L181_T0.7060.28
157_T160_E0.7020.28
119_E159_E0.7010.28
16_N38_L0.6980.27
160_E169_K0.6960.27
41_N82_G0.6950.27
59_N63_S0.6940.27
78_D81_S0.6870.27
171_R175_N0.6870.27
188_P191_P0.6860.27
94_P189_A0.6840.27
71_H76_V0.6830.27
100_L121_E0.6670.26
65_W102_P0.6670.26
14_I38_L0.6620.25
31_Y77_Y0.6610.25
152_D157_T0.6600.25
159_E162_S0.6600.25
156_A175_N0.6590.25
7_E10_R0.6570.25
143_H147_L0.6520.25
130_E179_T0.6520.25
155_I168_K0.6510.25
93_L99_W0.6500.25
10_R34_P0.6480.25
32_I43_T0.6430.24
16_N26_G0.6410.24
85_L105_E0.6390.24
133_K149_D0.6360.24
104_G121_E0.6320.24
63_S166_A0.6320.24
41_N89_E0.6310.24
98_T114_W0.6310.24
95_E123_L0.6300.24
129_A185_I0.6280.24
157_T175_N0.6210.23
9_P34_P0.6200.23
96_N105_E0.6200.23
12_I31_Y0.6070.23
108_K113_A0.6030.23
150_A169_K0.6030.23
121_E125_R0.6010.22
21_T28_G0.6010.22
157_T161_I0.5990.22
10_R43_T0.5980.22
34_P95_E0.5970.22
87_I115_V0.5970.22
30_A34_P0.5950.22
153_L157_T0.5950.22
160_E165_E0.5940.22
106_F127_R0.5940.22
30_A87_I0.5940.22
38_L46_A0.5900.22
22_N58_F0.5890.22
103_E107_Q0.5860.22
143_H167_W0.5810.21
10_R45_I0.5810.21
30_A37_G0.5800.21
84_A115_V0.5780.21
9_P54_F0.5780.21
36_T42_S0.5770.21
108_K112_T0.5770.21
26_G51_P0.5710.21
17_L30_A0.5680.21
151_A168_K0.5670.21
46_A68_V0.5670.21
134_N184_D0.5670.21
139_V190_L0.5670.21
141_S168_K0.5580.20
24_F87_I0.5580.20
161_I165_E0.5560.20
76_V99_W0.5540.20
48_P67_L0.5520.20
55_V60_S0.5460.20
48_P56_A0.5410.20
18_L41_N0.5400.20
155_I171_R0.5380.20
14_I28_G0.5370.20
93_L96_N0.5320.19
133_K171_R0.5310.19
22_N66_H0.5310.19
37_G42_S0.5290.19
24_F56_A0.5270.19
12_I42_S0.5270.19
181_T190_L0.5260.19
79_V86_F0.5250.19
130_E148_Q0.5240.19
87_I90_L0.5230.19
152_D163_L0.5180.19
179_T182_A0.5170.19
149_D169_K0.5170.19
20_G89_E0.5110.18
152_D165_E0.5110.18
132_T135_N0.5070.18
149_D160_E0.5070.18
27_E46_A0.5050.18
8_Q34_P0.5050.18
44_D54_F0.5030.18
137_M149_D0.5020.18
16_N41_N0.5000.18
18_L39_P0.5000.18
86_F90_L0.5000.18
146_P150_A0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kz6A 1 0.5026 99.6 0.762 Contact Map
3kvpA 3 0.2094 13.5 0.96 Contact Map
1mdaH 1 0.4346 13.2 0.961 Contact Map
4wsfA 1 0.5812 9.2 0.963 Contact Map
4dnyA 1 0.5079 6.5 0.966 Contact Map
2lieA 1 0.466 5.9 0.966 Contact Map
1aa0A 3 0.267 5.2 0.967 Contact Map
3dsmA 1 0.4555 5.1 0.967 Contact Map
4qfuA 5 0.3979 4.6 0.968 Contact Map
1r6vA 1 0.4607 4.6 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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